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Volumn 133, Issue 16, 2006, Pages 3055-3061

How does cholesterol affect the way Hedgehog works?

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; MORPHOGEN; PROTEOHEPARAN SULFATE; SONIC HEDGEHOG PROTEIN;

EID: 33748796068     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.02472     Document Type: Review
Times cited : (29)

References (48)
  • 1
    • 0035694931 scopus 로고    scopus 로고
    • Distinct roles of Central missing and Dispatched in sending the Hedgehog signal
    • Amanai, K. and Jiang, J. (2001). Distinct roles of Central missing and Dispatched in sending the Hedgehog signal. Development 128, 5119-5127.
    • (2001) Development , vol.128 , pp. 5119-5127
    • Amanai, K.1    Jiang, J.2
  • 2
    • 0028329349 scopus 로고
    • Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
    • Basler, K. and Struhl, G. (1994). Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208-214.
    • (1994) Nature , vol.368 , pp. 208-214
    • Basler, K.1    Struhl, G.2
  • 3
    • 0032474837 scopus 로고    scopus 로고
    • Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
    • Bellaiche, Y., The, I. and Perrimon, N. (1998). Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature 394, 85-88.
    • (1998) Nature , vol.394 , pp. 85-88
    • Bellaiche, Y.1    The, I.2    Perrimon, N.3
  • 4
    • 2542627320 scopus 로고    scopus 로고
    • Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways
    • Bornemann, D. J., Duncan, J. E., Staatz, W., Selleck, S. and Warrior, R. (2004). Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways. Development 131, 1927-1938.
    • (2004) Development , vol.131 , pp. 1927-1938
    • Bornemann, D.J.1    Duncan, J.E.2    Staatz, W.3    Selleck, S.4    Warrior, R.5
  • 5
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand, A. H. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 6
    • 0033598964 scopus 로고    scopus 로고
    • Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
    • Burke, R., Nellen, D., Bellotto, M., Hafen, E., Senti, K. A., Dickson, B. J. and Basler, K. (1999). Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell 99, 803-815.
    • (1999) Cell , vol.99 , pp. 803-815
    • Burke, R.1    Nellen, D.2    Bellotto, M.3    Hafen, E.4    Senti, K.A.5    Dickson, B.J.6    Basler, K.7
  • 7
    • 33244463974 scopus 로고    scopus 로고
    • Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix
    • Callejo, A., Torroja, C., Quijada, L. and Guerrero, I. (2006). Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix. Development 133, 471-483.
    • (2006) Development , vol.133 , pp. 471-483
    • Callejo, A.1    Torroja, C.2    Quijada, L.3    Guerrero, I.4
  • 8
    • 0028208698 scopus 로고
    • Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos
    • Capdevila, J., Pairente, F., Sampedro, J., Alonso, J. L. and Guerrero, I. (1994). Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos. Development 120, 987-998.
    • (1994) Development , vol.120 , pp. 987-998
    • Capdevila, J.1    Pairente, F.2    Sampedro, J.3    Alonso, J.L.4    Guerrero, I.5
  • 9
    • 27644523308 scopus 로고    scopus 로고
    • Heparan sulfate proteoglycans exert positive and negative effects in Shh activity
    • Carrasco, H., Olivares, G. H., Faunes, F, Oliva, C. and Larrain, J. (2005). Heparan sulfate proteoglycans exert positive and negative effects in Shh activity. J. Cell Biochem. 96, 831-838.
    • (2005) J. Cell Biochem. , vol.96 , pp. 831-838
    • Carrasco, H.1    Olivares, G.H.2    Faunes, F.3    Oliva, C.4    Larrain, J.5
  • 10
    • 0035860538 scopus 로고    scopus 로고
    • Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
    • Chamoun, Z., Mann, R. K., Nellen, D., von Kessler, D. R, Bellotto, M., Beachy, P. A. and Basler, K. (2001). Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science 293, 2080-2084.
    • (2001) Science , vol.293 , pp. 2080-2084
    • Chamoun, Z.1    Mann, R.K.2    Nellen, D.3    von Kessler, D.R.4    Bellotto, M.5    Beachy, P.A.6    Basler, K.7
  • 11
    • 1842853184 scopus 로고    scopus 로고
    • Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
    • Chen, M. H., Li, Y. J., Kawakami, T, Xu, S. M. and Chuang, R. T. (2004). Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 18, 641-659.
