p75(NGFR) and TrkA receptors collaborate to rapidly activate a p75(NGFR)-associated protein kinase

EMBO Journal

Volumn 15, Issue 13, 1996, Pages 3369-3376

  Canossa, Marco ^a,b   Twiss, Jeffery L ^b   Verity, A Neil ^b   Shooter, Eric M ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

p75(NGFR); Phosphorylation; Protein kinase; Signal transduction; TrkA

Indexed keywords

NERVE GROWTH FACTOR RECEPTOR; PROTEIN KINASE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; SPINAL GANGLION;

ANIMALIA;

EID: 0030016335     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00702.x     Document Type: Article

References (36)

1. Barbacid, M. (1993) The Trk family of neurotrophin receptors: molecular characterization and oncogenic activation in human tumors. In Levine, A.J. and Schmidek, H.H. (eds), Molecular Genetics of Nervous System Tumors. John Wiley & Sons, Inc., New York, pp. 123-135.
2. LNTR reduces NGF binding to TrkA on PC12 cells. Neuron, 13, 203-215.
3. LNTR, is palmitoylated by thioester formation through cysteine 279. J. Biol. Chem., 269, 30645-30650.
4. Barrett, G.L. and Bartlett, P.F. ( 1994) The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development. Proc. Natl Acad. Sci. USA, 91, 6501-6505.
5. Battleman, D.S., Geller, A.I. and Chao, M.V. (1993) HSV-1 vector-mediated transfer of the human nerve growth factor receptor p75hNGFR defines high-affinity NGF binding. J. Neurosci., 13, 941-951.
6. Benedetti, M., Levi, A. and Chao, M.V. (1993) Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness. Proc. Natl Acad. Sci. USA, 90, 7859-7863.
7. Berg, M.M., Sternberg, D.W., Hempstead, B.L. and Chao, M.V. (1991) The low affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation. Proc. Natl Acad. Sci. USA, 88, 7106-7110.
8. Boldin, M.P., Varfolomeev, E.E., Pancer, Z., Mett, I.L., Camonis, J.H. and Wallach, D. (1995) A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain, J. Biol. Chem., 270, 7795-7798.
9. Boulton, J.G., Nye, S.H., Robbins, D.J., Ip, N.Y., Radziejewska, E., Morgenbesser, S.D., DePinho, R.A., Panayotatos, N., Cobb, M.H. and Yoncopoulos, G.D. (1991) ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell, 65, 663-675.
10. Campos-Gonzalez, R. and Glenney, J.R., Jr (1992) Tyrosine phosphorylation of mitogen-activated protein kinase in cells with tyrosine kinase-negative epidermal growth factor receptors. J. Biol. Chem., 267, 14535-14538.
11. Canossa, M., Verity, A.N., Rovelli, G. and Shooter, E.M. (1994) Chimeric TNFR2-Trk receptors: a tool to investigate Trk-mediated gene expression. Soc. Neumsci. Abstr., 20, 38.
12. Chandler, C.E., Parsons, L.M., Hosang, M. and Shooter, E.M. (1984) A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells. J. Biol. Chem., 259, 6882-6889.
13. Chao, M.V. (1992) Neurotrophins receptors: a window into neuronal differentiation. Neuron, 9, 583-593.
14. Chao, M.V. and Hempstead, B.L. (1995) p75 and TrkA, a two receptor system. Trends Neurosci., 18, 321-326.
15. Dobrowsky, R.T., Werner, M.H., Castellino, A.M., Chao, M.V. and Hannun, Y.A. (1994) Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science, 265, 1596-1599.
16. Dobrowsky, R.T., Jenkins, G.M. and Hannun, Y.A. (1995) Neurotrophins induce sphingomyelin hydrolysis. J. Biol. Chem., 270, 22135-22142.
17. Feinstein, E., Wallach, D., Boldin, M.P., Varfolomeev, E.E. and Kimchi, A. (1995) The death domain: a module shared by proteins with diverse cellular functions. Trends Biochem. Sci., 20, 342-344.
18. Gorman, C. (1985) DNA Cloning: A Practical Approach. Vol. 2. IRL Press, Oxford, UK.
19. Green, S.H., Rydel, R.E., Connolly, J.L. and Greene, L.A. (1986) PC 12 cell mutants that possess low but not high affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor. J. Cell Biol., 102, 830-843.
20. Hantzopoulos, P.A., Suri, C., Glass, D.J., Goldfarb, M.P. and Yancopoulos, G.D. (1994) The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins. Neuron, 13, 187-201.
21. Hempstead, B.L, Patil, N., Thiel, B. and Chao, M.V. (1990) Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding. J. Biol. Chem., 265, 9595-9598.
22. Hempstead, B.L., Martin-Zanca, D., Kaplan, D.R., Parada, L.F. and Chao, M.V. (1991) High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature, 350, 678-683.
23. Ibáñez, C.F., Ebendal, T., Barbany, G., Murray-Rust, J., Blundell, T.L. and Perrson, H. (1992) Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product. Cell, 69, 329-341.
24. Kaplan, D., Hempstead, B., Martin-Zanca, D., Chao, M. and Parada, L. (1991) The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science, 252, 554-558.
25. 3 responses in PC12 cells. FEBS Lett., 324, 147-152.
26. Liu, J., Mathias, S., Yang, Z. and Kolesnick, R.N. (1994) Renaturation and tumor necrosis factor-α stimulation of a 97-kDa ceramide-activated protein kinase. J. Biol. Chem., 269, 3047-3052.
27. tri binding. J. Biol. Chem., 269, 6884-6891.
28. Meakin, S.O. and Shooter, E.M. (1992) The neurotrophin receptors. Trends Neurosci., 15, 323-331.
29. Omichi, M., Decker, S.J. and Saltiel, A.R. (1991) Nerve growth factor induces the association of a 130 kDa phosphoprotein with its receptor in PC-12 pheochromocytoma cells. Cell Regul., 2, 691-697.
30. Rabizadeh, S., Oh, J., Zhong, L.T., Yang, J., Bitler, C.M., Butcher, L.L. and Bredesen, D.E. (1993) Induction of apoptosis by the low-affinity NGF receptor. Science, 261, 345-348.
31. Radeke, M.J., Misko, T.P., Hsu, C., Herzenberg, L.A. and Shooter, E.M. (1987) Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature, 325, 593-597.
32. Rovelli, G., Heller, R.A., Canossa, M. and Shooter, E.M. (1993) Chimeric tumor necrosis factor-TrkA receptors reveal that ligand-dependent activation of the TrkA tyrosine kinase is sufficient for differentiation and survival of PC12 cells. Proc. Natl Acad. Sci. USA, 90, 8717-8721.
33. Snider, W.D. (1994) Function of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell, 77, 627-638.
34. LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells. Neuron, 12, 733-745.
35. Volonté, C., Ross, A.H. and Greene, L.A. (1993a) Association of a purine-analogue-sensitive protein kinase activity with p75 nerve growth factor receptors. Mol. Biol. Cell, 4, 71-78.
36. Volonte, C., Angelastro, J.M. and Greene, L.A. (1993b) Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors. J. Biol. Chem., 268, 21410-21415.