Target cell limited and immune control models of HIV infection: A comparison

Journal of Theoretical Biology

Volumn 190, Issue 3, 1998, Pages 201-214

  De Boer, Rob J ^a   Perelson, Alan S ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; VIRUS RNA;

ARTICLE; CELLULAR IMMUNITY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MATHEMATICAL MODEL; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TARGET CELL; VIRUS IMMUNITY; VIRUS LATENCY;

EID: 0032492107     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.1997.0548     Document Type: Article

References (74)

1. ABRAMS, P. A. (1994). The fallacies of "ratio-dependent" predation. Ecology 75, 1842-1850.
2. AHMED, R. & GRAY, D. (1996). Immunological memory and protective immunity: understanding their relation. Science 272, 54-60.
3. ANDRIEU, J. M., EVEN, P., VENET, A., TOURANI, J. M., STERN, M., LOWENSTEIN, W., et al. (1988). Effects of cyclosporin on T-cell subsets in human immunodeficiency virus disease. Clin. Immunol. Immunopathol. 47, 181-198.
4. ANDRIEU, J. M., LU, W. & LEVY, R. (1995). Sustained increases in CD4 cell counts in asymptomatic human immunodeficiency virus type 1-seropositive patients treated with prednisolone for 1 year. J. Infect. Dis. 171, 523-530.
5. BEDDINGTON, J. R. (1975). Mutual interference between parasites or predators and its effect on searching efficiency. J. Anim. Ecol. 51, 597-624.
6. BONHOEFFER, S., COFFIN, J. M. & NOWAK, M. A. (1997). Human immunodeficiency virus drug therapy and virus load. J. Virol. 71, 3275-3278.
7. BORROW, P., LEWICKI, H., WEI, X., HORWITZ, M. S., PEFFER, N., MEYERS, H., et al. (1997). Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat. Med. 3, 205-211.
8. BOUCHER, C. A., O'SULLIVAN, E., MULDER, J. W., RAMAUTARSING, C., KELLAM, P., DARBY, G., et al. (1992). Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects. J. Infect. Dis. 165, 105-110.
9. BRICHACEK, B., SWINDELLS, S., JANOFF, E. N., PIRRUCCELLO, S. & STEVENSON, M. (1996). Increased plasma human immunodeficiency virus type 1 burden following antigenic challenge with pneumococcal vaccine. J. Infect. Dis. 174, 1191-1199.
10. BUKRINSKY, M. I., STANWICK, T. L., DEMPSEY, M. P. & STEVENSON, M. (1991). Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection. Science 254, 423-427.
11. CAVERT, W., NOTERMANS, D. W., STASKUS, K., WIETGREFE, S. W., ZUPANCIC, M., GEBHARD, K., et al. (1997). Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science 276, 960-964.
12. CHEESEMAN, S. H., DAVARO, R. E. & ELLISON, 3RD, R. T. (1996). Hepatitis B vaccination and plasma HIV-1 RNA. N. Engl. J. Med. 334, 1272.
13. CHUN, T. W., CARRUTH, L., FINZI, D., SHEN, X., DIGIUSEPPE, J. A., TAYLOR, H., et al. (1997). Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387, 183-188.
14. COFFIN, J. M. (1995). HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267, 483-489.
15. CONNOR, R. I. & HO, D. D. (1994). Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression. J. Virol. 68, 4400-4408.
16. COREY, L. (1995). Reducing T cell activation as a therapy for human immunodeficiency virus infection. J. Infect. Dis. 171, 521-522.
17. DE BOER, R. J. & BOERLIJST, M. C. (1994). Diversity and virulence thresholds in AIDS. Proc. Natl. Acad. Sci. U.S.A. 91, 544-548.
18. DE BOER, R. J. & BOUCHER, C. A. (1996). Anti-CD4 therapy for AIDS suggested by mathematical models. Proc. R. Soc. Lond., B, Biol. Sci. 263, 899-905.
19. DE BOER, R. J. & PERELSON, A. S. (1994). T cell repertoires and competitive exclusion. J. theor. Biol. 169, 375-390.
20. DE BOER, R. J. & PERELSON, A. S. (1995). Towards a general function describing T cell proliferation. J. theor. Biol. 175, 567-576.
21. DE JONG, M. D., VEENSTRA, J., STILIANAKIS, N. I., SCHUURMAN, R., LANGE, J. M., DE BOER, R. J. & BOUCHER, C. A. (1996). Host-parasite dynamics and outgrowth of virus containing a single K70R amino acid change in reverse transcriptase are responsible for the loss of human immunodeficiency virus type 1 RNA load suppression by zidovudine. Proc. Natl. Acad. Sci. U.S.A. 93, 5501-5506.
22. + cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 10, 0.
23. + T-cell sub-populations. J. theor. Biol. 170, 367-391.
24. FAUCI, A. S. (1993). Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science 262, 1011-1018.
25. FROST, S. D. & MCLEAN, A. R. (1994). Quasispecies dynamics and the emergence of drug resistance during zidovudine therapy of HIV infection. AIDS 8, 323-332.
26. FROST, S. D. & MICHIE, C. A. (1996). Lymphocyte dynamics, apoptosis and HIV infection. Trends Microbiol. 4, 77-82.
27. GIACCA, M., ZANUSSI, S., COMAR, M., SIMONELLI, C., VACCHER, E., DE PAOLI, P. & TIRELLI, U. (1996). Treatment of human immunodeficiency virus infection with hydroxyurea: virologic and clinical evaluation. J. Infect. Dis. 174, 204-209.
28. GINZBURG, L. R. & AKÇAKAYA, H. R. (1992). Consequences of ratio-dependent predation for steady-state properties of ecosystems. Ecology 93, 1536-1543.
29. GOLETTI, D., WEISSMAN, D., JACKSON, R. W., GRAHAM, N. M., VLAHOV, D., KLEIN, R. S., et al. (1996). Effect of mycobacterium tuberculosis on HIV replication. Role of immune activation. J. Immunol. 157, 1271-1278.
30. GOULDER, P. J., PHILLIPS, R. E., COLBERT, R. A., MCADAM, S., OGG, G., NOWAK, M. A., et al. (1997). Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat. Med. 3, 212-217.
31. HAASE, A. T., HENRY, K., ZUPANCIC, M., SEDGEWICK, G., FAUST, R. A., MELROE, H., et al. (1996). Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science 274, 985-989.
32. HASTINGS, A. & POWELL, T. (1991). Chaos in a three-species food chain. Ecology 72, 896-903.
33. HO, D. D., NEUMANN, A. U., PERELSON, A. S., CHEN, W., LEONARD, J. M. & MARKOWITZ, M. (1995). Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373, 123-126.
34. HUISMAN, G. & DE BOER, R. J. (1997). A formal derivation of the "Beddington" functional response. J. theor. Biol. 185, 389-400.
35. IRVINE, D. H. & SAVAGEAU, M. A. (1985a). Network regulation of the immune response: alternative control points for suppressor modulation of effector lymphocytes. J. Immunol. 134, 2100-2116.
36. IRVINE, D. H. & SAVAGEAU, M. A. (1985b). Network regulation of the immune response: modulation of suppressor lymphocytes by alternative signals including contrasuppression. J. Immunol. 134, 2117-2130.
37. KLEIN, M. R., VAN BAALEN, C. A., HOLWERDA, A. M., KERKHOF GARDE, S. R., BENDE, R. J., KEET, I. P., et al. (1995). Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics. J. Exp. Med. 181, 1365-1372.
38. KLENERMAN, P., PHILLIPS, R. E., RINALDO, C. R., WAHL, L. M., OGG, G., MAY, R. M., et al. (1996). Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection. Proc. Natl. Acad. Sci. U.S.A. 93, 15323-15328.
39. KOVACS, J. A., BASELER, M., DEWAR, R. J., VOGEL, S., DAVEY, JR, R. T., FALLOON, J., et al. (1995). Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study. N. Engl. J. Med. 332, 567-575.
40. LARDER, B. A., DARBY, G. & RICHMAN, D. D. (1989). HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. Science 243, 1731-1734.
41. + T cells. Immunol. Today 17, 217-224.
42. LINEBERGER, D. W., KESSLER, J. A., WATERBURY, J. A., BYRNES, V. W., MASSARI, F., STASZEWSKI, S. & EMINI, E. A. (1995). Turnover of circulating virion RNA and of cell-associated viral DNA reflects active viral replication in human immunodeficiency virus type 1-infected individuals. J. Virol. 69, 2637-2639.
43. LORI, F., JESSEN, H., FOLI, A., LISZIEWICZ, J. & MATTEO, P. S. (1997). Long-term suppression of HIV-1 by hydroxyurea and didanosine. JAMA 277, 1437-1438.
44. MCLEAN, A. R. & KIRKWOOD, T. B. (1990). A model of human immunodeficiency virus infection in T helper cell clones. J. theor. Biol. 147, 177-203.
45. MCLEAN, A. R. & NOWAK, M. A. (1992a). Competition between zidovudine-sensitive and zidovudine-resistant strains of HIV. AIDS 6, 71-79.
46. MCLEAN, A. R. & NOWAK, M. A. (1992b). Models of interactions between HIV and other pathogens. J. theor. Biol. 155, 69-86.
