Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis

Journal of Neuroimmunology

Volumn 117, Issue 1-2, 2001, Pages 78-86

  Scott, G S ^a   Hake, P ^b   Kean, R B ^a   Virag L ^c   Szabo C ^c   Hooper, D C ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c INOTEK CORPORATION   (United States)

Author keywords

Blood brain barrier; Experimental allergic encephalomyelitis; Inflammation; Peroxynitrite; Poly(ADP ribose) synthetase

Indexed keywords

5 IODO 6 AMINO 1,2 BENZOPYRONE; ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CERVICAL SPINE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; MALE; MORBIDITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT;

ANIMALS; COUMARINS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; MALE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, INBRED LEW; SPINAL CORD; TYROSINE;

EID: 0035796895     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(01)00329-0     Document Type: Article

References (58)

1. Central nervous system endothelium in neuroinflammatory, neuroinfectious, and neurodegenerative disease
2. Metabolic consequences of DNA damage: DNA damage induces alterations in glucose metabolism by activation of poly(ADP-ribose) polymerase
3. The effects of the anti-glucocorticoid RU 38486 on steroid-mediated suppression of experimental allergic encephalomyelitis (EAE)
4. Prostaglandin and thromboxane levels in central nervous system tissue from rats during the induction and development of experimental allergic encephalomyelitis (EAE)
5. Activation of NF-κB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology
6. Inhibition of HIV-1 IIIb replication in AA-2 and MT-2 cells in culture by two ligands of poly(ADP-ribose)polymerase: 6-amino-1,2-benzopyrone and 5-iodo-6-amino-1,2-benzopyrone
7. Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma x spinal cord cell line: Role of poly(ADP-ribose) polymerase
8. Poly(ADP-ribose)polymerase: Early involvement in glutamate-induced neurotoxicity in cultured cerebellar granule cells
9. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice
10. Inducible nitric oxide synthase gene expression and enzyme activity correlate with disease activity in murine experimental autoimmune encephalomyelitis
11. Evidence for the production of peroxynitrite in inflammatory CNS demyelination
12. Peroxynitrite formation within the central nervous system in active multiple sclerosis
13. A catalyst of peroxynitrite decomposition inhibits murine experimental autoimmune encephalomyelitis
14. Astrocyte-enhanced neuronal survival is mediated by scavenging of extracellular reactive oxygen species
15. Poly(ADP-ribose)polymerase gene disruption renders mice resistant to cerebral ischemia
16. Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion
17. Protective effects of 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development
18. 2 and PARS mediate lung P-selectin upregulation in acute pancreatitis
19. Transcription factor NF-κB and inhibitor IκB are localized in macrophages in active multiple sclerosis lesions
20. A role of poly(ADP-ribose) polymerase in NF-κB transcriptional activation
21. Superoxide and peroxynitrite inactivate aconitase, but nitric oxide does not
22. Experimental autoimmune encephalomyelitis in NF-κB-deficient mice: Roles of NF-κB in the activation and differentiation of autoreactive T cells
23. Inhibitory effects of nicotinamide on intercellular adhesion molecule-1 expression on cultured human thyroid cells
24. Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: Implications for the treatment of multiple sclerosis
25. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis
26. Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis
27. Transcription factor NF-κB is activated in microglia during experimental autoimmune encephalomyelitis
28. Possible involvement of ADP-ribosylation of particular enzymes in cell death induced by nitric oxide-donors in human neuroblastoma cells
29. PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation
30. The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the central nervous system in experimental allergic encephalomyelitis through maintenance of blood-central nervous system barrier integrity
31. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic disease
32. Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa B activation
33. Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: An electron paramagnetic resonance study
34. Neuronal accumulation of poly(ADP-ribose) after brain ischaemia
35. Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease
36. Elevated secretion of reactive nitrogen and oxygen intermediates by inflammatory leukocytes in hyperacute experimental autoimmune encephalomyelitis: Enhancement by the soluble products of encephalitogenic T cells
37. Poly(ADP-ribose) polyerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism
38. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide
39. Activation of nuclear factor-κB in the spinal cord of experimental allergic encephalomyelitis
40. Further evidence for a role of nitric oxide in experimental allergic encephalomyelitis: Aminoguanidine modifies its clinical evolution
41. Astrocytes, brain aging, and neurodegeneration
42. Oxidant injury of cells. DNA strand breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide
43. A pharmacological study on the role of nitric oxide in the pathogenesis of experimental allergic encephalomyelitis
44. ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging
45. Demyelination: The role of reactive oxygen and nitrogen species
46. Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid
47. DNA strand breakage and activation of poly-ADP ribosyltransferase: A cytotoxic pathway triggered by peroxynitrite
48. Role of poly(ADP-ribose) synthetase in inflammation
49. Inhibition of poly(ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects
50. Regulation of the inflammatory response by 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways
51. Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose)synthetase
52. Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species
53. ADP-ribosylation
54. Extensive peroxynitrite activity during progressive stages of central nervous system inflammation
55. Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease
56. Nitric oxide activation of poly(ADP-ribose)synthetase in neurotoxicity
57. Peroxynitrite-mediated DNA strand breakage activates poly-adenosine-diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with lipopolysaccharide
58. Genetic disruption of poly(ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury