-
1
-
-
0036884733
-
Pathogenesis of Parkinson's disease: Dopamine, vesicles and alpha-synuclein
-
10.1038/nrn983
-
J Lotharius P Brundin 2002 Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein Nat Rev Neurosci 3 932 942 10.1038/nrn983
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 932-942
-
-
Lotharius, J.1
Brundin, P.2
-
2
-
-
37349004102
-
Parkinson's disease
-
10.1093/hmg/ddm159
-
B Thomas MF Beal 2007 Parkinson's disease Hum Mol Genet 16 Review issue 2 R183 R194 10.1093/hmg/ddm159
-
(2007)
Hum Mol Genet
, vol.16
, Issue.REVIEW ISSUE 2
-
-
Thomas, B.1
Beal, M.F.2
-
3
-
-
0025964041
-
The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method
-
10.1136/jnnp.54.1.30
-
B Pakkenberg A Moller HJ Gundersen, et al. 1991 The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method J Neurol Neurosurg Psychiatry 54 30 33 10.1136/jnnp.54.1.30
-
(1991)
J Neurol Neurosurg Psychiatry
, vol.54
, pp. 30-33
-
-
Pakkenberg, B.1
Moller, A.2
Gundersen, H.J.3
-
4
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
10.1016/S0197-4580(02)00065-9
-
H Braak K Del Tredici U Rub, et al. 2003 Staging of brain pathology related to sporadic Parkinson's disease Neurobiol Aging 24 197 211 10.1016/S0197-4580(02)00065-9
-
(2003)
Neurobiol Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
Del Tredici, K.2
Rub, U.3
-
5
-
-
0030882856
-
Alpha-synuclein in Lewy bodies
-
10.1038/42166
-
MG Spillantini ML Schmidt VM Lee, et al. 1997 Alpha-synuclein in Lewy bodies Nature 388 839 840 10.1038/42166
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
-
6
-
-
0032568534
-
Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
-
10.1073/pnas.95.11.6469
-
MG Spillantini RA Crowther R Jakes, et al. 1998 Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies Proc Natl Acad Sci USA 95 6469 6473 10.1073/pnas.95.11.6469
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
-
7
-
-
34648819365
-
The Lewy body in Parkinson's disease: Molecules implicated in the formation and degradation of alpha-synuclein aggregates
-
10.1111/j.1440-1789.2007.00803.x
-
K Wakabayashi K Tanji F Mori H Takahashi 2007 The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates Neuropathology 27 494 506 10.1111/j.1440-1789.2007. 00803.x
-
(2007)
Neuropathology
, vol.27
, pp. 494-506
-
-
Wakabayashi, K.1
Tanji, K.2
Mori, F.3
Takahashi, H.4
-
8
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
10.1126/science.276.5321.2045
-
MH Polymeropoulos C Lavedan E Leroy, et al. 1997 Mutation in the alpha-synuclein gene identified in families with Parkinson's disease Science 276 2045 2047 10.1126/science.276.5321.2045
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
-
9
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
-
10.1038/ng0298-106
-
R Kruger W Kuhn T Muller, et al. 1998 Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease Nat Genet 18 106 108 10.1038/ng0298-106
-
(1998)
Nat Genet
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
-
10
-
-
0242300619
-
Alpha-synuclein locus triplication causes Parkinson's disease
-
10.1126/science.1090278
-
AB Singleton M Farrer J Johnson, et al. 2003 Alpha-synuclein locus triplication causes Parkinson's disease Science 302 841 10.1126/science.1090278
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
-
11
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
-
10.1002/ana.10795
-
JJ Zarranz J Alegre JC Gomez-Esteban, et al. 2004 The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia Ann Neurol 55 164 173 10.1002/ana.10795
-
(2004)
Ann Neurol
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
-
12
-
-
4644290985
-
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease
-
10.1016/S0140-6736(04)17103-1
