-
1
-
-
0027513982
-
A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model
-
Samama P, Cotecchia S, Costa T, Lefkowitz RJ (1993) A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. J Biol Chem 268:4625-4636.
-
(1993)
J Biol Chem
, vol.268
, pp. 4625-4636
-
-
Samama, P.1
Cotecchia, S.2
Costa, T.3
Lefkowitz, R.J.4
-
2
-
-
0034784920
-
Rhodopsin: Structural basis of molecular physiology
-
Menon ST, Han M, Sakmar TP (2001) Rhodopsin: Structural basis of molecular physiology. Physiol Rev 81:1659-1688.
-
(2001)
Physiol Rev
, vol.81
, pp. 1659-1688
-
-
Menon, S.T.1
Han, M.2
Sakmar, T.P.3
-
3
-
-
0034051479
-
Absorption spectroscopy in studies of visual pigments: Spectral and kinetic characterization of intermediates
-
Lewis JW, Kliger DS (2000) Absorption spectroscopy in studies of visual pigments: Spectral and kinetic characterization of intermediates. Methods Enzymol 315:164-178.
-
(2000)
Methods Enzymol
, vol.315
, pp. 164-178
-
-
Lewis, J.W.1
Kliger, D.S.2
-
4
-
-
0032412196
-
Visual pigment: G-protein-coupled receptor for light signals
-
Shichida Y, Imai H (1998) Visual pigment: G-protein-coupled receptor for light signals. Cell Mol Life Sci 54:1299-1315.
-
(1998)
Cell Mol Life Sci
, vol.54
, pp. 1299-1315
-
-
Shichida, Y.1
Imai, H.2
-
5
-
-
34547700719
-
2H NMR of aligned membranes
-
2H NMR of aligned membranes. J Mol Biol 372:50-66.
-
(2007)
J Mol Biol
, vol.372
, pp. 50-66
-
-
Struts, A.V.1
-
6
-
-
33748088543
-
2H NMR structure of retinal in metarhodopsin I
-
2H NMR structure of retinal in metarhodopsin I. J Am Chem Soc 128:11067-11071.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 11067-11071
-
-
Salgado, G.F.1
-
7
-
-
23044486642
-
Structure of rhodopsin and the metarhodopsin I photointermediate
-
Schertler GFX (2005) Structure of rhodopsin and the metarhodopsin I photointermediate. Curr Opin Struct Biol 15:408-415.
-
(2005)
Curr Opin Struct Biol
, vol.15
, pp. 408-415
-
-
Schertler, G.F.X.1
-
8
-
-
0029778268
-
Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F
-
Sheikh SP, Zvyaga TA, Lichtarge O, Sakmar TP, Bourne HR (1996) Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature 383:347-350.
-
(1996)
Nature
, vol.383
, pp. 347-350
-
-
Sheikh, S.P.1
Zvyaga, T.A.2
Lichtarge, O.3
Sakmar, T.P.4
Bourne, H.R.5
-
9
-
-
44949236117
-
High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation
-
Altenbach C, Kusnetzow AK, Ernst OP, Hofmann KP, Hubbell WL (2008) High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation. Proc Natl Acad Sci USA 105:7439-7444.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 7439-7444
-
-
Altenbach, C.1
Kusnetzow, A.K.2
Ernst, O.P.3
Hofmann, K.P.4
Hubbell, W.L.5
-
10
-
-
0029907599
-
Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
-
Farrens DL, Altenbach C, Yang K, Hubbell WL, Khorana HG (1996) Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science 274:768-770.
-
(1996)
Science
, vol.274
, pp. 768-770
-
-
Farrens, D.L.1
Altenbach, C.2
Yang, K.3
Hubbell, W.L.4
Khorana, H.G.5
-
11
-
-
47049130668
-
Crystal structure of the ligand-free G-protein-coupled receptor opsin
-
Park JH, Scheerer P, Hofmann KP, Choe HW, Ernst OP (2008) Crystal structure of the ligand-free G-protein-coupled receptor opsin. Nature 454:183-187.
-
(2008)
Nature
, vol.454
, pp. 183-187
-
-
Park, J.H.1
Scheerer, P.2
Hofmann, K.P.3
Choe, H.W.4
Ernst, O.P.5
-
12
-
-
25144510053
-
The role of Glu 181 in the photoactivation of rhodopsin
-
Lüdeke S, et al. (2005) The role of Glu 181 in the photoactivation of rhodopsin. J Mol Biol 353:345-356.
-
(2005)
J Mol Biol
, vol.353
, pp. 345-356
-
-
Lüdeke, S.1
-
13
-
-
0028017506
-
Identification of glutamic acid 113 as the Schiff base proton acceptor in the Metarhodopsin II photointermediate of rhodopsin
-
Jäger F, Fahmy K, Sakmar TP, Siebert F (1994) Identification of glutamic acid 113 as the Schiff base proton acceptor in the Metarhodopsin II photointermediate of rhodopsin. Biochemistry 33:10878-10882.