    • (2004) Genes Dev. , vol.18 , pp. 641-659
    • Chen, M.H.1    Li, Y.J.2    Kawakami, T.3    Xu, S.M.4    Chuang, R.T.5
  • 12
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • Chen, Y. and Struhl, G. (1996). Dual roles for patched in sequestering and transducing Hedgehog. Cell 87, 553-563.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 13
    • 0032413830 scopus 로고    scopus 로고
    • In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex
    • Chen, Y. and Struhl, G. (1998). In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex. Development 125, 4943-4948.
    • (1998) Development , vol.125 , pp. 4943-4948
    • Chen, Y.1    Struhl, G.2
  • 16
    • 0346258165 scopus 로고    scopus 로고
    • The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila
    • Desbordes, S. C. and Sanson, B. (2003). The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila. Development 130, 6245-6255.
    • (2003) Development , vol.130 , pp. 6245-6255
    • Desbordes, S.C.1    Sanson, B.2
  • 17
    • 30644469247 scopus 로고    scopus 로고
    • Release and trafficking of lipid-linked morphogens
    • Eaton, S. (2006). Release and trafficking of lipid-linked morphogens. Curr. Opin. Genet Dev. 16, 17-22.
    • (2006) Curr. Opin. Genet Dev. , vol.16 , pp. 17-22
    • Eaton, S.1
  • 18
    • 9644264342 scopus 로고    scopus 로고
    • Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment
    • Gallet, A. and Therond, P. P. (2005). Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment. Dev. Biol. 277, 51-62.
    • (2005) Dev. Biol. , vol.277 , pp. 51-62
    • Gallet, A.1    Therond, P.P.2
  • 19
    • 0037321854 scopus 로고    scopus 로고
    • Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog
    • Gallet, A., Rodriguez, R., Ruel, L. and Therond, P. P., (2003). Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog. Dev. Cell 4, 191-204.
    • (2003) Dev. Cell , vol.4 , pp. 191-204
    • Gallet, A.R.1    Ruel, L.2    Therond, P.P.3
  • 20
    • 33244482560 scopus 로고    scopus 로고
    • Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia
    • Gallet, A., Ruel, L., Staccini-Lavenant L. and Therond, P. P. (2006). Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia. Development 133, 407-418.
    • (2006) Development , vol.133 , pp. 407-418
    • Gallet, A.1    Ruel, L.2    Staccini-Lavenant, L.3    Therond, P.P.4
  • 21
    • 13244292984 scopus 로고    scopus 로고
    • Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog
    • Glise, B., Miller, C. A., Crozatier, M., Halbisen, M. A., Wise, S., Olson, D. J., Vincent, A. and Blair, S. S. (2005). Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog. Dev. Cell 8, 255-266.
    • (2005) Dev. Cell , vol.8 , pp. 255-266
    • Glise, B.1    Miller, C.A.2    Crozatier, M.3    Halbisen, M.A.4    Wise, S.5    Olson, D.J.6    Vincent, A.7    Blair, S.S.8
  • 22
    • 33645228803 scopus 로고    scopus 로고
    • A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form
    • Goetz, J. A., Singh, S., Suber, L. M., Kull, F. J. and Robbins, D. J. (2006). A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form. J. Biol. Chem. 281, 4087-4093.
    • (2006) J. Biol. Chem. , vol.281 , pp. 4087-4093
    • Goetz, J.A.1    Singh, S.2    Suber, L.M.3    Kull, F.J.4    Robbins, D.J.5
  • 23
    • 13244257603 scopus 로고    scopus 로고
    • The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog
    • Gorfinkiel, N., Sierra, J., Callejo, A., Ibanez, C. and Guerrero, I. (2005). The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog. Dev. Cell 18, 241-253.
    • (2005) Dev. Cell , vol.18 , pp. 241-253
    • Gorfinkiel, N.1    Sierra, J.2    Callejo, A.3    Ibanez, C.4    Guerrero, I.5
  • 24
    • 2342440335 scopus 로고    scopus 로고
    • Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation
    • Han, C., Belenkaya, T. Y., Khodoun, M., Tauchi, M., Lin, X. and Lin, X. (2004a). Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation. Development 131, 1563-1575.