-
MC Chartier-Harlin J Kachergus C Roumier, et al. 2004 Alpha-synuclein locus duplication as a cause of familial Parkinson's disease Lancet 364 1167 1169 10.1016/S0140-6736(04)17103-1
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.C.1
Kachergus, J.2
Roumier, C.3
-
13
-
-
0032540327
-
Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes
-
10.1074/jbc.273.16.9443
-
WS Davidson A Jonas DF Clayton, et al. 1998 Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes J Biol Chem 273 9443 9449 10.1074/jbc.273.16.9443
-
(1998)
J Biol Chem
, vol.273
, pp. 9443-9449
-
-
Davidson, W.S.1
Jonas, A.2
Clayton, D.F.3
-
14
-
-
0035815115
-
Conformational properties of alpha-synuclein in its free and lipid-associated states
-
10.1006/jmbi.2001.4538
-
D Eliezer E Kutluay R Bussell Jr, et al. 2001 Conformational properties of alpha-synuclein in its free and lipid-associated states J Mol Biol 307 1061 1073 10.1006/jmbi.2001.4538
-
(2001)
J Mol Biol
, vol.307
, pp. 1061-1073
-
-
Eliezer, D.1
Kutluay, E.2
Bussell Jr., R.3
-
15
-
-
0038341134
-
A broken alpha-helix in folded alpha-synuclein
-
10.1074/jbc.M213128200
-
S Chandra X Chen J Rizo, et al. 2003 A broken alpha-helix in folded alpha-synuclein J Biol Chem 278 15313 15318 10.1074/jbc.M213128200
-
(2003)
J Biol Chem
, vol.278
, pp. 15313-15318
-
-
Chandra, S.1
Chen, X.2
Rizo, J.3
-
16
-
-
0027489773
-
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
-
10.1073/pnas.90.23.11282
-
K Ueda H Fukushima E Masliah, et al. 1993 Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease Proc Natl Acad Sci USA 90 11282 11286 10.1073/pnas.90.23.11282
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11282-11286
-
-
Ueda, K.1
Fukushima, H.2
Masliah, E.3
-
17
-
-
0032589409
-
Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid
-
JG Culvenor CA McLean S Cutt, et al. 1999 Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid Am J Pathol 155 1173 1181
-
(1999)
Am J Pathol
, vol.155
, pp. 1173-1181
-
-
Culvenor, J.G.1
McLean, C.A.2
Cutt, S.3
-
18
-
-
0035951869
-
A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly
-
10.1074/jbc.M008919200
-
BI Giasson IV Murray JQ Trojanowski, et al. 2001 A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly J Biol Chem 276 2380 2386 10.1074/jbc.M008919200
-
(2001)
J Biol Chem
, vol.276
, pp. 2380-2386
-
-
Giasson, B.I.1
Murray, I.V.2
Trojanowski, J.Q.3
-
19
-
-
0037092442
-
A role for alpha-synuclein in the regulation of dopamine biosynthesis
-
RG Perez JC Waymire E Lin, et al. 2002 A role for alpha-synuclein in the regulation of dopamine biosynthesis J Neurosci 22 3090 3099
-
(2002)
J Neurosci
, vol.22
, pp. 3090-3099
-
-
Perez, R.G.1
Waymire, J.C.2
Lin, E.3
-
20
-
-
0027535205
-
Molecular characterization of the dopamine transporter
-
10.1016/0165-6147(93)90029-J
-
B Giros MG Caron 1993 Molecular characterization of the dopamine transporter Trends Pharmacol Sci 14 43 49 10.1016/0165-6147(93)90029-J
-
(1993)
Trends Pharmacol Sci
, vol.14
, pp. 43-49
-
-
Giros, B.1
Caron, M.G.2
-
21
-
-
0034077041
-
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
-
10.1016/S0896-6273(00)80886-7
-
A Abeliovich Y Schmitz I Farinas, et al. 2000 Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system Neuron 25 239 252 10.1016/S0896-6273(00)80886-7
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
Schmitz, Y.2
Farinas, I.3
-
22
-
-
33751113009
-
Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis
-
10.1523/JNEUROSCI.3821-06.2006
-
KE Larsen Y Schmitz MD Troyer, et al. 2006 Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis J Neurosci 26 11915 11922 10.1523/JNEUROSCI.3821-06. 2006
-
(2006)
J Neurosci
, vol.26
