p75 neurotrophin receptor signaling in the nervous system

Biotechnology Annual Review

Volumn 10, Issue SPEC. ISS., 2004, Pages 123-149

  Hasegawa, Yuiko ^a,b   Yamagishi, Satoru ^a   Fujitani, Masashi ^a,b   Yamashita, Toshihide ^a  

^a CHIBA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Axon; Cell survival; Central nervous system; G protein; Glia; Growth factor; Migration; Myelin; Neurite; Neuron; Neurotrophin; Oligodendrocyte; p75; Peptide; Receptor; Regeneration; Rho; Signal; Synapse

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLYCOSYLPHOSPHATIDYLINOSITOL; MYELIN; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; NEUROTROPHIN 4; NEUROTROPHIN RECEPTOR; PROTEIN NOGO; PROTEIN P75; TYROSINE KINASE RECEPTOR;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; DEVELOPMENTAL STAGE; HUMAN; INHIBITION KINETICS; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NERVOUS SYSTEM; NERVOUS SYSTEM DEVELOPMENT; NEUROLOGIC DISEASE; NONHUMAN; PATHOGENESIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; RAT; REVIEW; SIGNAL TRANSDUCTION;

EID: 7044228082     PISSN: 13872656     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1387-2656(04)10005-7     Document Type: Article

References (133)

1. Levi-Montalcini R Neuronal regeneration in vitro Windle WF Regeneration in the Central Nervous System 1955 54-65 Thomas, CC Springfield
2. Levi-Montalcini R Nerve Growth Factor 35 years later Science 237 1987 1154-1162
3. Barde YA Edgar D Thoenen H New trophic factors Ann Rev Physiol 45 1983 601-612
4. Barde YA Edgar D Thoenen H Purification of a new neurotrophic factor from mammalian brain EMBO J 1 1982 549-553
5. Lewin GR Barde YA The physiology of neurotrophins Annu Rev Neurosci 19 1996 289-317
6. Kaplan DR Miller FD Neurotrophin signal transduction in the nervous system Curr Opin Neurobiol 10 2000 381-391
7. Lee FS Kim AH Khursigara G Chao MV The uniqueness of being a neurotrophin receptor Curr Opin Neurobiol 11 2001 281-286
8. Johnson D Lanahan A Buck CR Sehgal A Morgan C Mercer E Bothwell M Chao M Expression and structure of the human NGF receptor Cell 47 1986 545-554
9. Radeke MJ Misko TP Hsu C Herzenberg LA Shooter EM Gene transfer and molecular cloning of the rat nerve growth factor receptor Nature 325 1987 593-597
10. Rodriguez-Tebar A Dechant G Barde YA Binding of brain-derived neurotrophic factor to the nerve growth factor receptor Neuron 4 1990 487-492
11. Dechant G Tsoulfas P Parada LF Barde YA The neurotrophin receptor p75 binds neurotrophin-3 on sympathetic neurons with high affinity and specificity Neuroscience 17 1997 5281-5287
12. Mahadeo D Kaplan L Chao MV Hempstead BL High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors J Biol Chem 269 1994 6884-6891
13. NTR EMBO J 18 1999 616-622
14. Dechant G Barde YA The neurotrophin receptor p75(NTR): Novel functions and implications for diseases of the nervous system Nat Neurosci 5 2002 1131-1136
15. Barker PA Shooter EM Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells Neuron 13 1994 203-215
16. Verdi JM Birren SJ Ibanez CF Persson H Kaplan DR Benedetti M Chao MV Anderson DJ p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells Neuron 12 1994 733-745
17. Clary DO Reichardt LF An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3 Proc Natl Acad Sci USA 91 1994 11133-11137
18. Lachance C Belliveau DJ Barker PA Blocking nerve growth factor binding to the p75 neurotrophin receptor on sympathetic neurons transiently reduces trkA activation but does not affect neuronal survival Neuroscience 81 1997 861-871