    • (2004) Development , vol.131 , pp. 1563-1575
    • Han, C.1    Belenkaya, T.Y.2    Khodoun, M.3    Tauchi, M.4    Lin, X.5    Lin, X.6
  • 25
    • 1242329977 scopus 로고    scopus 로고
    • Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process
    • Han, C., Belenkaya, T. Y., Wang, B. and Lin, X. (2004b). Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process. Development 131, 601-611.
    • (2004) Development , vol.131 , pp. 601-611
    • Han, C.1    Belenkaya, T.Y.2    Wang, B.3    Lin, X.4
  • 26
    • 0001347357 scopus 로고
    • Simple and efficient generation of marked clones in Drosophila
    • Harrison, D. A. and Perrimon, N. (1993). Simple and efficient generation of marked clones in Drosophila. Curr. Biol. 3, 424-433.
    • (1993) Curr. Biol. , vol.3 , pp. 424-433
    • Harrison, D.A.1    Perrimon, N.2
  • 28
    • 0036733753 scopus 로고    scopus 로고
    • Cholesterol modification of Hedgehog family proteins
    • Jeong, J. and McMahon, A. P. (2002). Cholesterol modification of Hedgehog family proteins. J. Clin. Invest 110, 591-596.
    • (2002) J. Clin. Invest , vol.110 , pp. 591-596
    • Jeong, J.1    McMahon, A.P.2
  • 29
    • 0030450052 scopus 로고    scopus 로고
    • The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing
    • Kadowaki, T., Wilder, E., Klingensmith, J., Zachary K. and Perrimon, N. (1996). The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev 10, 3116-3128.
    • (1996) Genes Dev , vol.10 , pp. 3116-3128
    • Kadowaki, T.1    Wilder, E.2    Klingensmith, J.3    Zachary, K.4    Perrimon, N.5
  • 30
    • 5044249440 scopus 로고    scopus 로고
    • Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity
    • Kreuger, J., Perez, L., Giraldez, A. J. and Cohen, S. M. (2004). Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity. Dev. Cell 7, 503-512.
    • (2004) Dev. Cell , vol.7 , pp. 503-512
    • Kreuger, J.1    Perez, L.2    Giraldez, A.J.3    Cohen, S.M.4
  • 31
    • 0035942989 scopus 로고    scopus 로고
    • Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
    • Lee, J. D. and Treisman, J. E. (2001). Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein. Curr. Biol. 11, 1147-1152.
    • (2001) Curr. Biol. , vol.11 , pp. 1147-1152
    • Lee, J.D.1    Treisman, J.E.2
  • 32
    • 33646247878 scopus 로고    scopus 로고
    • Cholesterol modification restricts the spread of Shh gradient in the limb bud
    • Li, Y., Zhang, H., Litingtung, Y. and Chiang, C. (2006). Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc. Natl. Acad. Sci. USA 103, 6548-6553.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 6548-6553
    • Li, Y.1    Zhang, H.2    Litingtung, Y.3    Chiang, C.4
  • 33
    • 1242306884 scopus 로고    scopus 로고
    • Model organisms lead the way to protein palmitoyltransferases
    • Linder, M. E. and Deschenes, R. J. (2004). Model organisms lead the way to protein palmitoyltransferases. J. Cell Sci. 117, 521-526.
    • (2004) J. Cell Sci. , vol.117 , pp. 521-526
    • Linder, M.E.1    Deschenes, R.J.2
  • 34
    • 0037470952 scopus 로고    scopus 로고
    • Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
    • Lum, L., Yao, S., Mazer, B., Rovescalli, A., Von Kessler, D., Nirenberg, M. and Beachy, P. A. (2003). Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science 299, 2039-2045.
    • (2003) Science , vol.299 , pp. 2039-2045
    • Lum, L.1    Yao, S.2    Mazer, B.3    Rovescalli, A.4    Von Kessler, D.5    Nirenberg, M.6    Beachy, P.A.7
  • 35
    • 30644480899 scopus 로고    scopus 로고
    • The endocytic pathway and formation of the Wingless morphogen gradient
    • Marois, E., Mahmoud, A. and Eaton, S. (2006). The endocytic pathway and formation of the Wingless morphogen gradient. Development 133, 307-317.
    • (2006) Development , vol.133 , pp. 307-317
    • Marois, E.1    Mahmoud, A.2    Eaton, S.3
  • 36
    • 0036339605 scopus 로고    scopus 로고
    • Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling
    • Micchelli, C. A., The, I., Selva, E., Mogila, V. and Perrimon, N. (2002). Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development 129, 843-851.
