Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-β

Journal of Cell Science

Volumn 122, Issue 11, 2009, Pages 1917-1926

  Liu, Meng Lu ^a   Liu, Ming Jie ^a   Shen, Yan Fei ^a   Ryu, Hoon ^b,c   Kim, Hyeon Jin ^d   Klupsch, Kristina ^e   Downward, Julian ^e   Hong, Seong Tshool ^a  

^a Chonbuk National University Medical School   (South Korea)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Jinis Inc   (South Korea)

^e IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Disaggregation; Heat shock protein; HtrA2 (Omi); Mutual detoxification; Oligomeric amyloid protein; Protein interaction

Indexed keywords

AMYLOID BETA PROTEIN; SERINE PROTEINASE OMI;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MATURATION; CELL PROTECTION; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; MITOCHONDRION; MOUSE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; UPREGULATION;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOPTOSIS; CELLS, CULTURED; HEAT-SHOCK PROTEINS; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NEUROGENESIS; NEURONS; NEUROPROTECTIVE AGENTS; PROTEIN STRUCTURE, QUATERNARY; SERINE ENDOPEPTIDASES; STRESS, PHYSIOLOGICAL;

MAMMALIA; MUS;

EID: 69449098478     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.042226     Document Type: Article

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