, pp. 11915-11922
-
-
Larsen, K.E.1
Schmitz, Y.2
Troyer, M.D.3
-
23
-
-
33750284754
-
Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: A case for the selective vulnerability of the substantia nigra
-
10.1007/s00401-006-0096-2
-
JE Galvin 2006 Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: a case for the selective vulnerability of the substantia nigra Acta Neuropathol 112 115 126 10.1007/s00401-006-0096-2
-
(2006)
Acta Neuropathol
, vol.112
, pp. 115-126
-
-
Galvin, J.E.1
-
24
-
-
12944305793
-
Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles
-
10.1073/pnas.97.22.11869
-
D Sulzer J Bogulavsky KE Larsen, et al. 2000 Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles Proc Natl Acad Sci USA 97 11869 11874 10.1073/pnas.97.22.11869
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 11869-11874
-
-
Sulzer, D.1
Bogulavsky, J.2
Larsen, K.E.3
-
25
-
-
0018148688
-
Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro
-
DG Graham SM Tiffany WR Bell, et al. 1978 Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro Mol Pharmacol 14 644 653
-
(1978)
Mol Pharmacol
, vol.14
, pp. 644-653
-
-
Graham, D.G.1
Tiffany, S.M.2
Bell, W.R.3
-
26
-
-
0242285663
-
Neuromelanin of the substantia nigra: A neuronal black hole with protective and toxic characteristics
-
10.1016/j.tins.2003.08.009
-
L Zecca FA Zucca H Wilms, et al. 2003 Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics Trends Neurosci 26 578 580 10.1016/j.tins.2003.08.009
-
(2003)
Trends Neurosci
, vol.26
, pp. 578-580
-
-
Zecca, L.1
Zucca, F.A.2
Wilms, H.3
-
27
-
-
0023740954
-
Melanized dopaminergic neurons are differentially susceptible to degeneration in parkinson's disease
-
10.1038/334345a0
-
E Hirsch AM Graybiel YA Agid 1988 Melanized dopaminergic neurons are differentially susceptible to degeneration in parkinson's disease Nature 334 345 348 10.1038/334345a0
-
(1988)
Nature
, vol.334
, pp. 345-348
-
-
Hirsch, E.1
Graybiel, A.M.2
Agid, Y.A.3
-
28
-
-
34447500591
-
Kinetic and structural analysis of the early oxidation products of dopamine: Analysis of the interactions with alpha-synuclein
-
10.1074/jbc.M610893200
-
M Bisaglia S Mammi L Bubacco 2007 Kinetic and structural analysis of the early oxidation products of dopamine: analysis of the interactions with alpha-synuclein J Biol Chem 282 15597 15605 10.1074/jbc.M610893200
-
(2007)
J Biol Chem
, vol.282
, pp. 15597-15605
-
-
Bisaglia, M.1
Mammi, S.2
Bubacco, L.3
-
29
-
-
0035840318
-
3, 4-dihydroxyphenylacetaldehyde and hydrogen peroxide generate a hydroxyl radical: Possible role in Parkinson's disease pathogenesis
-
10.1016/S0169-328X(01)00120-6
-
SW Li TS Lin S Minteer, et al. 2001 3, 4-dihydroxyphenylacetaldehyde and hydrogen peroxide generate a hydroxyl radical: possible role in Parkinson's disease pathogenesis Brain Res Mol Brain Res 93 1 7 10.1016/S0169-328X(01)00120- 6
-
(2001)
Brain Res Mol Brain Res
, vol.93
, pp. 1-7
-
-
Li, S.W.1
Lin, T.S.2
Minteer, S.3
-
30
-
-
62049084616
-
Dopamine and the dopamine oxidation product 5, 6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of α-synuclein in a ph-dependent manner
-
10.1016/j.jmb.2009.02.007
-
CLL Pham SL Leong FE Ali, et al. 2009 Dopamine and the dopamine oxidation product 5, 6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of α-synuclein in a ph-dependent manner J Mol Biol 387 771 785 10.1016/j.jmb.2009.02.007
-
(2009)
J Mol Biol
, vol.387
, pp. 771-785
-
-
Pham, C.L.L.1
Leong, S.L.2
Ali, F.E.3
-
31
-
-
0031787871
-
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
-
10.1038/3311
-
KA Conway JD Harper PT Lansbury 1998 Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease Nat Med 4 1318 1320 10.1038/3311