    • (2002) Development , vol.129 , pp. 843-851
    • Micchelli, C.A.1    The, I.2    Selva, E.3    Mogila, V.4    Perrimon, N.5
  • 37
    • 31744439979 scopus 로고    scopus 로고
    • Palmitoylation of the EGFR ligand spitz by rasp increases spitz activity by restricting its diffusion
    • Miura, G. I., Buglino, J., Alvarado, D., Lemmon, M. A., Resh, M. D. and Treisman, J. E. (2006). Palmitoylation of the EGFR ligand spitz by rasp increases spitz activity by restricting its diffusion. Dev. Cell 10, 167-176.
    • (2006) Dev. Cell , vol.10 , pp. 167-176
    • Miura, G.I.1    Buglino, J.2    Alvarado, D.3    Lemmon, M.A.4    Resh, M.D.5    Treisman, J.E.6
  • 38
    • 24344447229 scopus 로고    scopus 로고
    • Signaling interactions between squamous and columnar epithelia of the Drosophila wing disc
    • Pallavi, S. K. and Shashidhara, L. S. (2005). Signaling interactions between squamous and columnar epithelia of the Drosophila wing disc. J. Cell Sci. 118, 3363-3370.
    • (2005) J. Cell Sci. , vol.118 , pp. 3363-3370
    • Pallavi, S.K.1    Shashidhara, L.S.2
  • 41
    • 0027479044 scopus 로고
    • Organizing activity of wingless protein in Drosophila
    • Struhl, G. and Basler, K. (1993). Organizing activity of wingless protein in Drosophila. Cell 72, 527-540.
    • (1993) Cell , vol.72 , pp. 527-540
    • Struhl, G.1    Basler, K.2
  • 42
    • 0028178786 scopus 로고
    • Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
    • Tabata, T. and Kornberg, T. B. (1994). Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89-102.
    • (1994) Cell , vol.76 , pp. 89-102
    • Tabata, T.1    Kornberg, T.B.2
  • 43
    • 1342341864 scopus 로고    scopus 로고
    • Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans
    • Takei, Y., Ozawa, Y., Sato, M., Watanabe, A. and Tabata, T. (2004). Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans. Development 131, 73-82.
    • (2004) Development , vol.131 , pp. 73-82
    • Takei, Y.1    Ozawa, Y.2    Sato, M.3    Watanabe, A.4    Tabata, T.5
  • 44
    • 23244466312 scopus 로고    scopus 로고
    • Expression of a secreted form of Daily, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog
    • Takeo, S., Akiyama, T., Firkus, C., Aigaki, T. and Nakato, H. (2005). Expression of a secreted form of Daily, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog. Dev. Biol. 284, 204-218.
    • (2005) Dev. Biol. , vol.284 , pp. 204-218
    • Takeo, S.1    Akiyama, T.2    Firkus, C.3    Aigaki, T.4    Nakato, H.5
  • 45
    • 3042799334 scopus 로고    scopus 로고
    • Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction
    • Torroja, C., Gorfinkiel, N. and Guerrero, I. (2004). Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction. Development 131, 2395-2408.
    • (2004) Development , vol.131 , pp. 2395-2408
    • Torroja, C.1    Gorfinkiel, N.2    Guerrero, I.3
  • 46
    • 23444443064 scopus 로고    scopus 로고
    • Mechanisms of Hedgehog gradient formation and interpretation
    • Torroja, C., Gorfinkiel, N. and Guerrero, I. (2005). Mechanisms of Hedgehog gradient formation and interpretation. J. Neurobiol. 64, 334-356.
    • (2005) J. Neurobiol. , vol.64 , pp. 334-356
    • Torroja, C.1    Gorfinkiel, N.2    Guerrero, I.3
  • 48
    • 0035822098 scopus 로고    scopus 로고
    • A freely diffusible form of Sonic hedgehog mediates long-range signalling
    • Zeng, X., Goetz, J. A., Suber, L. M., Scott, W. J., Jr. Schreiner, C. M. and Robbins, D. J. (2001). A freely diffusible form of Sonic hedgehog mediates long-range signalling. Nature 411, 716-720.
    • (2001) Nature , vol.411 , pp. 716-720
    • Zeng, X.1    Goetz, J.A.2    Suber, L.M.3    Scott Jr., W.J.4    Schreiner, C.M.5    Robbins, D.J.6


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