19. Ryden M Hempstead B Ibanez CF Differential modulation of neuron survival during development by nerve growth factor binding to the p75 neurotrophin receptor J Biol Chem 272 1997 16322-16328
20. Esposito D Patel P Stephens RM Perez P Chao MV Kaplan DR Hempstead BL The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factor J Biol Chem 276 2001 32687-32695
21. Liepinsh E Ilag LL Otting G Ibanez CF NMR structure of the death domain of the p75 neurotrophin receptor EMBO J 16 1997 4999-5005
22. Rabizadeh S Oh J Zhong LT Yang J Bitler CM Butcher LL Bredesen DE Induction of apoptosis by the low-affinity NGF receptor Science 261 1993 345-348
23. Casaccia-Bonnefil P Carter BD Dobrowsky RT Chao MV Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75 Nature 383 1996 716-719
24. Yoon SO Casaccia-Bonnefil P Carter B Chao MV Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival J Neurosci 18 1998 3273-3281
25. Gu C Casaccia-Bonnefil P Srinivasan A Chao MV Oligodendrocyte apoptosis mediated by caspase activation J Neurosci 19 1999 3043-3049
26. Soilu-Hanninen M Ekert P Bucci T Syroid D Bartlett PF Kilpatrick TJ Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway J Neurosci 19 1999 4828-4838
27. Trim N Morgan S Evans M Issa R Fine D Afford S Wilkins B Iredale J Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation Am Pathol 156 2000 1235-1243
28. Salehi AH Roux PP Kubu CJ Zeindler C Bhakar A Tannis LL Verdi JM Barker PA NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis Neuron 27 2000 279-288
29. Cotrina ML Gonzalez-Hoyuela M Barbas JA Rodriguez-Tebar A Programmed cell death in the developing somites is promoted by nerve growth factor via its p75(NTR) receptor Dev Biol 228 2000 326-336
30. von Bartheld CS Heuer JG Bothwell M Expression of nerve growth factor (NGF) receptors in the brain and retina of chick embryos: comparison with cholinergic development J Comp Neurol 310 1991 103-129
31. Davey F Davies AM TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons Curr Biol 8 1998 915-918
32. Frade JM Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones J Cell Sci 113 2000 1139-1148
33. Naumann T Casademunt E Hollerbach E Hofmann J Dechant G Frotscher M Barde YA Complete deletion of the neurotrophin receptor p75NTR leads to long-lasting increases in the number of basal forebrain cholinergic neurons J Neurosci 22 2002 2409-2418
34. Frade JM Rodriguez-Tebar A Barde YA Induction of cell death by endogenous nerve growth factor through its p75 receptor Nature 383 1996 166-168
35. Frade JM Barde YA Microglia-derived nerve growth factor causes cell death in the developing retina Neuron 20 1998 35-41
36. Majdan M Lachance C Gloster A Aloyz R Zeindler C Bamji S Bhakar A Belliveau D Fawcett J Miller FD Barker PA Transgenic mice expressing the intracellular domain of the p75 neurotrophin receptor undergo neuronal apoptosis J Neurosci 17 1997 6988-6998
37. Lee R Kermani P Teng KK Hempstead BL Regulation of cell survival by secreted proneurotrophins Science 294 2001 1945-1948
38. Fahnestock M Michalski B Xu B Coughlin MD The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease Mol Cell Neurosci 18 2001 210-220
39. Yaar M Zhai S Pilch PF Doyle SM Eisenhauer PB Fine RE Gilchrest BA Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease J Clin Invest 100 1997 2333-2340
40. Kuner P Schubenel R Hertel C Beta-amyloid binds to p57NTR and activates NFkappaB in human neuroblastoma cells J Neurosci Res 54 1998 798-804
41. Della-Bianca V Rossi F Armato U Dal-Pra I Costantini C Perini G Politi V Della G Valle, Neurotrophin p75 receptor is involved in neuronal damage by prion peptide-(106-126) J Biol Chem 276 2001 38929-38933
