메뉴 건너뛰기




Volumn 9, Issue 3, 2009, Pages 185-191

Gene therapy for allergic diseases

Author keywords

Allergen specific immunotherapy; Allergic disease; Cytokine; Gene therapy; Regulatory T cell; TH2; Viral vector

Indexed keywords

ADENOVIRUS VECTOR; ADJUVANT; CD40 ANTIGEN; CD86 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; DNA VACCINE; FAS LIGAND; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 5; OVALBUMIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR GATA 3; TRANSFORMING GROWTH FACTOR BETA; CYTOKINE;

EID: 70349579521     PISSN: 15665232     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652309788488604     Document Type: Review
Times cited : (18)

References (70)
  • 1
    • 29544438445 scopus 로고    scopus 로고
    • Allergic disease and sensitization in Steiner school children
    • Floistrup H, Swartz J, Bergstrom A, et al. Allergic disease and sensitization in Steiner school children. J Allergy Clin Immunol 2006; 117: 59-66.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 59-66
    • Floistrup, H.1    Swartz, J.2    Bergstrom, A.3
  • 2
    • 33749016485 scopus 로고    scopus 로고
    • Immunological mechanisms of allergen-specific immunotherapy
    • Larche M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 2006; 6: 761-71.
    • (2006) Nat Rev Immunol , vol.6 , pp. 761-771
    • Larche, M.1    Akdis, C.A.2    Valenta, R.3
  • 3
    • 40049092917 scopus 로고    scopus 로고
    • Treatment strategies for allergy and asthma
    • Holgate ST, Polosa R. Treatment strategies for allergy and asthma. Nat Rev Immunol 2008; 8: 218-30.
    • (2008) Nat Rev Immunol , vol.8 , pp. 218-230
    • Holgate, S.T.1    Polosa, R.2
  • 5
    • 35948991877 scopus 로고    scopus 로고
    • Regulatory T cell therapy as individualized medicine for asthma and allergy
    • Xystrakis E, Urry Z, Hawrylowicz CM. Regulatory T cell therapy as individualized medicine for asthma and allergy. Curr Opin Allergy Clin Immunol 2007; 7: 535-41.
    • (2007) Curr Opin Allergy Clin Immunol , vol.7 , pp. 535-541
    • Xystrakis, E.1    Urry, Z.2    Hawrylowicz, C.M.3
  • 6
    • 35448956045 scopus 로고    scopus 로고
    • T cells in allergy and asthma
    • Larche M. Regulatory T cells in allergy and asthma. Chest 2007; 132: 1007-14.
    • (2007) Chest , vol.132 , pp. 1007-1014
    • Regulatory, L.M.1
  • 7
    • 17144405680 scopus 로고    scopus 로고
    • Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma
    • Hawrylowicz CM, O'Garra A. Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. Nat Rev Immunol 2005; 5: 271-83.
    • (2005) Nat Rev Immunol , vol.5 , pp. 271-283
    • Hawrylowicz, C.M.1    O'Garra, A.2
  • 8
    • 28544433747 scopus 로고    scopus 로고
    • Hawrylowicz CM. Regulatory T cells and IL-10 in allergic inflammation. J Exp Med 2005; 202: 1459-63.
    • Hawrylowicz CM. Regulatory T cells and IL-10 in allergic inflammation. J Exp Med 2005; 202: 1459-63.
  • 10
    • 35748966479 scopus 로고    scopus 로고
    • Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation
    • Wan YY, Flavell RA. 'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunol Rev 2007; 220: 199-213.
    • (2007) Immunol Rev , vol.220 , pp. 199-213
    • Wan, Y.Y.1    Flavell, R.A.2
  • 11
    • 0142219250 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis
    • Kitani A, Fuss I, Nakamura K, et al. Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis. J Exp Med 2003; 198: 1179-88.
    • (2003) J Exp Med , vol.198 , pp. 1179-1188
    • Kitani, A.1    Fuss, I.2    Nakamura, K.3
  • 12
    • 1342308180 scopus 로고    scopus 로고
    • Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease
    • Ling EM, Smith T, Nguyen XD, et al. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 2004; 363: 608-15.
    • (2004) Lancet , vol.363 , pp. 608-615
    • Ling, E.M.1    Smith, T.2    Nguyen, X.D.3
  • 13
    • 11144354531 scopus 로고    scopus 로고
    • Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines
    • Cosmi L, Liotta F, Angeli R, et al. Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines. Blood 2004; 103: 3117-21.
    • (2004) Blood , vol.103 , pp. 3117-3121
    • Cosmi, L.1    Liotta, F.2    Angeli, R.3
  • 14
    • 4544256262 scopus 로고    scopus 로고
    • Defective suppression of Th2 cytokines by CD4CD25 regulatory T cells in birch allergics during birch pollen season
    • Grindebacke H, Wing K, Andersson AC, et al. Defective suppression of Th2 cytokines by CD4CD25 regulatory T cells in birch allergics during birch pollen season. Clin Exp Allergy 2004; 34: 1364-72.
    • (2004) Clin Exp Allergy , vol.34 , pp. 1364-1372
    • Grindebacke, H.1    Wing, K.2    Andersson, A.C.3
  • 15
    • 34247526094 scopus 로고    scopus 로고
    • Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma
    • Hartl D, Koller B, Mehlhorn AT, et al. Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma. J Allergy Clin Immunol 2007; 119: 1258-66.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 1258-1266
    • Hartl, D.1    Koller, B.2    Mehlhorn, A.T.3
  • 16
    • 22144479379 scopus 로고    scopus 로고
    • Oral tolerance in the absence of naturally occurring Tregs
    • Mucida D, Kutchukhidze N, Erazo A, et al. Oral tolerance in the absence of naturally occurring Tregs. J Clin Invest 2005; 115: 1923-33.
    • (2005) J Clin Invest , vol.115 , pp. 1923-1933
    • Mucida, D.1    Kutchukhidze, N.2    Erazo, A.3
  • 17
    • 46749126890 scopus 로고    scopus 로고
    • Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation
    • Curotto de Lafaille MA, Kutchukhidze N, Shen S, et al. Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation. Immunity 2008; 29: 114-26.
    • (2008) Immunity , vol.29 , pp. 114-126
    • Curotto de Lafaille, M.A.1    Kutchukhidze, N.2    Shen, S.3
  • 18
    • 56349118794 scopus 로고    scopus 로고
    • The IL-17 cytokine family and their role in allergic inflammation
    • Wang YH, Liu YJ. The IL-17 cytokine family and their role in allergic inflammation. Curr Opin Immunol 2008; 20: 697-702.
    • (2008) Curr Opin Immunol , vol.20 , pp. 697-702
    • Wang, Y.H.1    Liu, Y.J.2
  • 19
    • 0037636682 scopus 로고    scopus 로고
    • Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine
    • Barczyk A, Pierzchala W, Sozanska E. Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med 2003; 97: 726-33.
    • (2003) Respir Med , vol.97 , pp. 726-733
    • Barczyk, A.1    Pierzchala, W.2    Sozanska, E.3
  • 20
    • 20844455261 scopus 로고    scopus 로고
    • Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects
    • Hashimoto T, Akiyama K, Kobayashi N, Mori A. Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects. Int Arch Allergy Immunol 2005; 137 (Suppl 1): 51-4.
    • (2005) Int Arch Allergy Immunol , vol.137 , Issue.SUPPL. 1 , pp. 51-54
    • Hashimoto, T.1    Akiyama, K.2    Kobayashi, N.3    Mori, A.4
  • 21
    • 0036754255 scopus 로고    scopus 로고
    • Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    • Nakae S, Komiyama Y, Nambu A, et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 2002; 17: 375-87.
    • (2002) Immunity , vol.17 , pp. 375-387
    • Nakae, S.1    Komiyama, Y.2    Nambu, A.3
  • 22
    • 33751506710 scopus 로고    scopus 로고
    • Interleukin-17 is a negative regulator of established allergic asthma
    • Schnyder-Candrian S, Togbe D, Couillin I, et al. Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med 2006; 203: 2715-25.
    • (2006) J Exp Med , vol.203 , pp. 2715-2725
    • Schnyder-Candrian, S.1    Togbe, D.2    Couillin, I.3
  • 24
    • 0037302973 scopus 로고    scopus 로고
    • Gene therapy for asthma
    • Factor P. Gene therapy for asthma. Mol Ther 2003; 7: 148-52.