-
(1994)
Biochemistry
, vol.33
, pp. 10878-10882
-
-
Jäger, F.1
Fahmy, K.2
Sakmar, T.P.3
Siebert, F.4
-
14
-
-
0028061193
-
A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin
-
Arnis S, Fahmy K, Hofmann KP, Sakmar TP (1994) A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin. J Biol Chem 269:23879-23881.
-
(1994)
J Biol Chem
, vol.269
, pp. 23879-23881
-
-
Arnis, S.1
Fahmy, K.2
Hofmann, K.P.3
Sakmar, T.P.4
-
15
-
-
45649083187
-
Functional role of the "ionic lock" - an interhelical hydrogen-bond network in family A heptahelical receptors
-
Vogel R, et al. (2008) Functional role of the "ionic lock" - an interhelical hydrogen-bond network in family A heptahelical receptors. J Mol Biol 380:648-655.
-
(2008)
J Mol Biol
, vol.380
, pp. 648-655
-
-
Vogel, R.1
-
17
-
-
0021758996
-
Temperature and pH dependence of the Metarhodopsin I - Metarhodopsin II kinetics and equilibria in bovine rod disk membrane suspensions
-
Parkes JH, Liebman PA (1984) Temperature and pH dependence of the Metarhodopsin I - Metarhodopsin II kinetics and equilibria in bovine rod disk membrane suspensions. Biochemistry 23:5054-5061.
-
(1984)
Biochemistry
, vol.23
, pp. 5054-5061
-
-
Parkes, J.H.1
Liebman, P.A.2
-
18
-
-
0027317273
-
Two different forms of Metarhodopsin II: Schiff base deprotonation precedes proton uptake and signaling state
-
Arnis S, Hofmann KP (1993) Two different forms of Metarhodopsin II: Schiff base deprotonation precedes proton uptake and signaling state. Proc Natl Acad Sci USA 90:7849-7853.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 7849-7853
-
-
Arnis, S.1
Hofmann, K.P.2
-
20
-
-
0027757062
-
Effects of temperature on rhodopsin photointermediates from lumirhodopsin to metarhodopsin II
-
Thorgeirsson TE, Lewis JW, Wallace-Williams SE, Kliger DS (1993) Effects of temperature on rhodopsin photointermediates from lumirhodopsin to metarhodopsin II. Biochemistry 32:13861-13872.
-
(1993)
Biochemistry
, vol.32
, pp. 13861-13872
-
-
Thorgeirsson, T.E.1
Lewis, J.W.2
Wallace-Williams, S.E.3
Kliger, D.S.4
-
21
-
-
33747625451
-
a of the retinal Schiff base
-
a of the retinal Schiff base. J Am Chem Soc 128:10503-10512.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 10503-10512
-
-
Vogel, R.1
-
23
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
Palczewski K, et al. (2000) Crystal structure of rhodopsin: A G protein-coupled receptor. Science 289:739-745.
-
(2000)
Science
, vol.289
, pp. 739-745
-
-
Palczewski, K.1
-
24
-
-
4344581120
-
The retinal conformation and its environment in rhodopsin in light of a new 2.2 Å crystal structure
-
Okada T, et al. (2004) The retinal conformation and its environment in rhodopsin in light of a new 2.2 Å crystal structure. J Mol Biol 342:571-583.
-
(2004)
J Mol Biol
, vol.342
, pp. 571-583
-
-
Okada, T.1
-
25
-
-
6344248639
-
Structure of bovine rhodopsin in a trigonal crystal form
-
Li J, Edwards PC, Burghammer M, Villa C, Schertler GFX (2004) Structure of bovine rhodopsin in a trigonal crystal form. J Mol Biol 343:1409-1438.
-
(2004)
J Mol Biol
, vol.343
, pp. 1409-1438
-
-
Li, J.1
Edwards, P.C.2
Burghammer, M.3
Villa, C.4
Schertler, G.F.X.5
-
26
-
-
0027374544
-
Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and Metarhodopsin II: A Fourier-transform infrared spectroscopy study of site-directed mutants
-
Fahmy K, et al. (1993) Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and Metarhodopsin II: A Fourier-transform infrared spectroscopy study of site-directed mutants. Proc Natl Acad Sci USA 90:10206-10210.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 10206-10210
-
-
Fahmy, K.1
-
27
-
-
24344507257
-
-
Vogel R, Siebert F, Lüdeke S, Hirshfeld A, Sheves M (2005) Agonists and partial agonists of rhodopsin: Retinals with ring modifications. Biochemistry 44:11684-11699, and erratum (2005) 44:12914.
-
Vogel R, Siebert F, Lüdeke S, Hirshfeld A, Sheves M (2005) Agonists and partial agonists of rhodopsin: Retinals with ring modifications. Biochemistry 44:11684-11699, and erratum (2005) 44:12914.
-
-
-
-
28
-
-
32344443931
-
Agonists and partial agonists of rhodopsin: Retinal polyene methylation affects receptor activation
-
Vogel R, et al. (2006) Agonists and partial agonists of rhodopsin: Retinal polyene methylation affects receptor activation. Biochemistry 45:1640-1652.
