Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis

European Journal of Pharmacology

Volumn 469, Issue 1-3, 2003, Pages 183-194

  Zingarelli, Basilia ^a   O'Connor, Michael ^a   Hake, Paul W ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

1,5 Dihydroxyisoquinoline; 3 Aminobenzamide; Activator protein 1; Colitis; NF B (nuclear factor B); Poly (ADP ribose) polymerase

Indexed keywords

1,5 DIHYDROXYISOQUINOLINE; 3 AMINOBENZAMIDE; 3 NITROTYROSINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOPEROXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRATE; NITRIC OXIDE; NITRITE; QUINOLINE DERIVATIVE; TRANSCRIPTION FACTOR AP 1; TRINITROBENZENESULFONIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COLITIS; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EROSION; EVALUATION; INFLAMMATION; INTESTINE ULCER; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0038730507     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(03)01726-6     Document Type: Article

References (45)

1. Abreu-Martin M.T., Palladino A.A., Faris M., Carramanzana N.M., Nel A.E., Targan S.R. Fas activates the JNK pathway in human colonic epithelial cells: lack of a direct role in apoptosis. Am. J. Physiol. 276:1999;G599-G605.
2. Althaus F.R., Richter C. ADP-ribosylation of proteins. Enzymology and biological significance. Mol. Biol. Biochem. Biophys. 37:1987;1-237.
3. 2-terminal kinase and activator protein-1 in murine fibroblasts. J. Immunol. 170:2003;2113-2120.
4. Ardite E., Panes J., Miranda M., Salas A., Elizalde J.I., Sans M., Arce Y., Bordas J.M., Fernandez-Checa J.C., Pique J.M. Effects of steroid treatment on activation of nuclear factor-κB in patients with inflammatory bowel disease. Br. J. Pharmacol. 124:1998;431-433.
5. Baeuerle P.A. IκB-NF-κB structures: at the interface of inflammation control. Cell. 11:1998;729-731.
6. Banasik M., Komura H., Shimoyama M., Ueda K. Specific inhibitors of poly (ADP-ribose) synthetase and mono (ADP-ribosyl)transferase. J. Biol. Chem. 267:1992;1569-1575.
7. Boughton-Smith N.K., Evans S.M., Hawkey C.J., Cole A.T., Balsitis M., Whittle B.R.J., Moncada S. Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet. 341:1993;338-340.
8. Cantoni O., Sestili P., Spadoni G., Balsamini C., Cucchiarini L., Cattabeni F. Analogues of benzamide containing a sulfur atom as poly (ADP-ribose) transferase inhibitors. Biochem. Int. 15:1987;329-337.
9. Chatterjee P.K., Zacharowski K., Cuzzocrea S., Otto M., Thiemermann C. Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo. FASEB J. 14:2000;641-651.
10. Cochrane C.G. Mechanism of oxidant injury of cells. Mol. Aspects Med. 12:1991;137-147.
11. Conner E.M., Brand S.J., Davis J.M., Kang D.Y., Grisham M.B. Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease: toxins, mediators, and modulators of gene expression. Inflamm. Bowel Dis. 2:1996;133-147.
12. De Murcia G., Huletsky A., Poirier G.G. Modulation of chromatin structure by poly (ADP-ribosyl)ation. Biochem. Cell. Biol. 66:1988;626-635.
13. Elson C.O., Sartor R.B., Tennyson G.S., Riddell R.H. Experimental models of inflammatory bowel disease. Gastroenterology. 109:1995;1344-1367.
14. Fiocchi C. Inflammatory bowel disease: ethiology and pathogenesis. Gastroenterology. 115:1998;182-205.
15. Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:1992;493-501.
16. Gonsky R., Deem R.L., Hughes C.C., Targan S.R. Activation of the CD2 pathway in lamina propria T cells up-regulates functionally active AP-1 binding to the IL-2 promoter, resulting in messenger RNA transcription and IL-2 secretion. J. Immunol. 160:1998;4914-4922.
17. Grisham M.B. Oxidants and free radicals in inflammatory bowel disease. Lancet. 344:1994;859-861.
18. Hassa P.O., Hottiger M.O. A role of poly (ADP-ribose) polymerase in NF-κB transcriptional activation. Biol. Chem. 380:1999;953-959.
19. Hauschildt S., Scheipers P., Bessler W., Schwarz K., Ullmer A., Flad H.D., Heine H. Role of ADP-ribosylation in activated monocytes/macrophages. Adv. Exp. Med. Biol. 419:1997;249-252.
20. Jijon H.B., Churchill T., Malfair D., Wessler A., Jewell L.D., Parsons H.G., Madsen K.L. Inhibition of poly (ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis. Am. J. Physiol. 279:2000;G641-G651.