    • (2003) Mol Ther , vol.7 , pp. 148-152
    • Factor, P.1
  • 25
    • 0035216248 scopus 로고    scopus 로고
    • A double-blinded, comparative study of the effects of short preseason specific immunotherapy and topical steroids in patients with allergic rhinoconjunctivitis and asthma
    • Rak S, Heinrich C, Jacobsen L, Scheynius A, Venge P. A double-blinded, comparative study of the effects of short preseason specific immunotherapy and topical steroids in patients with allergic rhinoconjunctivitis and asthma. J Allergy Clin Immunol 2001; 108: 921-8.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 921-928
    • Rak, S.1    Heinrich, C.2    Jacobsen, L.3    Scheynius, A.4    Venge, P.5
  • 26
    • 0036687715 scopus 로고    scopus 로고
    • Conversion of grass pollen allergen-specific human IgE into a protective IgG(1) antibody
    • Flicker S, Steinberger P, Norderhaug L, et al. Conversion of grass pollen allergen-specific human IgE into a protective IgG(1) antibody. Eur J Immunol 2002; 32: 2156-62.
    • (2002) Eur J Immunol , vol.32 , pp. 2156-2162
    • Flicker, S.1    Steinberger, P.2    Norderhaug, L.3
  • 27
    • 0031713609 scopus 로고    scopus 로고
    • Near-fatal anaphylaxis after Hymenoptera venom immunotherapy
    • Wolf BL, Hamilton RG. Near-fatal anaphylaxis after Hymenoptera venom immunotherapy. J Allergy Clin Immunol 1998; 102: 527-8.
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 527-528
    • Wolf, B.L.1    Hamilton, R.G.2
  • 28
    • 0029925502 scopus 로고    scopus 로고
    • Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization
    • Hsu CH, Chua KY, Tao MH, et al. Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nat Med 1996; 2: 540-4.
    • (1996) Nat Med , vol.2 , pp. 540-544
    • Hsu, C.H.1    Chua, K.Y.2    Tao, M.H.3
  • 29
    • 0029664297 scopus 로고    scopus 로고
    • Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization
    • Raz E, Tighe H, Sato Y, et al. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci USA 1996; 93: 5141-5.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5141-5145
    • Raz, E.1    Tighe, H.2    Sato, Y.3
  • 30
    • 0842287300 scopus 로고    scopus 로고
    • Characterization of the protective and therapeutic efficiency of a DNA vaccine encoding the major birch pollen allergen Bet v 1a
    • Hartl A, Hochreiter R, Stepanoska T, Ferreira F, Thalhamer J. Characterization of the protective and therapeutic efficiency of a DNA vaccine encoding the major birch pollen allergen Bet v 1a. Allergy 2004; 59: 65-73.
    • (2004) Allergy , vol.59 , pp. 65-73
    • Hartl, A.1    Hochreiter, R.2    Stepanoska, T.3    Ferreira, F.4    Thalhamer, J.5
  • 31
    • 0032944136 scopus 로고    scopus 로고
    • Immune responses after immunization with plasmid DNA encoding Bet v 1, the major allergen of birch pollen
    • Hartl A, Kiesslich J, Weiss R, et al. Immune responses after immunization with plasmid DNA encoding Bet v 1, the major allergen of birch pollen. J Allergy Clin Immunol 1999; 103: 107-13.
    • (1999) J Allergy Clin Immunol , vol.103 , pp. 107-113
    • Hartl, A.1    Kiesslich, J.2    Weiss, R.3
  • 32
    • 0035284830 scopus 로고    scopus 로고
    • Antigen-independent suppression of the allergic immune response to bee venom phospholipase A(2) by DNA vaccination in CBA/J mice
    • Jilek S, Barbey C, Spertini F, Corthesy B. Antigen-independent suppression of the allergic immune response to bee venom phospholipase A(2) by DNA vaccination in CBA/J mice. J Immunol 2001; 166: 3612-21.
    • (2001) J Immunol , vol.166 , pp. 3612-3621
    • Jilek, S.1    Barbey, C.2    Spertini, F.3    Corthesy, B.4
  • 33
    • 0035863822 scopus 로고    scopus 로고
    • Vaccination with allergen-IL-18 fusion DNA protects against, and reverses established, airway hyperreactivity in a murine asthma model
    • Maecker HT, Hansen G, Walter DM, et al. Vaccination with allergen-IL-18 fusion DNA protects against, and reverses established, airway hyperreactivity in a murine asthma model. J Immunol 2001; 166: 959-65.
