Absence of immunoglobulin E synthesis and airway eosinophilia by vaccination with plasmid DNA encoding ProDer p 1

Clinical and Experimental Allergy

Volumn 33, Issue 2, 2003, Pages 218-225

  Jacquet, Alain ^a   Magi, M ^a   Haumont, M ^a   Jurado, M ^a   Garcia, L ^a   Bollen, A ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Allergy; DNA vaccination; Eosinophilia; IgE; ProDer p 1

Indexed keywords

ADJUVANT; ALUMINUM POTASSIUM SULFATE; DNA VACCINE; GAMMA INTERFERON; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 5; NAKED DNA; PLASMID DNA; PLASMID VECTOR; PRODER P 1 VACCINE; RECOMBINANT PRODER P 1 VACCINE; UNCLASSIFIED DRUG;

ALLERGIC REACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL INFILTRATION; CODON; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA VECTOR; EOSINOPHILIA; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IMMUNOGLOBULIN PRODUCTION; IMMUNOTHERAPY; INFLAMMATION; INFLAMMATORY CELL; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECOMBINANT PLASMID; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; VACCINATION;

ANIMALS; ANTIGENS, DERMATOPHAGOIDES; BRONCHOALVEOLAR LAVAGE FLUID; DNA, COMPLEMENTARY; EOSINOPHILIA; FEMALE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERFERON TYPE II; MICE; MICE, INBRED CBA; MITES; PLASMIDS; RECOMBINANT PROTEINS; RESPIRATORY HYPERSENSITIVITY; SPLEEN; TH2 CELLS; UP-REGULATION; VACCINATION; VACCINES, DNA;

EID: 0037326391     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2003.01584.x     Document Type: Article

References (48)

