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Volumn 9, Issue 2, 2007, Pages

Polymer-drug conjugates as modulators of cellular apoptosis

Author keywords

Apoptosis modulators; Polymer drug conjugates; Targeted delivery

Indexed keywords

2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAMPTOTHECIN; COPPER 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID MACROGOL ARGINYLGLYCYLASPARTIC ACID CO 64 CONJUGATE; CT 2106; CYCLODEXTRIN CAMPTOTHECIN CONJUGATE; CYTOKINE; DOXORUBICIN; EZ 246; FCE 28068; FUMAGILLOL CHLOROACETYLCARBAMATE; IODINE MACROGOL ARGINYLGLYCYLASPARTIC ACID 1 125 CONJUGATE; MACROGOL; MACROGOL AMINOADIPIC ACID EPIRUBICIN NITRIC OXIDE CONJUGATE; MACROGOL CAMPTOTHECIN BH3 PROTEIN CONJUGATE; MACROGOL CAMPTOTHECIN CONJUGATE; MACROGOL CAMPTOTHECIN GONADORELIN RECEPTOR CONJUGATE; MACROGOL PEPTOID CONJUGATE; MACROGOL PROTOPORPHYRIN ZINC CONJUGATE; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER AMINOGLUTETHIMIDE DOXORUBICIN CONJUGATE; N (2 HYDROXYPROPYL)METHACRYLAMIDE DOXORUBICIN CONJUGATE; PACLITAXEL; PACLITAXEL POLIGLUMEX; PK 1; POLYGLUTAMIC ACID; POLYGLUTAMIC ACID CAMPTOTHECIN CONJUGATE; POLYGLUTAMIC ACID PACLITAXEL CONJUGATE; POLYMER; POLYSACCHARIDE; PROTEIN DERIVATIVE; T 101; TECHNETIUM N (2 HYDROXYPROPYL)METHACRYLAMIDE ARGINYLGLYCYLASPARTIC ACID 4C TC 993 CONJUGATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 34347207622     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/aapsj0902022     Document Type: Review
Times cited : (42)

References (78)
  • 1
    • 0344378602 scopus 로고    scopus 로고
    • Polymer-drug conjugates
    • Budman D, Calvert H, Rowinsky E, eds, Baltimore, MD: Lippincott Williams & Wilkins;
    • Duncan R. Polymer-drug conjugates. In: Budman D, Calvert H, Rowinsky E, eds. Handbook of Anticancer Drug Development. Baltimore, MD: Lippincott Williams & Wilkins;2003:239-260.
    • (2003) Handbook of Anticancer Drug Development , pp. 239-260
    • Duncan, R.1
  • 2
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 1986;46:6387-6392.
    • (1986) Cancer Res , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 3
    • 33747840618 scopus 로고    scopus 로고
    • Polymer conjugates as anticancer nanomedicines
    • Duncan R. Polymer conjugates as anticancer nanomedicines. Nat Rev Cancer. 2006;6:688-701.
    • (2006) Nat Rev Cancer , vol.6 , pp. 688-701
    • Duncan, R.1
  • 4
    • 33747758790 scopus 로고    scopus 로고
    • Polymer therapeutics for cancer: Current status and future challenges
    • Satchi-Fainaro R, Duncan R, Barnes CM. Polymer therapeutics for cancer: current status and future challenges. Adv Polym Sci. 2006; 193:1-65.
    • (2006) Adv Polym Sci , vol.193 , pp. 1-65
    • Satchi-Fainaro, R.1    Duncan, R.2    Barnes, C.M.3
  • 5
    • 29544448116 scopus 로고    scopus 로고
    • Polymer conjugates: Nanosized medicines for treating cancer
    • Vicent MJ, Duncan R. Polymer conjugates: nanosized medicines for treating cancer. Trends Biotechnol. 2006;24:39-47.
    • (2006) Trends Biotechnol , vol.24 , pp. 39-47
    • Vicent, M.J.1    Duncan, R.2
  • 6
    • 33646255225 scopus 로고    scopus 로고
    • Polymer-drug conjugates: Progress in polymeric prodrugs
    • Khandare J, Minko T. Polymer-drug conjugates: progress in polymeric prodrugs. Prog Polym Sci. 2006;31:359-397.
    • (2006) Prog Polym Sci , vol.31 , pp. 359-397
    • Khandare, J.1    Minko, T.2
  • 7
    • 0142217555 scopus 로고    scopus 로고
    • Apoptosis: Target for novel drugs
    • Alam JJ. Apoptosis: target for novel drugs. Trends Biotechnol. 2003;21:479-483.