42. Perini G Della-Bianca V Politi V Della Valle G Dal-Pra I Rossi F Armato U Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines J Exp Med 195 2002 907-918
43. Tuffereau C Benejean J Blondel D Kieffer B Flamand A Low-affinity nerve-growth factor receptor (P75NTR) can serve as a receptor for rabies virus EMBO J 17 1998 7250-7259
44. Fainzilber M Smit AB Syed NI Wildering WC Herman van der Schors RC Jimenez C Li KW van Minnen J Bulloch AG Ibanez CF Geraerts WP CRNF, a molluscan neurotrophic factor that interacts with the p75 neurotrophin receptor Science 274 1996 1540-1543
45. Yamashita T Tucker KL Barde YA Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth Neuron 24 1999 585-593
46. Bentley CA Lee K-F p75 is important for axon growth and Schwann cell migration during development J Neurosci 20 2000 7706-7715
47. Brann AB Scott R Neuberger Y Abulafia D Boldin S Frainzilber M Futerman AH Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons J Neurosci 19 1999 8199-8206
48. Anton ES Weskamp G Reichardt LF Matthew WD Nerve growth factor and its low-affinity receptor promote Schwann cell migration Proc Natl Acad Sci USA 91 1994 2795-2799
49. Cosgaya JM Chan JR Shooter EM The neurotrophin receptor p75NTR as a positive modulator of myelination Science 298 2002 1245-1248
50. Lntr receptors J Biol Chem 271 1996 21100-21107
51. Stucky CL Koltzenburg M The low-affinity neurotrophin p75 regulates the function but not the selective survival of specific subpopulations of sensory neurons J Neurosci 17 1997 4398-4405
52. Jiang H Takeda K Lazarovici P Katagiri Y Yu Z-X Dickens G Chabuk A Liu X-W Ferrans V Guroff G Nerve Growth Factor (NGF)-induced calcium influx and intracellular calcium mobilization in 3T3 cells expressing NGF receptors J Biol Chem 274 1999 26209-26216
53. von Schack D Casademunt E Schweigreiter R Meyer M Bibel M Dechant G Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system Nat Neurosci 4 2001 977-978
54. Lee KF Li E Huber LJ Landis SC Sharpe AH Chao MV Jaenisch R Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system Cell 69 1992 737-749
55. Roux PP Colicos MA Barker PA Kennedy TE p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure J Neurosci 19 1999 6887-6896
56. Cheema SS Barrett GL Bartlett PF Reducing p75 nerve growth factor receptor levels using antisense oligonucleotides prevents the loss of axotomized sensory neurons in the dorsal root ganglia of newborn rats J Neurosci Res 46 1996 239-245
57. Ferri CC Moore FA Bisby MA Effects of facial nerve injury on mouse motoneurons lacking the p75 low-affinity neurotrophin receptor J Neurobiol 34 1998 1-9
58. Ferri CC Bisby MA Improved survival of injured sciatic nerve Schwann cells in mice lacking the p75 receptor Neurosci Lett 272 1999 191-194
59. Sendtner M Holtmann B Kolbeck R Thoenen H Barde YA Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section Nature 360 1992 757-759
60. Mufson EJ Kordower JH Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease Proc Natl Acad Sci USA 89 1992 569-573
61. Lowry KS Murray SS McLean CA Talman P Mathers S Lopes EC Cheema SS A potential role for the p75 low-affinity neurotrophin receptor in spinal motor neuron degeneration in murine and human amyotrophic lateral sclerosis Amyotroph Lateral Scler Other Motor Neuron Disord 2 2001 127-134
62. Giehl KM Rohrig S Bonatz H Gutjahr M Leiner B Bartke I Yan Q Reichardt LF Backus C Welcher AA Dethleffsen K Mestres P Meyer M Endogenous brain-derived neurotrophic factor and neurotrophin-3 antagonistically regulate survival of axotomized corticospinal neurons in vivo J Neurosci 21 2001 3492-3502
