Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsiveness in an animal model of asthma

Human Gene Therapy

Volumn 12, Issue 17, 2001, Pages 2065-2079

  Lee, Yueh Lun ^a   Ye, Yi Ling ^a   Yu, Chun I ^a   Wu, Ya Ling ^a   Lai, Yih Loong ^a   Ku, Ping Hung ^a   Hong, Ruey Long ^a   Chiang, Bor Luen ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GAMMA INTERFERON; HOUSE DUST ALLERGEN; INTERLEUKIN 12; INTERLEUKIN 5; PROTEIN P35; PROTEIN P40; VIRUS VECTOR;

AIRWAY; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CELL DIFFERENTIATION; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; EOSINOPHILIA; FEMALE; FUSION GENE; GENE TARGETING; GENE TRANSFER; IMMUNOTHERAPY; LUNG PARENCHYMA; MOUSE; NONHUMAN; PHENOTYPE; PLASMID; PROTEIN EXPRESSION; RESPIRATORY TRACT DISEASE; T LYMPHOCYTE; TH1 CELL;

ALLERGENS; ANIMALS; ASTHMA; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; COS CELLS; DISEASE MODELS, ANIMAL; FEMALE; GENE THERAPY; IMMUNOTHERAPY; INFLAMMATION; INTERLEUKIN-12; LUNG; METHACHOLINE CHLORIDE; MICE; MICE, INBRED C57BL; PLASMIDS; TRANSFECTION; VACCINES, DNA;

ACARI; ANIMALIA; ASTIGMATA; MURINAE; PYROGLYPHIDAE;

EID: 0035680992     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340152677412     Document Type: Article

References (42)

1. The pathobiology of bronchial asthma
2. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma
3. Induction of natural killer activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
4. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice
5. Attenuation of allergic airway inflammation in IL-4-deficient mice
6. Role of IFN-γ in the inhibition of the allergic airway inflammation caused by IL-12
7. Interleukin-5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
8. Elemental signals regulating eosinophil accumulation in the lung
9. Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: Cationic lipid complexes
10. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo
11. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation and Th2 cytokine expression in mice
12. Mouse interleukin-12 (IL-12) p40 homodimer: A potent IL-12 antagonist
13. Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha
14. + T cells in the development of airway hyperresponsiveness in a murine model of airway sensitization
15. Non-invasive measurement of airway responsiveness in allergic mice using barometric plethysmography
16. Prevention of Th2-like cell responses by co-administration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia and serum IgE levels
17. Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity
18. + T cells through IL-12 produced by Listeria-induced macrophages
19. Allergen gene transfer
20. Interleukin-12 prevents antigen-induced eosinophil recruitment into mouse airways
21. Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice
22. Construction of vectors expressing bioactive heterodimeric and single-chain murine interleukin-12 for gene therapy
23. Administration of interleukin-12 prevents mite Der p I allergen-IgE antibody production and airway eosinophil infiltration in an animal model of airway inflammation
24. Administration of interleukin-12 exerts a therapeutic instead of a long-term preventive effect in mite Der p I allergen-induced animal model of airway inflammation
25. Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo
26. Natural killer cell stimulatory factor (interleukin 12[IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4 production Th cells
27. Immunologic basis of antigen-induced airway hyperresponsiveness
28. Induction of apoptosis in human eosinphils by anti-Fas antibody treatment in vitro
29. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer
30. Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice
31. The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity
32. Cloning of a new cytokine that induces IFN-γ production by T cells
33. Conformational stability, folding, and ligand-binding affinity of single-chain Fv immunoglobulin fragments expressed in Escherichia coli
34. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma
35. Biological effects of recombinant human interleukin-12 in squirrel monkeys (Sciureus saimiri)
36. Cloning and expression of murine IL-12
37. The role of eosinophils in the pathogenesis of asthma
38. Immunomodulatory effect of IL-12 on allergic lung inflammation depend on timing of doses
39. An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability
40. Interleukin 12: A key modulator of immune function
41. Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid: pDNA complexes