-
(1998)
Nat Med
, vol.4
, pp. 1318-1320
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury, P.T.3
-
32
-
-
0033538541
-
Alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease
-
10.1074/jbc.274.28.19509
-
SJ Wood J Wypych S Steavenson, et al. 1999 Alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease J Biol Chem 274 19509 19512 10.1074/jbc.274.28.19509
-
(1999)
J Biol Chem
, vol.274
, pp. 19509-19512
-
-
Wood, S.J.1
Wypych, J.2
Steavenson, S.3
-
33
-
-
0030908095
-
Models of amyloid seeding in alzheimer's disease and scrapie: Mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins
-
10.1146/annurev.biochem.66.1.385
-
JD Harper PT Lansbury Jr 1997 Models of amyloid seeding in alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins Annu Rev Biochem 66 385 407 10.1146/annurev.biochem.66.1.385
-
(1997)
Annu Rev Biochem
, vol.66
, pp. 385-407
-
-
Harper, J.D.1
Lansbury Jr., P.T.2
-
34
-
-
34548620297
-
Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation
-
VN Uversky 2007 Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation J Neurochem 103 17 37
-
(2007)
J Neurochem
, vol.103
, pp. 17-37
-
-
Uversky, V.N.1
-
35
-
-
0035815664
-
Evidence for a partially folded intermediate in alpha-synuclein fibril formation
-
10.1074/jbc.M010907200
-
VN Uversky J Li AL Fink 2001 Evidence for a partially folded intermediate in alpha-synuclein fibril formation J Biol Chem 276 10737 10744 10.1074/jbc.M010907200
-
(2001)
J Biol Chem
, vol.276
, pp. 10737-10744
-
-
Uversky, V.N.1
Li, J.2
Fink, A.L.3
-
36
-
-
0035941305
-
Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations
-
10.1074/jbc.C100551200
-
VN Uversky HJ Lee J Li, et al. 2001 Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations J Biol Chem 276 43495 43498 10.1074/jbc.C100551200
-
(2001)
J Biol Chem
, vol.276
, pp. 43495-43498
-
-
Uversky, V.N.1
Lee, H.J.2
Li, J.3
-
37
-
-
0036386364
-
Dependence of alpha-synuclein aggregate morphology on solution conditions
-
10.1016/S0022-2836(02)00775-1
-
W Hoyer T Antony D Cherny, et al. 2002 Dependence of alpha-synuclein aggregate morphology on solution conditions J Mol Biol 322 383 393 10.1016/S0022-2836(02)00775-1
-
(2002)
J Mol Biol
, vol.322
, pp. 383-393
-
-
Hoyer, W.1
Antony, T.2
Cherny, D.3
-
38
-
-
0035941201
-
Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. a possible molecular NK between Parkinson's disease and heavy metal exposure
-
10.1074/jbc.M105343200
-
VN Uversky J Li AL Fink 2001 Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure J Biol Chem 276 44284 44296 10.1074/jbc.M105343200
-
(2001)
J Biol Chem
, vol.276
, pp. 44284-44296
-
-
Uversky, V.N.1
Li, J.2
Fink, A.L.3
-
39
-
-
0037165646
-
Methionine oxidation inhibits fibrillation of human alpha-synuclein in vitro
-
10.1016/S0014-5793(02)02638-8
-
VN Uversky G Yamin PO Souillac, et al. 2002 Methionine oxidation inhibits fibrillation of human alpha-synuclein in vitro FEBS Lett 517 239 244 10.1016/S0014-5793(02)02638-8
-
(2002)
FEBS Lett
, vol.517
, pp. 239-244
-
-
Uversky, V.N.1
Yamin, G.2
Souillac, P.O.3
-
40
-
-
62049085927
-
Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation
-
10.1016/j.freeradbiomed.2009.02.009
-
SL Leong CLL Pham D Galatis, et al. 2009 Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation Free Radic Biol Med 46 1328 1337 10.1016/j.freeradbiomed.2009.02.009
-
(2009)
Free Radic Biol Med
, vol.46
, pp. 1328-1337
-
-
Leong, S.L.1
Pham, C.L.L.2
Galatis, D.3
-
41
-
-
15544381031
-
Effects of nitration on the structure and aggregation of alpha-synuclein
-
10.1016/j.molbrainres.2004.11.014
-
