Adenovirus-mediated interferon γ gene therapy for allergic asthma: Involvement of interleukin 12 and STAT4 signaling

Human Gene Therapy

Volumn 13, Issue 14, 2002, Pages 1697-1709

  Behera, Aruna K ^a   Kumar, Mukesh ^a   Lockey, Richard F ^a   Mohapatra, Shyam S ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN E; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; METHACHOLINE; OVALBUMIN; RECOMBINANT GAMMA INTERFERON; STAT4 PROTEIN;

ADENOVIRUS; ALLERGIC ASTHMA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; CELL INFILTRATION; CONTROLLED STUDY; EMBRYO; EOSINOPHIL; FEMALE; GENE THERAPY; GENE TRANSFER; HUMAN; LOEFFLER PNEUMONIA; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TH2 CELL;

ADENOVIRUSES, HUMAN; ANIMALS; ASTHMA; DNA-BINDING PROTEINS; EOSINOPHILIA; FEMALE; GENE THERAPY; GENETIC VECTORS; IMMUNIZATION; INFLAMMATION; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; INTERLEUKIN-5; LUNG; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; OVALBUMIN; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STAT4 TRANSCRIPTION FACTOR; TH2 CELLS; TRANS-ACTIVATORS;

ADENOVIRIDAE; ANIMALIA; BRONCHUS; DNA VIRUSES;

EID: 0036401603     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303402760293547     Document Type: Article

References (57)

