Inhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding

Journal of Biological Chemistry

Volumn 283, Issue 24, 2008, Pages 16772-16780

  Mikkelsen, Jakob H ^a   Gyrup, Claus ^a   Kristensen, Peter ^a   Overgaard, Michael T ^a   Poulsen, Christine B ^a   Laursen, Lisbeth S ^a   Oxvig, Claus ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; ANTIBODIES; CALCIUM; CALCIUM ALLOYS; KNOWLEDGE BASED SYSTEMS; OBSTETRICS; ORGANIC ACIDS; PLANNING; PLASMAS; STRATEGIC PLANNING; SUBSTRATES;

ACTIVE SITES; ANTIBODY BINDINGS; BINDING PROTEINS; CALCIUM IONS; DO-MAINS; GROWTH FACTORS; HUMAN DISEASES; INHIBITORY COMPOUNDS; METALLOPROTEINASE; PLASMA PROTEINS; PROTEOLYTIC ACTIVITIES; PROTEOLYTIC ENZYMES; SELECTIVE INHIBITIONS; SINGLE CHAIN FRAGMENT VARIABLES; SINGLE SITES; SUBSTRATE BINDINGS;

BINDING SITES;

CALCIUM ION; PREGNANCY ASSOCIATED PLASMA PROTEIN A; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 4; MONOCLONAL ANTIBODY; PEPTIDE LIBRARY; SOMATOMEDIN C;

ANTIGEN BINDING; ARTICLE; CALCIUM BINDING; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DEGRADATION; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CELL LINE; CHEMISTRY; CHICKEN; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SURFACE PLASMON RESONANCE;

ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES; CELL LINE; CHICKENS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 4; INSULIN-LIKE GROWTH FACTOR I; MODELS, GENETIC; PEPTIDE LIBRARY; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SURFACE PLASMON RESONANCE;

EID: 47749087856     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802429200     Document Type: Article

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