VN Uversky G Yamin LA Munishkina, et al. 2005 Effects of nitration on the structure and aggregation of alpha-synuclein Brain Res Mol Brain Res 134 84 102 10.1016/j.molbrainres.2004.11.014
-
(2005)
Brain Res Mol Brain Res
, vol.134
, pp. 84-102
-
-
Uversky, V.N.1
Yamin, G.2
Munishkina, L.A.3
-
42
-
-
0038404977
-
Nitration inhibits fibrillation of human alpha-synuclein in vitro by formation of soluble oligomers
-
10.1016/S0014-5793(03)00367-3
-
G Yamin VN Uversky AL Fink 2003 Nitration inhibits fibrillation of human alpha-synuclein in vitro by formation of soluble oligomers FEBS Lett 542 147 152 10.1016/S0014-5793(03)00367-3
-
(2003)
FEBS Lett
, vol.542
, pp. 147-152
-
-
Yamin, G.1
Uversky, V.N.2
Fink, A.L.3
-
43
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
10.1126/science.1079469
-
R Kayed E Head JL Thompson, et al. 2003 Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis Science 300 486 489 10.1126/science.1079469
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
-
44
-
-
0037041420
-
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
-
10.1038/416507a
-
M Bucciantini E Giannoni F Chiti, et al. 2002 Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases Nature 416 507 511 10.1038/416507a
-
(2002)
Nature
, vol.416
, pp. 507-511
-
-
Bucciantini, M.1
Giannoni, E.2
Chiti, F.3
-
45
-
-
0037551741
-
Protofibrils, pores, fibrils, and neurodegeneration: Separating the responsible protein aggregates from the innocent bystanders
-
10.1146/annurev.neuro.26.010302.081142
-
B Caughey PT Lansbury 2003 Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders Annu Rev Neurosci 26 267 298 10.1146/annurev.neuro.26. 010302.081142
-
(2003)
Annu Rev Neurosci
, vol.26
, pp. 267-298
-
-
Caughey, B.1
Lansbury, P.T.2
-
46
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
10.1073/pnas.95.11.6448
-
MP Lambert AK Barlow BA Chromy, et al. 1998 Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins Proc Natl Acad Sci USA 95 6448 6453 10.1073/pnas.95.11.6448
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
-
47
-
-
0034528027
-
Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants
-
KA Conway SJ Lee JC Rochet, et al. 2000 Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants Ann N Y Acad Sci 920 42 45
-
(2000)
Ann N Y Acad Sci
, vol.920
, pp. 42-45
-
-
Conway, K.A.1
Lee, S.J.2
Rochet, J.C.3
-
48
-
-
0034646391
-
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid
-
10.1021/bi991447r
-
KA Conway JD Harper PT Lansbury Jr 2000 Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid Biochemistry 39 2552 2563 10.1021/bi991447r
-
(2000)
Biochemistry
, vol.39
, pp. 2552-2563
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury Jr., P.T.3
-
49
-
-
14844335694
-
The E46K mutation in alpha-synuclein increases amyloid fibril formation
-
10.1074/jbc.M411638200
-
EA Greenbaum CL Graves AJ Mishizen-Eberz, et al. 2005 The E46K mutation in alpha-synuclein increases amyloid fibril formation J Biol Chem 280 7800 7807 10.1074/jbc.M411638200
-
(2005)
J Biol Chem
, vol.280
, pp. 7800-7807
-
-
Greenbaum, E.A.1
Graves, C.L.2
Mishizen-Eberz, A.J.3
-
50
-
-
38849179462
-
Formation of a high affinity lipid-binding intermediate during the early aggregation phase of alpha-synuclein
-
10.1021/bi701522m
-
DP Smith DJ Tew AF Hill, et al. 2008 Formation of a high affinity lipid-binding intermediate during the early aggregation phase of alpha-synuclein Biochemistry 47 1425 1434 10.1021/bi701522m
-
(2008)
Biochemistry
, vol.47
, pp. 1425-1434
-
-
Smith, D.P.1
Tew, D.J.2
Hill, A.F.3
-
51
-
-
0034326816
-
Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity
-
10.1093/hmg/9.18.2683
-
SJ Tabrizi M Orth JM Wilkinson, et al. 2000 Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity Hum Mol Genet 9 2683 2689 10.1093/hmg/9.18.2683
