-
1
-
-
0344378602
-
Polymer-drug conjugates
-
Budman D, Calvert H, Rowinsky E, eds, Baltimore, MD: Lippincott Williams & Wilkins;
-
Duncan R. Polymer-drug conjugates. In: Budman D, Calvert H, Rowinsky E, eds. Handbook of Anticancer Drug Development. Baltimore, MD: Lippincott Williams & Wilkins;2003:239-260.
-
(2003)
Handbook of Anticancer Drug Development
, pp. 239-260
-
-
Duncan, R.1
-
2
-
-
0022858683
-
A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
-
Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 1986;46:6387-6392.
-
(1986)
Cancer Res
, vol.46
, pp. 6387-6392
-
-
Matsumura, Y.1
Maeda, H.2
-
3
-
-
33747840618
-
Polymer conjugates as anticancer nanomedicines
-
Duncan R. Polymer conjugates as anticancer nanomedicines. Nat Rev Cancer. 2006;6:688-701.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 688-701
-
-
Duncan, R.1
-
4
-
-
33747758790
-
Polymer therapeutics for cancer: Current status and future challenges
-
Satchi-Fainaro R, Duncan R, Barnes CM. Polymer therapeutics for cancer: current status and future challenges. Adv Polym Sci. 2006; 193:1-65.
-
(2006)
Adv Polym Sci
, vol.193
, pp. 1-65
-
-
Satchi-Fainaro, R.1
Duncan, R.2
Barnes, C.M.3
-
5
-
-
29544448116
-
Polymer conjugates: Nanosized medicines for treating cancer
-
Vicent MJ, Duncan R. Polymer conjugates: nanosized medicines for treating cancer. Trends Biotechnol. 2006;24:39-47.
-
(2006)
Trends Biotechnol
, vol.24
, pp. 39-47
-
-
Vicent, M.J.1
Duncan, R.2
-
6
-
-
33646255225
-
Polymer-drug conjugates: Progress in polymeric prodrugs
-
Khandare J, Minko T. Polymer-drug conjugates: progress in polymeric prodrugs. Prog Polym Sci. 2006;31:359-397.
-
(2006)
Prog Polym Sci
, vol.31
, pp. 359-397
-
-
Khandare, J.1
Minko, T.2
-
7
-
-
0142217555
-
Apoptosis: Target for novel drugs
-
Alam JJ. Apoptosis: target for novel drugs. Trends Biotechnol. 2003;21:479-483.
-
(2003)
Trends Biotechnol
, vol.21
, pp. 479-483
-
-
Alam, J.J.1
-
9
-
-
21244493239
-
Polymer therapeutics designed for a combination therapy of hormone-dependent cancer
-
Vicent MJ, Greco F, Nicholson RI, Paul A, Griffiths PC, Duncan R. Polymer therapeutics designed for a combination therapy of hormone-dependent cancer. Angew Chem Int Ed Engl. 2005;44:4061-4066.
-
(2005)
Angew Chem Int Ed Engl
, vol.44
, pp. 4061-4066
-
-
Vicent, M.J.1
Greco, F.2
Nicholson, R.I.3
Paul, A.4
Griffiths, P.C.5
Duncan, R.6
-
10
-
-
0036463649
-
Apoptosis-based therapies
-
Reed JC. Apoptosis-based therapies. Nat Rev Drug Discov. 2002;1:111-121.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 111-121
-
-
Reed, J.C.1
-
11
-
-
26444434342
-
Pharmacological manipulation of cell death: Clinical applications in sight?
-
Green DR, Kroemer G. Pharmacological manipulation of cell death: clinical applications in sight? J Clin Invest. 2005;115:2610-2617.
-
(2005)
J Clin Invest
, vol.115
, pp. 2610-2617
-
-
Green, D.R.1
Kroemer, G.2
-
12
-
-
20444430478
-
Apoptotic pathways: Ten minutes to dead
-
Green DR. Apoptotic pathways: ten minutes to dead. Cell. 2005;121:671-674.
-
(2005)
Cell
, vol.121
, pp. 671-674
-
-
Green, D.R.1
-
13
-
-
26444489119
-
Connected to death: The (unexpurgated) mitochondrial pathway of apoptosis
-
Spierings D, McStay G, Saleh M, et al. Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis. Science. 2005;310:66-67.