    • (2003) Trends Biotechnol , vol.21 , pp. 479-483
    • Alam, J.J.1
  • 10
    • 0036463649 scopus 로고    scopus 로고
    • Apoptosis-based therapies
    • Reed JC. Apoptosis-based therapies. Nat Rev Drug Discov. 2002;1:111-121.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 111-121
    • Reed, J.C.1
  • 11
    • 26444434342 scopus 로고    scopus 로고
    • Pharmacological manipulation of cell death: Clinical applications in sight?
    • Green DR, Kroemer G. Pharmacological manipulation of cell death: clinical applications in sight? J Clin Invest. 2005;115:2610-2617.
    • (2005) J Clin Invest , vol.115 , pp. 2610-2617
    • Green, D.R.1    Kroemer, G.2
  • 12
    • 20444430478 scopus 로고    scopus 로고
    • Apoptotic pathways: Ten minutes to dead
    • Green DR. Apoptotic pathways: ten minutes to dead. Cell. 2005;121:671-674.
    • (2005) Cell , vol.121 , pp. 671-674
    • Green, D.R.1
  • 13
    • 26444489119 scopus 로고    scopus 로고
    • Connected to death: The (unexpurgated) mitochondrial pathway of apoptosis
    • Spierings D, McStay G, Saleh M, et al. Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis. Science. 2005;310:66-67.
    • (2005) Science , vol.310 , pp. 66-67
    • Spierings, D.1    McStay, G.2    Saleh, M.3
  • 15
    • 0033596980 scopus 로고    scopus 로고
    • An APAF-1 center dot cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
    • Zou H, Li YC, Liu HS, Wang XD. An APAF-1 center dot cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem. 1999;274:11549-11556.
    • (1999) J Biol Chem , vol.274 , pp. 11549-11556
    • Zou, H.1    Li, Y.C.2    Liu, H.S.3    Wang, X.D.4
  • 16
    • 0034710649 scopus 로고    scopus 로고
    • Structural and biochemical basis of apoptotic activation by Smac/DIABLO
    • Chai JJ, Du CY, Wu JW, Kyin S, Wang XD, Shi YG. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature. 2000;406:855-862.
    • (2000) Nature , vol.406 , pp. 855-862
    • Chai, J.J.1    Du, C.Y.2    Wu, J.W.3    Kyin, S.4    Wang, X.D.5    Shi, Y.G.6
  • 17
    • 21144451097 scopus 로고    scopus 로고
    • Specific ablation of the apoptotic functions of cytochrome c reveals a differential requirement for cytochrome c and apaf-1 in apoptosis
    • Hao ZY, Duncan GS, Chang CC, et al. Specific ablation of the apoptotic functions of cytochrome c reveals a differential requirement for cytochrome c and apaf-1 in apoptosis. Cell. 2005;121:579-591.
    • (2005) Cell , vol.121 , pp. 579-591
    • Hao, Z.Y.1    Duncan, G.S.2    Chang, C.C.3
  • 18
    • 17244368276 scopus 로고    scopus 로고
    • Structure of the apoptotic protease-activating factor 1 bound to ADP
    • Riedl SJ, Li WY, Chao Y, Schwarzenbacher R, Shi YG. Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature. 2005;434:926-933.
    • (2005) Nature , vol.434 , pp. 926-933
    • Riedl, S.J.1    Li, W.Y.2    Chao, Y.3    Schwarzenbacher, R.4    Shi, Y.G.5
  • 19
    • 16344362141 scopus 로고    scopus 로고
    • A nucleotide binding site in caspase-9 regulates apoptosome activation
    • Chereau D, Zou H, Spada AP, Wu JC. A nucleotide binding site in caspase-9 regulates apoptosome activation. Biochemistry. 2005;44:4971-4976.
    • (2005) Biochemistry , vol.44 , pp. 4971-4976
    • Chereau, D.1    Zou, H.2    Spada, A.P.3    Wu, J.C.4
  • 20
    • 0034630167 scopus 로고    scopus 로고
    • Induction of apoptosis by cancer chemotherapy
    • Kaufmann SH, Earnshaw WC. Induction of apoptosis by cancer chemotherapy. Exp Cell Res. 2000;256:42-49.
    • (2000) Exp Cell Res , vol.256 , pp. 42-49
    • Kaufmann, S.H.1    Earnshaw, W.C.2
  • 21
    • 0032959549 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of PK1 N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin: Fi rst member of a new class of chemotherapeutic agents - drug-polymer conjugates
    • Vasey PA, Kaye SB, Morrison R, et al. Phase I clinical and pharmacokinetic study of PK1 N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin: fi rst member of a new class of chemotherapeutic agents - drug-polymer conjugates. Clin Cancer Res. 1999;5:83-94.