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2683-2689
-
-
Tabrizi, S.J.1
Orth, M.2
Wilkinson, J.M.3
-
52
-
-
0033515471
-
Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation
-
10.1074/jbc.274.14.9843
-
L Narhi SJ Wood S Steavenson, et al. 1999 Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation J Biol Chem 274 9843 9846 10.1074/jbc.274.14.9843
-
(1999)
J Biol Chem
, vol.274
, pp. 9843-9846
-
-
Narhi, L.1
Wood, S.J.2
Steavenson, S.3
-
53
-
-
0034681163
-
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
-
10.1073/pnas.97.2.571
-
KA Conway SJ Lee JC Rochet, et al. 2000 Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy Proc Natl Acad Sci USA 97 571 576 10.1073/pnas.97.2.571
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 571-576
-
-
Conway, K.A.1
Lee, S.J.2
Rochet, J.C.3
-
54
-
-
0035949542
-
Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein
-
10.1021/bi010616g
-
J Li VN Uversky AL Fink 2001 Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein Biochemistry 40 11604 11613 10.1021/bi010616g
-
(2001)
Biochemistry
, vol.40
, pp. 11604-11613
-
-
Li, J.1
Uversky, V.N.2
Fink, A.L.3
-
55
-
-
0034609561
-
Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein
-
10.1021/bi001315u
-
JC Rochet KA Conway PT Lansbury Jr 2000 Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein Biochemistry 39 10619 10626 10.1021/bi001315u
-
(2000)
Biochemistry
, vol.39
, pp. 10619-10626
-
-
Rochet, J.C.1
Conway, K.A.2
Lansbury Jr., P.T.3
-
56
-
-
0037130174
-
Neurodegenerative disease: Amyloid pores from pathogenic mutations
-
10.1038/418291a
-
HA Lashuel D Hartley BM Petre, et al. 2002 Neurodegenerative disease: amyloid pores from pathogenic mutations Nature 418 291 10.1038/418291a
-
(2002)
Nature
, vol.418
, pp. 291
-
-
Lashuel, H.A.1
Hartley, D.2
Petre, B.M.3
-
57
-
-
0036415838
-
Alpha-synuclein, especially the parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils
-
10.1016/S0022-2836(02)00735-0
-
HA Lashuel BM Petre J Wall, et al. 2002 Alpha-synuclein, especially the parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils J Mol Biol 322 1089 1102 10.1016/S0022-2836(02)00735-0
-
(2002)
J Mol Biol
, vol.322
, pp. 1089-1102
-
-
Lashuel, H.A.1
Petre, B.M.2
Wall, J.3
-
58
-
-
0037046163
-
Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism
-
10.1021/bi0121353
-
MJ Volles PT Lansbury Jr 2002 Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism Biochemistry 41 4595 4602 10.1021/bi0121353
-
(2002)
Biochemistry
, vol.41
, pp. 4595-4602
-
-
Volles, M.J.1
Lansbury Jr., P.T.2
-
59
-
-
15844403848
-
Annular alpha-synuclein oligomers are potentially toxic agents in alpha-synucleinopathy. Hypothesis
-
DL Pountney NH Voelcker WP Gai 2005 Annular alpha-synuclein oligomers are potentially toxic agents in alpha-synucleinopathy. Hypothesis Neurotox Res 7 59 67
-
(2005)
Neurotox Res
, vol.7
, pp. 59-67
-
-
Pountney, D.L.1
Voelcker, N.H.2
Gai, W.P.3
-
60
-
-
34548172773
-
Different species of alpha-synuclein oligomers induce calcium influx and seeding
-
10.1523/JNEUROSCI.2617-07.2007
-
KM Danzer D Haasen AR Karow, et al. 2007 Different species of alpha-synuclein oligomers induce calcium influx and seeding J Neurosci 27 9220 9232 10.1523/JNEUROSCI.2617-07.2007
-
(2007)
J Neurosci
, vol.27
, pp. 9220-9232
-
-
Danzer, K.M.1
Haasen, D.2
Karow, A.R.3
-
61
-
-
77951976610
-
Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome
-
doi: 10.1016/j.neurobiolaging.2008.07.008
-
Emmanouilidou E, Stefanis L, Vekrellis K (2008) Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome. Neurobiol Aging. doi: 10.1016/j.neurobiolaging.2008.07.008
-
(2008)
Neurobiol Aging