-
(2005)
Science
, vol.310
, pp. 66-67
-
-
Spierings, D.1
McStay, G.2
Saleh, M.3
-
15
-
-
0033596980
-
An APAF-1 center dot cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
-
Zou H, Li YC, Liu HS, Wang XD. An APAF-1 center dot cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem. 1999;274:11549-11556.
-
(1999)
J Biol Chem
, vol.274
, pp. 11549-11556
-
-
Zou, H.1
Li, Y.C.2
Liu, H.S.3
Wang, X.D.4
-
16
-
-
0034710649
-
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
-
Chai JJ, Du CY, Wu JW, Kyin S, Wang XD, Shi YG. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature. 2000;406:855-862.
-
(2000)
Nature
, vol.406
, pp. 855-862
-
-
Chai, J.J.1
Du, C.Y.2
Wu, J.W.3
Kyin, S.4
Wang, X.D.5
Shi, Y.G.6
-
17
-
-
21144451097
-
Specific ablation of the apoptotic functions of cytochrome c reveals a differential requirement for cytochrome c and apaf-1 in apoptosis
-
Hao ZY, Duncan GS, Chang CC, et al. Specific ablation of the apoptotic functions of cytochrome c reveals a differential requirement for cytochrome c and apaf-1 in apoptosis. Cell. 2005;121:579-591.
-
(2005)
Cell
, vol.121
, pp. 579-591
-
-
Hao, Z.Y.1
Duncan, G.S.2
Chang, C.C.3
-
18
-
-
17244368276
-
Structure of the apoptotic protease-activating factor 1 bound to ADP
-
Riedl SJ, Li WY, Chao Y, Schwarzenbacher R, Shi YG. Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature. 2005;434:926-933.
-
(2005)
Nature
, vol.434
, pp. 926-933
-
-
Riedl, S.J.1
Li, W.Y.2
Chao, Y.3
Schwarzenbacher, R.4
Shi, Y.G.5
-
19
-
-
16344362141
-
A nucleotide binding site in caspase-9 regulates apoptosome activation
-
Chereau D, Zou H, Spada AP, Wu JC. A nucleotide binding site in caspase-9 regulates apoptosome activation. Biochemistry. 2005;44:4971-4976.
-
(2005)
Biochemistry
, vol.44
, pp. 4971-4976
-
-
Chereau, D.1
Zou, H.2
Spada, A.P.3
Wu, J.C.4
-
20
-
-
0034630167
-
Induction of apoptosis by cancer chemotherapy
-
Kaufmann SH, Earnshaw WC. Induction of apoptosis by cancer chemotherapy. Exp Cell Res. 2000;256:42-49.
-
(2000)
Exp Cell Res
, vol.256
, pp. 42-49
-
-
Kaufmann, S.H.1
Earnshaw, W.C.2
-
21
-
-
0032959549
-
Phase I clinical and pharmacokinetic study of PK1 N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin: Fi rst member of a new class of chemotherapeutic agents - drug-polymer conjugates
-
Vasey PA, Kaye SB, Morrison R, et al. Phase I clinical and pharmacokinetic study of PK1 N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin: fi rst member of a new class of chemotherapeutic agents - drug-polymer conjugates. Clin Cancer Res. 1999;5:83-94.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 83-94
-
-
Vasey, P.A.1
Kaye, S.B.2
Morrison, R.3
-
22
-
-
0034883396
-
Mechanisms of anticancer action of HPMA copolymer-bound doxorubicin
-
Minko T, Kopeckova P, Kopecek J. Mechanisms of anticancer action of HPMA copolymer-bound doxorubicin. Macromol Symp. 2001;172:35-48.
-
(2001)
Macromol Symp
, vol.172
, pp. 35-48
-
-
Minko, T.1
Kopeckova, P.2
Kopecek, J.3
-
23
-
-
1042288957
-
HPMA copolymer-bound doxorubicin targeted to tumor-specifi c antigen of BCL1 mouse B cell leukemia
-
Kovar M, Mrkvan T, Strohalm J, et al. HPMA copolymer-bound doxorubicin targeted to tumor-specifi c antigen of BCL1 mouse B cell leukemia. J Control Release. 2003;92:315-330.