-
(2006)
Biochemistry
, vol.45
, pp. 1640-1652
-
-
Vogel, R.1
-
29
-
-
0037014696
-
Electrostatic properties of membrane lipids coupled to metarhodopsin II formation in visual transduction
-
Wang Y, Botelho AV, Martinez GV, Brown MF (2002) Electrostatic properties of membrane lipids coupled to metarhodopsin II formation in visual transduction. J Am Chem Soc 124:7690-7701.
-
(2002)
J Am Chem Soc
, vol.124
, pp. 7690-7701
-
-
Wang, Y.1
Botelho, A.V.2
Martinez, G.V.3
Brown, M.F.4
-
30
-
-
0027518957
-
Lipid headgroup and acyl chain composition modulate the MI-MII equilibrium of rhodopsin in recombinant membranes
-
Gibson NJ, Brown MF (1993) Lipid headgroup and acyl chain composition modulate the MI-MII equilibrium of rhodopsin in recombinant membranes. Biochemistry 32:2438-2454.
-
(1993)
Biochemistry
, vol.32
, pp. 2438-2454
-
-
Gibson, N.J.1
Brown, M.F.2
-
31
-
-
33845505655
-
Curvature and hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes
-
Botelho AV, Huber T, Sakmar TP, Brown MF (2006) Curvature and hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes. Biophys J 91:4464-4477.
-
(2006)
Biophys J
, vol.91
, pp. 4464-4477
-
-
Botelho, A.V.1
Huber, T.2
Sakmar, T.P.3
Brown, M.F.4
-
32
-
-
0040141552
-
Signaling states of rhodopsin: Retinal provides a scaffold for activating proton transfer switches
-
Meyer CK, et al. (2000) Signaling states of rhodopsin: Retinal provides a scaffold for activating proton transfer switches. J Biol Chem 275:19713-19718.
-
(2000)
J Biol Chem
, vol.275
, pp. 19713-19718
-
-
Meyer, C.K.1
-
33
-
-
33947356279
-
G protein coupled receptor structure and activation
-
Kobilka BK (2007) G protein coupled receptor structure and activation. Biochim Biophys Acta 1768:794-807.
-
(2007)
Biochim Biophys Acta
, vol.1768
, pp. 794-807
-
-
Kobilka, B.K.1
-
34
-
-
36248970132
-
Crystal structure of thehumanbeta-2 adrenergic G-protein-coupled receptor
-
Rasmussen SG, et al. (2007) Crystal structure of thehumanbeta-2 adrenergic G-protein-coupled receptor. Nature 450:383-387.
-
(2007)
Nature
, vol.450
, pp. 383-387
-
-
Rasmussen, S.G.1
-
35
-
-
47949129742
-
1- adrenergic G-protein-coupled receptor
-
1- adrenergic G-protein-coupled receptor. Nature 454:486-491.
-
(2008)
Nature
, vol.454
, pp. 486-491
-
-
Warne, T.1
-
36
-
-
36448995359
-
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
-
Cherezov V, et al. (2007) High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318:1258-1265.
-
(2007)
Science
, vol.318
, pp. 1258-1265
-
-
Cherezov, V.1
-
37
-
-
4344674667
-
Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge
-
Kim JM, et al. (2004) Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge. Proc Natl Acad Sci USA 101:12508-12513.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12508-12513
-
-
Kim, J.M.1
-
38
-
-
0027270898
-
Regulation of the rhodopsin-transducin interaction by a highly conserved carboxylic acid group
-
Fahmy K, Sakmar TP (1993) Regulation of the rhodopsin-transducin interaction by a highly conserved carboxylic acid group. Biochemistry 32:7229-7236.
-
(1993)
Biochemistry
, vol.32
, pp. 7229-7236
-
-
Fahmy, K.1
Sakmar, T.P.2
-
39
-
-
3142773613
-
Rhodopsin activation exposes a key hydrophobic binding site for the transducin α-subunit C terminus
-
Janz JM, Farrens DL (2004) Rhodopsin activation exposes a key hydrophobic binding site for the transducin α-subunit C terminus. J Biol Chem 279:29767-29773.
-
(2004)
J Biol Chem
, vol.279
, pp. 29767-29773
-
-
Janz, J.M.1
Farrens, D.L.2
-
40
-
-
0020020855
-
Preparation of retinal rod outer segments
-
Papermaster DS (1982) Preparation of retinal rod outer segments. Methods Enzymol 81:48-52.
-
(1982)
Methods Enzymol
, vol.81
, pp. 48-52
-
-
Papermaster, D.S.1
-
41
-
-
0037150089
-
Conformational energetics of rhodopsin modulated by nonlamellar-forming lipids
-
Botelho AV, Gibson NJ, Thurmond RL, Wang Y, Brown MF (2002) Conformational energetics of rhodopsin modulated by nonlamellar-forming lipids. Biochemistry 41:6354-6368.
-
(2002)
Biochemistry
, vol.41
, pp. 6354-6368
-
-
Botelho, A.V.1
Gibson, N.J.2
Thurmond, R.L.3
Wang, Y.4
Brown, M.F.5
|