메뉴 건너뛰기




Volumn 260, Issue 2, 2009, Pages 308-331

Modeling HIV persistence, the latent reservoir, and viral blips

Author keywords

Blips; HAART; HIV 1; Latency; Low level viremia; Mathematical models; Viral reservoirs

Indexed keywords

ALPHA INTERFERON; ATAZANAVIR PLUS RITONAVIR; EFAVIRENZ; ENFUVIRTIDE; INTERLEUKIN 2; INTERLEUKIN 6; LOPINAVIR PLUS RITONAVIR; MARAVIROC; NELFINAVIR; NEVIRAPINE; OKT 3; PROTEINASE INHIBITOR; RALTEGRAVIR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; TUMOR NECROSIS FACTOR ALPHA; VALPROIC ACID;

EID: 68949196315     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2009.06.011     Document Type: Review
Times cited : (216)

References (237)
  • 1
  • 2
    • 0030001674 scopus 로고    scopus 로고
    • Immunological memory and protective immunity: understanding their relation
    • Ahmed R., and Gray D. Immunological memory and protective immunity: understanding their relation. Science 272 (1996) 54-60
    • (1996) Science , vol.272 , pp. 54-60
    • Ahmed, R.1    Gray, D.2
  • 4
    • 3843075353 scopus 로고    scopus 로고
    • Predicting differential responses to structured treatment interruptions during HAART
    • Bajaria S.H., Webb G., and Kirschner D.E. Predicting differential responses to structured treatment interruptions during HAART. Bull. Math. Biol. 66 (2004) 1093-1118
    • (2004) Bull. Math. Biol. , vol.66 , pp. 1093-1118
    • Bajaria, S.H.1    Webb, G.2    Kirschner, D.E.3
  • 5
    • 33750614139 scopus 로고    scopus 로고
    • Structured treatment interruptions-new findings
    • Benson C.A. Structured treatment interruptions-new findings. Top. HIV Med. 14 (2006) 107-111
    • (2006) Top. HIV Med. , vol.14 , pp. 107-111
    • Benson, C.A.1
  • 6
    • 0034303872 scopus 로고    scopus 로고
    • Proviral HIV-1 dynamics and evolution in patients receiving efficient long-term antiretroviral combination therapy
    • Birk M., Aleman S., Visco-Comandini U., and Sonnerborg A. Proviral HIV-1 dynamics and evolution in patients receiving efficient long-term antiretroviral combination therapy. HIV Med. 1 (2000) 205-211
    • (2000) HIV Med. , vol.1 , pp. 205-211
    • Birk, M.1    Aleman, S.2    Visco-Comandini, U.3    Sonnerborg, A.4
  • 8
    • 0036176509 scopus 로고    scopus 로고
    • The challenge of viral reservoirs in HIV-1 infection
    • Blankson J.N., Persaud D., and Siliciano R.F. The challenge of viral reservoirs in HIV-1 infection. Annu. Rev. Med. 53 (2002) 557-593
    • (2002) Annu. Rev. Med. , vol.53 , pp. 557-593
    • Blankson, J.N.1    Persaud, D.2    Siliciano, R.F.3
  • 9
    • 17644376178 scopus 로고    scopus 로고
    • The effect of early treatment on the latent reservoir of HIV-1
    • Blankson J.N., Siliciano J.D., and Siliciano R.F. The effect of early treatment on the latent reservoir of HIV-1. J. Infect. Dis. 191 (2005) 1394-1396
    • (2005) J. Infect. Dis. , vol.191 , pp. 1394-1396
    • Blankson, J.N.1    Siliciano, J.D.2    Siliciano, R.F.3
  • 10
    • 0031000756 scopus 로고    scopus 로고
    • Human immunodeficiency virus drug therapy and virus load
    • Bonhoeffer S., Coffin J.M., and Nowak M.A. Human immunodeficiency virus drug therapy and virus load. J. Virol. 71 (1997) 3275-3278
    • (1997) J. Virol. , vol.71 , pp. 3275-3278
    • Bonhoeffer, S.1    Coffin, J.M.2    Nowak, M.A.3
  • 12
    • 0030902875 scopus 로고    scopus 로고
    • Pre-existence and emergence of drug resistance in HIV-1 infection
    • Bonhoeffer S., and Nowak M.A. Pre-existence and emergence of drug resistance in HIV-1 infection. Proc. R. Soc. London B 264 (1997) 631-637
    • (1997) Proc. R. Soc. London B , vol.264 , pp. 631-637
    • Bonhoeffer, S.1    Nowak, M.A.2
  • 13
    • 0033028912 scopus 로고    scopus 로고
    • Immune clearance of HIV type 1 replication-active cells: a model of two patterns of steady state HIV infection
    • Bucy R.P. Immune clearance of HIV type 1 replication-active cells: a model of two patterns of steady state HIV infection. AIDS Res. Hum. Retroviruses 15 (1999) 223-227
    • (1999) AIDS Res. Hum. Retroviruses , vol.15 , pp. 223-227
    • Bucy, R.P.1
  • 14
    • 0036381110 scopus 로고    scopus 로고
    • HIV-1 infection and low steady state viral loads
    • Callaway D.S., and Perelson A.S. HIV-1 infection and low steady state viral loads. Bull. Math. Biol. 64 (2002) 29-64
    • (2002) Bull. Math. Biol. , vol.64 , pp. 29-64
    • Callaway, D.S.1    Perelson, A.S.2
  • 16
    • 37649007699 scopus 로고    scopus 로고
    • Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques
    • Chen H.Y., Di Mascio M., Perelson A.S., Ho D.D., and Zhang L. Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques. Proc. Natl. Acad. Sci. USA 104 (2007) 19079-19084
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 19079-19084
    • Chen, H.Y.1    Di Mascio, M.2    Perelson, A.S.3    Ho, D.D.4    Zhang, L.5
  • 17
    • 34249038894 scopus 로고    scopus 로고
    • Pediatric HIV-1-specific cytotoxic T-lymphocyte responses suggesting ongoing viral replication despite combination antiretroviral therapy
    • Ching N., Yang O.O., Deville J.G., Nielsen-Saines K., Ank B.J., Sim M.S., and Bryson Y.J. Pediatric HIV-1-specific cytotoxic T-lymphocyte responses suggesting ongoing viral replication despite combination antiretroviral therapy. Pediatr. Res. 61 (2007) 692-697
    • (2007) Pediatr. Res. , vol.61 , pp. 692-697
    • Ching, N.1    Yang, O.O.2    Deville, J.G.3    Nielsen-Saines, K.4    Ank, B.J.5    Sim, M.S.6    Bryson, Y.J.7
  • 18
    • 68349139711 scopus 로고    scopus 로고
    • HIV reservoir size and persistence are driven by T-cell survival and homeostatic proliferaiton
    • in press, doi:10.1038/nm.1972
    • Chomont, N., et al., 2009. HIV reservoir size and persistence are driven by T-cell survival and homeostatic proliferaiton. Nat. Med., in press, doi:10.1038/nm.1972.
