Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity

European Journal of Immunology

Volumn 28, Issue 2, 1998, Pages 413-423

  Hogan, Simon P ^a   Foster, Paul S ^a   Tan, Xiaoyun ^a   Ramsay, Alistair J ^a  

^a Biology and Environment   (Australia)

Author keywords

Airways allergy; Antiviral immunity; Gene therapy; IL 12; Vaccinia vector

Indexed keywords

INTERLEUKIN 12;

ANIMAL EXPERIMENT; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; GENE TARGETING; LUNG INFECTION; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; VACCINIA VIRUS; VIRUS IMMUNITY; VIRUS INFECTION;

ANIMALS; ANTIBODIES, VIRAL; CYTOKINES; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; IMMUNITY, MUCOSAL; INFLAMMATION; INTERFERON TYPE II; INTERLEUKIN-12; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RESPIRATORY HYPERSENSITIVITY; VACCINIA; VACCINIA VIRUS;

EID: 0031952393     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199802)28:02<413::AID-IMMU413>3.0.CO;2-1     Document Type: Article

References (45)

1. Robinson, D. S., Hamid, Q., Ying, S., Tsicopoulos, A., Barkans, J., Bentley, A. M., Corrigan, C., Durham, S. R. and Kay, A. B., Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 1992. 326: 298-304.
2. Geha, R. S., Regulation of IgE synthesis in humans. J. Allergy Clin. Immunol. 1992. 90: 143-150.
3. Sanderson, C. J., Interleukin-5, eosinophils, and disease. Blood 1992. 79: 3101-3109.
4. Azzawi, M., Bradley, B., Jeffery, P. K., Frew, A. J., Wardlaw, A. J., Knowles, G., Assoufi, B., Collins, J. V., Durham, S. and Kay, A. B., Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am. Rev. Respir. Dis. 1990. 142: 1407.
5. Nakajima, H., Iwamoto, I., Tomoe, S., Matsumura, R., Tomioka, H., Takatsu, K. and Yoshida, S., CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am. Rev. Respir. Dis. 1992. 146: 374-377.
6. Brusselle, G. G., Kips, J. C., Tavernier, J. H., Van Der Heyden, J. G., Cuvelier, C. A., Pauwels, R. A. and Bluethmann, H., Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin. Exp. Allergy 1994. 24: 73-80.
7. Corry, D. B., Folkesson, H. G., Warnock, M. L., Erle, D. J., Matthay, M. A., Wiener-Kronish, J. P. and Locksley, R. C., Interleukin-4, but not interleukin 5 or eosinophils, is required in an acute model of airway hyperreactivity. J. Exp. Med. 1996. 183: 109-117.
8. Foster, P. S., Hogan, S. P., Ramsay, A. J., Matthaei, K. I. and Young, I. G., Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 1996. 183: 195-201.
9. Blanden, R. V., T cell responses to viral and bacterial infection. Transplant. Rev. 1974. 19: 56-88.
10. Huang, S., Hendriks, W., Althage, A., Hemmi, S., Bluethmann, H., Kamigo, R., Vilcek, J., Zinkernagel, R. and Aguet, M., Immune response in mice that lack the interferon-γ receptor. Science 1993. 259: 1742-1745.
11. Ramsay, A. J., Ruby, J. and Ramshaw, I. A., A case for cytokines as effector molecules in the resolution of virus infection, Immunol. Today 1993. 14: 155-157.
12. Ruby, J. and Ramshaw, I., The antiviral activity of immune CD8+ T cells is dependent on interferon-gamma. Lymphokine Cytokine Res. 1991. 10: 353-358.
13. Kagi, D., Seiler, P., Pavlovic, J., Ledermann, B., Burki, K., Zinkernagel, R. M. and Hengartner, H., The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and non-cytopathic viruses. Eur. J. Immunol. 1995. 25: 3256-3262.
14. Sharma, D. P., Ramsay, A. J., Maguire, D. J., Rolph, M. S. and Ramshaw, I. A., Interleukin-4 mediates down regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo. J. Virol. 1996. 70: 7103-7107.
15. Salgame, P., Abrams, J. S., Clayberger, C., Goldstein, H., Convit, J., Modlin, R. J. and Bloom, B. R., Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 1991. 254: 279-282.
16. Actor, J.K., Shirai, M., Kullberg, M. C., Buller, R. M., Sher, A. and Berzofsky, J. A., Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance. Proc. Natl. Acad. Sci. USA 1993. 90: 948-952.
17. Coyle, A. J., Erard, F., Bertrand, C., Welti, S., Pircher, H. and LeGros, G., Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia. J. Exp. Med. 1995. 181: 1229-1233.
18. Snapper, C. M. and Paul, W. E., Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 1987. 236: 944-947.
19. Mosmann, T. R. and Coffman, R. L., TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 1989. 7: 145-173.
20. Yssel, H., Schneider, P. and Spits, H., Production of IL-4 by human T cells and regulation of differentiation of T-cell subsets by IL-4. Res. Immunol. 1993. 144: 610-616.