    • (1999) Clin Cancer Res , vol.5 , pp. 83-94
    • Vasey, P.A.1    Kaye, S.B.2    Morrison, R.3
  • 22
    • 0034883396 scopus 로고    scopus 로고
    • Mechanisms of anticancer action of HPMA copolymer-bound doxorubicin
    • Minko T, Kopeckova P, Kopecek J. Mechanisms of anticancer action of HPMA copolymer-bound doxorubicin. Macromol Symp. 2001;172:35-48.
    • (2001) Macromol Symp , vol.172 , pp. 35-48
    • Minko, T.1    Kopeckova, P.2    Kopecek, J.3
  • 23
    • 1042288957 scopus 로고    scopus 로고
    • HPMA copolymer-bound doxorubicin targeted to tumor-specifi c antigen of BCL1 mouse B cell leukemia
    • Kovar M, Mrkvan T, Strohalm J, et al. HPMA copolymer-bound doxorubicin targeted to tumor-specifi c antigen of BCL1 mouse B cell leukemia. J Control Release. 2003;92:315-330.
    • (2003) J Control Release , vol.92 , pp. 315-330
    • Kovar, M.1    Mrkvan, T.2    Strohalm, J.3
  • 24
    • 0037122737 scopus 로고    scopus 로고
    • Acquired and specific immunological mechanism co-responsible for effi cacy of polymer-bound drugs
    • Rihova B, Strohalm J, Kubackova K, et al. Acquired and specific immunological mechanism co-responsible for effi cacy of polymer-bound drugs. J Control Release. 2002;78:97-114.
    • (2002) J Control Release , vol.78 , pp. 97-114
    • Rihova, B.1    Strohalm, J.2    Kubackova, K.3
  • 25
    • 0141548120 scopus 로고    scopus 로고
    • Cytostatic and immunomobilizing activities of polymer-bound drugs: Experimental and first clinical data
    • Rihova B, Strohalm J, Prausova J, et al. Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data. J Control Release. 2003;91:1-16.
    • (2003) J Control Release , vol.91 , pp. 1-16
    • Rihova, B.1    Strohalm, J.2    Prausova, J.3
  • 26
    • 84969784315 scopus 로고    scopus 로고
    • N-(2-hydroxypropyl)methacrylamide copolymer conjugates
    • Kwon GS, ed, New York, NY: Marcel Dekker, Inc;
    • Duncan R. N-(2-hydroxypropyl)methacrylamide copolymer conjugates. In: Kwon GS, ed. Polymeric Drug Delivery Systems. New York, NY: Marcel Dekker, Inc; 2005:1-92.
    • (2005) Polymeric Drug Delivery Systems , pp. 1-92
    • Duncan, R.1
  • 27
    • 0032101105 scopus 로고    scopus 로고
    • Complete regression of well-established tumors using novel water-soluable poly(L-glutamic acid)-paclitaxel conjugate
    • Li C, Yu DF, Newman R, et al. Complete regression of well-established tumors using novel water-soluable poly(L-glutamic acid)-paclitaxel conjugate. Cancer Res. 1998;58:2404-2409.
    • (1998) Cancer Res , vol.58 , pp. 2404-2409
    • Li, C.1    Yu, D.F.2    Newman, R.3
  • 28
    • 28444450450 scopus 로고    scopus 로고
    • Paclitaxel poliglumex (XYOTAX™, CT-2103): A macromolecular taxane
    • Singer JW. Paclitaxel poliglumex (XYOTAX™, CT-2103): a macromolecular taxane. J Control Release. 2005;109:120-126.
    • (2005) J Control Release , vol.109 , pp. 120-126
    • Singer, J.W.1
  • 29
    • 33750967313 scopus 로고    scopus 로고
    • Effect of gender on outcome in two randomized phase III trials of paclitaxel poliglumex (PPX) in chemonaive patients with advanced NSCLC and poor performance status (PS2) [abstract]
    • Ross H, Bonomi P, Langer C. Effect of gender on outcome in two randomized phase III trials of paclitaxel poliglumex (PPX) in chemonaive patients with advanced NSCLC and poor performance status (PS2) [abstract]. Clin Oncol. 2006;97:.
