Vaccination with allergen-IL-18 fusion DNA protects against, and reverses established, airway hyperreactivity in a murine asthma model

Journal of Immunology

Volumn 166, Issue 2, 2001, Pages 959-965

  Maecker, H T ^a   Hansen, G ^a   Walter, D M ^a   DeKruyff, R H ^a   Levy, S ^a   Umetsu, D T ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; COMPLEMENTARY DNA; DNA VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERFERON ANTIBODY; INTERLEUKIN 18; OKT 8;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DRUG EFFICACY; FUSION GENE; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; T LYMPHOCYTE; VACCINATION;

EID: 0035863822     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.2.959     Document Type: Article

References (58)

1. The inverse association between tuberculin responses and atopic disorder
2. Forecasted state-specific estimates of self-reported asthma prevalence-United States
3. + cells in allergic diseases
4. Interleukin-13: Central mediator of allergic asthma
5. + T lymphocytes
6. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization
7. Gene immunization for allergic disorders
8. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
9. DNA vact creation with cytokine fusion constructs biases the immune response to ovalbumin
10. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle
11. DNA vaccines
12. Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization
13. Inhibition of specific IgE response in vivo by allergen-gene transfer
14. Heterologous protection against influenza by injection of DNA encoding a viral protein
15. DNA-based immunization by in vivo transfection of dendritic cells
16. Vaccination against tuberculosis by DNA injection
17. DNA vaccination for cancer treatment
18. DNA immunization induces protective immunity against B-cell lymphoma
19. A nine-amino acid peptide frora IL-1β augments antitumor immune responses induced by protein and DNA vaccines
20. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity
21. Cloning of a new cytokine that induces IFN-γ production by T cells
22. Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme
23. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production
24. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells
25. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12
26. Interferon-γ-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells
27. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells
28. An OVA-IL-12 fusion protein is more effective than OVA plus rIL-12 in inducing a Th1-dominated immune response and inhibiting antigen-specific IgE production
29. Current protocols in immunology
30. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation
31. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography
32. + T cells to produce IL-4
33. Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40
34. Interleukin-18 enhances antigen-induced eosinophil recruitment into the mouse airways
35. Oral gene delivery with chitosan - DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
36. Immunostimulatory DNA sequences inhibit IL-5, eosinophililc inflammation, and airway hyperresponsiveness in mice
37. Cancer trial of interleukin-12 halted
38. IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response
39. IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite
40. Administration of IL-12 during ongoing immune responses fails to permanently suppress and can even enhance the synthesis of antigen-specific IgE
41. IFN-γ inducing factor (IL- 18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma
42. IL-18 deficiency selectively enhances allergen-induced eosinophilia in mice
43. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-γ production
44. Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels
45. Induction of IgE-secreting cells and IgE isotype-specific suppressor T cells in the respiratory lymph nodes of rats in response to antigen inhalation
46. Role of CD8 T cells in rat IgE responses
47. + T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production
48. Inhibition of IgE production and normalization of airways responsiveness by sensitized CD8 T cells in a mouse model of allergen-induced sensitization
49. + effector T cells is differentially regulated by IL-18 and IL-12
50. The cell biology of antigen processing and presentation
51. Mucosal IFN-γ gene transfer inhibits pulmonary allergic responses in mice
52. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice
53. Long-term clinical efficacy of grass-pollen immunotherapy
54. + T cells from allergic individuals
55. Venom immunotherapy modulates interleukin-4 and interferon-γ messenger RNA expression of peripheral T lymphocytes
56. Direct gene transfer into mouse muscle in vivo
57. DNA-mediated immunization to hepatitis B surface antigen: Longevity of primary response and effect of boost
58. Characterization of humoral immune responses induced by an influenza hemagglutinin DNA vaccine