    • (2009) Nat. Med
    • Chomont, N.1
  • 23
    • 0033914367 scopus 로고    scopus 로고
    • Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy
    • Chun T.W., Davey Jr. R.T., Ostrowski M., Shawn Justement J., Engel D., Mullins J.I., and Fauci A.S. Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy. Nat. Med. 6 (2000) 757-761
    • (2000) Nat. Med. , vol.6 , pp. 757-761
    • Chun, T.W.1    Davey Jr., R.T.2    Ostrowski, M.3    Shawn Justement, J.4    Engel, D.5    Mullins, J.I.6    Fauci, A.S.7
  • 24
    • 0032555117 scopus 로고    scopus 로고
    • Early establishment of a pool of latently infected, resting CD 4 (+) T cells during primary HIV-1 infection
    • Chun T.W., Engel D., Berrey M.M., Shea T., Corey L., and Fauci A.S. Early establishment of a pool of latently infected, resting CD 4 (+) T cells during primary HIV-1 infection. Proc. Natl. Acad. Sci. USA 95 (1998) 8869-8873
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8869-8873
    • Chun, T.W.1    Engel, D.2    Berrey, M.M.3    Shea, T.4    Corey, L.5    Fauci, A.S.6
  • 25
    • 0032490570 scopus 로고    scopus 로고
    • Induction of HIV-1 replication in latently infected CD 4 + T cells using a combination of cytokines
    • Chun T.W., Engel D., Mizell S.B., Ehler L.A., and Fauci A.S. Induction of HIV-1 replication in latently infected CD 4 + T cells using a combination of cytokines. J. Exp. Med. 188 (1998) 83-91
    • (1998) J. Exp. Med. , vol.188 , pp. 83-91
    • Chun, T.W.1    Engel, D.2    Mizell, S.B.3    Ehler, L.A.4    Fauci, A.S.5
  • 26
    • 0033613070 scopus 로고    scopus 로고
    • Latent reservoirs of HIV: obstacles to the eradication of virus
    • Chun T.W., and Fauci A.S. Latent reservoirs of HIV: obstacles to the eradication of virus. Proc. Natl. Acad. Sci. USA 96 (1999) 10958-10961
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 10958-10961
    • Chun, T.W.1    Fauci, A.S.2
  • 27
    • 0028792184 scopus 로고
    • In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency
    • Chun T.W., Finzi D., Margolick J., Chadwick K., Schwartz D., and Siliciano R.F. In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency. Nat. Med. 1 (1995) 1284-1290
    • (1995) Nat. Med. , vol.1 , pp. 1284-1290
    • Chun, T.W.1    Finzi, D.2    Margolick, J.3    Chadwick, K.4    Schwartz, D.5    Siliciano, R.F.6
  • 28
    • 34249883292 scopus 로고    scopus 로고
    • Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virus
    • Chun T.W., Justement J.S., Moir S., Hallahan C.W., Maenza J., Mullins J.I., Collier A.C., Corey L., and Fauci A.S. Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virus. J. Infect. Dis. 195 (2007) 1762-1764
    • (2007) J. Infect. Dis. , vol.195 , pp. 1762-1764
    • Chun, T.W.1    Justement, J.S.2    Moir, S.3    Hallahan, C.W.4    Maenza, J.5    Mullins, J.I.6    Collier, A.C.7    Corey, L.8    Fauci, A.S.9
  • 29
    • 0036606456 scopus 로고    scopus 로고
    • Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD 4 + T cells and CD 4 +:CD 8 + T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy
    • Chun T.W., Justement J.S., Pandya P., Hallahan C.W., McLaughlin M., Liu S., Ehler L.A., Kovacs C., and Fauci A.S. Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD 4 + T cells and CD 4 +:CD 8 + T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy. J. Infect. Dis. 185 (2002) 1672-1676
    • (2002) J. Infect. Dis. , vol.185 , pp. 1672-1676
    • Chun, T.W.1    Justement, J.S.2    Pandya, P.3    Hallahan, C.W.4    McLaughlin, M.5    Liu, S.6    Ehler, L.A.7    Kovacs, C.8    Fauci, A.S.9
  • 31
  • 32
    • 55949130714 scopus 로고    scopus 로고
    • Raltegravir: the first HIV integrase inhibitor
    • Cocohoba J., and Dong B.J. Raltegravir: the first HIV integrase inhibitor. Clin. Ther. 30 (2008) 1747-1765
    • (2008) Clin. Ther. , vol.30 , pp. 1747-1765
    • Cocohoba, J.1    Dong, B.J.2
  • 33
    • 0028952146 scopus 로고
    • HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy
    • Coffin J.M. HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267 (1995) 483-489
    • (1995) Science , vol.267 , pp. 483-489
    • Coffin, J.M.1
  • 37
    • 33947417697 scopus 로고    scopus 로고
    • Understanding the failure of CD 8 + T-cell vaccination against simian/human immunodeficiency virus
    • De Boer R.J. Understanding the failure of CD 8 + T-cell vaccination against simian/human immunodeficiency virus. J. Virol. 81 (2007) 2838-2848
    • (2007) J. Virol. , vol.81 , pp. 2838-2848
    • De Boer, R.J.1
  • 39
    • 0141958258 scopus 로고    scopus 로고
    • Different dynamics of CD 4 + and CD 8 + T cell responses during and after acute lymphocytic choriomeningitis virus infection
    • De Boer R.J., Homann D., and Perelson A.S. Different dynamics of CD 4 + and CD 8 + T cell responses during and after acute lymphocytic choriomeningitis virus infection. J. Immunol. 171 (2003) 3928-3935
    • (2003) J. Immunol. , vol.171 , pp. 3928-3935
    • De Boer, R.J.1    Homann, D.2    Perelson, A.S.3
  • 40
    • 0034765725 scopus 로고    scopus 로고
    • Recruitment times, proliferation, and apoptosis rates during the CD 8 (+) T-cell response to lymphocytic choriomeningitis virus
    • De Boer R.J., Oprea M., Antia R., Murali-Krishna K., Ahmed R., and Perelson A.S. Recruitment times, proliferation, and apoptosis rates during the CD 8 (+) T-cell response to lymphocytic choriomeningitis virus. J. Virol. 75 (2001) 10663-10669
    • (2001) J. Virol. , vol.75 , pp. 10663-10669
    • De Boer, R.J.1    Oprea, M.2    Antia, R.3    Murali-Krishna, K.4    Ahmed, R.5    Perelson, A.S.6
  • 41
    • 0032492107 scopus 로고    scopus 로고
    • Target cell limited and immune control models of HIV infection: a comparison
    • De Boer R.J., and Perelson A.S. Target cell limited and immune control models of HIV infection: a comparison. J. Theor. Biol. 190 (1998) 201-214
    • (1998) J. Theor. Biol. , vol.190 , pp. 201-214
    • De Boer, R.J.1    Perelson, A.S.2
  • 42
    • 23344445378 scopus 로고    scopus 로고
    • Estimating division and death rates from CFSE data
    • De Boer R.J., and Perelson A.S. Estimating division and death rates from CFSE data. J. Comput. Appl. Math. 184 (2005) 140-164
    • (2005) J. Comput. Appl. Math. , vol.184 , pp. 140-164
    • De Boer, R.J.1    Perelson, A.S.2
  • 44
    • 0033385403 scopus 로고    scopus 로고
    • Rapid decline in detectability of HIV-1 drug resistance mutations after stopping therapy
    • Devereux H.L., Youle M., Johnson M.A., and Loveday C. Rapid decline in detectability of HIV-1 drug resistance mutations after stopping therapy. AIDS 13 (1999) 123-127
    • (1999) AIDS , vol.13 , pp. 123-127
    • Devereux, H.L.1    Youle, M.2    Johnson, M.A.3    Loveday, C.4
  • 46
    • 4544262243 scopus 로고    scopus 로고
    • Dynamics of intermittent viremia during highly active antiretroviral therapy in patients who initiate therapy during chronic versus acute and early human immunodeficiency virus type 1 infection
    • Di Mascio M., Markowitz M., Louie M., Hurley A., Hogan C., Simon V., Follmann D., Ho D.D., and Perelson A.S. Dynamics of intermittent viremia during highly active antiretroviral therapy in patients who initiate therapy during chronic versus acute and early human immunodeficiency virus type 1 infection. J. Virol. 78 (2004) 10566-10573
    • (2004) J. Virol. , vol.78 , pp. 10566-10573
    • Di Mascio, M.1    Markowitz, M.2    Louie, M.3    Hurley, A.4    Hogan, C.5    Simon, V.6    Follmann, D.7    Ho, D.D.8    Perelson, A.S.9
  • 48
    • 0842346379 scopus 로고    scopus 로고
    • Modeling the long-term control of viremia in HIV-1 infected patients treated with antiretroviral therapy