63. Dobrowsky RT Werner MH Castellino AM Chao MV Hannun YA Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor Science 265 1994 1596-1599
64. Wiegmann K Schutze S Machleidt T Witte D Kronke M Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling Cell 78 1994 1005-1015
65. Carter BD Kaltschmidt C Kaltschmidt B Offenhauser N Bohm-Matthaei R Baeuerle PA Barde YA Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75 Science 272 1996 542-545
66. Liu ZG Hsu H Goeddel DV Karin M Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death Cell 87 1996 565-576
67. Hamanoue M Middleton G Wyatt S Jaffray E Hay RT Davies AM p75-Mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor Mol Cell Neurosci 14 1999 28-40
68. Coulson EJ Reid K Barrett GL Bartlett PF p75 neurotrophin receptor-mediated neuronal death is promoted by Bcl-2 and prevented by Bcl-xL J Biol Chem 274 1999 16387-16391
69. Yoon SO Casaccia-Bonnefil P Carter B Chao MV Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival J Neurosci 18 1998 3273-3281
70. Pozniak CD Radinovic S Yang A McKeon F Kaplan DR Miller FD An anti-apoptotic role for the p53 family member, p73, during developmental neuron death Science 289 2000 304-306
71. Casademunt E Carter BD Benzel I Frade JM Dechant G Barde YA The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death EMBO J 18 1999 6050-6061
72. Mukai J Hachiya T Shoji-Hoshino S Kimura MT Nadano D Suvanto P Hanaoka T Li Y Irie S Greene LA Sato TA NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR J Biol Chem 275 2000 17566-17570
73. Hosomi S Yamashita T Aoki M Tohyama M The p75 receptor is required for BDNF-induced differentiation of neural precursor cells Biochem Biophys Res Commun 301 2003 1011-1015
74. Chittka A Chao MV Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor Proc Natl Acad Sci USA 96 1999 10705-10710
75. Canossa M Twiss JL Verity AN Shooter EM p75(NGFR) and TrkA receptors collaborate to rapidly activate a p75(NGFR)-associated protein kinase EMBO J 15 1996 3369-3376
76. Volonte C Ross AH Greene LA Association of a purine-analogue-sensitive protein kinase activity with p75 nerve growth factor receptors Mol Biol Cell 4 1993 71-78
77. Higuchi H Yamashita T Yoshikaw H Tohyama M PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts EMBO J 22 2003 1790-1800
78. Buck CR Martinez HJ Black IB Chao MV Developmentally regulated expression of the nerve growth factor receptor gene in the periphery and brain Proc Natl Acad Sci USA 84 1987 3060-3063
79. Ernfors P Hallbook F Ebendal T Shooter EM Radeke MJ Misko TP Persson H Developmental and regional expression of beta-nerve growth factor receptor mRNA in the chick and rat Neuron 1 1988 983-996
80. Large TH Weskamp G Helder JC Radeke MJ Misko TP Shooter EM Reichardt LF Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system Neuron 2 1989 1123-1134
81. von Bartheld CS Kinoshita Y Prevette D Yin QW Oppenheim RW Bothwell M Positive and negative effects of neurotrophins on the isthmo-optic nucleus in chick embryos Neuron 12 1994 639-654
82. Yan Q Johnson EMJr An immunohistochemical study of the nerve growth factor receptor in developing rats J Neurosci 8 1988 3481-3498
83. Ernfors P Henschen A Olson L Persson H Expression of nerve growth factor receptor mRNA is developmentally regulated and increased after axotomy in rat spinal cord motoneurons Neuron 2 1989 1605-1613
84. Bentley CA Lee KF p75 is important for axon growth and schwann cell migration during development J Neurosci 20 2000 7706-7715
85. Lee KF Bachman K Landis S Jaenisch R Dependence on p75 for innervation of some sympathetic targets Science 263 1994 1447-1449
