Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

Genes and Development

Volumn 17, Issue 12, 2003, Pages 1487-1496

  Yang, Qi Heng ^a   Church Hajduk, Robin ^b   Ren, Jinyu ^a   Newton, Michelle L ^a   Du, Chunying ^a  

^a STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b ST LUKE S HOSPITAL   (United States)

Author keywords

Apoptosis; Caspases; IAPs; Mitochondria; Omi HtrA2; Smac

Indexed keywords

CELL PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; MUTANT PROTEIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SERINE PROTEINASE; SERINE PROTEINASE OMI; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UBIQUITIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CATALYSIS; CELL PROTECTION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME STRUCTURE; GENE OVEREXPRESSION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BINDING SITES; CARRIER PROTEINS; CASPASES; CATALYSIS; ENZYME ACTIVATION; HELA CELLS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGASES; MEMBRANE GLYCOPROTEINS; MITOCHONDRIAL PROTEINS; MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEINS; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN;

INTRACISTERNAL A-PARTICLES;

EID: 0038722727     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1097903     Document Type: Article

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