-
-
Emmanouilidou, E.1
Stefanis, L.2
Vekrellis, K.3
-
62
-
-
23444455247
-
Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
-
R Cappai SL Leck DJ Tew, et al. 2005 Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway FASEB J 19 1377 1379
-
(2005)
FASEB J
, vol.19
, pp. 1377-1379
-
-
Cappai, R.1
Leck, S.L.2
Tew, D.J.3
-
63
-
-
4344650564
-
Dopamine and L-dopa disaggregate amyloid fibrils: Implications for Parkinson's and Alzheimer's disease
-
10.1096/fj.04-2273com
-
J Li M Zhu AB Manning-Bog, et al. 2004 Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease FASEB J 18 962 964 10.1096/fj.04-2273com
-
(2004)
FASEB J
, vol.18
, pp. 962-964
-
-
Li, J.1
Zhu, M.2
Manning-Bog, A.B.3
-
64
-
-
20444401187
-
Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations
-
10.1074/jbc.M412621200
-
EH Norris BI Giasson R Hodara, et al. 2005 Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations J Biol Chem 280 21212 21219 10.1074/jbc.M412621200
-
(2005)
J Biol Chem
, vol.280
, pp. 21212-21219
-
-
Norris, E.H.1
Giasson, B.I.2
Hodara, R.3
-
65
-
-
0032842040
-
Tyrosine hydroxylase is inactivated by catechol-quinones and converted to a redox-cycling quinoprotein: Possible relevance to Parkinson's disease
-
10.1046/j.1471-4159.1999.0731309.x
-
DM Kuhn RE Arthur Jr DM Thomas, et al. 1999 Tyrosine hydroxylase is inactivated by catechol-quinones and converted to a redox-cycling quinoprotein: possible relevance to Parkinson's disease J Neurochem 73 1309 1317 10.1046/j.1471-4159.1999.0731309.x
-
(1999)
J Neurochem
, vol.73
, pp. 1309-1317
-
-
Kuhn, D.M.1
Arthur Jr., R.E.2
Thomas, D.M.3
-
66
-
-
0032403510
-
Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase
-
10.1002/(SICI)1097-4547(19981201)54:5<691::AID-JNR14>3.0.CO;2-F
-
Y Xu AH Stokes R Roskoski Jr, et al. 1998 Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase J Neurosci Res 54 691 697 10.1002/(SICI)1097-4547(19981201)54:5<691::AID-JNR14>3.0. CO;2-F
-
(1998)
J Neurosci Res
, vol.54
, pp. 691-697
-
-
Xu, Y.1
Stokes, A.H.2
Roskoski Jr., R.3
-
67
-
-
0035112815
-
Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter
-
10.1046/j.1471-4159.2001.00125.x
-
RE Whitehead JV Ferrer JA Javitch, et al. 2001 Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter J Neurochem 76 1242 1251 10.1046/j.1471-4159.2001.00125.x
-
(2001)
J Neurochem
, vol.76
, pp. 1242-1251
-
-
Whitehead, R.E.1
Ferrer, J.V.2
Javitch, J.A.3
-
68
-
-
36849059324
-
Dopamine differentially induces aggregation of A53T mutant and wild type alpha-synuclein: Insights into the protein chemistry of Parkinson's disease
-
10.1016/j.bbrc.2007.11.075
-
CE Moussa F Mahmoodian Y Tomita, et al. 2008 Dopamine differentially induces aggregation of A53T mutant and wild type alpha-synuclein: insights into the protein chemistry of Parkinson's disease Biochem Biophys Res Commun 365 833 839 10.1016/j.bbrc.2007.11.075
-
(2008)
Biochem Biophys Res Commun
, vol.365
, pp. 833-839
-
-
Moussa, C.E.1
Mahmoodian, F.2
Tomita, Y.3
-
69
-
-
33749170166
-
Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates
-
10.1523/JNEUROSCI.0896-06.2006
-
JR Mazzulli AJ Mishizen BI Giasson, et al. 2006 Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates J Neurosci 26 10068 10078 10.1523/JNEUROSCI.0896-06.2006
-
(2006)
J Neurosci
, vol.26
, pp. 10068-10078
-
-
Mazzulli, J.R.1
Mishizen, A.J.2
Giasson, B.I.3
-
70
-
-
33846210629
-
Dopamine affects the stability, hydration, and packing of protofibrils and fibrils of the wild type and variants of alpha-synuclein
-
10.1021/bi061871+
-
C Follmer L Romao CM Einsiedler, et al. 2007 Dopamine affects the stability, hydration, and packing of protofibrils and fibrils of the wild type and variants of alpha-synuclein Biochemistry 46 472 482 10.1021/bi061871+