-
(2003)
J Control Release
, vol.92
, pp. 315-330
-
-
Kovar, M.1
Mrkvan, T.2
Strohalm, J.3
-
24
-
-
0037122737
-
Acquired and specific immunological mechanism co-responsible for effi cacy of polymer-bound drugs
-
Rihova B, Strohalm J, Kubackova K, et al. Acquired and specific immunological mechanism co-responsible for effi cacy of polymer-bound drugs. J Control Release. 2002;78:97-114.
-
(2002)
J Control Release
, vol.78
, pp. 97-114
-
-
Rihova, B.1
Strohalm, J.2
Kubackova, K.3
-
25
-
-
0141548120
-
Cytostatic and immunomobilizing activities of polymer-bound drugs: Experimental and first clinical data
-
Rihova B, Strohalm J, Prausova J, et al. Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data. J Control Release. 2003;91:1-16.
-
(2003)
J Control Release
, vol.91
, pp. 1-16
-
-
Rihova, B.1
Strohalm, J.2
Prausova, J.3
-
26
-
-
84969784315
-
N-(2-hydroxypropyl)methacrylamide copolymer conjugates
-
Kwon GS, ed, New York, NY: Marcel Dekker, Inc;
-
Duncan R. N-(2-hydroxypropyl)methacrylamide copolymer conjugates. In: Kwon GS, ed. Polymeric Drug Delivery Systems. New York, NY: Marcel Dekker, Inc; 2005:1-92.
-
(2005)
Polymeric Drug Delivery Systems
, pp. 1-92
-
-
Duncan, R.1
-
27
-
-
0032101105
-
Complete regression of well-established tumors using novel water-soluable poly(L-glutamic acid)-paclitaxel conjugate
-
Li C, Yu DF, Newman R, et al. Complete regression of well-established tumors using novel water-soluable poly(L-glutamic acid)-paclitaxel conjugate. Cancer Res. 1998;58:2404-2409.
-
(1998)
Cancer Res
, vol.58
, pp. 2404-2409
-
-
Li, C.1
Yu, D.F.2
Newman, R.3
-
28
-
-
28444450450
-
Paclitaxel poliglumex (XYOTAX™, CT-2103): A macromolecular taxane
-
Singer JW. Paclitaxel poliglumex (XYOTAX™, CT-2103): a macromolecular taxane. J Control Release. 2005;109:120-126.
-
(2005)
J Control Release
, vol.109
, pp. 120-126
-
-
Singer, J.W.1
-
29
-
-
33750967313
-
Effect of gender on outcome in two randomized phase III trials of paclitaxel poliglumex (PPX) in chemonaive patients with advanced NSCLC and poor performance status (PS2) [abstract]
-
Ross H, Bonomi P, Langer C. Effect of gender on outcome in two randomized phase III trials of paclitaxel poliglumex (PPX) in chemonaive patients with advanced NSCLC and poor performance status (PS2) [abstract]. Clin Oncol. 2006;97:.
-
(2006)
Clin Oncol
, pp. 97
-
-
Ross, H.1
Bonomi, P.2
Langer, C.3
-
30
-
-
84863621092
-
Analysis of prognostic factors in chemo-naive patients with advanced NSCLC and poor performance status (PS): Cox regression analysis of two phase III trials [abstract]
-
O'Brien M, Bonomi P, Langer C. Analysis of prognostic factors in chemo-naive patients with advanced NSCLC and poor performance status (PS): Cox regression analysis of two phase III trials [abstract]. Clin Oncol. 2006;97:.
-
(2006)
Clin Oncol
, pp. 97
-
-
O'Brien, M.1
Bonomi, P.2
Langer, C.3
-
31
-
-
0033629139
-
Comparison of action of paclitaxel and poly(L-glutamic acid)paclitaxel conjugate in human breast cancer cells
-
Oldham EA, Li C, Ke S, Wallace S, Huang P. Comparison of action of paclitaxel and poly(L-glutamic acid)paclitaxel conjugate in human breast cancer cells. Int J Oncol. 2000;16:125-132.
-
(2000)
Int J Oncol
, vol.16
, pp. 125-132
-
-
Oldham, E.A.1
Li, C.2
Ke, S.3
Wallace, S.4
Huang, P.5
-
32
-
-
0037413560
-
Synthesis and in vivo antitumor activity of poly(L-glutamic acid) conjugates of 20(S)-camptothecin
-
Bhatt R, de Vries P, Tulinsky J, et al. Synthesis and in vivo antitumor activity of poly(L-glutamic acid) conjugates of 20(S)-camptothecin. J Med Chem. 2003;46:190-193.