    • Di Mascio M., Ribeiro R.M., Markowitz M., Ho D.D., and Perelson A.S. Modeling the long-term control of viremia in HIV-1 infected patients treated with antiretroviral therapy. Math. Biosci. 188 (2004) 47-62
    • (2004) Math. Biosci. , vol.188 , pp. 47-62
    • Di Mascio, M.1    Ribeiro, R.M.2    Markowitz, M.3    Ho, D.D.4    Perelson, A.S.5
  • 52
    • 0001488150 scopus 로고
    • Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat
    • Duh E.J., Maury W.J., Folks T.M., Fauci A.S., and Rabson A.B. Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat. Proc. Natl. Acad. Sci. USA 86 (1989) 5974-5978
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 5974-5978
    • Duh, E.J.1    Maury, W.J.2    Folks, T.M.3    Fauci, A.S.4    Rabson, A.B.5
  • 57
    • 0032577449 scopus 로고    scopus 로고
    • Viral dynamics in HIV-1 infection
    • Finzi D., and Siliciano R. Viral dynamics in HIV-1 infection. Cell 93 (1998) 665-671
    • (1998) Cell , vol.93 , pp. 665-671
    • Finzi, D.1    Siliciano, R.2
  • 59
    • 0035909915 scopus 로고    scopus 로고
    • Quantification of intrinsic residual viral replication in treated HIV-infected patients
    • Fraser C., Ferguson N.M., and Anderson R.M. Quantification of intrinsic residual viral replication in treated HIV-infected patients. Proc. Natl. Acad. Sci. USA 98 (2001) 15167-15172
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 15167-15172
    • Fraser, C.1    Ferguson, N.M.2    Anderson, R.M.3
  • 60
    • 0035934874 scopus 로고    scopus 로고
    • The role of antigenic stimulation and cytotoxic T cell activity in regulating the long-term immunopathogenesis of HIV: mechanisms and clinical implications
    • Fraser C., Ferguson N.M., de Wolf F., and Anderson R.M. The role of antigenic stimulation and cytotoxic T cell activity in regulating the long-term immunopathogenesis of HIV: mechanisms and clinical implications. Proc. Biol. Sci. 268 (2001) 2085-2095
    • (2001) Proc. Biol. Sci. , vol.268 , pp. 2085-2095
    • Fraser, C.1    Ferguson, N.M.2    de Wolf, F.3    Anderson, R.M.4
  • 61
    • 52049123299 scopus 로고    scopus 로고
    • The bacterial superantigen and superantigen-like proteins
    • Fraser J.D., and Proft T. The bacterial superantigen and superantigen-like proteins. Immunol. Rev. 225 (2008) 226-243
    • (2008) Immunol. Rev. , vol.225 , pp. 226-243
    • Fraser, J.D.1    Proft, T.2
  • 64
    • 39649105458 scopus 로고    scopus 로고
    • Hide-and-seek: the challenge of viral persistence in HIV-1 infection
    • Geeraert L., Kraus G., and Pomerantz R.J. Hide-and-seek: the challenge of viral persistence in HIV-1 infection. Annu. Rev. Med. 59 (2008) 215-229
    • (2008) Annu. Rev. Med. , vol.59 , pp. 215-229
    • Geeraert, L.1    Kraus, G.2    Pomerantz, R.J.3
  • 65
    • 0034280834 scopus 로고    scopus 로고
    • A cellular calculus for signal integration by T cells
    • Gett A.V., and Hodgkin P.D. A cellular calculus for signal integration by T cells. Nat. Immunol. 1 (2000) 239-244
    • (2000) Nat. Immunol. , vol.1 , pp. 239-244
    • Gett, A.V.1    Hodgkin, P.D.2
  • 69
    • 0036183470 scopus 로고    scopus 로고
    • Structured treatment interruption in patients infected with HIV
    • Gulick R.M. Structured treatment interruption in patients infected with HIV. Drugs 62 (2002) 245-253
    • (2002) Drugs , vol.62 , pp. 245-253
    • Gulick, R.M.1
  • 73
    • 2642704250 scopus 로고    scopus 로고
    • Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy
    • Gunthard H.F., Wong J.K., Ignacio C.C., Guatelli J.C., Riggs N.L., Havlir D.V., and Richman D.D. Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy. J. Virol. 72 (1998) 2422-2428
    • (1998) J. Virol. , vol.72 , pp. 2422-2428
    • Gunthard, H.F.1    Wong, J.K.2    Ignacio, C.C.3    Guatelli, J.C.4    Riggs, N.L.5    Havlir, D.V.6    Richman, D.D.7
  • 74
    • 0034092682 scopus 로고    scopus 로고
    • Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy
    • Gunthard H.F., Wong J.K., Spina C.A., Ignacio C., Kwok S., Christopherson C., Hwang J., Haubrich R., Havlir D., and Richman D.D. Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy. J. Infect. Dis. 181 (2000) 522-531
    • (2000) J. Infect. Dis. , vol.181 , pp. 522-531
    • Gunthard, H.F.1    Wong, J.K.2    Spina, C.A.3    Ignacio, C.4    Kwok, S.5    Christopherson, C.6    Hwang, J.7    Haubrich, R.8    Havlir, D.9    Richman, D.D.10
  • 76
    • 33745836478 scopus 로고    scopus 로고
    • The latent reservoir for HIV-1 in resting CD 4 + T cells and other viral reservoirs during chronic infection: insights from treatment and treatment-interruption trials
    • Haggerty C.M., Pitt E., and Siliciano R.F. The latent reservoir for HIV-1 in resting CD 4 + T cells and other viral reservoirs during chronic infection: insights from treatment and treatment-interruption trials. Curr. Opin. HIV AIDS 1 (2006) 62-68
    • (2006) Curr. Opin. HIV AIDS , vol.1 , pp. 62-68
    • Haggerty, C.M.1    Pitt, E.2    Siliciano, R.F.3
  • 77
    • 0024425529 scopus 로고
    • Stem cells: the generation and maintenance of cellular diversity
    • Hall P.A., and Watt F.M. Stem cells: the generation and maintenance of cellular diversity. Development 106 (1989) 619-633
    • (1989) Development , vol.106 , pp. 619-633
    • Hall, P.A.1    Watt, F.M.2
  • 79
    • 2642523580 scopus 로고    scopus 로고
    • Resting CD 4 + T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes
    • Han Y., Lassen K., Monie D., Sedaghat A.R., Shimoji S., Liu X., Pierson T.C., Margolick J.B., Siliciano R.F., and Siliciano J.D. Resting CD 4 + T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes. J. Virol. 78 (2004) 6122-6133
    • (2004) J. Virol. , vol.78 , pp. 6122-6133
    • Han, Y.1    Lassen, K.2    Monie, D.3    Sedaghat, A.R.4    Shimoji, S.5    Liu, X.6    Pierson, T.C.7    Margolick, J.B.8    Siliciano, R.F.9    Siliciano, J.D.10
  • 81
    • 0141676556 scopus 로고    scopus 로고
    • Productive infection maintains a dynamic steady state of residual viremia in human immunodeficiency virus type 1-infected persons treated with suppressive antiretroviral therapy for five years
    • Havlir D.V., Strain M.C., Clerici M., Ignacio C., Trabattoni D., Ferrante P., and Wong J.K. Productive infection maintains a dynamic steady state of residual viremia in human immunodeficiency virus type 1-infected persons treated with suppressive antiretroviral therapy for five years. J. Virol. 77 (2003) 11212-11219
    • (2003) J. Virol. , vol.77 , pp. 11212-11219
    • Havlir, D.V.1    Strain, M.C.2    Clerici, M.3    Ignacio, C.4    Trabattoni, D.5    Ferrante, P.6    Wong, J.K.7
  • 82
    • 33947238281 scopus 로고    scopus 로고
    • A model of immune regulation as a consequence of randomized lymphocyte division and death times
    • Hawkins E.D., Turner M.L., Dowling M.R., van Gend C., and Hodgkin P.D. A model of immune regulation as a consequence of randomized lymphocyte division and death times. Proc. Natl. Acad. Sci. USA 104 (2007) 5032-5037
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 5032-5037
    • Hawkins, E.D.1    Turner, M.L.2    Dowling, M.R.3    van Gend, C.4    Hodgkin, P.D.5
  • 84
    • 0038468339 scopus 로고    scopus 로고
    • Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD 4 + T lymphocytes in vivo
    • Hermankova M., Siliciano J.D., Zhou Y., Monie D., Chadwick K., Margolick J.B., Quinn T.C., and Siliciano R.F. Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD 4 + T lymphocytes in vivo. J. Virol. 77 (2003) 7383-7392
    • (2003) J. Virol. , vol.77 , pp. 7383-7392
    • Hermankova, M.1    Siliciano, J.D.2    Zhou, Y.3    Monie, D.4    Chadwick, K.5    Margolick, J.B.6    Quinn, T.C.7    Siliciano, R.F.8
  • 87