    • (2006) Clin Oncol , pp. 97
    • Ross, H.1    Bonomi, P.2    Langer, C.3
  • 30
    • 84863621092 scopus 로고    scopus 로고
    • Analysis of prognostic factors in chemo-naive patients with advanced NSCLC and poor performance status (PS): Cox regression analysis of two phase III trials [abstract]
    • O'Brien M, Bonomi P, Langer C. Analysis of prognostic factors in chemo-naive patients with advanced NSCLC and poor performance status (PS): Cox regression analysis of two phase III trials [abstract]. Clin Oncol. 2006;97:.
    • (2006) Clin Oncol , pp. 97
    • O'Brien, M.1    Bonomi, P.2    Langer, C.3
  • 31
    • 0033629139 scopus 로고    scopus 로고
    • Comparison of action of paclitaxel and poly(L-glutamic acid)paclitaxel conjugate in human breast cancer cells
    • Oldham EA, Li C, Ke S, Wallace S, Huang P. Comparison of action of paclitaxel and poly(L-glutamic acid)paclitaxel conjugate in human breast cancer cells. Int J Oncol. 2000;16:125-132.
    • (2000) Int J Oncol , vol.16 , pp. 125-132
    • Oldham, E.A.1    Li, C.2    Ke, S.3    Wallace, S.4    Huang, P.5
  • 32
    • 0037413560 scopus 로고    scopus 로고
    • Synthesis and in vivo antitumor activity of poly(L-glutamic acid) conjugates of 20(S)-camptothecin
    • Bhatt R, de Vries P, Tulinsky J, et al. Synthesis and in vivo antitumor activity of poly(L-glutamic acid) conjugates of 20(S)-camptothecin. J Med Chem. 2003;46:190-193.
    • (2003) J Med Chem , vol.46 , pp. 190-193
    • Bhatt, R.1    de Vries, P.2    Tulinsky, J.3
  • 33
    • 0024324205 scopus 로고
    • On the mechanism of topoisomerase-I inhibition by camptothecin - evidence for binding to an enzyme DNA complex
    • Hertzberg RP, Caranfa MJ, Hecht SM. On the mechanism of topoisomerase-I inhibition by camptothecin - evidence for binding to an enzyme DNA complex. Biochemistry. 1989;28:4629-4638.
    • (1989) Biochemistry , vol.28 , pp. 4629-4638
    • Hertzberg, R.P.1    Caranfa, M.J.2    Hecht, S.M.3
  • 34
    • 27744554658 scopus 로고    scopus 로고
    • Phase 1 study of weekly polyethylene glycol-camptothecin in patients with advanced solid tumors and lymphomas
    • Posey JA, Saif MW, Carlisle R, et al. Phase 1 study of weekly polyethylene glycol-camptothecin in patients with advanced solid tumors and lymphomas. Clin Cancer Res. 2005;11:7866-7871.
    • (2005) Clin Cancer Res , vol.11 , pp. 7866-7871
    • Posey, J.A.1    Saif, M.W.2    Carlisle, R.3
  • 35
    • 33645087362 scopus 로고    scopus 로고
    • Preclinical efficacy of the camptothecin-polymer conjugate IT-101 in multiple cancer models
    • Schluep T, Hwang J, Cheng JJ, et al. Preclinical efficacy of the camptothecin-polymer conjugate IT-101 in multiple cancer models. Clin Cancer Res. 2006;12:1606-1614.
    • (2006) Clin Cancer Res , vol.12 , pp. 1606-1614
    • Schluep, T.1    Hwang, J.2    Cheng, J.J.3
  • 36
    • 32544451450 scopus 로고    scopus 로고
    • Clinical and pharmacokinetic study evaluating the effect of food on the disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in patients with solid tumors
    • Zamboni WC, Goel S, Iqbal T, et al. Clinical and pharmacokinetic study evaluating the effect of food on the disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in patients with solid tumors. Cancer Chem Pharmacol. 2006;57:631-639.
    • (2006) Cancer Chem Pharmacol , vol.57 , pp. 631-639
    • Zamboni, W.C.1    Goel, S.2    Iqbal, T.3
  • 37
    • 32544454332 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor-bearing mice
    • Schluep T, Cheng JJ, Khin KT, Davis ME. Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor-bearing mice. Cancer Chem Pharmacol. 2006;57:654-662.
    • (2006) Cancer Chem Pharmacol , vol.57 , pp. 654-662
    • Schluep, T.1    Cheng, J.J.2    Khin, K.T.3    Davis, M.E.4
  • 38
    • 0036354863 scopus 로고    scopus 로고
    • Enhancing the anticancer efficacy of camptothecin using biotinylated poly(ethyleneglycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells
    • Minko T, Paranjpe PV, Qiu B, et al. Enhancing the anticancer efficacy of camptothecin using biotinylated poly(ethyleneglycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells. Cancer Chem Pharmacol. 2002;50:143-150.