21. Jourd'heuil D., Morise Z., Conner E.M., Grisham M.B. Oxidants, transcription factors, and intestinal inflammation. J. Clin. Gastroenterol., Suppl. 1(25):1997;S61-S72.
22. Karin M., Liu Zg., Zandi E. AP-1 function and regulation. Curr. Opin. Cell Biol. 9:1997;240-246.
23. Krawisz J.E., Sharon P., Stenson W.F. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology. 87:1984;1344-1350.
24. Lih-Brody L., Powell S.R., Collier K.P., Reddy G.M., Cerchia R., Kahn E., Weissman G.S., Katz S., Floyd R.A., McKinley M.J., Fisher S.E., Mullin G.E. Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease. Dig. Dis. Sci. 41:1996;2078-2086.
25. Meisterernst M., Steltzer G., Roeder R.G. Poly (ADP-ribose) polymerase enhances activator-dependent transcription in vitro. Proc. Natl. Acad. Sci. U. S. A. 94:1997;2261-2265.
26. Miller M.J.S., Thompson J.H., Zhang X.-J., Sadowska-Krowicka H., Kakkis J.L., Munshi U.K., Sandoval M., Rossi J.L., Eloby-Childress S., Beckman J.S., Ye Y.Z., Rodi C.P., Manning P.T., Currie M.G., Clark D.A. Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology. 109:1995;1475-1483.
27. Morris G.P., Beck P.L., Herridge M.S., Drew W.T., Szewczuk M.R., Wallace J.L. Hapten-induced model of chronic inflammation and ulceration in the rat. Gastroenterology. 96:1989;795-803.
28. Neurath M.F., Fuss I., Schurmann G., Pettersson S., Arnold K., Muller-Lobeck H., Strober W., Herfarth C., Buschenfelde K.H. Cytokine gene transcription by NF-κB family members in patients with inflammatory bowel disease. Ann. N.Y. Acad. Sci. 859:1998;149-159.
29. Oliver F.J., Menissier-de Murcia J., Nacci C., Decker P., Andriantsitohaina R., Muller S., de la Rubia G., Stoclet J.C., De Murcia G. Resistance to endotoxic shock as a consequence of defective NF-κB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J. 18:1999;4446-4454.
30. Pieper A.A., Verma A., Zhang J., Snyder S.H. Poly (ADP-ribose) polymerase, nitric oxide and cell death. Trends Pharmacol. Sci. 20:1999;171-181.
31. 2 and tumor necrosis factor-α activate intercellular adhesion molecule 1 (ICAM-1) gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter. J. Biol. Chem. 270:1995;18966-18974.
32. Schreiber S., Nikolaus S., Hampe J. Activation of nuclear factor-κB inflammatory bowel disease. Gut. 42:1998;477-484.
33. Simmonds N.J., Allen R.E., Stevens T.R.J., Van Someren R.N.M., Blake D.R., Rampton D.S. Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease. Gastroenterology. 103:1992;186-196.
34. Szabó C., Dawson V.L. Role of poly (ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol. Sci. 19:1998;287-298.
35. Vispé S., Yung T.M., Richot J., Serizawa H., Satoh M.S. A cellular defense pathway regulating transcription through poly (ADP-ribosyl)ation in response to DNA damage. Proc. Natl. Acad. Sci. U. S. A. 97:2000;9881-9886.
36. Wahl C., Liptay S., Adler G., Schmid R.M. Sulfasalazine: a potent and specific inhibitor of nuclear factor-κB. J. Clin. Invest. 101:1998;1163-1174.
37. Wiseman H., Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem. J. 313:1996;17-29.
38. Wissink S., van Heerde E.C., vand der Burg B., van der Saag P.T. A dual mechanism mediates repression of NF-κB activity by glucocorticoids. Mol. Endocrinol. 12:1998;355-363.
39. Zhang J., Dawson V.L., Dawson T.M., Snyder S.H. Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity. Science. 263:1994;687-689.
40. Zingarelli B., O'Connor M., Wong H., Salzman A.L., Szabó C. Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. J. Immunol. 156:1996;350-358.
41. Zingarelli B., Cuzzocrea S., Zsengeller Z., Salzman A.L., Szabó C. Inhibition of poly (ADP ribose) synthetase protects against myocardial ischemia and reperfusion injury. Cardiovasc. Res. 36:1997;205-212.
42. Zingarelli B., Szabó C., Salzman A.L. Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J. Pharmacol. Exp. Ther. 287:1998;1048-1055.
43. Zingarelli B., Szabó C., Salzman A.L. Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase. Gut. 45:1999;199-209.
44. Zingarelli B., Szabó C., Salzman A.L. Blockade of poly (ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis. Gastroenterology. 116:1999;335-345.
45. Zingarelli B., Yang Z., Hake P.W., Denenberg A., Wong H.R. Absence of endogenous interleukin-10 enhances early stress response during postischemic injury in mice intestine. Gut. 5:2001;610-622.