    • 0033592858 scopus 로고    scopus 로고
    • Dissociation of HIV-1 from follicular dendritic cells during HAART: mathematical analysis
    • Hlavacek W.S., Wofsy C., and Perelson A.S. Dissociation of HIV-1 from follicular dendritic cells during HAART: mathematical analysis. Proc. Natl. Acad. Sci. USA 96 (1999) 14681-14686
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14681-14686
    • Hlavacek, W.S.1    Wofsy, C.2    Perelson, A.S.3
  • 88
    • 0029940354 scopus 로고    scopus 로고
    • Viral counts count in HIV infection
    • Ho D.D. Viral counts count in HIV infection. Science 272 (1996) 1124-1125
    • (1996) Science , vol.272 , pp. 1124-1125
    • Ho, D.D.1
  • 89
    • 0032546919 scopus 로고    scopus 로고
    • Toward HIV eradication or remission: the tasks ahead
    • Ho D.D. Toward HIV eradication or remission: the tasks ahead. Science 280 (1998) 1866-1867
    • (1998) Science , vol.280 , pp. 1866-1867
    • Ho, D.D.1
  • 91
    • 0022551277 scopus 로고
    • Infection of monocyte/macrophages by human T lymphotropic virus type III
    • Ho D., Rota T., and Hirsch M. Infection of monocyte/macrophages by human T lymphotropic virus type III. J. Clin. Invest. 77 (1986) 1712-1715
    • (1986) J. Clin. Invest. , vol.77 , pp. 1712-1715
    • Ho, D.1    Rota, T.2    Hirsch, M.3
  • 94
    • 0034887110 scopus 로고    scopus 로고
    • Differential regulation of antiviral T-cell immunity results in stable CD 8 + but declining CD 4 + T-cell memory
    • Homann D., Teyton L., and Oldstone M.B. Differential regulation of antiviral T-cell immunity results in stable CD 8 + but declining CD 4 + T-cell memory. Nat. Med. 7 (2001) 913-919
    • (2001) Nat. Med. , vol.7 , pp. 913-919
    • Homann, D.1    Teyton, L.2    Oldstone, M.B.3
  • 95
    • 0026601244 scopus 로고
    • Mechanisms of asymmetric cell division: two Bs or not two Bs, that is the question
    • Horvitz H.R., and Herskowitz I. Mechanisms of asymmetric cell division: two Bs or not two Bs, that is the question. Cell 68 (1992) 237-255
    • (1992) Cell , vol.68 , pp. 237-255
    • Horvitz, H.R.1    Herskowitz, I.2
  • 96
    • 0035173896 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 quasi species that rebound after discontinuation of highly active antiretroviral therapy are similar to the viral quasi species present before initiation of therapy
    • Imamichi H., Crandall K.A., Natarajan V., Jiang M.K., Dewar R.L., Berg S., Gaddam A., Bosche M., Metcalf J.A., Davey Jr. R.T., and Lane H.C. Human immunodeficiency virus type 1 quasi species that rebound after discontinuation of highly active antiretroviral therapy are similar to the viral quasi species present before initiation of therapy. J. Infect. Dis. 183 (2001) 36-50
    • (2001) J. Infect. Dis. , vol.183 , pp. 36-50
    • Imamichi, H.1    Crandall, K.A.2    Natarajan, V.3    Jiang, M.K.4    Dewar, R.L.5    Berg, S.6    Gaddam, A.7    Bosche, M.8    Metcalf, J.A.9    Davey Jr., R.T.10    Lane, H.C.11
  • 97
    • 0000063597 scopus 로고    scopus 로고
    • Asymmetric cell division
    • Jan Y.N., and Jan L.Y. Asymmetric cell division. Nature 392 (1998) 775-778
    • (1998) Nature , vol.392 , pp. 775-778
    • Jan, Y.N.1    Jan, L.Y.2
  • 99
    • 0036892645 scopus 로고    scopus 로고
    • Modeling the effects of vaccination on chronically infected HIV-positive patients
    • Jones L.E., and Perelson A.S. Modeling the effects of vaccination on chronically infected HIV-positive patients. J. Acquir. Immune Defic. Syndr. 31 (2002) 369-377
    • (2002) J. Acquir. Immune Defic. Syndr. , vol.31 , pp. 369-377
    • Jones, L.E.1    Perelson, A.S.2
  • 100
    • 24944439857 scopus 로고    scopus 로고
    • Opportunistic infection as a cause of transient viremia in chronically infected HIV patients under treatment with HAART
    • Jones L.E., and Perelson A.S. Opportunistic infection as a cause of transient viremia in chronically infected HIV patients under treatment with HAART. Bull. Math. Biol. 67 (2005) 1227-1251
    • (2005) Bull. Math. Biol. , vol.67 , pp. 1227-1251
    • Jones, L.E.1    Perelson, A.S.2
  • 101
    • 34548088101 scopus 로고    scopus 로고
    • Transient viremia, plasma viral load, and reservoir replenishment in HIV-infected patients on antiretroviral therapy
    • Jones L.E., and Perelson A.S. Transient viremia, plasma viral load, and reservoir replenishment in HIV-infected patients on antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 45 (2007) 483-493
    • (2007) J. Acquir. Immune Defic. Syndr. , vol.45 , pp. 483-493
    • Jones, L.E.1    Perelson, A.S.2
  • 102
    • 0037446948 scopus 로고    scopus 로고
    • HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
    • Jordan A., Bisgrove D., and Verdin E. HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J. 22 (2003) 1868-1877
    • (2003) EMBO J. , vol.22 , pp. 1868-1877
    • Jordan, A.1    Bisgrove, D.2    Verdin, E.3
  • 103
    • 0035348175 scopus 로고    scopus 로고
    • Memory CD 8 + T cell differentiation: initial antigen encounter triggers a developmental program in naive cells
    • Kaech S.M., and Ahmed R. Memory CD 8 + T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2 (2001) 415-422
    • (2001) Nat. Immunol. , vol.2 , pp. 415-422
    • Kaech, S.M.1    Ahmed, R.2
  • 104
    • 0023513563 scopus 로고
    • Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product
    • Kao S.Y., Calman A.F., Luciw P.A., and Peterlin B.M. Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product. Nature 330 (1987) 489-493
    • (1987) Nature , vol.330 , pp. 489-493
    • Kao, S.Y.1    Calman, A.F.2    Luciw, P.A.3    Peterlin, B.M.4
  • 105
    • 0032578396 scopus 로고    scopus 로고
    • Drug concentration heterogeneity facilitates the evolution of drug resistance
    • Kepler T.B., and Perelson A.S. Drug concentration heterogeneity facilitates the evolution of drug resistance. Proc. Natl. Acad. Sci. USA 95 (1998) 11514-11519
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 11514-11519
    • Kepler, T.B.1    Perelson, A.S.2
  • 106
    • 2142829435 scopus 로고    scopus 로고
    • Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads
    • Kieffer T.L., Finucane M.M., Nettles R.E., Quinn T.C., Broman K.W., Ray S.C., Persaud D., and Siliciano R.F. Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads. J. Infect. Dis. 189 (2004) 1452-1465
    • (2004) J. Infect. Dis. , vol.189 , pp. 1452-1465
    • Kieffer, T.L.1    Finucane, M.M.2    Nettles, R.E.3    Quinn, T.C.4    Broman, K.W.5    Ray, S.C.6    Persaud, D.7    Siliciano, R.F.8
  • 107
    • 33750451933 scopus 로고    scopus 로고
    • Viral and latent reservoir persistence in HIV-1-infected patients on therapy
    • Kim H., and Perelson A.S. Viral and latent reservoir persistence in HIV-1-infected patients on therapy. PLoS Comput. Biol. 2 (2006) e135
    • (2006) PLoS Comput. Biol. , vol.2
    • Kim, H.1    Perelson, A.S.2
  • 108
    • 33750483370 scopus 로고    scopus 로고
    • Dynamic characteristics of HIV-1 reservoirs
    • Kim H., and Perelson A.S. Dynamic characteristics of HIV-1 reservoirs. Curr. Opin. HIV AIDS 1 (2006) 152-156
    • (2006) Curr. Opin. HIV AIDS , vol.1 , pp. 152-156
    • Kim, H.1    Perelson, A.S.2
  • 109
    • 0031177707 scopus 로고    scopus 로고
    • Understanding drug resistance for montherapy treatment of HIV infection
    • Kirschner D.E., and Webb G.F. Understanding drug resistance for montherapy treatment of HIV infection. Bull. Math. Biol. 59 (1997) 763-786
    • (1997) Bull. Math. Biol. , vol.59 , pp. 763-786
    • Kirschner, D.E.1    Webb, G.F.2
  • 110
    • 7044271206 scopus 로고    scopus 로고
    • Development of anti-retroviral resistance of HIV-1 infected individuals on therapy: is it inevitable?