    • (2002) Cancer Chem Pharmacol , vol.50 , pp. 143-150
    • Minko, T.1    Paranjpe, P.V.2    Qiu, B.3
  • 39
    • 0141886989 scopus 로고    scopus 로고
    • Molecular targeting of drug delivery systems to ovarian cancer by BH3 and LHRH peptides
    • Dharap SS, Qiu B, Williams GC, Sinko P, Stein S, Minko T. Molecular targeting of drug delivery systems to ovarian cancer by BH3 and LHRH peptides. J Control Release. 2003;91:61-73.
    • (2003) J Control Release , vol.91 , pp. 61-73
    • Dharap, S.S.1    Qiu, B.2    Williams, G.C.3    Sinko, P.4    Stein, S.5    Minko, T.6
  • 40
    • 24644496584 scopus 로고    scopus 로고
    • Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide
    • Dharap SS, Wang Y, Chandna P, et al. Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide. Proc Natl Acad Sci USA. 2005;102:12962-12967.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 12962-12967
    • Dharap, S.S.1    Wang, Y.2    Chandna, P.3
  • 41
    • 33751562849 scopus 로고    scopus 로고
    • Polymer genomics: An insight into pharmacology and toxicology of nanomedicines
    • Kabanov AV. Polymer genomics: an insight into pharmacology and toxicology of nanomedicines. Adv Drug Deliv Rev. 2006; 58:1597-1621.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1597-1621
    • Kabanov, A.V.1
  • 42
    • 34347222792 scopus 로고    scopus 로고
    • Target-directed in vitro and in vivo testing procedures for the discovery of anticancer agents
    • Fiebig HH, Burger AM. Target-directed in vitro and in vivo testing procedures for the discovery of anticancer agents. Clin Cancer Res. 1999;5:S3870-S3870.
    • (1999) Clin Cancer Res , vol.5
    • Fiebig, H.H.1    Burger, A.M.2
  • 43
    • 33845313345 scopus 로고    scopus 로고
    • The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review
    • Eskens F, Verweij J. The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review. Eur J Cancer. 2006;42:3127-3139.
    • (2006) Eur J Cancer , vol.42 , pp. 3127-3139
    • Eskens, F.1    Verweij, J.2
  • 44
    • 33845286942 scopus 로고    scopus 로고
    • Vascular disrupting agents
    • Lippert JW, III. Vascular disrupting agents. Bioorg Med Chem. 2007;15:605-615.
    • (2007) Bioorg Med Chem , vol.15 , pp. 605-615
    • Lippert III, J.W.1
  • 45
    • 33846179026 scopus 로고    scopus 로고
    • Recent advances in the design and discovery of small-molecule therapeutics targeting HER2/neu
    • Dayam R, Grande F, Al-Mawsawi LQ, Neamati N. Recent advances in the design and discovery of small-molecule therapeutics targeting HER2/neu. Expert Opin Ther Pat. 2007;17:83-102.
    • (2007) Expert Opin Ther Pat , vol.17 , pp. 83-102
    • Dayam, R.1    Grande, F.2    Al-Mawsawi, L.Q.3    Neamati, N.4
  • 46
    • 2342586114 scopus 로고    scopus 로고
    • Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470
    • Satchi-Fainaro R, Puder M, Davies JW, et al. Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470. Nat Med. 2004;10:255-261.
    • (2004) Nat Med , vol.10 , pp. 255-261
    • Satchi-Fainaro, R.1    Puder, M.2    Davies, J.W.3
  • 47
    • 4444296218 scopus 로고    scopus 로고
    • TNP-470 promotes initial vascular sprouting in xenograft tumors
    • Huang JZ, Frischer JS, New T, et al. TNP-470 promotes initial vascular sprouting in xenograft tumors. Mol Cancer Ther. 2004;3:335-343.
    • (2004) Mol Cancer Ther , vol.3 , pp. 335-343
    • Huang, J.Z.1    Frischer, J.S.2    New, T.3
  • 48
    • 0037312485 scopus 로고    scopus 로고
    • Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma
    • Inoue K, Chikazawa M, Fukata S, Yoshikawa C, Shuin T. Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma. Clin Cancer Res. 2003;9:886-899.
