Neuroprotective effects of ONO-1924H, an inhibitor of poly ADP-ribose polymerase (PARP), on cytotoxicity of PC12 cells and ischemic cerebral damage

Life Sciences

Volumn 76, Issue 2, 2004, Pages 151-162

  Kamanaka, Yoshihisa ^a,b   Kondo, Kazunao ^c   Ikeda, Yasuhiko ^c   Kamoshima, Wataru ^a   Kitajima, Takashi ^a   Suzuki, Yasuhiro ^c   Nakamura, Yoichi ^b   Umemura, Kazuo ^c  

^a ONO PHARMACEUTICAL CO   (Japan)

^b Osaka Prefecture University   (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytotoxicity; Middle cerebral artery (MCA) thrombosis occlusion; PC12 cells; Poly ADP ribose polymerase (PARP)

Indexed keywords

HYDROGEN PEROXIDE; N [3 (4 OXO 3,4 DIHYDROPHTHALAZIN 1 YL)PHENYL] 4 (MORPHOLIN 4 YL)BUTANAMIDE METHANESULFONATE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; ONO 1924 H; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CELL DEATH; CELL DIFFERENTIATION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY TEST; DRUG EFFECT; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; RAT; STATISTICAL SIGNIFICANCE;

ANIMALS; BRAIN ISCHEMIA; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GAIT DISORDERS, NEUROLOGIC; HYDROGEN PEROXIDE; INFUSIONS, INTRAVENOUS; MALE; MORPHOLINES; NEUROPROTECTIVE AGENTS; PC12 CELLS; PHTHALAZINES; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY;

THROMBUS;

EID: 7044232068     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.04.057     Document Type: Article

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