-
(2003)
J Med Chem
, vol.46
, pp. 190-193
-
-
Bhatt, R.1
de Vries, P.2
Tulinsky, J.3
-
33
-
-
0024324205
-
On the mechanism of topoisomerase-I inhibition by camptothecin - evidence for binding to an enzyme DNA complex
-
Hertzberg RP, Caranfa MJ, Hecht SM. On the mechanism of topoisomerase-I inhibition by camptothecin - evidence for binding to an enzyme DNA complex. Biochemistry. 1989;28:4629-4638.
-
(1989)
Biochemistry
, vol.28
, pp. 4629-4638
-
-
Hertzberg, R.P.1
Caranfa, M.J.2
Hecht, S.M.3
-
34
-
-
27744554658
-
Phase 1 study of weekly polyethylene glycol-camptothecin in patients with advanced solid tumors and lymphomas
-
Posey JA, Saif MW, Carlisle R, et al. Phase 1 study of weekly polyethylene glycol-camptothecin in patients with advanced solid tumors and lymphomas. Clin Cancer Res. 2005;11:7866-7871.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7866-7871
-
-
Posey, J.A.1
Saif, M.W.2
Carlisle, R.3
-
35
-
-
33645087362
-
Preclinical efficacy of the camptothecin-polymer conjugate IT-101 in multiple cancer models
-
Schluep T, Hwang J, Cheng JJ, et al. Preclinical efficacy of the camptothecin-polymer conjugate IT-101 in multiple cancer models. Clin Cancer Res. 2006;12:1606-1614.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1606-1614
-
-
Schluep, T.1
Hwang, J.2
Cheng, J.J.3
-
36
-
-
32544451450
-
Clinical and pharmacokinetic study evaluating the effect of food on the disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in patients with solid tumors
-
Zamboni WC, Goel S, Iqbal T, et al. Clinical and pharmacokinetic study evaluating the effect of food on the disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in patients with solid tumors. Cancer Chem Pharmacol. 2006;57:631-639.
-
(2006)
Cancer Chem Pharmacol
, vol.57
, pp. 631-639
-
-
Zamboni, W.C.1
Goel, S.2
Iqbal, T.3
-
37
-
-
32544454332
-
Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor-bearing mice
-
Schluep T, Cheng JJ, Khin KT, Davis ME. Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor-bearing mice. Cancer Chem Pharmacol. 2006;57:654-662.
-
(2006)
Cancer Chem Pharmacol
, vol.57
, pp. 654-662
-
-
Schluep, T.1
Cheng, J.J.2
Khin, K.T.3
Davis, M.E.4
-
38
-
-
0036354863
-
Enhancing the anticancer efficacy of camptothecin using biotinylated poly(ethyleneglycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells
-
Minko T, Paranjpe PV, Qiu B, et al. Enhancing the anticancer efficacy of camptothecin using biotinylated poly(ethyleneglycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells. Cancer Chem Pharmacol. 2002;50:143-150.
-
(2002)
Cancer Chem Pharmacol
, vol.50
, pp. 143-150
-
-
Minko, T.1
Paranjpe, P.V.2
Qiu, B.3
-
39
-
-
0141886989
-
Molecular targeting of drug delivery systems to ovarian cancer by BH3 and LHRH peptides
-
Dharap SS, Qiu B, Williams GC, Sinko P, Stein S, Minko T. Molecular targeting of drug delivery systems to ovarian cancer by BH3 and LHRH peptides. J Control Release. 2003;91:61-73.
-
(2003)
J Control Release
, vol.91
, pp. 61-73
-
-
Dharap, S.S.1
Qiu, B.2
Williams, G.C.3
Sinko, P.4
Stein, S.5
Minko, T.6
-
40
-
-
24644496584
-
Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide
-
Dharap SS, Wang Y, Chandna P, et al. Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide. Proc Natl Acad Sci USA. 2005;102:12962-12967.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 12962-12967
-
-
Dharap, S.S.1
Wang, Y.2
Chandna, P.3
-
41
-
-
33751562849
-
Polymer genomics: An insight into pharmacology and toxicology of nanomedicines
-
Kabanov AV. Polymer genomics: an insight into pharmacology and toxicology of nanomedicines. Adv Drug Deliv Rev. 2006; 58:1597-1621.
