Intramuscular immunization with DNA construct containing Der p 2 and signal peptide sequences primed strong IgE production

Vaccine

Volumn 24, Issue 29-30, 2006, Pages 5762-5771

  Tan, Li Kiang ^a   Huang, Chiung Hui ^a   Kuo, I Chun ^b   Liew, Lee Mei ^a   Chua, Kaw Yan ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

Author keywords

Allergen vaccination; Dendritic cell; Der p 2; LAMP 1; Signal peptide

Indexed keywords

DNA VACCINE; GAMMA INTERFERON; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G2A; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PROTEIN P52; SIGNAL PEPTIDE;

ADOPTIVE TRANSFER; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DERMATOPHAGOIDES PTERONYSSINUS; DRUG EFFICACY; DRUG SAFETY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HOUSE DUST ALLERGY; HUMORAL IMMUNITY; IMMUNOGLOBULIN PRODUCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SENSITIZATION; T LYMPHOCYTE; TH1 CELL; TH2 CELL; VACCINATION;

ANIMALS; ANTIGENS, DERMATOPHAGOIDES; DESENSITIZATION, IMMUNOLOGIC; FEMALE; HYPERSENSITIVITY; IMMUNIZATION; IMMUNOGLOBULIN E; INJECTIONS, INTRAMUSCULAR; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; MICE; MICE, INBRED CBA; MITES; PROTEIN SORTING SIGNALS; VACCINES, DNA;

EID: 33745245276     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2006.04.064     Document Type: Article

References (33)