-
(2007)
Biochemistry
, vol.46
, pp. 472-482
-
-
Follmer, C.1
Romao, L.2
Einsiedler, C.M.3
-
71
-
-
0035834360
-
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
-
10.1126/science.1063522
-
KA Conway JC Rochet RM Bieganski, et al. 2001 Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct Science 294 1346 1349 10.1126/science.1063522
-
(2001)
Science
, vol.294
, pp. 1346-1349
-
-
Conway, K.A.1
Rochet, J.C.2
Bieganski, R.M.3
-
72
-
-
22544478124
-
Inhibition of alpha-synuclein fibrillization by dopamine analogs via reaction with the amino groups of alpha-synuclein. Implication for dopaminergic neurodegeneration
-
10.1111/j.1742-4658.2005.04792.x
-
HT Li DH Lin XY Luo, et al. 2005 Inhibition of alpha-synuclein fibrillization by dopamine analogs via reaction with the amino groups of alpha-synuclein. Implication for dopaminergic neurodegeneration FEBS J 272 3661 3672 10.1111/j.1742-4658.2005.04792.x
-
(2005)
FEBS J
, vol.272
, pp. 3661-3672
-
-
Li, H.T.1
Lin, D.H.2
Luo, X.Y.3
-
73
-
-
30744443484
-
Dopamine covalently modifies and functionally inactivates Parkin
-
10.1038/nm1314
-
MJ LaVoie BL Ostaszewski A Weihofen, et al. 2005 Dopamine covalently modifies and functionally inactivates Parkin Nat Med 11 1214 1221 10.1038/nm1314
-
(2005)
Nat Med
, vol.11
, pp. 1214-1221
-
-
Lavoie, M.J.1
Ostaszewski, B.L.2
Weihofen, A.3
-
74
-
-
11144353557
-
The relevance of iron in the pathogenesis of Parkinson's disease
-
10.1196/annals.1306.017
-
ME Gotz K Double M Gerlach, et al. 2004 The relevance of iron in the pathogenesis of Parkinson's disease Ann N Y Acad Sci 1012 193 208 10.1196/annals.1306.017
-
(2004)
Ann N Y Acad Sci
, vol.1012
, pp. 193-208
-
-
Gotz, M.E.1
Double, K.2
Gerlach, M.3
-
75
-
-
38149073317
-
Aggregation of alpha-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine
-
10.1007/s00401-007-0303-9
-
WJ Burke VB Kumar N Pandey, et al. 2008 Aggregation of alpha-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine Acta Neuropathol 115 193 203 10.1007/s00401-007-0303-9
-
(2008)
Acta Neuropathol
, vol.115
, pp. 193-203
-
-
Burke, W.J.1
Kumar, V.B.2
Pandey, N.3
-
76
-
-
64649090221
-
At low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillation
-
10.1016/j.jmb.2009.03.053
-
W Zhou A Gallagher DP Hong, et al. 2009 At low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillation J Mol Biol 388 597 610 10.1016/j.jmb.2009.03.053
-
(2009)
J Mol Biol
, vol.388
, pp. 597-610
-
-
Zhou, W.1
Gallagher, A.2
Hong, D.P.3
-
77
-
-
35748975424
-
Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence
-
10.1074/jbc.M704737200
-
JR Mazzulli M Armakola M Dumoulin, et al. 2007 Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence J Biol Chem 282 31621 31630 10.1074/jbc.M704737200
-
(2007)
J Biol Chem
, vol.282
, pp. 31621-31630
-
-
Mazzulli, J.R.1
Armakola, M.2
Dumoulin, M.3
-
78
-
-
54849423681
-
Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region
-
10.1371/journal.pone.0003394
-
FE Herrera A Chesi KE Paleologou, et al. 2008 Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region PLoS ONE 3 E3394 10.1371/journal.pone.0003394
-
(2008)
PLoS ONE
, vol.3
, pp. 3394
-
-
Herrera, F.E.1
Chesi, A.2
Paleologou, K.E.3
-
79
-
-
9144274018
-
Role of individual methionines in the fibrillation of methionine-oxidized alpha-synuclein
-
10.1021/bi049979h
-
MJ Hokenson VN Uversky J Goers, et al. 2004 Role of individual methionines in the fibrillation of methionine-oxidized alpha-synuclein Biochemistry 43 4621 4633 10.1021/bi049979h
-
(2004)
Biochemistry
, vol.43
, pp. 4621-4633
-
-
Hokenson, M.J.1
Uversky, V.N.2
Goers, J.3
|