    • Kolber M.A., Campo R.E., and Dickinson G.M. Development of anti-retroviral resistance of HIV-1 infected individuals on therapy: is it inevitable?. IUBMB Life 56 (2004) 301-307
    • (2004) IUBMB Life , vol.56 , pp. 301-307
    • Kolber, M.A.1    Campo, R.E.2    Dickinson, G.M.3
  • 111
    • 0036315848 scopus 로고    scopus 로고
    • Effects of prostratin on T-cell activation and human immunodeficiency virus latency
    • Korin Y.D., Brooks D.G., Brown S., Korotzer A., and Zack J.A. Effects of prostratin on T-cell activation and human immunodeficiency virus latency. J. Virol. 76 (2002) 8118-8123
    • (2002) J. Virol. , vol.76 , pp. 8118-8123
    • Korin, Y.D.1    Brooks, D.G.2    Brown, S.3    Korotzer, A.4    Zack, J.A.5
  • 112
    • 35649020838 scopus 로고    scopus 로고
    • Drug-sparing regimens for HIV combination therapy: benefits predicted for "drug coasting"
    • Krakovska O., and Wahl L.M. Drug-sparing regimens for HIV combination therapy: benefits predicted for "drug coasting". Bull. Math. Biol. 69 (2007) 2627-2647
    • (2007) Bull. Math. Biol. , vol.69 , pp. 2627-2647
    • Krakovska, O.1    Wahl, L.M.2
  • 113
    • 0035892120 scopus 로고    scopus 로고
    • Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART
    • Kulkosky J., Culnan D.M., Roman J., Dornadula G., Schnell M., Boyd M.R., and Pomerantz R.J. Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART. Blood 98 (2001) 3006-3015
    • (2001) Blood , vol.98 , pp. 3006-3015
    • Kulkosky, J.1    Culnan, D.M.2    Roman, J.3    Dornadula, G.4    Schnell, M.5    Boyd, M.R.6    Pomerantz, R.J.7
  • 120
    • 0026755629 scopus 로고
    • Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus
    • Layne S.P., et al. Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus. Virology 189 (1992) 695-714
    • (1992) Virology , vol.189 , pp. 695-714
    • Layne, S.P.1
  • 121
    • 38049059954 scopus 로고    scopus 로고
    • Modeling T cell proliferation and death in vitro based on labeling data: generalizations of the Smith-Martin cell cycle model
    • Lee H.Y., and Perelson A.S. Modeling T cell proliferation and death in vitro based on labeling data: generalizations of the Smith-Martin cell cycle model. Bull. Math. Biol. 70 (2008) 21-44
    • (2008) Bull. Math. Biol. , vol.70 , pp. 21-44
    • Lee, H.Y.1    Perelson, A.S.2
  • 126
    • 0036668103 scopus 로고    scopus 로고
    • Structured treatment interruptions as a potential alternative therapeutic regimen for HIV-infected patients: a review of recent clinical data and future prospects
    • Lori F., Foli A., and Lisziewicz J. Structured treatment interruptions as a potential alternative therapeutic regimen for HIV-infected patients: a review of recent clinical data and future prospects. J. Antimicrob. Chemother. 50 (2002) 155-160
    • (2002) J. Antimicrob. Chemother. , vol.50 , pp. 155-160
    • Lori, F.1    Foli, A.2    Lisziewicz, J.3
  • 127
    • 0032710328 scopus 로고    scopus 로고
    • Treatment of human immunodeficiency virus infection with hydroxyurea, didanosine, and a protease inhibitor before seroconversion is associated with normalized immune parameters and limited viral reservoir
    • Lori F., Jessen H., Lieberman J., Finzi D., Rosenberg E., Tinelli C., Walker B., Siliciano R.F., and Lisziewicz J. Treatment of human immunodeficiency virus infection with hydroxyurea, didanosine, and a protease inhibitor before seroconversion is associated with normalized immune parameters and limited viral reservoir. J. Infect. Dis. 180 (1999) 1827-1832
    • (1999) J. Infect. Dis. , vol.180 , pp. 1827-1832
    • Lori, F.1    Jessen, H.2    Lieberman, J.3    Finzi, D.4    Rosenberg, E.5    Tinelli, C.6    Walker, B.7    Siliciano, R.F.8    Lisziewicz, J.9
  • 128
    • 0035915372 scopus 로고    scopus 로고
    • Structured treatment interruptions for the management of HIV infection
    • Lori F., and Lisziewicz J. Structured treatment interruptions for the management of HIV infection. JAMA 286 (2001) 2981-2987
    • (2001) JAMA , vol.286 , pp. 2981-2987
    • Lori, F.1    Lisziewicz, J.2
  • 129
    • 46349097362 scopus 로고    scopus 로고
    • Reviews of anti-infective agents: maraviroc: the first of a new class of antiretroviral agents
    • MacArthur R.D., and Novak R.M. Reviews of anti-infective agents: maraviroc: the first of a new class of antiretroviral agents. Clin. Infect. Dis. 47 (2008) 236-241
    • (2008) Clin. Infect. Dis. , vol.47 , pp. 236-241
    • MacArthur, R.D.1    Novak, R.M.2
  • 130
    • 27644580383 scopus 로고    scopus 로고
    • Transient rebounds of HIV plasma viremia are associated with the emergence of drug resistance mutations in patients on highly active antiretroviral therapy
    • Macias J., Palomares J.C., Mira J.A., Torres M.J., Garcia-Garcia J.A., Rodriquez J.M., Vergera S., and Pineda J.A. Transient rebounds of HIV plasma viremia are associated with the emergence of drug resistance mutations in patients on highly active antiretroviral therapy. J. Infect. 51 (2005) 195-200
    • (2005) J. Infect. , vol.51 , pp. 195-200
    • Macias, J.1    Palomares, J.C.2    Mira, J.A.3    Torres, M.J.4    Garcia-Garcia, J.A.5    Rodriquez, J.M.6    Vergera, S.7    Pineda, J.A.8
  • 132
    • 34249869267 scopus 로고    scopus 로고
    • Eliminating persistent HIV infection: getting to the end of the rainbow
    • Margolis D.M., and Archin N.M. Eliminating persistent HIV infection: getting to the end of the rainbow. J. Infect. Dis. 195 (2007) 1734-1736
    • (2007) J. Infect. Dis. , vol.195 , pp. 1734-1736
    • Margolis, D.M.1    Archin, N.M.2
  • 134
    • 34748860363 scopus 로고    scopus 로고
    • Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study
    • Markowitz M., et al. Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. J. Acquir. Immune Defic. Syndr. 46 (2007) 125-133
    • (2007) J. Acquir. Immune Defic. Syndr. , vol.46 , pp. 125-133
    • Markowitz, M.1
  • 135
    • 57649193118 scopus 로고    scopus 로고
    • Eradication of HIV: current challenges and new directions
    • Marsden M.D., and Zack J.A. Eradication of HIV: current challenges and new directions. J. Antimicrob. Chemother. 63 (2009) 7-10
    • (2009) J. Antimicrob. Chemother. , vol.63 , pp. 7-10
    • Marsden, M.D.1    Zack, J.A.2
  • 136
    • 2542510364 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 genetic evolution in patients with prolonged suppression of plasma viremia
    • Martinez M.A., Cabana M., Ibanez A., Clotet B., Arno A., and Ruiz L. Human immunodeficiency virus type 1 genetic evolution in patients with prolonged suppression of plasma viremia. Virology 256 (1999) 180-187
    • (1999) Virology , vol.256 , pp. 180-187
    • Martinez, M.A.1    Cabana, M.2    Ibanez, A.3    Clotet, B.4    Arno, A.5    Ruiz, L.6
  • 140
    • 0029008045 scopus 로고
    • In vivo estimates of division and death rates of human T lymphocytes
    • McLean A.R., and Michie C.A. In vivo estimates of division and death rates of human T lymphocytes. Proc. Natl. Acad. Sci. USA 92 (1995) 3707-3711
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3707-3711
    • McLean, A.R.1    Michie, C.A.2
  • 141
    • 0026564571 scopus 로고
    • Competition between zidovudine-sensitive and zidovudine-resistant strains of HIV
    • McLean A.R., and Nowak M.A. Competition between zidovudine-sensitive and zidovudine-resistant strains of HIV. AIDS 6 (1992) 71-79
    • (1992) AIDS , vol.6 , pp. 71-79
    • McLean, A.R.1    Nowak, M.A.2
  • 142
    • 0026574212 scopus 로고
    • Models of interactions between HIV and other pathogens
    • McLean A.R., and Nowak M.A. Models of interactions between HIV and other pathogens. J. Theor. Biol. 155 (1992) 69-86
    • (1992) J. Theor. Biol. , vol.155 , pp. 69-86
    • McLean, A.R.1    Nowak, M.A.2
  • 144
    • 0026445567 scopus 로고
    • Lifespan of human lymphocyte subsets defined by CD45 isoforms
    • Michie C.A., Mclean A.R., Alcock C., and Beverley P.C. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 360 (1992) 264-265
    • (1992) Nature , vol.360 , pp. 264-265
    • Michie, C.A.1    Mclean, A.R.2    Alcock, C.3    Beverley, P.C.4
  • 146
    • 0036972299 scopus 로고    scopus 로고
    • Transient rebounds of low-level viraemia among HIV-infected patients under HAART are not associated with virological or immunological failure
    • Mira J.A., Macias J., Nogales C., Fernandez-Rivera J., Garcia-Garcia J.A., Ramos A., and Pineda J.A. Transient rebounds of low-level viraemia among HIV-infected patients under HAART are not associated with virological or immunological failure. Antivir. Ther. 7 (2002) 251-256
    • (2002) Antivir. Ther. , vol.7 , pp. 251-256
    • Mira, J.A.1    Macias, J.2    Nogales, C.3    Fernandez-Rivera, J.4    Garcia-Garcia, J.A.5    Ramos, A.6    Pineda, J.A.7
  • 147
    • 0032840595 scopus 로고    scopus 로고