1. Platt-Mills TAE, Chapman MD. Dust mites: immunology, allergic disease and environmental control. J Allergy Clin Immunol 1987; 80:755-75.
2. Tovey ER, Chapman MD, Platts-Mills TAE. Mite faeces are a major source of house dust allergens. Nature 1981; 289:592-3.
3. Krillis S, Baldo BA, Sutton R, Basten A. Antigens and allergens from the common house dust mite Dermatophagoides pteronyssinus. I. Demonstration of multiple allergens by immunochemical and biologic analysis. J Allergy Clin Immunol 1984; 74:132-41.
4. Stewart GA, Holt PG. Immunogenicity and tolerogenicity of a major house dust mite allergen, Der p I from Dermatophagoides pteronyssinus, in mice and rats. Int Arch Allergy Appl Immunol 1987; 83:44-51.
5. Clarke AH, Thomas WR, Rolland JM, Dow C, O'Brien RM. Murine allergic respiratory responses to the major house dust mite allergen Der p 1. Int Arch Allergy Immunol 1999; 120:126-34.
6. Tournoy KG, Kips JC, Schou C, Pauwels RA. Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness. Clin Exp Allergy 2000; 30:79-85.
7. Lee YL, Fu CL,Ye YL, Chiang BL. Administration of interleukin-12 prevents mite Der p 1 allergen-IgE antibody production and airway eosinophil infiltration in an animal model of airway inflammation. Scand J Immunol 1999; 49:229-36.
8. Shakib F, Gough L. The proteolytic activity older p 1 selectively enhances IgE synthesis: a link between allergenicity and cysteine protease activity. Clin Exp Allergy 2000; 30:751-2.
9. Gough L, Schulz O, Sewell HF, Shakib F. The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response. J Exp Med 1999; 190:1897-902.
10. Schulz O, Sutton BJ, Beavil RL et al. Cleavage of the low-affinity receptor for human IgE (CD23) by a mite cysteine protease: nature of the cleaved fragment in relation to the structure and function of CD23. Eur J Immunol 1997; 27:584-8.
11. Schulz O, Sewell HF, Shakib F. Proteolytic cleavage of CD25, the alpha subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity. J Exp Med 1998; 187:271-5.
12. Ghaemmaghami AM, Robins A, Gough L, Sewell HF, Shakib F. Human T cell subset commitment determined by the intrinsic property of antigen: the proteolytic activity of the major mite allergen Der p 1 conditions T cells to produce more IL-4 and less IFN-gamma. Eur J Immunol 2001; 31:1211-6.
13. Ghaemmaghami AM, Shakib F. Human T cells that have been conditioned by the proteolytic activity of the major dust mite allergen Der p 1 trigger enhanced immunoglobulin E synthesis by B cells. Clin Exp Allergy 2002; 32:728-32.
14. Walker C, Zuany-Amorim C. New trends in immunotherapy to prevent atopic diseases. Trends Pharmacol Sci 2001; 22:84-90.
15. Reyes-Sandoval A, Ertl HC. DNA vaccines. Curr Mol Med 2001; 1:217-43.
16. Toda M, Sato H, Takebe Y et al. Inhibition of immunoglobulin E response to Japanese cedar pollen allergen (Cry j 1) in mice by DNA immunisation: different outcomes dependent on the plasmid DNA inoculation method. Immunology 2000; 99:179-86.
17. Raz E, Spiegelberg HL. Deviation of the allergic IgE to an IgG response by gene immunotherapy. Int Rev Immunol 1999; 18:271-89.
18. Hartl A, Kiesslich J, Weiss R et al. Isoforms of the major allergen of birch pollen induce different immune responses after genetic immunisation. Int Arch Allergy Immunol 1999; 120:17-29.
19. Roy K, Mao HQ, Huang SK, Leong KW. Oral gene delivery with chitosan - DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med 1999; 5:387-91.
20. Spiegelberg HL, Broide D, Tighe H, Roman M, Raz E. Inhibition of allergic inflammation in the lung by plasmid DNA allergen immunisation. Pediatr Pulmonol Suppl 1999; 18:118-21.
21. Hartl A, Kiesslich J, Weiss R et al. Immune responses after immunisation with plasmid DNA encoding Bet v 1, the major allergen of birch pollen. J Allergy Clin Immunol 1999; 103:107-13.
22. Adel-Patient K, Creminon C, Boquet D, Wal JM, Chatel JM. Genetic immunisation with bovine beta-lactoglobulin cDNA induces a preventive and persistent inhibition of specific anti-BLG IgE response in mice. Int Arch Allergy Immunol 2001; 126:59-67.
23. Kwon SS, Kim N, Yoo TJ. The effect of vaccination with DNA encoding murine T-cell epitopes on the Der p 1 and 2 induced immunoglobulin E synthesis. Allergy 2001; 56:741-8.
24. Slater JE, Paupore E, Zhang YT, Colberg-Poley AM. The latex allergen Hev b 5 transcript is widely distributed after subcutaneous injection in BALB/c mice of its DNA vaccine. J Allergy Clin Immunol 1998; 102:469-75.
25. Hsu CH, Chua KY, Tao MH et al. Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunisation. Nat Med 1996; 2:540-4.
26. Peng HJ, Su SN, Chang ZN, Chao PL, Kuo SW, Tsai LC. Induction of specific Th1 responses and suppression of IgE antibody formation by vaccination with plasmid DNA encoding Der f 11. Vaccine 2002; 20:1761-8.
27. Lee DJ, Tighe H, Corr M et al. Inhibition of IgE antibody formation by plasmid DNA immunisation is mediated by both CD4+ and CD8+ T cells. Int Arch Allergy Immunol 1997; 113:227-30.
28. Massaer M, Mazzu P, Haumont M et al. High-level expression in mammalian cells of recombinant house dust mite allergen ProDer p 1 with optimized codon usage. Int Arch Allergy Immunol 2001; 125:32-43.
29. Wohlleben G, Erb KJ. Atopic disorders: a vaccine around the corner. Trends Immunol 2001; 22:618-26.
30. Horner AA, van Uden JH, Zubeldia JM, Broide D, Raz E. DNA-based immunotherapeutics for the treatment of allergic disease. Immunol Rev 2001; 179:102-18.
31. Herz U, Lumpp U, Da Palma JC et al. The relevance of murine animal models to study the development of allergic bronchial asthma. Immunol Cell Biol 1996; 74:209-17.
32. Hamelmann E, Gelfand EW. IL-5-induced airway eosinophilia: the key to asthma? Immunol Rev 2001; 179:182-91.
33. Mekori YA, Metcalfe DD. Mast cell-T cell interactions. J Allergy Clin Immunol 1999; 104:517-23.
34. Kobayashi T, Miura T, Haba T et al. An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model. J Immunol 2000; 164:3855-61.
35. Hogan SP, Mould A, Kikutani H, Ramsay AJ, Foster PS. Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins. J Clin Invest 1997; 99:1329-99.
36. Hamelmann E, Takeda K, Gelfand EW. Differential requirements for the induction of airway inflammation and airway hyperresponsiveness in IgE-receptor-deficient mice. J Allergy Clin Immunol 2000; 105:110A.
37. Haczku A, Takeda K, Hamelmann E et al. CD23 deficient mice develop allergic airway hyperresponsiveness following sensitization with ovalbumin. Am J Respir Crit Care Med 1997; 156:1945-55.
38. Oettgen HC, Martin TR, Wynshaw-Boris A, Deng C, Drazen JM, Leder P. Active anaphylaxis in IgE-deficient mice. Nature 1994; 370:367-70.
39. Hamelmann E, Takeda K, Haczku A et al. Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice. Am J Respir Cell Mol Biol 2000; 23:327-34.
40. Hamelmann E, Tadeda K, Oshiba A, Gelfand EW. Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness - a murine model. Allergy 1999; 54:297-305.
41. Hamelmann E, Vella AT, Oshiba A, Kappler JW, Marrack P, Gelfand EW. Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice. Proc Natl Acad Sci USA 1997; 94:1350-5.
42. Coyle AJ, Wagner K, Bertrand C, Tsuyuki S, Bews J, Heusser C. Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody. J Exp Med 1996; 183:1303-10.
43. Mayr SI, Zuberi RI, Zhang M et al. IgE-dependent mast cell activation potentiates airway responses in murine asthma models. J Immunol 2002; 169:2061-8.
44. Andre S, Seed B, Eberle J, Schraut W, Bultmann A, Haas J. Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage. J Virol 1998; 72:1497-503.
45. Reyes L, Hartikka J, Bozoukova V et al. Vaxfectin enhances antigen specific antibody titers and maintains Th1 type immune responses to plasmid DNA immunisation. Vaccine 2001; 19:3778-86.
46. Sasaki S, Fukushima J, Arai H et al. Human immunodeficiency virus type-1-specific immune responses induced by DNA vaccination are greatly enhanced by mannan-coated diC14-amidine. Eur J Immunol 1997; 27:3121-9.
47. Durham SR, Till SJ. Immunologic changes associated with allergen immunotherapy. J Allergy Clin Immunol 1998; 102:157-64.
48. van Neerven RJ, Wikborg T, Lund G et al. Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum-IgE-facilitated allergen presentation. J Immunol 1999; 163:2944-52.