1. Alvarez, D., Wiley, R.E., and Jordana, M. (2001). Cytokine therapeutics for asthma: An appraisal of current evidence and future prospects. Curr. Pharm. Des. 7, 1059-1081.
2. Barnes, P.J. (2001). Cytokine-directed therapies for asthma. J. Allergy Clin. Immunol. 108, S72-S76.
3. Becker, T.C., Noel, R.J., Coats, W.S., Gomez-Foix, A.M., Alam, T., Gerard, R.D., and Newgard, C.B. (1994). Use of recombinant adenovirus for metabolic engineering of mammalian cells. Methods Cell Biol. 43, 161-189.
4. Boraschi, D., Censini, S., Bartalini, M., Ghiara, P., Di Simplicio, P., and Tagliabue, A. (1987). Interferons inhibit LTC4 production in murine macrophages. J. Immunol. 138, 4341-4346.
5. Byrnes, A.A., Ma, X., Cuomo, P., Park, K., Wahl, L., Wolf, S.F., Zhou, H., Trinchieri, G., and Karp, C.L. (2001). Type I interferons and IL-12: Convergence and cross-regulation among mediators of cellular immunity. Eur. J. Immunol. 31, 2026-2034.
6. Chen, Q., Ghilardi, N., Wang, H., Baker, T., Xie, M.H., Gurney, A., Grewal, I.S., and De Sauvage, F.J. (2000). Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407, 916-920.
7. Chung, F. (2001). Anti-inflammatory cytokines in asthma and allergy: Interleukin-10, interleukin-12, interferon-γ. Mediators Inflamm. 10, 51-59.
8. Cohen, J. (1995). IL-12 deaths: Explanation and a puzzle. Science 270, 908.
9. Daines, M.O., and Hershey, G.K. (2002). A novel mechanism by which interferon-γ can regulate interleukin (IL)-13 responses: Evidence for intracellular stores of IL-13 receptor α-2 and their rapid mobilization by interferon-γ. J. Biol. Chem. 277, 10387-10393.
10. Deng, J.C., Tateda, K., Zeng, X., and Standiford, T.J. (2001). Transient transgenic expression of γ-interferon promotes Legionella pneumophila clearance in immunocompetent hosts. Infect. Immun. 69, 6382-6390.
11. Dow, S.W., Schwarze, J., Heath, T.D., Potter, T.A., and Gelfand, E.W. (1999). Systemic and local interferon γ gene delivery to the lungs for treatment of allergen-induced airway hyperresponsiveness in mice. Hum. Gene Ther. 10, 1905-1914.
12. Ford, J.G., Rennick, D., Donaldson, D.D., Venkayya, R., Mcarthur, C., Hansell, E., Kurup, V.P., Warnock, M., and Grunig, G. (2001). IL-13 and IFN-γ-Interactions in lung inflammation. J. Immunol. 167, 1769-1777.
13. Frucht, D.M. (2002). IL-23: A cytokine that acts on memory T cells. Sci STKE 114, PE1.
14. Gavett, S.H., O'Hearn, D.J., Li, X., Huang, S.K., Finkelman, F.D., and Wills-Karp, M. (1995). Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J. Exp. Med. 182, 1527-1536.
15. Gurujeyalakshmi, G., and Giri, S.N. (1995). Molecular mechanisms of antifibrotic effect of interferon γ in bleomycin-mouse model of lung fibrosis: Downregulation of TGF-β and procollagen I and III gene expression. Exp. Lung Res. 21, 791-808.
16. Hansen, G., Berry, G., Dekruyff, R.H., and Umetsu, D.T. (1999). Allergen-specific Th1 cells fail to counterbalance Th2 cellinduced airway hyperreactivity but cause severe airway inflammation. J. Clin. Invest. 103, 175-183.
17. + T helper cells engineered to produce latent TGF-β1 reverse allergen-induced airway hyperreactivity and inflammation. J. Clin. Invest. 105, 61-70.
18. Hasko, G., and Szabo, C. (1999). IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases: Regulation of T helper 1/T helper 2 responses. Br. J. Pharmacol. 127, 1295-1304.
19. Hernberg, M., Pyrhonen, S., and Muhonen, T. (1999). Regimens with or without interferon-α as treatment for metastatic melanoma and renal cell carcinoma: An overview of randomized trials. J. Immunother. 22, 145-154.
20. Kaplan, M.H., Sun, Y.L., Hoey, T., and Grusby, M.J. (1996). Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382, 174-177.
21. Kaplan, M.H., Wurster, A.L., and Grusby, M.J. (1998). A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells. J. Exp. Med. 188, 1191-1196.
22. Khasbold, J., Hong, J.S., Kehry, M.R., and Hodgkin, P.D. (1999). Integrating signals from IFN-γ and IL-4 by B cells: Positive and negative effects on CD40 ligand-induced proliferation, survival, and division-linked isotype switching to IgG1, IgE, and IgG2a. J. Immunol. 163, 4175-4181.
23. Kirkwood, J.M., Strawderman, M.H., Ernstoff, M.S., Smith, T.J., Borden, E.C., and Blum, R.H. (1996). Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: The Eastern Cooperative Oncology Group Trial EST 1684. J. Clin. Oncol. 14, 7-17.
24. Kitagawa, M., Suzuki, H., Adachi, Y., Nakamura, H., Yoshino, S., and Sumida, T. (2001). Interferon-γ enhances interleukin 12 production in rheumatoid synovial cells via CD40-CD154 dependent and independent pathways. J. Rheumatol. 28, 1764-1771.
25. Krasnowska, M., Medrala, W., Malolepszy, J., and Krasnowski, R. (2000). Effect of recombinant IFN-γ on IgE-dependent leukotriene generation by peripheral blood leukocytes in patients with pollinosis and asthma. Arch. Immunol. Ther. Exp. (Warsz.) 48, 287-292.
26. Kumar, M., Behera, A.K., Matsuse, H., Lockey, R.F., and Mohapatra, S.S. (1999). Intranasal IFN-γ gene transfer protects BALB/c mice against respiratory syncytial virus infection. Vaccine 18, 558-567.
27. Kumar, M., Behera, A.K., Hu, J., Lockey, R.F., and Mohapatra, S.S. (2001). IFN-γ and IL-12 plasmid DNAs as vaccine adjuvant in a murine model of grass allergy. J. Allergy Clin. Immunol. 108, 402-408.
28. Lack, G., Renz, H., Saloga, J., Bradley, K.L., Loader, J., Leung, D.Y., Larsen, G., and Gelfand, E.W. (1994). Nebulized but not parenteral IFN-γ decreases IgE production and normalizes airways function in a murine model of allergen sensitization. J. Immunol. 152, 2546-2554.