-
(2006)
Adv Drug Deliv Rev
, vol.58
, pp. 1597-1621
-
-
Kabanov, A.V.1
-
42
-
-
34347222792
-
Target-directed in vitro and in vivo testing procedures for the discovery of anticancer agents
-
Fiebig HH, Burger AM. Target-directed in vitro and in vivo testing procedures for the discovery of anticancer agents. Clin Cancer Res. 1999;5:S3870-S3870.
-
(1999)
Clin Cancer Res
, vol.5
-
-
Fiebig, H.H.1
Burger, A.M.2
-
43
-
-
33845313345
-
The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review
-
Eskens F, Verweij J. The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review. Eur J Cancer. 2006;42:3127-3139.
-
(2006)
Eur J Cancer
, vol.42
, pp. 3127-3139
-
-
Eskens, F.1
Verweij, J.2
-
44
-
-
33845286942
-
Vascular disrupting agents
-
Lippert JW, III. Vascular disrupting agents. Bioorg Med Chem. 2007;15:605-615.
-
(2007)
Bioorg Med Chem
, vol.15
, pp. 605-615
-
-
Lippert III, J.W.1
-
45
-
-
33846179026
-
Recent advances in the design and discovery of small-molecule therapeutics targeting HER2/neu
-
Dayam R, Grande F, Al-Mawsawi LQ, Neamati N. Recent advances in the design and discovery of small-molecule therapeutics targeting HER2/neu. Expert Opin Ther Pat. 2007;17:83-102.
-
(2007)
Expert Opin Ther Pat
, vol.17
, pp. 83-102
-
-
Dayam, R.1
Grande, F.2
Al-Mawsawi, L.Q.3
Neamati, N.4
-
46
-
-
2342586114
-
Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470
-
Satchi-Fainaro R, Puder M, Davies JW, et al. Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470. Nat Med. 2004;10:255-261.
-
(2004)
Nat Med
, vol.10
, pp. 255-261
-
-
Satchi-Fainaro, R.1
Puder, M.2
Davies, J.W.3
-
47
-
-
4444296218
-
TNP-470 promotes initial vascular sprouting in xenograft tumors
-
Huang JZ, Frischer JS, New T, et al. TNP-470 promotes initial vascular sprouting in xenograft tumors. Mol Cancer Ther. 2004;3:335-343.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 335-343
-
-
Huang, J.Z.1
Frischer, J.S.2
New, T.3
-
48
-
-
0037312485
-
Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma
-
Inoue K, Chikazawa M, Fukata S, Yoshikawa C, Shuin T. Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma. Clin Cancer Res. 2003;9:886-899.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 886-899
-
-
Inoue, K.1
Chikazawa, M.2
Fukata, S.3
Yoshikawa, C.4
Shuin, T.5
-
49
-
-
0037242284
-
Reduction of vascular and permeable regions in solid tumors detected by macromolecular contrast magnetic resonance imaging after treatment with antiangiogenic agent TNP-470
-
Bhujwalla ZM, Artemov D, Natarajan K, Solaiyappan M, Kollars P, Kristjansen PEG. Reduction of vascular and permeable regions in solid tumors detected by macromolecular contrast magnetic resonance imaging after treatment with antiangiogenic agent TNP-470. Clin Cancer Res. 2003;9:355-362.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 355-362
-
-
Bhujwalla, Z.M.1
Artemov, D.2
Natarajan, K.3
Solaiyappan, M.4
Kollars, P.5
Kristjansen, P.E.G.6
-
50
-
-
31844433076
-
Polymer-peptide conjugates for angiogenesis targeted tumor radiotherapy
-
Mitra A, Nan A, Papadimitriou JC, Ghandehari H, Line BR. Polymer-peptide conjugates for angiogenesis targeted tumor radiotherapy. Nucl Med Biol. 2006;33:43-52.
-
(2006)
Nucl Med Biol
, vol.33
, pp. 43-52
-
-
Mitra, A.1
Nan, A.2
Papadimitriou, J.C.3
Ghandehari, H.4
Line, B.R.5
-
51
-
-
13944263708
-
Pegylated Arg-Gly-Asp peptide: Cu-64 labeling and PET imaging of brain tumor alpha(v)beta(3)-integrin expression
-
Chen X, Hou Y, Tohme M, et al. Pegylated Arg-Gly-Asp peptide: Cu-64 labeling and PET imaging of brain tumor alpha(v)beta(3)-integrin expression. J Nucl Med. 2004;45:1776-1783.