21. Manetti, R., Parronchi, P., Giudizi, M. G., Piccinni, M. P., Maggi, E., Trinchieri, G. and Romagnani, S., Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4 producing Th cells. J. Exp. Med. 1993. 177: 1199-1204.
22. Hsieh, C. S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A. and Murphy, K. M., Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993. 260: 547-549.
23. Trinchieri, G., Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 1995. 13: 251-276.
24. Wang, Z. E., Zheng, S., Corry, D. B., Dalton, D. K., Seder, R. A., Reiner, S. L. and Locksley, R. M., Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major. Proc. Natl. Acad. Sci. USA 1994. 91: 12932-12936.
25. Marshall, J. D., Secrist, H., DeKruyff, R. H., Wolf, S. F. and Umetsu, D. T., IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes. J. Immunol. 1995. 155: 111-117.
26. Gavett, S. H., O'Hearn, D. J., Li, X., Huang, S. K., Finkelman, F. D. and Wills, K. M., Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J. Exp. Med. 1995. 182: 1527-1536.
27. Kips, J. C., Brusselle, G. J., Joos, G. F., Peleman, R. A., Tavernier, J. H., Devos, R. R. and Pauwels, R. A., Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice. Am. Rev. Respir. Crit. Care Med. 1996. 153: 535-539.
28. Sur, S., Lam, J., Bouchard, P., Sigounas, A., Holbert, D. and Metzger, W. J., Immunomodulatory effects of IL-12 on allergic lung inflammation depend on timing of doses. J. Immunol. 1996. 157: 4173-4180.
29. Ramsay, A. J., Husband, A. J., Ramshaw, I. A., Bao, S., Matthaei, K. I., Koehler, G. and Kopf, M., The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science 1994. 264: 561-563.
30. Ramshaw, I. A., Ramsay, A. J., Karupiah, G., Rolph, M. S., Mahalingam, S. and Ruby, J. C., Cytokines and immunity to viral infection, Immunol. Rev. 1997. 159: in press.
31. Nakajima, H., Iwamoto, I. and Yoshida, S., Aerosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment in mouse trachea. Am. Rev. Respir. Dis. 1993. 148: 1102-1104.
32. Lack, G., Bradley, K. L., Hamelmann, E., Renz, H., Loader, J., Leung, D. Y. M., Larsen, G. and Gelfand, E. W., Nebulized IFN-γ inhibits the development of secondary allergic responses in mice. J. Immunol. 1996. 157: 1432-1439.
33. Fujisawa, T., Abu-Ghazaleh, R., Kita, H., Sanderson, C. J. and Gleich, G. J., Regulatory effects of cytokines on eosinophil degranulation. J. Immunol. 1990. 144: 642-646.
34. Gauchat, J. F., Lebman, D. A., Coffman, R. L., Gascan, H. and DeVries, J., Structure and expression of germline E transcripts induced by interleukin-4 to switch to IgE production. J. Exp. Med. 1990. 172: 463-473.
35. Li, X.-M., Chopra, R. K., Chou, T.-Y., Schofield, B. H., Wills-Karp, M. and Huang, S.-K., Mucosal IFN-γ gene transfer inhibits pulmonary allergic responses in mice. J. Immunol. 1996. 157: 3216-3219.
36. Ramsay, A. J., Leong, K. H. and Ramshaw, I. A., DNA vaccination against virus infection and enhancement of antiviral immunity following consecutive immunisation with DNA and viral vectors. Immunol. Cell. Biol. 1997. 75: 382-388.
37. Shaheen, S. O., Aaby, P., Hall, A. J., Barker, D., Heyes, C., Shiell, A. W. and Goudiaby, A., Measles and atopy in Guinea-Bisau. Lancet 1996. 347: 1792-1796.
38. Shirakawa, T., Enomoto, T., Shimazu, S. and Hopkin, J., The inverse association between tuberculin responses and atopic disorder. Science 1997. 275: 77-79.
39. Holt, P. G., A potential vaccine strategy for asthma and allied atopic diseases during early childhood. Lancet 1994. 344: 456-458.
40. Hu-Li, J., Ohara, J., Watson, C., Tsang, W. and Paul, W. E., Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that cell line (CT.4S). J. Immunol. 1989. 142: 800-807.
41. Swain, S. L. and Dutton, R. W., Production of a B cell growth-promoting activity, (DL) BCGF, from a cloned T cell line and its assay on the BCL1B cell line. J. Exp. Med. 1982. 156: 1821-1834.
42. Coupar, B. E. H., Andrew, M. E. and Boyle, D. B., A general method for the construction of recombinant vaccinia viruses expressing multiple foreign genes. Gene 1988. 68: 1-10.
43. Andrew, M. E., Coupar, B. E. H., Ada, G. L. and Boyle, D. B., Cell-mediated immune responses to influenza virus antigens expressed by vaccinia virus recombinants. Microb. Pathog. 1986. 1: 443-452.
44. Karupiah, G., Coupar, B. E., Andrew, M. E., Boyle, D. B., Phillips, S. M., Mullbacher, A., Blanden, R. V. and Ramshaw, I.A., Elevated natural killer cell responses in mice infected with recombinant vaccinia virus encoding murine IL-2. J. Immunol. 1990. 144: 290-298.
45. Cobbold, S. P., Jayasuria, A., Nash, A., Prospero, T. D. and Waldmann, H., Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 1984. 312: 548-551.