1. Johansson S.G., Hourihane J.O., Bousquet J., Bruijnzeel-Koomen C., Dreborg S., Haahtela T., et al. EAACI (The European Academy of Allergology and Clinical Immunology) nomenclature task force. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 56 (2001) 813-824
2. Hamelmann E., Rolinck-Werninghaus C., and Wahn U. Is there a role for anti-IgE in combination with specific allergen immunotherapy?. Curr Opin Allergy Clin Immunol 3 (2003) 501-510
3. Creticos P.S., Chen Y.H., and Schroeder J.T. New approaches in immunotherapy: allergen vaccination with immunostimulatory DNA. Immunol Allergy Clin North Am 24 (2004) 569-581
4. Kwon S.S., Kim N., and Yoo T.J. The effect of vaccination with DNA encoding murine T-cell epitopes on the Der p 1 and 2 induced immunoglobulin E synthesis. Allergy 56 (2001) 741-748
5. Hsu C.H., Chua K.Y., Tao M.H., Lai Y.L., Wu H.D., and Huang S.K. Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nat Med 2 (1996) 540-544
6. Peng H.J., Su S.N., Chang Z.N., Chao P.L., Kuo S.W., and Tsai L.C. Induction of specific TH1 responses and suppression of IgE antibody formation by vaccination with plasmid DNA encoding Der f 11. Vaccine 20 (2002) 1761-1768
7. Porgador A., Irvine K.R., Iwasaki A., Barber B.H., Restifo N.P., and Germain R.N. Predominant role for directly transfected DCs in antigen presentation to CD8+ T-cells after gene gun immunization. J Exp Med 188 (1998) 1075-1082
8. Akbari O., Panjwani N., Garcia S., Tasocon R., Lowrie D., and Stockinger B. DNA vaccination: transfection and activation of DCs as key events for immunity. J Exp Med 189 (1999) 169-178
9. Coombes B.K., and Mahony J.B. DC discoveries provide new insight into the cellular immunobiology of DNA vaccines. Immunol Lett 78 (2001) 103-111
10. Charbonnier A.S., Hammad H., Gosset P., Stewart G.A., Alkan S., Tonnel A.B., et al. Der p 1-pulsed myeloid and plasmacytoid dendritic cells from house dust-mite sensitized allergic patients dysregulate the T-cell response. J Leukoc Biol 73 (2003) 91-99
11. Van Rijt L.S., Jung S., Kleinjan A., Vos N., Willart M., Duez C., et al. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med 201 (2005) 981-991
12. Kojima Y., Xin K.Q., Ooki T., Hamajima K., Oikawa T., Shinoda K., et al. Adjuvant effect of multi-CpG motifs on an HIV-1 DNA vaccine. Vaccine 20 (2002) 2857-2865
13. Zhang A., Jin H., Zhang F., Ma Z., Tu Y., Ren Z., et al. Effects of multiple copies of CpG on DNA vaccination. DNA Cell Biol 24 (2005) 292-298
14. Widera G., Austin M., Rabussay D., Goldbeck C., Barnett S.W., Chen M., et al. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J Immunol 164 (2000) 4635-4640
15. Otten G., Schaefer M., Doe B., Liu H., Srivastava I., zur Megede J., et al. Enhancement of DNA vaccine potency in rhesus macaques by electroporation. Vaccine 22 (2004) 2489-2493
16. Baldwin S.L., D'Souza C.D., Orme I.M., Liu M.A., Huygen K., Denis O., et al. Immunogenicity and protective efficacy of DNA vaccines encoding secreted and non-secreted forms of Mycobacterium tuberculosis Ag85A. Tuber Lung Dis 79 (1999) 251-259
17. Drew D.R., Lightowlers M., and Strugnell R.A. Humoral immune response to DNA vaccines expressing secreted membrane bound and non-secreted forms of the Taenia ovis 45W antigen. Vaccine 18 (2000) 2522-2532
18. Jiang C., Magee D.M., Ivey F.D., and Cox R.A. Role of signal sequence in vaccine-induced protection against experimental coccidioidomycosis. Infect Immunol 70 (2002) 3539-3545
19. Barouch D.H., Letvin N.L., and Seder R.A. The role of cytokine DNAs as vaccine adjuvants for optimizing cellular immune responses. Immunol Rev 202 (2004) 266-274
20. Heymann P.W., Chapman M.D., Aalberse R.C., Fox J.W., and Plattis-Mills T.A.E. Antigenic and structural analysis of group II allergens (Der f II and Der p II) from house dust mites (Dermatophagoides spp.). J Allergy Clin Immunol 83 (1989) 1055-1067
21. Chua K.Y., Dilworth R.J., and Thomas W.R. Expression of Dermatophagoides pteronyssinus allergen, Der p II, in Escherichia coli and the binding studies with human IgE. Int Arch Allergy Appl Immunol 91 (1990) 124-129
22. Chua K.Y., Huang C.H., Shen H.D., and Thomas W.R. Analysis of sequence polymorphism of a major mite allergen, Der p 2. Clin Exp Allergy 26 (1996) 829-837
23. Wolfowicz C.B., Huangfu T.Q., and Chua K.Y. Expression and immunogenicity of the major house dust mite allergen Der p 1 following DNA immunization. Vaccine 21 (2003) 1195-1204
24. Tsai J.J., Shen H.D., and Chua K.Y. Purification of group 2 Dermatophagoides pteronyssinus allergen and prevalence of its specific IgE in asthmatics. Int Arch Allergy Immunol 121 (2000) 205-210
25. Zelenay S., Elias F., and Flo J. Immunostimulatory effects of plasmid DNA and synthetic oligodeoxynucleotides. Eur J Immunol 33 (2003) 1382-1392
26. Lambrecht B.N., De Veerman M., Coyle A.J., Gutierrez-Ramos J.C., Thielemans K., and Pauwels R.A. Myeloid DCs induce TH2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J Clin Invest 106 (2000) 551-559
27. Sung S., Rose Jr. C.E., and Fu S.M. Intratracheal priming with ovalbumin- and ovalbumin 323-339 peptide-pulsed DCs induces airway hyperresponsiveness, lung eosinophilia, goblet cell hyperplasia, and inflammation. J Immunol 166 (2001) 1261-1271
28. Graffi S.J., Dekan G., Stingl G., and Epstein M.M. Systemic administration of antigen-pulsed DCs induces experimental allergic asthma in mice upon aerosol antigen rechallenge. Clin Immunol 103 (2002) 176-184
29. Trujillo-Vargas C.M., Ramirez-Pineda J.R., Palmetshofer A., Grunewald S., Moll H., Berberich C., et al. Mice vaccinated with allergen-pulsed myeloid dendritic cells are not protected from developing allergen-induced TH2 responses. Int Arch Allergy Immunol 137 (2005) 219-228
30. Wu T.C., Guarnieri F.G., Staveley-O'Carroll K.F., Viscidi R.P., Levitsky H.I., Hedrick L., et al. Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens. Proc Natl Acad Sci USA 92 (1995) 11671
31. Kim T.W., Hung C.F., Boyd D., Juang J., He L., Kim J.W., et al. Enhancing DNA vaccine potency by combining a strategy to prolong DC life with intracellular targeting strategies. J Immunol 171 (2003) 2970-2976
32. Marques Jr. E.T., Chikhlikar P., de Arruda L.B., Leao I.C., Lu Y., Wong J., et al. HIV-1 p55Gag encoded in the lysosome-associated membrane protein-1 as a DNA plasmid vaccine chimera is highly expressed, traffics to the major histocompatibility class II compartment, and elicits enhanced immune responses. J Biol Chem 278 (2003) 37926-37936
33. de Arruda L.B., Chikhlikar P.R., August J.T., and Marques E.T. DNA vaccine encoding human immunodeficiency virus-1 Gag, targeted to the major histocompatibility complex II compartment by lysosomal-associated membrane protein, elicits enhanced long-term memory response. Immunology 112 (2004) 126-133