-
(2004)
J Nucl Med
, vol.45
, pp. 1776-1783
-
-
Chen, X.1
Hou, Y.2
Tohme, M.3
-
52
-
-
4544291850
-
MicroPET and autoradiographic imaging of GRP receptor expression with Cu-64-DOTA-Lys(3) bombesin in human prostate adenocarcinoma xenografts
-
Chen X, Park R, Hou Y, et al. MicroPET and autoradiographic imaging of GRP receptor expression with Cu-64-DOTA-Lys(3) bombesin in human prostate adenocarcinoma xenografts. J Nucl Med. 2004;45:1390-1397.
-
(2004)
J Nucl Med
, vol.45
, pp. 1390-1397
-
-
Chen, X.1
Park, R.2
Hou, Y.3
-
53
-
-
1442335327
-
Shooting at survivors: Bcl-2 family members as drug targets for cancer
-
Juin P, Geneste O, Raimbaud E, Hickman JA. Shooting at survivors: Bcl-2 family members as drug targets for cancer. Biochim Biophys Acta. 2004;1644:251-260.
-
(2004)
Biochim Biophys Acta
, vol.1644
, pp. 251-260
-
-
Juin, P.1
Geneste, O.2
Raimbaud, E.3
Hickman, J.A.4
-
54
-
-
0038387390
-
The dawning era of polymer therapeutics
-
Duncan R. The dawning era of polymer therapeutics. Nat Rev Drug Discov. 2003;2:347-360.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 347-360
-
-
Duncan, R.1
-
55
-
-
34347210918
-
Using N-(2-hydroxypropyl) methacrylamide copolymer drug bioconjugate as a novel approach to deliver a Bcl-2-targeting compound HA14-1 in vivo
-
Oman M, Liu JH, Chen J, et al. Using N-(2-hydroxypropyl) methacrylamide copolymer drug bioconjugate as a novel approach to deliver a Bcl-2-targeting compound HA14-1 in vivo. Gene Ther Mol Biol. 2006;10A:113-122.
-
(2006)
Gene Ther Mol Biol
, vol.10 A
, pp. 113-122
-
-
Oman, M.1
Liu, J.H.2
Chen, J.3
-
56
-
-
0036606394
-
Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide
-
Fang J, Sawa T, Akaike T, Maeda H. Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide. Cancer Res. 2002;62:3138-3143.
-
(2002)
Cancer Res
, vol.62
, pp. 3138-3143
-
-
Fang, J.1
Sawa, T.2
Akaike, T.3
Maeda, H.4
-
57
-
-
34347221448
-
-
Fang J, Sawa T, Maeda H. Factors and Mechanism of EPR Effect and the Enhanced Antitumor Effects of Macromolecular Drugs Including SMANCS Book Series Advances in Experimental Medicine and Biology. In: Maeda H, Kabanov A, Kataoka K, Okano T, eds. Polymer Drugs in the Clinical Stage. Dordrecht, The Netherlands: SpringerLink Netherlands; 2004:29-49.
-
Fang J, Sawa T, Maeda H. Factors and Mechanism of "EPR" Effect and the Enhanced Antitumor Effects of Macromolecular Drugs Including SMANCS Book Series Advances in Experimental Medicine and Biology. In: Maeda H, Kabanov A, Kataoka K, Okano T, eds. Polymer Drugs in the Clinical Stage. Dordrecht, The Netherlands: SpringerLink Netherlands; 2004:29-49.
-
-
-
-
58
-
-
1442326158
-
Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment
-
Fang J, Akaike T, Maeda H. Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment. Apoptosis. 2004;9:27-35.
-
(2004)
Apoptosis
, vol.9
, pp. 27-35
-
-
Fang, J.1
Akaike, T.2
Maeda, H.3
-
59
-
-
0842308157
-
Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin
-
Fang J, Sawa T, Akaike T, Greish K, Maeda H. Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin. Int J Cancer. 2004;109:1-8.