86. McQuillen PS DeFreitas MF Zada G Shatz CJ A novel role for p75NTR in subplate growth cone complexity and visual thalamocortical innervation J Neurosci 22 2002 3580-3593
87. Brann AB Scott R Neuberger Y Abulafia D Boldin S Fainzilber M Futerman AH Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons J Neurosci 19 1999 8199-8206
88. Lehmann M Fournier A Selles-Navarro I Dergham P Sebok A Leclerc N Tigyi G McKerracher L Inactivation of Rho signaling pathway promotes CNS axon regeneration J Neurosci 19 1999 7537-7547
89. Luo L Jan LY Jan YN Rho family GTP-binding proteins in growth cone signalling Curr Opin Neurobiol 7 1997 81-86
90. Luo L Rho GTPases in neuronal morphogenesis Nat Rev Neurosci 1 2000 260-264
91. Higuchi H Yamashita T Yoshikawa H Tohyama M PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts EMBO J 22 2003 1790-1800
92. Lang P Gesbert-Carmagnat F Delespine M Stancou R Pouchelet M Bertoglio J Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes EMBO J 15 1996 510-519
93. Walsh GS Krol KM Kawaja MD Absence of the p75 neurotrophin receptor alters the pattern of sympathosensory sprouting in the trigeminal ganglia of mice overexpressing nerve growth factor J Neurosci 19 1999 258-273
94. Yeo TT Chua-Couzens J Butcher LL Bredesen DE Cooper JD Valletta JS Mobley WC Longo FM Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation J Neurosci 17 1997 7594-7605
95. Tello F La influencia del neurotropismo en la regeneracion de los centros nerviosos Trab Lab Invest Biol 9 1911 123-159
96. Ramon y Cajal S Degeneration and Regeneration of the Nervous System 1928 Oxford Unversity Press London
97. David S Aguayo AJ Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats Science 214 1981 931-933
98. Richardson PM Issa VM Aguayo AJ Regeneration of long spinal axons in the rat J Neurocytol 13 1984 165-182
99. Keirstead SA Rasminsky M Fukuda Y Carter DA Aguayo AJ Vidal-Sanz M Electrophysiologic responses in hamster superior colliculus evoked by regenerating retinal axons Science 246 1989 255-257
100. Berry M Post-injury myelin-breakdown products inhibit axonal growth: An hypothesis to explain the failure of axonal regeneration in the mammalian central nervous system Bibliotheca Anatomica 23 1982 1-11
101. Schwab ME Thoenen H Dissociated neurons regenerate into sciatic but not optic nerve explants in culture irrespective of neurotrophic factors J Neurosci 5 1985 2415-2423
102. Caroni P Schwab ME Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading J Cell Biol 106 1988 1281-1288
103. Spillmann AA Bandtlow CE Lottspeich F Keller F Schwab ME Identification and characterization of a bovine neurite growth inhibitor (bNI-220) J Biol Chem 273 1998 19283-19293
104. Prinjha R Moore SE Vinson M Blake S Morrow R Christie G Michalovich D Simmons DL Walsh FS Inhibitor of neurite outgrowth in humans Nature 403 2000 383-384
105. GrandPre T Nakamura F Vartanian T Strittmatter SM Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein Nature 403 2000 439-444
106. Chen MS Huber AB van der Haar ME Frank M Schnell L Spillmann AA Christ F Schwab ME Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1 Nature 403 2000 434-439
107. Fournier AE GrandPre T Strittmatter SM Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration Nature 409 2001 341-346
108. Huber AB Weinmann O Brosamle C Oertle T Schwab ME Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions J Neurosci 22 2002 3553-3567
109. McKerracher L David S Jackson DL Kottis V Dunn RJ Braun PE Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth Neuron 13 1994 805-811
110. Mukhopadhyay G Doherty P Walsh FS Crocker PR Filbin MT A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration Neuron 13 1994 757-767