29. Li, X.M., Chopra, R.K., Chou, T.Y., Schofield, B.H., Willskarp, M., and Huang, S.K. (1996). Mucosal IFN-γ gene transfer inhibits pulmonary allergic responses in mice. J. Immunol. 157, 3216-3219.
30. Lighvani, A.A., Frucht, D.M., Jankovic, D., Yamane, H., Aliberti, J., Hissong, B.D., Nguyen, B.V., Gadina, M., Sher, A., Paul, W.E., and O'Shea, J.J. (2001). T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. U.S.A. 98, 15137-15142.
31. Matsuse, H., Behera, A.K., Kumar, M., Rabb, H., Lockey, R.F., and Mohapatra, S.S. (2000). Recurrent respiratory syncytial virus infections in allergen-sensitized mice lead to persistent airway inflammation and hyperresponsiveness. J. Immunol. 164, 6583-6592.
32. Minshall, E.M, Leung, D.Y., Martin, R.J., Song, Y.L., Cameron, L., Ernst, P., and Hamid, Q. (1997). Eosinophil-associated TGF-β1 mRNA expression and airways fibrosis in bronchial asthma. Am. J. Respir. Cell Mol. Biol. 17, 326-333.
33. Mohapatra, S.S. (1995). IL-12 possibilities. Science 269, 1499.
34. Morrison, D.F., and Murtaugh, M.P. (2001). Adenovirus-mediated expression of interleukin-1 receptor antagonist in swine cells in vitro and in vivo. Vet. Immunol. Immunopathol. 78, 71-81.
35. H2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145-173.
36. H1 cells before IL-12-dependent selection. Science 292, 1907-1910.
37. O'Garra, A., and Arai, N. (2000). The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol. 10, 542-550.
38. Oppmann, B., Lesley, R., Blom, B., Timans, J.C., Xu, Y., Hunte, B., Vegam, F., Yu, N., Wang, J., Singh, K., Zonin, F., Vaisberg, E., Churakova, T., Liu, M., Gorman, D., Wagner, J., Zurawski, S., Liu, Y., Abrams, J.S., Moore, K.W., Rennick, D., De Waal-Malefyt, R., Hannum, C., Bazan, J.F., and Kastelein, R.A. (2000). Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13, 715-725.
39. Pierkes, M., Bellinghausen, I., Hultsch, T., Metz G, Knop, J., and Saloga, J. (1999). Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-γ production of T cells. J. Allergy Clin. Immunol. 103, 326-332.
40. Randolph, D.A., Carruthers, C.J., Szabo, S.J., Murphy, K.M., and Chaplin, D.D. (1999). Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma. J. Immunol. 162, 2375-2383.
41. H2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326, 298-304.
42. Rudick, R.A., Cohen, J.A., Weinstock-Guttman, B., Kinkel, R.P., and Ransohoff, R.M. (1997). Management of multiple sclerosis. N. Engl. J. Med. 337, 1604-1611.
43. Schwarze, J., Hamelmann, E., Cieslewicz, G., Tomkinson, A., Joetham, A., Bradley, K., and Gelfand, E.W. (1998). Local treatment with IL-12 is an effective inhibitor of airway hyperresponsiveness and lung eosinophilia after airway challenge in sensitized mice. J. Allergy Clin. Immunol. 102, 86-93.
44. Stämpfli, M.R., Wiley, R.E., Neigh, G.S., Gajewska, B.U., Lei, X., Snider, D.P., Xing, Z., and Jordana, M. (1998). GMCSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice. J. Clin. Invest. 102, 1704-1714.
45. Stirling, R.G, and Chung, K.F. (2000). New immunological approaches and cytokine targets in asthma and allergy. Eur. Respir. J. 16, 1158-174.
46. Sur, S., Bouchard, P., Holbert, D., and Van Scott, M.R. (2000). Mucosal IL-12 inhibits airway reactivity to methacholine and respiratory failure in murine asthma. Exp. Lung Res. 26, 477-489.
47. Suzuki, M., Suzuki, S., Yamamoto, N., Komatsu, S., Inoue, S., Hashiba, T., Nishikawa, M., and Ishigatsubo, Y. (2000). Immune responses against replication-deficient adenovirus inhibit ovalbumin-specific allergic reactions in mice. Hum. Gene Ther. 11, 827-838.
48. Szabo, S.J., Kim, S.T., Costa, G.L., Zhang, X., Fathman, C.G., and Glimcher, L.H. (2000). A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100, 655-669.
49. Tang, C., Inman, M.D., Van Rooijen, N., Yang, P., Shen, H., Matsumoto, K., and O'Byrne, P.M. (2001). The type 1-stimulating activity of lung macrophages inhibits Th2-mediated allergic airway inflammation by an IFN-γ-dependent mechanism. J. Immunol. 166, 1471-1481.
50. Thierfelder, W.E., Van Deursen, J.M., Yamamoto, K., Tripp, R.A., Sarawar, S.R., Carson, R.T., Sangster, M.Y., Vignali, D.A., Doherty, P.C., Grosveld, G.C., and Ihle, J.N. (1996). Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382, 171-174.
51. Thivierge, M., Stankova, J., and Rola-Pleszczynski, M. (2001). IL-13 and IL-4 up-regulate cysteinyl leukotriene 1 receptor expression in human monocytes and macrophages. J. Immunol. 167, 2855-2860.
52. Trinchieri, G. (1994). Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84, 4008-4027.
53. + cells in human allergic diseases. J. Allergy Clin. Immunol. 100, 1-6.
54. Walter, D.M., Wong, C.P., Dekruyff, R.H., Berry, G.J., Levy, S., and Umetsu, D.T. (2001). IL-18 gene transfer by adenovirus prevents the development of and reverses established allergen-induced airway hyperreactivity. J. Immunol. 166, 6392-6398.
55. Wang, I.M., Contursi, C., Masumi, A., Ma, X., Trinchieri, G., and Ozato, K. (2001). An IFN-γ-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages. J. Immunol. 165, 271-279.
56. Xiu, Q., Chen, J., and Chen, H. (2001). Effect of intratracheally administered IL-12 recombinant adenovirus on ovalbumin induced bronchial hyperresponsiveness in mouse model. Zhonghua Jie He He Hu Xi Za Zhi 24, 298-301.
57. Zabner, J., Ramsey, B.W., Meeker, D.P., Aitken, M.L., Balfour, R.P., Gibson, R.L., Launspach, J., Moscicki, R.A., Richards, S.M., Standaert, T.A., Williams-Warren, J., Wadsworth, S.C., Smith, A.E., and Welsh, M.J. (1996). Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis. J. Clin. Invest. 97, 1505-1511.