-
(2004)
Int J Cancer
, vol.109
, pp. 1-8
-
-
Fang, J.1
Sawa, T.2
Akaike, T.3
Greish, K.4
Maeda, H.5
-
60
-
-
0036740180
-
Pegylated zinc protoporphyrin: A water-soluble heme oxygenase inhibitor with tumor-targeting capacity
-
Sahoo SK, Sawa T, Fang J, et al. Pegylated zinc protoporphyrin: a water-soluble heme oxygenase inhibitor with tumor-targeting capacity. Bioconjugate Chem. 2002;13:1031-1038.
-
(2002)
Bioconjugate Chem
, vol.13
, pp. 1031-1038
-
-
Sahoo, S.K.1
Sawa, T.2
Fang, J.3
-
61
-
-
0038418359
-
In vivo antitumor activity of pegylated zinc protoporphyrin: Targeted inhibition of heme oxygenase in solid tumor
-
Fang J, Sawa T, Akaike T, et al. In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor. Cancer Res. 2003;63:3567-3574.
-
(2003)
Cancer Res
, vol.63
, pp. 3567-3574
-
-
Fang, J.1
Sawa, T.2
Akaike, T.3
-
62
-
-
29444447454
-
Phase II study of paclitaxel poliglumex (PPX)/carboplatin (C) for 1st line induction and maintenance therapy of stage III/IV ovarian or primary peritoneal carcinoma
-
Herzog T, Barret RJ, Edwards R, Oldham FB. Phase II study of paclitaxel poliglumex (PPX)/carboplatin (C) for 1st line induction and maintenance therapy of stage III/IV ovarian or primary peritoneal carcinoma. J Clin Oncol. 2005;23:16S.
-
(2005)
J Clin Oncol
, vol.23
-
-
Herzog, T.1
Barret, R.J.2
Edwards, R.3
Oldham, F.B.4
-
63
-
-
33846549188
-
Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells
-
Greco F, Vicent MJ, Gee S, et al. Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells. J Control Release. 2007;117:28-39.
-
(2007)
J Control Release
, vol.117
, pp. 28-39
-
-
Greco, F.1
Vicent, M.J.2
Gee, S.3
-
64
-
-
33646248643
-
Nitric oxide modulates proapoptotic and antiapoptotic properties of chemotherapy agents: The case of NO-pegylated epirubicin
-
Santucci L, Mencarelli A, Renga B, et al. Nitric oxide modulates proapoptotic and antiapoptotic properties of chemotherapy agents: the case of NO-pegylated epirubicin. FASEB J. 2006;20:765-775.
-
(2006)
FASEB J
, vol.20
, pp. 765-775
-
-
Santucci, L.1
Mencarelli, A.2
Renga, B.3
-
65
-
-
33646768989
-
Novel polymeric prodrug with multivalent components for cancer therapy
-
Khandare JJ, Chandna P, Wang Y, Pozharov VP, Minko T. Novel polymeric prodrug with multivalent components for cancer therapy. J Pharmacol Exp Ther. 2006;317:929-937.
-
(2006)
J Pharmacol Exp Ther
, vol.317
, pp. 929-937
-
-
Khandare, J.J.1
Chandna, P.2
Wang, Y.3
Pozharov, V.P.4
Minko, T.5
-
66
-
-
34347241224
-
Novel PEG conjugates releasing nitric oxide: Preparation and activity against oxidative stress in ischemia reperfusion injury
-
Paper presented at: June 21-26, Vienna, Austria
-
Pasut G, Mero A, Bertuglia S, Veronese FM. Novel PEG conjugates releasing nitric oxide: preparation and activity against oxidative stress in ischemia reperfusion injury. Paper presented at: 33rd Annual Meeting & Expo of the Controlled Release Society; June 21-26, 2006; Vienna, Austria.
-
(2006)
33rd Annual Meeting & Expo of the Controlled Release Society
-
-
Pasut, G.1
Mero, A.2
Bertuglia, S.3
Veronese, F.M.4
-
67
-
-
0036187036
-
Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
-
Acehan D, Jiang XJ, Morgan DG, Heuser JE, Wang XD, Akey CW. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell. 2002;9:423-432.