    • (2003) Clin Cancer Res , vol.9 , pp. 886-899
    • Inoue, K.1    Chikazawa, M.2    Fukata, S.3    Yoshikawa, C.4    Shuin, T.5
  • 49
    • 0037242284 scopus 로고    scopus 로고
    • Reduction of vascular and permeable regions in solid tumors detected by macromolecular contrast magnetic resonance imaging after treatment with antiangiogenic agent TNP-470
    • Bhujwalla ZM, Artemov D, Natarajan K, Solaiyappan M, Kollars P, Kristjansen PEG. Reduction of vascular and permeable regions in solid tumors detected by macromolecular contrast magnetic resonance imaging after treatment with antiangiogenic agent TNP-470. Clin Cancer Res. 2003;9:355-362.
    • (2003) Clin Cancer Res , vol.9 , pp. 355-362
    • Bhujwalla, Z.M.1    Artemov, D.2    Natarajan, K.3    Solaiyappan, M.4    Kollars, P.5    Kristjansen, P.E.G.6
  • 51
    • 13944263708 scopus 로고    scopus 로고
    • Pegylated Arg-Gly-Asp peptide: Cu-64 labeling and PET imaging of brain tumor alpha(v)beta(3)-integrin expression
    • Chen X, Hou Y, Tohme M, et al. Pegylated Arg-Gly-Asp peptide: Cu-64 labeling and PET imaging of brain tumor alpha(v)beta(3)-integrin expression. J Nucl Med. 2004;45:1776-1783.
    • (2004) J Nucl Med , vol.45 , pp. 1776-1783
    • Chen, X.1    Hou, Y.2    Tohme, M.3
  • 52
    • 4544291850 scopus 로고    scopus 로고
    • MicroPET and autoradiographic imaging of GRP receptor expression with Cu-64-DOTA-Lys(3) bombesin in human prostate adenocarcinoma xenografts
    • Chen X, Park R, Hou Y, et al. MicroPET and autoradiographic imaging of GRP receptor expression with Cu-64-DOTA-Lys(3) bombesin in human prostate adenocarcinoma xenografts. J Nucl Med. 2004;45:1390-1397.
    • (2004) J Nucl Med , vol.45 , pp. 1390-1397
    • Chen, X.1    Park, R.2    Hou, Y.3
  • 53
    • 1442335327 scopus 로고    scopus 로고
    • Shooting at survivors: Bcl-2 family members as drug targets for cancer
    • Juin P, Geneste O, Raimbaud E, Hickman JA. Shooting at survivors: Bcl-2 family members as drug targets for cancer. Biochim Biophys Acta. 2004;1644:251-260.
    • (2004) Biochim Biophys Acta , vol.1644 , pp. 251-260
    • Juin, P.1    Geneste, O.2    Raimbaud, E.3    Hickman, J.A.4
  • 54
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • Duncan R. The dawning era of polymer therapeutics. Nat Rev Drug Discov. 2003;2:347-360.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 347-360
    • Duncan, R.1
  • 55
    • 34347210918 scopus 로고    scopus 로고
    • Using N-(2-hydroxypropyl) methacrylamide copolymer drug bioconjugate as a novel approach to deliver a Bcl-2-targeting compound HA14-1 in vivo
    • Oman M, Liu JH, Chen J, et al. Using N-(2-hydroxypropyl) methacrylamide copolymer drug bioconjugate as a novel approach to deliver a Bcl-2-targeting compound HA14-1 in vivo. Gene Ther Mol Biol. 2006;10A:113-122.
    • (2006) Gene Ther Mol Biol , vol.10 A , pp. 113-122
    • Oman, M.1    Liu, J.H.2    Chen, J.3
  • 56
    • 0036606394 scopus 로고    scopus 로고
    • Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide
    • Fang J, Sawa T, Akaike T, Maeda H. Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide. Cancer Res. 2002;62:3138-3143.
    • (2002) Cancer Res , vol.62 , pp. 3138-3143
    • Fang, J.1    Sawa, T.2    Akaike, T.3    Maeda, H.4
  • 57
    • 34347221448 scopus 로고    scopus 로고
    • Fang J, Sawa T, Maeda H. Factors and Mechanism of EPR Effect and the Enhanced Antitumor Effects of Macromolecular Drugs Including SMANCS Book Series Advances in Experimental Medicine and Biology. In: Maeda H, Kabanov A, Kataoka K, Okano T, eds. Polymer Drugs in the Clinical Stage. Dordrecht, The Netherlands: SpringerLink Netherlands; 2004:29-49.