    • (2001) J Immunol , vol.166 , pp. 959-965
    • Maecker, H.T.1    Hansen, G.2    Walter, D.M.3
  • 34
    • 0032958073 scopus 로고    scopus 로고
    • Oral gene delivery with chitosan - DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
    • Roy K, Mao HQ, Huang SK, Leong KW. Oral gene delivery with chitosan - DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med 1999; 5: 387-91.
    • (1999) Nat Med , vol.5 , pp. 387-391
    • Roy, K.1    Mao, H.Q.2    Huang, S.K.3    Leong, K.W.4
  • 35
    • 0037326391 scopus 로고    scopus 로고
    • Absence of immunoglobulin E synthesis and airway eosinophilia by vaccination with plasmid DNA encoding ProDer p 1
    • Jacquet A, Magi M, Haumont M, et al. Absence of immunoglobulin E synthesis and airway eosinophilia by vaccination with plasmid DNA encoding ProDer p 1. Clin Exp Allergy 2003; 33: 218-25.
    • (2003) Clin Exp Allergy , vol.33 , pp. 218-225
    • Jacquet, A.1    Magi, M.2    Haumont, M.3
  • 36
    • 33745245276 scopus 로고    scopus 로고
    • Intramuscular immunization with DNA construct containing Der p 2 and signal peptide sequences primed strong IgE production
    • Tan LK, Huang CH, Kuo IC, Liew LM, Chua KY. Intramuscular immunization with DNA construct containing Der p 2 and signal peptide sequences primed strong IgE production. Vaccine 2006; 24: 5762-71.
    • (2006) Vaccine , vol.24 , pp. 5762-5771
    • Tan, L.K.1    Huang, C.H.2    Kuo, I.C.3    Liew, L.M.4    Chua, K.Y.5
  • 37
    • 33748088980 scopus 로고    scopus 로고
    • Immunization with a low-dose replicon DNA vaccine encoding Phl p 5 effectively prevents allergic sensitization
    • Gabler M, Scheiblhofer S, Kern K, et al. Immunization with a low-dose replicon DNA vaccine encoding Phl p 5 effectively prevents allergic sensitization. J Allergy Clin Immunol 2006; 118: 734-41.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 734-741
    • Gabler, M.1    Scheiblhofer, S.2    Kern, K.3
  • 38
    • 45949086201 scopus 로고    scopus 로고
    • Induction of adaptive T regulatory cells that suppress the allergic response by coimmunization of DNA and protein vaccines
    • Jin H, Kang Y, Zhao L, et al. Induction of adaptive T regulatory cells that suppress the allergic response by coimmunization of DNA and protein vaccines. J Immunol 2008; 180: 5360-72.
    • (2008) J Immunol , vol.180 , pp. 5360-5372
    • Jin, H.1    Kang, Y.2    Zhao, L.3
  • 39
    • 0031716080 scopus 로고    scopus 로고
    • The latex allergen Hev b 5 transcript is widely distributed after subcutaneous injection in BALB/c mice of its DNA vaccine
    • Slater JE, Paupore E, Zhang YT, Colberg-Poley AM. The latex allergen Hev b 5 transcript is widely distributed after subcutaneous injection in BALB/c mice of its DNA vaccine. J Allergy Clin Immunol 1998; 102: 469-75.
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 469-475
    • Slater, J.E.1    Paupore, E.2    Zhang, Y.T.3    Colberg-Poley, A.M.4
  • 40
    • 0033967316 scopus 로고    scopus 로고
    • Inhibition of immunoglobulin E response to Japanese cedar pollen allergen (Cry j 1) in mice by DNA immunization: Different outcomes dependent on the plasmid DNA inoculation method
    • Toda M, Sato H, Takebe Y, et al. Inhibition of immunoglobulin E response to Japanese cedar pollen allergen (Cry j 1) in mice by DNA immunization: different outcomes dependent on the plasmid DNA inoculation method. Immunology 2000; 99: 179-86.
    • (2000) Immunology , vol.99 , pp. 179-186
    • Toda, M.1    Sato, H.2    Takebe, Y.3
  • 41
    • 0036738405 scopus 로고    scopus 로고
    • Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity
    • Horner AA, Takabayashi K, Beck L, et al. Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity. J Allergy Clin Immunol 2002; 110: 413-20.
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 413-420
    • Horner, A.A.1    Takabayashi, K.2    Beck, L.3
  • 42
    • 0032521274 scopus 로고    scopus 로고
    • Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
    • Kline JN, Waldschmidt TJ, Businga TR, et al. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol 1998; 160: 2555-9.