    • Refined estimates for HIV-1 clearance rate and intracellular delay
    • Mittler J.E., Markowitz M., Ho D.D., and Perelson A.S. Refined estimates for HIV-1 clearance rate and intracellular delay. AIDS 13 (1999) 1415-1417
    • (1999) AIDS , vol.13 , pp. 1415-1417
    • Mittler, J.E.1    Markowitz, M.2    Ho, D.D.3    Perelson, A.S.4
  • 149
    • 0036334097 scopus 로고    scopus 로고
    • Decelerating decay of latently infected cells during prolonged therapy for human immunodeficiency virus type 1 infection
    • Muller V., Vigueras-Gomez J.F., and Bonhoeffer S. Decelerating decay of latently infected cells during prolonged therapy for human immunodeficiency virus type 1 infection. J. Virol. 76 (2002) 8963-8965
    • (2002) J. Virol. , vol.76 , pp. 8963-8965
    • Muller, V.1    Vigueras-Gomez, J.F.2    Bonhoeffer, S.3
  • 150
  • 151
    • 37349120701 scopus 로고    scopus 로고
    • Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase
    • Murray J.M., Emery S., Kelleher A.D., Law M., Chen J., Hazuda D.J., Nguyen B.Y., Teppler H., and Cooper D.A. Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase. AIDS 21 (2007) 2315-2321
    • (2007) AIDS , vol.21 , pp. 2315-2321
    • Murray, J.M.1    Emery, S.2    Kelleher, A.D.3    Law, M.4    Chen, J.5    Hazuda, D.J.6    Nguyen, B.Y.7    Teppler, H.8    Cooper, D.A.9
  • 152
    • 21844464046 scopus 로고    scopus 로고
    • Human immunodeficiency virus: quasi-species and drug resistance
    • Murray J.M., and Perelson A.S. Human immunodeficiency virus: quasi-species and drug resistance. Multiscale Model. Simul. 3 (2005) 300-311
    • (2005) Multiscale Model. Simul. , vol.3 , pp. 300-311
    • Murray, J.M.1    Perelson, A.S.2
  • 153
    • 0023176085 scopus 로고
    • An inducible transcription factor activates expression of human immunodeficiency virus in T cells
    • Nabel G., and Baltimore D. An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326 (1987) 711-713
    • (1987) Nature , vol.326 , pp. 711-713
    • Nabel, G.1    Baltimore, D.2
  • 154
    • 0033537355 scopus 로고    scopus 로고
    • HIV-1 replication in patients with undetectable plasma virus receiving HAART
    • Natarajan V., Bosche M., Metcalf J.A., Ward D.J., Lane H.C., and Kovacs J.A. HIV-1 replication in patients with undetectable plasma virus receiving HAART. Lancet 353 (1999) 119-120
    • (1999) Lancet , vol.353 , pp. 119-120
    • Natarajan, V.1    Bosche, M.2    Metcalf, J.A.3    Ward, D.J.4    Lane, H.C.5    Kovacs, J.A.6
  • 155
    • 0036297271 scopus 로고    scopus 로고
    • Mathematical analysis of delay differential equation models of HIV-1 infection
    • Nelson P.W., and Perelson A.S. Mathematical analysis of delay differential equation models of HIV-1 infection. Math. Biosci. 179 (2002) 73-94
    • (2002) Math. Biosci. , vol.179 , pp. 73-94
    • Nelson, P.W.1    Perelson, A.S.2
  • 157
    • 4744362201 scopus 로고    scopus 로고
    • Genotypic resistance in HIV-1-infected patients with persistently detectable low-level viremia while receiving highly active antiretroviral therapy
    • Nettles R.E., Kieffer T.L., Simmons R.P., Cofrancesco Jr. J., Moore R.D., Gallant J.E., Persaud D., and Siliciano R.F. Genotypic resistance in HIV-1-infected patients with persistently detectable low-level viremia while receiving highly active antiretroviral therapy. Clin. Infect. Dis. 39 (2004) 1030-1037
    • (2004) Clin. Infect. Dis. , vol.39 , pp. 1030-1037
    • Nettles, R.E.1    Kieffer, T.L.2    Simmons, R.P.3    Cofrancesco Jr., J.4    Moore, R.D.5    Gallant, J.E.6    Persaud, D.7    Siliciano, R.F.8
  • 158
    • 17444367748 scopus 로고    scopus 로고
    • The latent HIV-1 reservoir in patients undergoing HAART: an archive of pre-HAART drug resistance
    • Noë A., Plum J., and Verhofstede C. The latent HIV-1 reservoir in patients undergoing HAART: an archive of pre-HAART drug resistance. J. Antimicrob. Chemother. 55 (2005) 410-412
    • (2005) J. Antimicrob. Chemother. , vol.55 , pp. 410-412
    • Noë, A.1    Plum, J.2    Verhofstede, C.3
  • 159
    • 0029985351 scopus 로고    scopus 로고
    • Population dynamics of immune responses to persistent viruses
    • Nowak M.A., and Bangham C.R. Population dynamics of immune responses to persistent viruses. Science 272 (1996) 74-79
    • (1996) Science , vol.272 , pp. 74-79
    • Nowak, M.A.1    Bangham, C.R.2
  • 160
    • 0031581661 scopus 로고    scopus 로고
    • Anti-viral drug treatment: dynamics of resistance in free virus and infected cell populations
    • Nowak M.A., Bonhoeffer S., Shaw G.M., and May R.M. Anti-viral drug treatment: dynamics of resistance in free virus and infected cell populations. J. Theor. Biol. 184 (1997) 203-217
    • (1997) J. Theor. Biol. , vol.184 , pp. 203-217
    • Nowak, M.A.1    Bonhoeffer, S.2    Shaw, G.M.3    May, R.M.4
  • 165
    • 2142772598 scopus 로고    scopus 로고
    • Lack of evidence for protease evolution in HIV-1-infected patients after 2 years of successful highly active antiretroviral therapy
    • Parera M., Ibanez A., Clotet B., and Martinez M.A. Lack of evidence for protease evolution in HIV-1-infected patients after 2 years of successful highly active antiretroviral therapy. J. Infect. Dis. 189 (2004) 1444-1451
    • (2004) J. Infect. Dis. , vol.189 , pp. 1444-1451
    • Parera, M.1    Ibanez, A.2    Clotet, B.3    Martinez, M.A.4
  • 167
    • 0035822946 scopus 로고    scopus 로고
    • Persistence of intracellular HIV-1 mRNA correlates with HIV-1-specific immune responses in infected subjects on stable HAART
    • Patterson B.K., McCallister S., Schutz M., Siegel J.N., Shults K., Flener Z., and Landay A. Persistence of intracellular HIV-1 mRNA correlates with HIV-1-specific immune responses in infected subjects on stable HAART. AIDS 15 (2001) 1635-1641
    • (2001) AIDS , vol.15 , pp. 1635-1641
    • Patterson, B.K.1    McCallister, S.2    Schutz, M.3    Siegel, J.N.4    Shults, K.5    Flener, Z.6    Landay, A.7
  • 168
    • 0037338785 scopus 로고    scopus 로고
    • The distribution of viral blips observed in HIV-1 infected patients treated with combination antiretroviral therapy
    • Percus J.K., Percus O.E., Markowitz M., Ho D.D., Di Mascio M., and Perelson A.S. The distribution of viral blips observed in HIV-1 infected patients treated with combination antiretroviral therapy. Bull. Math. Biol. 65 (2003) 263-277
    • (2003) Bull. Math. Biol. , vol.65 , pp. 263-277
    • Percus, J.K.1    Percus, O.E.2    Markowitz, M.3    Ho, D.D.4    Di Mascio, M.5    Perelson, A.S.6
  • 169
    • 0036371443 scopus 로고    scopus 로고
    • Modelling viral and immune system dynamics
    • Perelson A.S. Modelling viral and immune system dynamics. Nat. Rev. Immunol. 2 (2002) 28-36
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 28-36
    • Perelson, A.S.1
  • 171
    • 0031301825 scopus 로고    scopus 로고
    • Dynamics of HIV-1 and CD 4 + lymphocytes in vivo
    • Perelson A.S., Essunger P., and Ho D.D. Dynamics of HIV-1 and CD 4 + lymphocytes in vivo. AIDS 11 Suppl. A (1997) S17-S24
    • (1997) AIDS , vol.11 , Issue.SUPPL. A
    • Perelson, A.S.1    Essunger, P.2    Ho, D.D.3
  • 172
    • 0001918317 scopus 로고    scopus 로고
    • Mathematical analysis of HIV-1 dynamics in vivo
    • Perelson A.S., and Nelson P.W. Mathematical analysis of HIV-1 dynamics in vivo. SIAM Rev. 41 (1999) 3-44
    • (1999) SIAM Rev. , vol.41 , pp. 3-44
    • Perelson, A.S.1    Nelson, P.W.2
  • 173
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time
    • Perelson A.S., Neumann A.U., Markowitz M., Leonard J.M., and Ho D.D. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 271 (1996) 1582-1586
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 175
    • 9144270766 scopus 로고    scopus 로고
    • Continued production of drug-sensitive human immunodeficiency virus type 1 in children on combination antiretroviral therapy who have undetectable viral loads
    • Persaud D., Siberry G.K., Ahonkhai A., Kajdas J., Monie D., Hutton N., Watson D.C., Quinn T.C., Ray S.C., and Siliciano R.F. Continued production of drug-sensitive human immunodeficiency virus type 1 in children on combination antiretroviral therapy who have undetectable viral loads. J. Virol. 78 (2004) 968-979
    • (2004) J. Virol. , vol.78 , pp. 968-979
    • Persaud, D.1    Siberry, G.K.2    Ahonkhai, A.3    Kajdas, J.4    Monie, D.5    Hutton, N.6    Watson, D.C.7    Quinn, T.C.8    Ray, S.C.9    Siliciano, R.F.10
  • 176
    • 0037302334 scopus 로고    scopus 로고
    • Latency in human immunodeficiency virus type 1 infection: no easy answers
    • Persaud D., Zhou Y., Siliciano J.M., and Siliciano R.F. Latency in human immunodeficiency virus type 1 infection: no easy answers. J. Virol. 77 (2003) 1659-1665
    • (2003) J. Virol. , vol.77 , pp. 1659-1665
    • Persaud, D.1    Zhou, Y.2    Siliciano, J.M.3    Siliciano, R.F.4
  • 177
    • 34250349582 scopus 로고    scopus 로고