    • Fang J, Sawa T, Maeda H. Factors and Mechanism of "EPR" Effect and the Enhanced Antitumor Effects of Macromolecular Drugs Including SMANCS Book Series Advances in Experimental Medicine and Biology. In: Maeda H, Kabanov A, Kataoka K, Okano T, eds. Polymer Drugs in the Clinical Stage. Dordrecht, The Netherlands: SpringerLink Netherlands; 2004:29-49.
  • 58
    • 1442326158 scopus 로고    scopus 로고
    • Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment
    • Fang J, Akaike T, Maeda H. Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment. Apoptosis. 2004;9:27-35.
    • (2004) Apoptosis , vol.9 , pp. 27-35
    • Fang, J.1    Akaike, T.2    Maeda, H.3
  • 59
    • 0842308157 scopus 로고    scopus 로고
    • Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin
    • Fang J, Sawa T, Akaike T, Greish K, Maeda H. Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin. Int J Cancer. 2004;109:1-8.
    • (2004) Int J Cancer , vol.109 , pp. 1-8
    • Fang, J.1    Sawa, T.2    Akaike, T.3    Greish, K.4    Maeda, H.5
  • 60
    • 0036740180 scopus 로고    scopus 로고
    • Pegylated zinc protoporphyrin: A water-soluble heme oxygenase inhibitor with tumor-targeting capacity
    • Sahoo SK, Sawa T, Fang J, et al. Pegylated zinc protoporphyrin: a water-soluble heme oxygenase inhibitor with tumor-targeting capacity. Bioconjugate Chem. 2002;13:1031-1038.
    • (2002) Bioconjugate Chem , vol.13 , pp. 1031-1038
    • Sahoo, S.K.1    Sawa, T.2    Fang, J.3
  • 61
    • 0038418359 scopus 로고    scopus 로고
    • In vivo antitumor activity of pegylated zinc protoporphyrin: Targeted inhibition of heme oxygenase in solid tumor
    • Fang J, Sawa T, Akaike T, et al. In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor. Cancer Res. 2003;63:3567-3574.
    • (2003) Cancer Res , vol.63 , pp. 3567-3574
    • Fang, J.1    Sawa, T.2    Akaike, T.3
  • 62
    • 29444447454 scopus 로고    scopus 로고
    • Phase II study of paclitaxel poliglumex (PPX)/carboplatin (C) for 1st line induction and maintenance therapy of stage III/IV ovarian or primary peritoneal carcinoma
    • Herzog T, Barret RJ, Edwards R, Oldham FB. Phase II study of paclitaxel poliglumex (PPX)/carboplatin (C) for 1st line induction and maintenance therapy of stage III/IV ovarian or primary peritoneal carcinoma. J Clin Oncol. 2005;23:16S.
    • (2005) J Clin Oncol , vol.23
    • Herzog, T.1    Barret, R.J.2    Edwards, R.3    Oldham, F.B.4
  • 63
    • 33846549188 scopus 로고    scopus 로고
    • Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells
    • Greco F, Vicent MJ, Gee S, et al. Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells. J Control Release. 2007;117:28-39.
    • (2007) J Control Release , vol.117 , pp. 28-39
    • Greco, F.1    Vicent, M.J.2    Gee, S.3
  • 64
    • 33646248643 scopus 로고    scopus 로고
    • Nitric oxide modulates proapoptotic and antiapoptotic properties of chemotherapy agents: The case of NO-pegylated epirubicin
    • Santucci L, Mencarelli A, Renga B, et al. Nitric oxide modulates proapoptotic and antiapoptotic properties of chemotherapy agents: the case of NO-pegylated epirubicin. FASEB J. 2006;20:765-775.
    • (2006) FASEB J , vol.20 , pp. 765-775
    • Santucci, L.1    Mencarelli, A.2    Renga, B.3
  • 66
    • 34347241224 scopus 로고    scopus 로고
    • Novel PEG conjugates releasing nitric oxide: Preparation and activity against oxidative stress in ischemia reperfusion injury
    • Paper presented at: June 21-26, Vienna, Austria
    • Pasut G, Mero A, Bertuglia S, Veronese FM. Novel PEG conjugates releasing nitric oxide: preparation and activity against oxidative stress in ischemia reperfusion injury. Paper presented at: 33rd Annual Meeting & Expo of the Controlled Release Society; June 21-26, 2006; Vienna, Austria.
    • (2006) 33rd Annual Meeting & Expo of the Controlled Release Society
    • Pasut, G.1    Mero, A.2    Bertuglia, S.3    Veronese, F.M.4
  • 67
    • 0036187036 scopus 로고    scopus 로고
    • Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
    • Acehan D, Jiang XJ, Morgan DG, Heuser JE, Wang XD, Akey CW. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell. 2002;9:423-432.