    • (1998) J Immunol , vol.160 , pp. 2555-2559
    • Kline, J.N.1    Waldschmidt, T.J.2    Businga, T.R.3
  • 43
    • 0042877077 scopus 로고    scopus 로고
    • Ribavirin or CpG DNA sequence-modulated dendritic cells decrease the IgE level and airway inflammation
    • Chiang DJ, Ye YL, Chen WL, et al. Ribavirin or CpG DNA sequence-modulated dendritic cells decrease the IgE level and airway inflammation. Am J Respir Crit Care Med 2003; 168: 575-80.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 575-580
    • Chiang, D.J.1    Ye, Y.L.2    Chen, W.L.3
  • 44
    • 0036126748 scopus 로고    scopus 로고
    • Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma
    • Santeliz JV, Van Nest G, Traquina P, Larsen E, Wills-Karp M. Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J Allergy Clin Immunol 2002; 109: 455-62.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 455-462
    • Santeliz, J.V.1    Van Nest, G.2    Traquina, P.3    Larsen, E.4    Wills-Karp, M.5
  • 45
    • 10344222650 scopus 로고    scopus 로고
    • Immunostimulatory DNA reverses established allergen-induced airway remodeling
    • Youn CJ, Miller M, Baek KJ, et al. Immunostimulatory DNA reverses established allergen-induced airway remodeling. J Immunol 2004; 173: 7556-64.
    • (2004) J Immunol , vol.173 , pp. 7556-7564
    • Youn, C.J.1    Miller, M.2    Baek, K.J.3
  • 46
    • 0036858610 scopus 로고    scopus 로고
    • Immunostimulatory sequence oligodeoxynucleotide-based vaccination and immunomodulation: Two unique but complementary strategies for the treatment of allergic diseases
    • Horner AA, Raz E. Immunostimulatory sequence oligodeoxynucleotide-based vaccination and immunomodulation: two unique but complementary strategies for the treatment of allergic diseases. J Allergy Clin Immunol 2002; 110: 706-12.
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 706-712
    • Horner, A.A.1    Raz, E.2
  • 47
    • 33646827686 scopus 로고    scopus 로고
    • Efficacy evaluation of Der p 1 DNA vaccine for allergic asthma in an experimental mouse model
    • Huang FT, Lim LH, Chua KY. Efficacy evaluation of Der p 1 DNA vaccine for allergic asthma in an experimental mouse model. Vaccine 2006; 24: 4576-81.
    • (2006) Vaccine , vol.24 , pp. 4576-4581
    • Huang, F.T.1    Lim, L.H.2    Chua, K.Y.3
  • 48
    • 0032747388 scopus 로고    scopus 로고
    • DNA and RNA-based vaccines: Principles, progress and prospects
    • Leitner WW, Ying H, Restifo NP. DNA and RNA-based vaccines: principles, progress and prospects. Vaccine 1999; 18: 765-77.
    • (1999) Vaccine , vol.18 , pp. 765-777
    • Leitner, W.W.1    Ying, H.2    Restifo, N.P.3
  • 49
    • 0036401603 scopus 로고    scopus 로고
    • Adenovirus-mediated interferon gamma gene therapy for allergic asthma: Involvement of interleukin 12 and STAT4 signaling
    • Behera AK, Kumar M, Lockey RF, Mohapatra SS. Adenovirus-mediated interferon gamma gene therapy for allergic asthma: involvement of interleukin 12 and STAT4 signaling. Hum Gene Ther 2002; 13: 1697-709.
    • (2002) Hum Gene Ther , vol.13 , pp. 1697-1709
    • Behera, A.K.1    Kumar, M.2    Lockey, R.F.3    Mohapatra, S.S.4
  • 50
    • 0031952393 scopus 로고    scopus 로고
    • Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity
    • Hogan SP, Foster PS, Tan X, Ramsay AJ. Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity. Eur J Immunol 1998; 28: 413-23.
    • (1998) Eur J Immunol , vol.28 , pp. 413-423
    • Hogan, S.P.1    Foster, P.S.2    Tan, X.3    Ramsay, A.J.4
  • 51
    • 0035680992 scopus 로고    scopus 로고
    • Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsiveness in an animal model of asthma
    • Lee YL, Ye YL, Yu CI, et al. Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsiveness in an animal model of asthma. Hum Gene Ther 2001; 12: 2065-79.