111. Cai D Qiu J Cao Z McAtee M Bregman BS Filbin MT Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate J Neurosci 21 2001 4731-4739
112. Tang S Qiu J Nikulina E Filbin MT Soluble myelin-associated glycoprotein released from damaged white matter inhibits axonal regeneration Mol Cell Neurosci 18 2001 259-269
113. Kottis V Thibault P Mikol D Xiao ZC Zhang R Dergham P Braun PE Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth J Neurochem 82 2002 1566-1569
114. Wang KC Koprivica V Kim JA Sivasankaran R Guo Y Neve RL He Z Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth Nature 417 2002 941-944
115. Habib AA Marton LS Allwardt B Gulcher JR Mikol DD Hognason T Chattopadhyay N Stefansson K Expression of the oligodendrocyte-myelin glycoprotein by neurons in the mouse central nervous system J Neurochem 70 1998 1704-1711
116. Fournier AE GrandPre T Strittmatter SM Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration Nature 409 2001 341-346
117. Josephson A Trifunovski A Widmer HR Widenfalk J Olson L Spenger C Nogo-receptor gene activity: Cellular localization and developmental regulation of mRNA in mice and humans J Comp Neurol 453 2002 292-304
118. Wang X Chun SJ Treloar H Vartanian T Greer CA Strittmatter SM Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact J Neurosci 22 2002 5505-5515
119. Liu BP Fournier A GrandPre T Strittmatter SM Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor Science 297 2002 1190-1193
120. Domeniconi M Cao Z Spencer T Sivasankaran R Wang K Nikulina E Kimura N Cai H Deng K Gao Y He Z Filbin M Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth Neuron 35 2002 283-290
121. Hunt D Mason MR Campbell G Coffin R Anderson PN Nogo receptor mRNA expression in intact and regenerating CNS neurons Mol Cell Neurosci 20 2002 537-552
122. Niederost B Oertle T Fritsche J McKinney RA Bandtlow CE Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1 J Neurosci 22 2002 10368-10376
123. GrandPre T Li S Strittmatter SM Nogo-66 receptor antagonist peptide promotes axonal regeneration Nature 417 2002 547-551
124. Cai D Shen Y De Bellard M Tang S Filbin MT Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism Neuron 22 1999 89-101
125. Yamashita T Higuchi H Tohyama M The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho J Cell Biol 157 2002 565-570
126. Wang KC Kim JA Sivasankaran R Segal R He Z p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp Nature 420 2002 74-78
127. Wong ST Henley JR Kanning KC Huang KH Bothwell M Poo MM A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein Nat Neurosci 5 2002 1302-1308
128. Yamashita T Tohyama M The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI Nat Neurosci 6 2003 461-467
129. Sasaki T Takai Y The Rho small G protein family-Rho GDI system as a temporal and spatial determinant for cytoskeletal control Biochem Biophys Res Commun 245 1998 641-645
130. Dergham P Ellezam B Essagian C Avedissian H Lubell WD McKerracher L Rho signaling pathway targeted to promote spinal cord repair J Neurosci 22 2002 6570-6577
131. Fournier AE Takizawa BT Strittmatter SM Rho kinase inhibition enhances axonal regeneration in the injured CNS J Neurosci 23 2003 1416-1423
132. Koch G Haberman B Mohr C Just I Aktories K Interaction of mastoparan with the low molecular mass GTP-binding proteins rho/rac FEBS Lett 291 1991 336-340
133. Ilag LL Rottenberger C Liepinsh E Wellnhofer G Rudert F Otting G Ilag LL Selection of a peptide ligand to the p75 neurotrophin receptor death domain and determination of its binding sites by NMR Biochem. Biophys Res Commun 255 1999 104-109