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This paper identifies that expression of CD127 can be used to discriminate between human regulatory and activated T cells. The capacity to identify and track natural Tregs in patients would represent a major advance in our capacity to study these cells in human disease
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Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006; 203:1701-1711. This paper identifies that expression of CD127 can be used to discriminate between human regulatory and activated T cells. The capacity to identify and track natural Tregs in patients would represent a major advance in our capacity to study these cells in human disease.
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This paper identifies that expression of CD127 can be used to discriminate between human regulatory and activated T cells. The capacity to identify and track natural Tregs in patients would represent a major advance in our capacity to study these cells in human disease
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Seddiki N, Santner-Nanan B, Martinson J, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006; 203:1693-1700. This paper identifies that expression of CD127 can be used to discriminate between human regulatory and activated T cells. The capacity to identify and track natural Tregs in patients would represent a major advance in our capacity to study these cells in human disease.
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Caudy AA, Reddy ST, Chatila T, et al. CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J Allergy Clin Immunol 2007; 119:482-487. This is one of a series of papers that are the most recent to describe mutations leading to loss of the natural Treg compartment in humans (it is unclear whether this represents a loss of natural or adaptive Treg) resulting in immune-mediated pathology including allergy.
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Marangoni F, Trifari S, Scaramuzza S, et al. WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells. J Exp Med 2007; 204:369-380. This is one of a series of papers that are the most recent to describe mutations leading to loss of the natural Treg compartment in humans (it is unclear whether this represents a loss of natural or adaptive Treg) resulting in immune-mediated pathology including allergy.
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Chen X, Oppenheim JJ, Winkler-Pickett RT, et al. Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE. Eur J Immunol 2006; 36:2139-2149. This paper suggests the capacity of commonly used anti-inflammatory agents to promote natural Treg activity.
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