    • (2001) Hum Gene Ther , vol.12 , pp. 2065-2079
    • Lee, Y.L.1    Ye, Y.L.2    Yu, C.I.3
  • 52
    • 0028845730 scopus 로고
    • Cloning of a new cytokine that induces IFN-gamma production by T cells
    • Okamura H, Tsutsi H, Komatsu T, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995; 378: 88-91.
    • (1995) Nature , vol.378 , pp. 88-91
    • Okamura, H.1    Tsutsi, H.2    Komatsu, T.3
  • 53
    • 0035873683 scopus 로고    scopus 로고
    • Il-18 gene transfer by adenovirus prevents the development of and reverses established allergen-induced airway hyperreactivity
    • Walter DM, Wong CP, DeKruyff RH, et al. Il-18 gene transfer by adenovirus prevents the development of and reverses established allergen-induced airway hyperreactivity. J Immunol 2001; 166: 6392-8.
    • (2001) J Immunol , vol.166 , pp. 6392-6398
    • Walter, D.M.1    Wong, C.P.2    DeKruyff, R.H.3
  • 54
    • 3442901898 scopus 로고    scopus 로고
    • Dendritic cells modulated by cytokine-expressing adenoviruses alleviate eosinophilia and airway hyperresponsiveness in an animal model of asthma
    • Ye YL, Lee YL, Chuang ZJ, et al. Dendritic cells modulated by cytokine-expressing adenoviruses alleviate eosinophilia and airway hyperresponsiveness in an animal model of asthma. J Allergy Clin Immunol 2004; 114: 88-96.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 88-96
    • Ye, Y.L.1    Lee, Y.L.2    Chuang, Z.J.3
  • 55
    • 33846025977 scopus 로고    scopus 로고
    • Effects of adenovirus-expressing IL-10 in alleviating airway inflammation in asthma
    • Fu CL, Chuang YH, Chau LY, Chiang BL. Effects of adenovirus-expressing IL-10 in alleviating airway inflammation in asthma. J Gene Med 2006; 8: 1393-9.
    • (2006) J Gene Med , vol.8 , pp. 1393-1399
    • Fu, C.L.1    Chuang, Y.H.2    Chau, L.Y.3    Chiang, B.L.4
  • 56
    • 0033987397 scopus 로고    scopus 로고
    • CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation
    • Hansen G, McIntire JJ, Yeung VP, et al. CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation. J Clin Invest 2000; 105: 61-70.
    • (2000) J Clin Invest , vol.105 , pp. 61-70
    • Hansen, G.1    McIntire, J.J.2    Yeung, V.P.3
  • 57
    • 5444276007 scopus 로고    scopus 로고
    • Adenovirus expressing Fas ligand gene decreases airway hyper-responsiveness and eosinophilia in a murine model of asthma
    • Chuang YH, Fu CL, Lo YC, Chiang BL. Adenovirus expressing Fas ligand gene decreases airway hyper-responsiveness and eosinophilia in a murine model of asthma. Gene Ther 2004; 11: 1497-505.
    • (2004) Gene Ther , vol.11 , pp. 1497-1505
    • Chuang, Y.H.1    Fu, C.L.2    Lo, Y.C.3    Chiang, B.L.4
  • 58
    • 33745597325 scopus 로고    scopus 로고
    • Fas-ligand-expressing adenovirus-transfected dendritic cells decrease allergen-specific T cells and airway inflammation in a murine model of asthma
    • Chuang YH, Suen JL, Chiang BL. Fas-ligand-expressing adenovirus-transfected dendritic cells decrease allergen-specific T cells and airway inflammation in a murine model of asthma. J Mol Med 2006; 84: 595-603.
    • (2006) J Mol Med , vol.84 , pp. 595-603
    • Chuang, Y.H.1    Suen, J.L.2    Chiang, B.L.3
  • 59
    • 33748879109 scopus 로고    scopus 로고
    • Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma
    • Wang CC, Fu CL, Yang YH, et al. Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma. Gene Ther 2006; 13: 1414-21.
