Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs

International Journal of Pharmaceutics

Volumn 312, Issue 1-2, 2006, Pages 179-186

  Kocbek, P ^a   Baumgartner, S ^a   Kristl, J ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Dissolution rate; Granules; Ibuprofen; Melt emulsification method; Nanoparticles; Solvent diffusion method

Indexed keywords

IBUPROFEN; ORGANIC SOLVENT; POLYSORBATE 80; POVIDONE; SOLID LIPID NANOPARTICLE; STABILIZING AGENT;

ARTICLE; COOLING; DIFFUSION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG SOLUBILITY; EMULSION; FREEZE DRYING; PARTICLE SIZE; PATIENT SAFETY; POWDER; PRIORITY JOURNAL; STOMACH IRRITATION; SUSPENSION;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIFFUSION; EXCIPIENTS; IBUPROFEN; NANOSTRUCTURES; PARTICLE SIZE; SOLUBILITY; SOLVENTS; SUSPENSIONS;

EID: 33645030096     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.01.008     Document Type: Article

References (25)

1. A. Akkar, and R.H. Müller Intravenous itraconazole emulsions produced by SolEmuls technology Eur. J. Pharm. Biopharm. 56 2003 29 36
2. F. Debuigne, J. Cuisenaire, L. Jeunieau, B. Masereel, and J.B. Nagy Synthesis of nimesulid nanoparticles in the microemulsion epikuron/isopropyl myristate/water/n-butanol (or isopropanol) J. Colloid. Interface Sci. 243 2001 90 101
3. A. Fini, G. Fazio, and G. Feroci Solubility and solubilisation properties of non-steroidal anti-inflammatory drugs Int. J. Pharm. 126 1995 95 102
4. J. Hecq, M. Deleers, D. Fanara, H. Vranckx, and K. Amighi Preparation and characterisation of nanocrystals for solubility and dissolution rate enhancement of nifedipine Int. J. Pharm. 299 2005 167 177
5. C. Jacobs, O. Kayser, and R.H. Müller Production and characterisation of mucoadhesive nanosuspensions for the formulation of bupravaquone Int. J. Pharm. 214 2001 3 7
6. O. Kayser, C. Olbrich, V. Yardley, A.F. Kinderlen, and S.L. Croft Formulation of amphotericin B as nanosuspension for oral administration Int. J. Pharm. 254 2003 73 75
7. Kipp, J.E., Wong, J.C.T., Doty, M.J., Rebbeck, C.L., 2003. Microprecipitation method for preparing submicron suspensions, United States Patent 6,607,784, Baxter International Inc., Deerfield, IL, USA.
8. P. Langguth, A. Hanafy, D. Frenzel, P. Grenier, A. Nhamias, T. Ohlig, G. Vergnault, and H. Spahn-Langguth Nanosuspension formulations for low-soluble drugs: pharmacokinetic evaluation using spironolactone as model compound Drug. Dev. Ind. Pharm. 31 2005 319 329
9. M. Lindenberg, S. Knopp, and J.B. Dressman Classification of orally administered drugs on the World Health Organization model list of essential medicines according to the biopharmaceutics classification system Eur. J. Pharm. Biopharm. 58 2004 265 278
10. G.G. Liversidge, and P. Conzentino Drug particle size reduction for decreasing gastric irritancy and enhancing absorption of naproxen in rats Int. J. Pharm. 125 1995 309 313
11. J. Möschwitzer, G. Achleitner, H. Pomper, and R.H. Müller Development of an intravenously injectable chemically stable aqueous omeprazole formulation using nanosuspension technology Eur. J. Pharm. Biopharm. 58 2004 615 619
12. R.H. Müller, B.H.L. Böhm, and M.J. Grau Nanosuspensions: a formulation approach for poorly soluble and poorly bioavailable drugs D.L. Wise Handbook of Pharmaceutical Controlled Release Technology first ed. 2000 Marcel Dekker New York 345 357
13. R.H. Müller, and C.M. Keck Challenges and solutions for the delivery of biotech drugs - a review of drug nanocrystal technology and lipid nanoparticles J. Biotechnol. 113 2004 151 170
14. D. Myers Surfaces, Interfaces and Colloids: Principles and Applications second ed. 1999 Wiley-VCH New York pp. 253-294
15. B.J. Palla, and D.O. Shah Stabilization of high ionic strength slurries using surfactant mixtures: molecular factors that determine optimal stability J. Colloid. Interface Sci. 256 2002 143 152
16. N. Passerini, B. Albertini, M.L. González-Rodríguez, C. Cavallari, and L. Rodrigez Preparation and characterisation of ibuprofen-poloxamer 188 granules obtained by melt granulation Eur. J. Pharm. Sci. 15 2002 71 78
17. V.B. Patravale, A.A. Date, and R.M. Kulkarni Nanosuspensions: a promising drug delivery strategy J. Pharm. Pharmacol. 56 2004 827 840
18. K. Peters, S. Leitzke, J.E. Diederichs, K. Borner, H. Hahn, R.H. Müller, and S. Ehlers Preparation of clofazamine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in Mycobacterium avium infection J. Antimicrob. Chem. 45 2000 77 83
19. W. Peukert, H.C. Schwarzer, and F. Stenger Control of aggregation in production and handling of nanoparticles Chem. Eng. Process. 44 2005 245 252
20. G. Ponchel, M.J. Montisci, A. Dembri, C. Durrer, and D. Duchêne Mucoadhesion of colloidal particulate systems in the gastro-intestinal tract Eur. J. Pharm. Biopharm. 44 1997 25 31
21. D. Quintanar-Guerrero, D. Tamayo-Esquivel, A. Ganem-Quintanar, E. Allémann, and E. Doelker Adaptation and optimization of the emulsification-diffusion technique to prepare lipidic nanospheres Eur. J. Pharm. Sci. 26 2005 211 218
22. B.E. Rabinow Nanosuspensions in drug delivery Nat. Rev. Drug Discov. 3 2004 785 796
23. H. Sucker Hydrosole, eine Alternative für die Parenterale Anwendung von schwer wasser löslichen Wirkstoffen R.H. Müller G.E. Hildebrand Pharmazeutische Technologie: Moderne Arzneiformen, Lerbuch für Studierende der Pharmazie second ed. 1998 Wisserschaftliche Verlagsgesellshaft mbH Stuttgart 383 391
24. M. Trotta, M. Gallarete, F. Pattarino, and S. Morel Emulsions containing partially water-miscible solvents for the preparation of drug nanosuspensions J. Control. Release 76 2001 119 128
25. Y. Yeo, O.A. Basaran, and K. Park A new process for making reservoir-type microcapsules using inkjet technology and interfacial phase separation J. Control. Release 93 2003 161 173