    • Treatment implications of the latent reservoir for HIV-1
    • Peterson S., Reid A.P., Kim S., and Siliciano R.F. Treatment implications of the latent reservoir for HIV-1. Adv. Pharmacol. 55 (2007) 411-425
    • (2007) Adv. Pharmacol. , vol.55 , pp. 411-425
    • Peterson, S.1    Reid, A.P.2    Kim, S.3    Siliciano, R.F.4
  • 178
    • 0030026113 scopus 로고    scopus 로고
    • Reduction of HIV concentration during acute infection: independence from a specific immune response
    • Phillips A.N. Reduction of HIV concentration during acute infection: independence from a specific immune response. Science 271 (1996) 497-499
    • (1996) Science , vol.271 , pp. 497-499
    • Phillips, A.N.1
  • 180
    • 0034040118 scopus 로고    scopus 로고
    • Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy
    • Pierson T., McArthur J., and Siliciano R.F. Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy. Annu. Rev. Immunol. 18 (2000) 665-708
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 665-708
    • Pierson, T.1    McArthur, J.2    Siliciano, R.F.3
  • 182
    • 27944455637 scopus 로고    scopus 로고
    • Enfuvirtide, the first fusion inhibitor to treat HIV infection
    • Poveda E., Briz V., and Soriano V. Enfuvirtide, the first fusion inhibitor to treat HIV infection. AIDS Rev. 7 (2005) 139-147
    • (2005) AIDS Rev. , vol.7 , pp. 139-147
    • Poveda, E.1    Briz, V.2    Soriano, V.3
  • 183
    • 0033520846 scopus 로고    scopus 로고
    • Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy
    • Prins J.M., et al. Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy. AIDS 13 (1999) 2405-2410
    • (1999) AIDS , vol.13 , pp. 2405-2410
    • Prins, J.M.1
  • 184
    • 0033984045 scopus 로고    scopus 로고
    • The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy
    • Ramratnam B., Mittler J.E., Zhang L., Boden D., Hurley A., Fang F., Macken C.A., Perelson A.S., Markowitz M., and Ho D.D. The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat. Med. 6 (2000) 82-85
    • (2000) Nat. Med. , vol.6 , pp. 82-85
    • Ramratnam, B.1    Mittler, J.E.2    Zhang, L.3    Boden, D.4    Hurley, A.5    Fang, F.6    Macken, C.A.7    Perelson, A.S.8    Markowitz, M.9    Ho, D.D.10
  • 186
    • 0032554603 scopus 로고    scopus 로고
    • Virus dynamics: the effect of target cell limitation and immune responses on virus evolution
    • Regoes R.R., Wodarz D., and Nowak M.A. Virus dynamics: the effect of target cell limitation and immune responses on virus evolution. J. Theor. Biol. 191 (1998) 451-462
    • (1998) J. Theor. Biol. , vol.191 , pp. 451-462
    • Regoes, R.R.1    Wodarz, D.2    Nowak, M.A.3
  • 187
    • 0034608864 scopus 로고    scopus 로고
    • Production of resistant HIV mutants during antiretroviral therapy
    • Ribeiro R.M., and Bonhoeffer S. Production of resistant HIV mutants during antiretroviral therapy. Proc. Natl. Acad. Sci. USA 97 (2000) 7681-7686
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7681-7686
    • Ribeiro, R.M.1    Bonhoeffer, S.2
  • 188
    • 33747095403 scopus 로고    scopus 로고
    • Antiviral drug resistance
    • Richman D.D. Antiviral drug resistance. Antiviral Res. 71 (2006) 117-121
    • (2006) Antiviral Res. , vol.71 , pp. 117-121
    • Richman, D.D.1
  • 190
    • 34547673061 scopus 로고    scopus 로고
    • Emergence of HIV-1 drug resistance during antiretroviral treatment
    • Rong L., Feng Z., and Perelson A.S. Emergence of HIV-1 drug resistance during antiretroviral treatment. Bull. Math. Biol. 69 (2007) 2027-2060
    • (2007) Bull. Math. Biol. , vol.69 , pp. 2027-2060
    • Rong, L.1    Feng, Z.2    Perelson, A.S.3
  • 191
    • 34447546095 scopus 로고    scopus 로고
    • Mathematical analysis of age-structured HIV-1 dynamics with combination antiretroviral therapy
    • Rong L., Feng Z., and Perelson A.S. Mathematical analysis of age-structured HIV-1 dynamics with combination antiretroviral therapy. SIAM J. Appl. Math. 67 (2007) 731-756
    • (2007) SIAM J. Appl. Math. , vol.67 , pp. 731-756
    • Rong, L.1    Feng, Z.2    Perelson, A.S.3
  • 192
    • 34447528803 scopus 로고    scopus 로고
    • Modeling within-host HIV-1 dynamics and the evolution of drug resistance: trade-offs between viral enzyme function and drug susceptibility
    • Rong L., Gilchrist M.A., Feng Z., and Perelson A.S. Modeling within-host HIV-1 dynamics and the evolution of drug resistance: trade-offs between viral enzyme function and drug susceptibility. J. Theor. Biol. 247 (2007) 804-818
    • (2007) J. Theor. Biol. , vol.247 , pp. 804-818
    • Rong, L.1    Gilchrist, M.A.2    Feng, Z.3    Perelson, A.S.4
  • 193
    • 57749177930 scopus 로고    scopus 로고
    • Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips
    • Rong L., and Perelson A.S. Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips. Math. Biosci. 217 (2009) 77-87
    • (2009) Math. Biosci. , vol.217 , pp. 77-87
    • Rong, L.1    Perelson, A.S.2
  • 194
    • 68949173993 scopus 로고    scopus 로고
    • Modeling latently infected cell activation: Viral and latent reservoir persistence, and viral blips in HIV-1 infected patients on potent therapy
    • Submitted
    • Rong, L., Perelson, A.S., 2009b. Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-1 infected patients on potent therapy. Submitted.
    • (2009)
    • Rong, L.1    Perelson, A.S.2
  • 195
    • 0036720438 scopus 로고    scopus 로고
    • Persistence of wild-type virus and lack of temporal structure in the latent reservoir for human immunodeficiency virus type 1 in pediatric patients with extensive antiretroviral exposure
    • Ruff C.T., Ray S.C., Kwon P., Zinn R., Pendleton A., Hutton N., Ashworth R., Gange S., Quinn T.C., Siliciano R.F., and Persaud D. Persistence of wild-type virus and lack of temporal structure in the latent reservoir for human immunodeficiency virus type 1 in pediatric patients with extensive antiretroviral exposure. J. Virol. 76 (2002) 9481-9492
    • (2002) J. Virol. , vol.76 , pp. 9481-9492
    • Ruff, C.T.1    Ray, S.C.2    Kwon, P.3    Zinn, R.4    Pendleton, A.5    Hutton, N.6    Ashworth, R.7    Gange, S.8    Quinn, T.C.9    Siliciano, R.F.10    Persaud, D.11
  • 196
    • 0032122490 scopus 로고    scopus 로고
    • Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy
    • Schrager L.K., and D'Souza M.P. Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy. JAMA 280 (1998) 67-71
    • (1998) JAMA , vol.280 , pp. 67-71
    • Schrager, L.K.1    D'Souza, M.P.2
  • 198
  • 200
    • 16244362723 scopus 로고    scopus 로고
    • In vivo evidence for instability of episomal human immunodeficiency virus type 1 cDNA
    • Sharkey M., Triques K., Kuritzkes D.R., and Stevenson M. In vivo evidence for instability of episomal human immunodeficiency virus type 1 cDNA. J. Virol. 79 (2005) 5203-5210
    • (2005) J. Virol. , vol.79 , pp. 5203-5210
    • Sharkey, M.1    Triques, K.2    Kuritzkes, D.R.3    Stevenson, M.4
  • 203
    • 3543125970 scopus 로고    scopus 로고
    • A long-term latent reservoir for HIV-1: discovery and clinical implications
    • Siliciano J.D., and Siliciano R.F. A long-term latent reservoir for HIV-1: discovery and clinical implications. J. Antimicrob. Chemother. 54 (2004) 6-9
    • (2004) J. Antimicrob. Chemother. , vol.54 , pp. 6-9
    • Siliciano, J.D.1    Siliciano, R.F.2
  • 204
    • 32944464685 scopus 로고    scopus 로고
    • Scientific rationale for antiretroviral therapy in 2005: viral reservoirs and resistance evolution
    • Siliciano R.F. Scientific rationale for antiretroviral therapy in 2005: viral reservoirs and resistance evolution. Top. HIV Med. 13 (2005) 96-100
    • (2005) Top. HIV Med. , vol.13 , pp. 96-100
    • Siliciano, R.F.1
  • 205
    • 1842613542 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: implications for therapy
    • Simon V., and Ho D.D. HIV-1 dynamics in vivo: implications for therapy. Nat. Rev. Microbiol. 1 (2003) 181-190
    • (2003) Nat. Rev. Microbiol. , vol.1 , pp. 181-190
    • Simon, V.1    Ho, D.D.2
  • 206
    • 0037131203 scopus 로고    scopus 로고
    • Prevalence and clinical correlates of HIV viremia ('blips') in patients with previous suppression below the limits of quantification
    • HIV Outpatient Study (HOPS) Investigators
    • Sklar P.A., Ward D.J., Baker R.K., Wood K.C., Gafoor Z., Alzola C.F., Moorman A.C., Holmberg S.D., and HIV Outpatient Study (HOPS) Investigators. Prevalence and clinical correlates of HIV viremia ('blips') in patients with previous suppression below the limits of quantification. AIDS 16 (2002) 2035-2041
    • (2002) AIDS , vol.16 , pp. 2035-2041
    • Sklar, P.A.1    Ward, D.J.2    Baker, R.K.3    Wood, K.C.4    Gafoor, Z.5    Alzola, C.F.6    Moorman, A.C.7    Holmberg, S.D.8
  • 207
    • 34248674034 scopus 로고    scopus 로고
    • Adherence to antiretroviral HIV drugs: how many doses can you miss before resistance emerges?