    • (2006) Gene Ther , vol.13 , pp. 1414-1421
    • Wang, C.C.1    Fu, C.L.2    Yang, Y.H.3
  • 60
    • 50949119217 scopus 로고    scopus 로고
    • Novel vaccination for allergy through gene silencing of CD40 using small interfering RNA
    • Suzuki M, Zheng X, Zhang X, et al. Novel vaccination for allergy through gene silencing of CD40 using small interfering RNA. J Immunol 2008; 180: 8461-9.
    • (2008) J Immunol , vol.180 , pp. 8461-8469
    • Suzuki, M.1    Zheng, X.2    Zhang, X.3
  • 61
    • 45749085675 scopus 로고    scopus 로고
    • Topical application of cream-emulsified CD86 siRNA ameliorates allergic skin disease by targeting cutaneous dendritic cells
    • Ritprajak P, Hashiguchi M, Azuma M. Topical application of cream-emulsified CD86 siRNA ameliorates allergic skin disease by targeting cutaneous dendritic cells. Mol Ther 2008; 16: 1323-30.
    • (2008) Mol Ther , vol.16 , pp. 1323-1330
    • Ritprajak, P.1    Hashiguchi, M.2    Azuma, M.3
  • 62
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997; 89: 587-96.
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 63
    • 0033916858 scopus 로고    scopus 로고
    • Upregulation of the transcription factor GATA-3 in upper airway mucosa after in vivo and in vitro allergen challenge
    • Nakamura Y, Christodoulopoulos P, Cameron L, et al. Upregulation of the transcription factor GATA-3 in upper airway mucosa after in vivo and in vitro allergen challenge. J Allergy Clin Immunol 2000; 105: 1146-52.
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 1146-1152
    • Nakamura, Y.1    Christodoulopoulos, P.2    Cameron, L.3
  • 64
    • 33745748325 scopus 로고    scopus 로고
    • Transcription factors Tbet and GATA-3 regulate development of airway remodeling
    • Kiwamoto T, Ishii Y, Morishima Y, et al. Transcription factors Tbet and GATA-3 regulate development of airway remodeling. Am J Respir Crit Care Med 2006; 174: 142-51.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 142-151
    • Kiwamoto, T.1    Ishii, Y.2    Morishima, Y.3
  • 65
    • 0035806279 scopus 로고    scopus 로고
    • Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression
    • Finotto S, De Sanctis GT, Lehr HA, et al. Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression. J Exp Med 2001; 193: 1247-60.
    • (2001) J Exp Med , vol.193 , pp. 1247-1260
    • Finotto, S.1    De Sanctis, G.T.2    Lehr, H.A.3
  • 66
    • 37549010258 scopus 로고    scopus 로고
    • Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness
    • Lee CC, Huang HY, Chiang BL. Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness. Mol Ther 2008; 16: 60-5.
    • (2008) Mol Ther , vol.16 , pp. 60-65
    • Lee, C.C.1    Huang, H.Y.2    Chiang, B.L.3
  • 67
    • 54749147546 scopus 로고    scopus 로고
    • RNA interference: New therapeutics in allergic diseases
    • Lee CC, Chiang BL. RNA interference: new therapeutics in allergic diseases. Curr Gene Ther 2008; 8: 236-46.
    • (2008) Curr Gene Ther , vol.8 , pp. 236-246
    • Lee, C.C.1    Chiang, B.L.2
  • 68
    • 9144221389 scopus 로고    scopus 로고
    • Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes
    • Garrett JK, Jameson SC, Thomson B, et al. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol 2004; 113: 115-9.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 115-119
    • Garrett, J.K.1    Jameson, S.C.2    Thomson, B.3
  • 69
    • 42149136164 scopus 로고    scopus 로고
    • Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness
    • Huang HY, Lee CC, Chiang BL. Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness. Gene Ther 2008; 15: 660-7.
    • (2008) Gene Ther , vol.15 , pp. 660-667
    • Huang, H.Y.1    Lee, C.C.2    Chiang, B.L.3
  • 70
    • 33745217889 scopus 로고    scopus 로고
    • Effects of overexpression of IL-10, IL-12, TGF-beta and IL-4 on allergen induced change in bronchial responsiveness
    • Fu CL, Ye YL, Lee YL, Chiang BL. Effects of overexpression of IL-10, IL-12, TGF-beta and IL-4 on allergen induced change in bronchial responsiveness. Respir Res 2006; 7: 72.
    • (2006) Respir Res , vol.7 , pp. 72
    • Fu, C.L.1    Ye, Y.L.2    Lee, Y.L.3    Chiang, B.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.