    • (2002) Mol Cell , vol.9 , pp. 423-432
    • Acehan, D.1    Jiang, X.J.2    Morgan, D.G.3    Heuser, J.E.4    Wang, X.D.5    Akey, C.W.6
  • 68
    • 0142027846 scopus 로고    scopus 로고
    • Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex
    • Lademann U, Cain K, Gyrd-Hansen M, Brown D, Peters D, Jaattela M. Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex. Mol Cell Biol. 2003;23:7829-7837.
    • (2003) Mol Cell Biol , vol.23 , pp. 7829-7837
    • Lademann, U.1    Cain, K.2    Gyrd-Hansen, M.3    Brown, D.4    Peters, D.5    Jaattela, M.6
  • 69
    • 33747055098 scopus 로고    scopus 로고
    • Small molecule inhibitors of Apaf-1-related caspase-3/-9 activation that control mitochondrial-dependent apoptosis
    • Malet G, Martín AG, Orzáez M, et al. Small molecule inhibitors of Apaf-1-related caspase-3/-9 activation that control mitochondrial-dependent apoptosis. Cell Death Differ. 2006;13:1523-1532.
    • (2006) Cell Death Differ , vol.13 , pp. 1523-1532
    • Malet, G.1    Martín, A.G.2    Orzáez, M.3
  • 70
    • 33745667947 scopus 로고    scopus 로고
    • Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): An antiapoptotic polymeric nanomedicine
    • Vicent MJ, Pérez-Payá E. Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine. J Med Chem. 2006;49:3763-3765.
    • (2006) J Med Chem , vol.49 , pp. 3763-3765
    • Vicent, M.J.1    Pérez-Payá, E.2
  • 71
    • 26844501695 scopus 로고    scopus 로고
    • Anticancer therapeutics: "addictive" targets, multi-targeted drugs, new drug combinations
    • Broxterman HJ, Georgopapadakou NH. Anticancer therapeutics: "addictive" targets, multi-targeted drugs, new drug combinations. Drug Resist Updat. 2005;8:183-197.
    • (2005) Drug Resist Updat , vol.8 , pp. 183-197
    • Broxterman, H.J.1    Georgopapadakou, N.H.2
  • 72
    • 33748794547 scopus 로고    scopus 로고
    • Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
    • Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 2006;58:621-681.
    • (2006) Pharmacol Rev , vol.58 , pp. 621-681
    • Chou, T.C.1
  • 73
    • 33745937903 scopus 로고    scopus 로고
    • Drug combination strategies for osteoporosis
    • Audran M. Drug combination strategies for osteoporosis. Joint Bone Spine. 2006;73:374-378.
    • (2006) Joint Bone Spine , vol.73 , pp. 374-378
    • Audran, M.1
  • 74
    • 33745823505 scopus 로고    scopus 로고
    • Successful treatment with novel triple drug combination consisting of interferongamma, interferon alfacon-1, and ribavirin in a nonresponder HCV patient to pegylated interferon therapy
    • Balan V, Rosati MJ, Anderson MH, Rakela J. Successful treatment with novel triple drug combination consisting of interferongamma, interferon alfacon-1, and ribavirin in a nonresponder HCV patient to pegylated interferon therapy. Dig Dis Sci. 2006; 51:956-959.
    • (2006) Dig Dis Sci , vol.51 , pp. 956-959
    • Balan, V.1    Rosati, M.J.2    Anderson, M.H.3    Rakela, J.4
  • 76
    • 34347229299 scopus 로고    scopus 로고
    • Strategies for assessment of drug combination therapy: Response surface modeling of MTT assays to assess target agent synergy via cell survival
    • Gupta M, Robinson B, Felix C, Barrett J. Strategies for assessment of drug combination therapy: response surface modeling of MTT assays to assess target agent synergy via cell survival. J Clin Pharmacol. 2005;45:1093.
    • (2005) J Clin Pharmacol , vol.45 , pp. 1093
    • Gupta, M.1    Robinson, B.2    Felix, C.3    Barrett, J.4
  • 77
    • 33745703563 scopus 로고    scopus 로고
    • Polymer therapeutics: Concepts and applications
    • Haag R, Kratz F. Polymer therapeutics: concepts and applications. Angew Chem Int Ed Engl. 2006;45:1198-1215.
    • (2006) Angew Chem Int Ed Engl , vol.45 , pp. 1198-1215
    • Haag, R.1    Kratz, F.2


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