The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho

Journal of Cell Biology

Volumn 157, Issue 4, 2002, Pages 565-570

  Yamashita, Toshihide ^a,b,c   Higuchi, Haruhisa ^a,b   Tohyama, Masaya ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Ganglioside; Myelin associated glycoprotein; Neurotrophin; p75; Rho

Indexed keywords

GANGLIOSIDE GT 1B; MYELIN ASSOCIATED GLYCOPROTEIN; PROTEIN P75; RHO FACTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVATION; GENE FUNCTION; GENE MUTATION; GROWTH INHIBITION; GROWTH RETARDATION; MOUSE; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SPINAL GANGLION;

ANIMALS; BINDING SITES; CELL DIFFERENTIATION; CELL MEMBRANE; CELLS, CULTURED; CEREBELLUM; GANGLIA, SPINAL; GANGLIOSIDES; MICE; MICE, KNOCKOUT; MUTATION; MYELIN-ASSOCIATED GLYCOPROTEIN; NERVOUS SYSTEM; NEURITES; RECEPTOR, NERVE GROWTH FACTOR; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0037071537     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200202010     Document Type: Article

References (28)

1. ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons
2. Developmentally regulated expression of the nerve growth factor receptor gene in the periphery and brain
3. Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism
4. Neurotrophins: Neurotrophic modulation of neurite growth
5. Developmental and regional expression of beta-nerve growth factor receptor mRNA in the chick and rat
6. Expression of nerve growth factor receptor mRNA is developmentally regulated and increased after axotomy in rat spinal cord motoneurons
7. CRNF, a molluscan neurotrophic factor that interacts with the p75 neurorrophin receptor
8. The anti-p75 antibody, MC192, and brain-derived neurotrophic factor inhibit nerve growth factor-dependent neurite growth from adult sensory neurons
9. Functionally antagonistic interactions between the TrkA and p75 neurotrophin receptors regulate sympathetic neuron growth and target innervation
10. Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system
11. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
12. Inactivation of Rho signaling pathway promotes CNS axon regeneration
13. Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth
14. A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration
15. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskelton
16. p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure
17. Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects
18. Myelin-associated glycoprotein interacts with neurons via a sialic acid binding site at ARG118 and a distinct neurite inhibition site
19. Soluble myelin-associated glycoprotein found in vivo inhibits axonal regeneration
20. Low-affinity nerve-growth factor receptor (P75NTR) can serve as a receptor for rabies virus
21. Nerve growth factor modulates myelin-associated glycoprotein binding to sensory neurons
22. Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibition
23. Expression of nerve growth factor (NGF) receptors in the brain and retina of chick embryos: Comparison with cholinergic development
24. Enhanced neurotrophin-induced axon growth in myelinated portions of the CNS in mice lacking the p75 neurotrophin receprot
25. Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth
26. An immunohistochemical study of the nerve growth factor receptor in developing rats
27. Gangliosides are neuronal ligands for myelin-associated glycoprotein
28. Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline aceryltransferase activity, and target innervation