    • Smith R.J. Adherence to antiretroviral HIV drugs: how many doses can you miss before resistance emerges?. Proc. R. Soc. B 273 (2006) 617-624
    • (2006) Proc. R. Soc. B , vol.273 , pp. 617-624
    • Smith, R.J.1
  • 208
    • 19044391635 scopus 로고    scopus 로고
    • Drug resistance in an immunological model of HIV-1 infection with impulsive drug effects
    • Smith R.J., and Wahl L.M. Drug resistance in an immunological model of HIV-1 infection with impulsive drug effects. Bull. Math. Biol. 67 (2005) 783-813
    • (2005) Bull. Math. Biol. , vol.67 , pp. 783-813
    • Smith, R.J.1    Wahl, L.M.2
  • 213
    • 0038299654 scopus 로고    scopus 로고
    • HIV-1 pathogenesis
    • Stevenson M. HIV-1 pathogenesis. Nat. Med. 9 (2003) 853-860
    • (2003) Nat. Med. , vol.9 , pp. 853-860
    • Stevenson, M.1
  • 216
    • 22544461340 scopus 로고    scopus 로고
    • Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: expression of archival virus and replication of virus
    • Tobin N.H., Learn G.H., Holte S.E., Wang Y., Melvin A.J., McKernan J.L., Pawluk D.M., Mohan K.M., Lewis P.F., Mullins J.I., and Frenkel L.M. Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: expression of archival virus and replication of virus. J. Virol. 79 (2005) 9625-9634
    • (2005) J. Virol. , vol.79 , pp. 9625-9634
    • Tobin, N.H.1    Learn, G.H.2    Holte, S.E.3    Wang, Y.4    Melvin, A.J.5    McKernan, J.L.6    Pawluk, D.M.7    Mohan, K.M.8    Lewis, P.F.9    Mullins, J.I.10    Frenkel, L.M.11
  • 217
    • 0028267677 scopus 로고
    • Turnover of naive- and memory-phenotype T cells
    • Tough D.F., and Sprent J. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179 (1994) 1127-1135
    • (1994) J. Exp. Med. , vol.179 , pp. 1127-1135
    • Tough, D.F.1    Sprent, J.2
  • 218
    • 0027935476 scopus 로고
    • Antigen-independent activation of naive and memory resting T cells by a cytokine combination
    • Unutmaz D., Pileri P., and Abrignani S. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J. Exp. Med. 180 (1994) 1159-1164
    • (1994) J. Exp. Med. , vol.180 , pp. 1159-1164
    • Unutmaz, D.1    Pileri, P.2    Abrignani, S.3
  • 219
    • 1842458366 scopus 로고    scopus 로고
    • Drug-resistant variants that evolve during nonsuppressive therapy persist in HIV-1-infected peripheral blood mononuclear cells after long-term highly active antiretroviral therapy
    • Verhofstede C., Noë A., Demecheleer E., De Cabooter N., Van Wanzeele F., Van Der Gucht B., Vogelaers D., and Plum J. Drug-resistant variants that evolve during nonsuppressive therapy persist in HIV-1-infected peripheral blood mononuclear cells after long-term highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 35 (2004) 473-483
    • (2004) J. Acquir. Immune Defic. Syndr. , vol.35 , pp. 473-483
    • Verhofstede, C.1    Noë, A.2    Demecheleer, E.3    De Cabooter, N.4    Van Wanzeele, F.5    Van Der Gucht, B.6    Vogelaers, D.7    Plum, J.8
  • 220
    • 0033389039 scopus 로고    scopus 로고
    • Interruption of reverse transcriptase inhibitors or a switch from reverse transcriptase to protease inhibitors resulted in a fast reappearance of virus strains with a reverse transcriptase inhibitor-sensitive genotype
    • Verhofstede C., Wanzeele F.V., Van Der Gucht B., De Cabooter N., and Plum J. Interruption of reverse transcriptase inhibitors or a switch from reverse transcriptase to protease inhibitors resulted in a fast reappearance of virus strains with a reverse transcriptase inhibitor-sensitive genotype. AIDS 13 (1999) 2541-2546
    • (1999) AIDS , vol.13 , pp. 2541-2546
    • Verhofstede, C.1    Wanzeele, F.V.2    Van Der Gucht, B.3    De Cabooter, N.4    Plum, J.5
  • 221
    • 0034701490 scopus 로고    scopus 로고
    • Adherence and drug resistance: predictions for therapy outcome
    • Wahl L.M., and Nowak M.A. Adherence and drug resistance: predictions for therapy outcome. Proc. R. Soc. London B 267 (2000) 835-843
    • (2000) Proc. R. Soc. London B , vol.267 , pp. 835-843
    • Wahl, L.M.1    Nowak, M.A.2
  • 223
    • 22744441386 scopus 로고    scopus 로고
    • Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity
    • Weinberger L.S., Burnett J.C., Toettcher J.E., Arkin A.P., and Schaffer D.V. Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity. Cell 122 (2005) 169-182
    • (2005) Cell , vol.122 , pp. 169-182
    • Weinberger, L.S.1    Burnett, J.C.2    Toettcher, J.E.3    Arkin, A.P.4    Schaffer, D.V.5
  • 225
    • 0034037955 scopus 로고    scopus 로고
    • The role of antigen-independent persistence of memory cytotoxic T lymphocytes
    • Wodarz D., May R.M., and Nowak M.A. The role of antigen-independent persistence of memory cytotoxic T lymphocytes. Int. Immunol. 12 (2000) 467-477
    • (2000) Int. Immunol. , vol.12 , pp. 467-477
    • Wodarz, D.1    May, R.M.2    Nowak, M.A.3
  • 226
    • 0033830108 scopus 로고    scopus 로고
    • CD8 memory, immunodominance, and antigenic escape
    • Wodarz D., and Nowak M.A. CD8 memory, immunodominance, and antigenic escape. Eur. J. Immunol. 30 (2000) 2704-2712
    • (2000) Eur. J. Immunol. , vol.30 , pp. 2704-2712
    • Wodarz, D.1    Nowak, M.A.2
  • 227
    • 0036901603 scopus 로고    scopus 로고
    • Mathematical models of HIV pathogenesis and treatment
    • Wodarz D., and Nowak M.A. Mathematical models of HIV pathogenesis and treatment. Bioessays 24 (2002) 1178-1187
    • (2002) Bioessays , vol.24 , pp. 1178-1187
    • Wodarz, D.1    Nowak, M.A.2
  • 230
    • 41049103588 scopus 로고    scopus 로고
    • Parameter identifiability and estimation of HIV/AIDS dynamic models
    • Wu H., Zhu H., Miao H., and Perelson A.S. Parameter identifiability and estimation of HIV/AIDS dynamic models. Bull. Math. Biol. 70 (2008) 785-799
    • (2008) Bull. Math. Biol. , vol.70 , pp. 785-799
    • Wu, H.1    Zhu, H.2    Miao, H.3    Perelson, A.S.4
  • 231
    • 2942586974 scopus 로고    scopus 로고
    • Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression
    • Ylisastigui L., Archin N.M., Lehrman G., Bosch R.J., and Margolis D.M. Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression. AIDS 18 (2004) 1101-1108
    • (2004) AIDS , vol.18 , pp. 1101-1108
    • Ylisastigui, L.1    Archin, N.M.2    Lehrman, G.3    Bosch, R.J.4    Margolis, D.M.5
  • 236
    • 0032742547 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Science 286 (1999) 1353-1357
    • (1999) Science , vol.286 , pp. 1353-1357
    • Zhang, Z.1
  • 237
    • 0036138852 scopus 로고    scopus 로고
    • Evidence for human immunodeficiency virus type 1 replication in vivo in CD 14 (+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy
    • Zhu T., Muthui D., Holte S., Nickle D., Feng F., Brodie S., Hwangbo Y., Mullins J.I., and Corey L. Evidence for human immunodeficiency virus type 1 replication in vivo in CD 14 (+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy. J. Virol. 76 (2002) 707-716
    • (2002) J. Virol. , vol.76 , pp. 707-716
    • Zhu, T.1    Muthui, D.2    Holte, S.3    Nickle, D.4    Feng, F.5    Brodie, S.6    Hwangbo, Y.7    Mullins, J.I.8    Corey, L.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.