-
(2002)
Mol Cell
, vol.9
, pp. 423-432
-
-
Acehan, D.1
Jiang, X.J.2
Morgan, D.G.3
Heuser, J.E.4
Wang, X.D.5
Akey, C.W.6
-
68
-
-
0142027846
-
Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex
-
Lademann U, Cain K, Gyrd-Hansen M, Brown D, Peters D, Jaattela M. Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex. Mol Cell Biol. 2003;23:7829-7837.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7829-7837
-
-
Lademann, U.1
Cain, K.2
Gyrd-Hansen, M.3
Brown, D.4
Peters, D.5
Jaattela, M.6
-
69
-
-
33747055098
-
Small molecule inhibitors of Apaf-1-related caspase-3/-9 activation that control mitochondrial-dependent apoptosis
-
Malet G, Martín AG, Orzáez M, et al. Small molecule inhibitors of Apaf-1-related caspase-3/-9 activation that control mitochondrial-dependent apoptosis. Cell Death Differ. 2006;13:1523-1532.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1523-1532
-
-
Malet, G.1
Martín, A.G.2
Orzáez, M.3
-
70
-
-
33745667947
-
Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): An antiapoptotic polymeric nanomedicine
-
Vicent MJ, Pérez-Payá E. Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine. J Med Chem. 2006;49:3763-3765.
-
(2006)
J Med Chem
, vol.49
, pp. 3763-3765
-
-
Vicent, M.J.1
Pérez-Payá, E.2
-
71
-
-
26844501695
-
Anticancer therapeutics: "addictive" targets, multi-targeted drugs, new drug combinations
-
Broxterman HJ, Georgopapadakou NH. Anticancer therapeutics: "addictive" targets, multi-targeted drugs, new drug combinations. Drug Resist Updat. 2005;8:183-197.
-
(2005)
Drug Resist Updat
, vol.8
, pp. 183-197
-
-
Broxterman, H.J.1
Georgopapadakou, N.H.2
-
72
-
-
33748794547
-
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
-
Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 2006;58:621-681.
-
(2006)
Pharmacol Rev
, vol.58
, pp. 621-681
-
-
Chou, T.C.1
-
73
-
-
33745937903
-
Drug combination strategies for osteoporosis
-
Audran M. Drug combination strategies for osteoporosis. Joint Bone Spine. 2006;73:374-378.
-
(2006)
Joint Bone Spine
, vol.73
, pp. 374-378
-
-
Audran, M.1
-
74
-
-
33745823505
-
Successful treatment with novel triple drug combination consisting of interferongamma, interferon alfacon-1, and ribavirin in a nonresponder HCV patient to pegylated interferon therapy
-
Balan V, Rosati MJ, Anderson MH, Rakela J. Successful treatment with novel triple drug combination consisting of interferongamma, interferon alfacon-1, and ribavirin in a nonresponder HCV patient to pegylated interferon therapy. Dig Dis Sci. 2006; 51:956-959.
-
(2006)
Dig Dis Sci
, vol.51
, pp. 956-959
-
-
Balan, V.1
Rosati, M.J.2
Anderson, M.H.3
Rakela, J.4
-
75
-
-
34347210196
-
In vitro drug combination investigation could assist clinical study design
-
Blank-Porat D, Nudelman A, Berkovitch G, Malik Z, Rephaeli A. In vitro drug combination investigation could assist clinical study design. Clin Cancer Res. 2005;11:8988S.
-
(2005)
Clin Cancer Res
, vol.11
-
-
Blank-Porat, D.1
Nudelman, A.2
Berkovitch, G.3
Malik, Z.4
Rephaeli, A.5
-
76
-
-
34347229299
-
Strategies for assessment of drug combination therapy: Response surface modeling of MTT assays to assess target agent synergy via cell survival
-
Gupta M, Robinson B, Felix C, Barrett J. Strategies for assessment of drug combination therapy: response surface modeling of MTT assays to assess target agent synergy via cell survival. J Clin Pharmacol. 2005;45:1093.
-
(2005)
J Clin Pharmacol
, vol.45
, pp. 1093
-
-
Gupta, M.1
Robinson, B.2
Felix, C.3
Barrett, J.4
-
77
-
-
33745703563
-
Polymer therapeutics: Concepts and applications
-
Haag R, Kratz F. Polymer therapeutics: concepts and applications. Angew Chem Int Ed Engl. 2006;45:1198-1215.
-
(2006)
Angew Chem Int Ed Engl
, vol.45
, pp. 1198-1215
-
-
Haag, R.1
Kratz, F.2
|