47. MELLORS, J. W., RINALDO, JR, C. R., GUPTA, P., WHITE, R. M., TODD, J. A. & KINGSLEY, L. A. (1996). Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 272, 1167-1170.
48. MEYAARD, L., OTTO, S. A., JONKER, R. R., MIJNSTER, M. J., KEET, R. P. & MIEDEMA, F. (1992). Programmed death of T cells in HIV-1 infection. Science 257, 217-219.
49. NOWAK, M. A., ANDERSON, R. M., MCLEAN, A. R., WOLFS, T. F., GOUDSMIT, J. & MAY, R. M. (1991). Antigenic diversity thresholds and the development of AIDS. Science 254, 963-969.
50. NOWAK, M. A. & BANGHAM, C. R. (1996). Population dynamics of immune responses to persistent viruses. Science 272, 74-79.
51. NOWAK, M. A. & MAY, R. M. (1991). Mathematical biology of HIV infections: antigenic variation and diversity threshold. Math. Biosci. 106, 1-21.
52. O'BRIEN, W. A., GROVIT-FERBAS, K., NAMAZI, A., OVCAK-DERZIC, S., WANG, H. J., PARK, J., et al. (1995). Human immunodeficiency virus-type 1 replication can be increased in peripheral blood of seropositive patients after influenza vaccination. Blood 86, 1082-1089.
53. PANTALEO, G. (1997). How immune-based interventions can change HIV therapy. Nat. Med. 3, 483-486.
54. PANTALEO, G., GRAZIOSI, C., DEMAREST, J. F., BUTINI, L., MONTRONI, M., Fox, C. H., et al. (1993). HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362, 355-358.
55. PERELSON, A. S., ESSUNGER, P., CAO, Y., VESANEN, M., HURLEY, A., SAKSELA, K., et al. (1997). Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387, 188-191.
56. PERELSON, A. S., NEUMANN, A. U., MARKOWITZ, M., LEONARD, J. M. & HO, D. D. (1996). HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 271, 1582-1586.
57. PHILLIPS, A. N. (1996). Reduction of HIV concentration during acute infection: independence from a specific immune response. Science 271, 497-499.
58. RINALDO, C., HUANG, X. L., FAN, Z. F., DING, M., BELTZ, L., LOGAR, A., et al. (1995). High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors. J. Virol. 69, 5838-5842.
59. + cell count decline during progression to AIDS correlates with HIV-1 phenotype. AIDS 6, 665-669.
60. SCHENZLE, D. (1994). A model for AIDS pathogenesis. Stat. Med. 13, 2067-2079.
61. SCHWARZ, A., OFFERMANN, G., KELLER, F., BENNHOLD, I., L'AGE-STEHR, J., KRAUSE, P. H. & MIHATSCH, M. J. (1993). The effect of cyclosporine on the progression of human immunodeficiency virus type 1 infection transmitted by transplantation-data on four cases and review of the literature. Transplantation 55, 95-103.
62. SHEARER, G. M. & CLERICI, M. (1996). Protective immunity against HIV infection: has nature done the experiment for us? Immunol. Today 17, 21-24.
63. SIMONELLI, C., NASTI, G., VACCHER, E., TIRELLI, U., ZANUSSI, S., DE PAOLI, P., COMAR, M. & GIACCA, M. (1996). Hydroxyurea treatment in HIV-infected patients. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 13, 462-464.
64. STANLEY, S. K., OSTROWSKI, M. A., JUSTEMENT, J. S., GANTT, K., HEDAYATI, S., MANNIX, M., et al. (1996). Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1. N. Engl. J. Med. 334, 1222-1230.
65. STAPRANS, S. I., HAMILTON, B. L., FOLLANSBEE, S. E., ELBEIK, T., BARBOSA, P., GRANT, R. M. & FEINBERG, M. B. (1995). Activation of virus replication after vaccination of HIV-1-infected individuals. J. Exp. Med. 182, 1727-1737.
66. STILIANAKIS, N. I., BOUCHER, C. A., DE JONG, M. D., VAN LEEUWEN, R., SCHUURMAN, R. & DE BOER, R. J. (1997). Clinical data sets of human immunodeficiency virus type 1 reverse transcriptase-resistant mutants explained by a mathematical model. J. Virol. 71, 161-168.
67. TERSMETTE, M., GRUTERS, R. A., DE WOLF, F., DE GOEDE, R. E., LANGE, J. M., SCHELLEKENS, P. T., et al. (1989). Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates. J. Virol. 63, 2118-2125.
68. VILA, J., BIRON, F., NUGIER, F., VALLET, T. & PEYRAMOND, D. (1996). 1-year follow-up of the use of hydroxycarbamide and didanosine in HIV infection. Lancet 348, 203-204.
69. WEBER, J. & GALPIN, S. (1995). HIV results in the frame. Cyclosporin A. Nature 375, 198.
70. WEI, X., GHOSH, S. K., TAYLOR, M. E., JOHNSON, V. A., EMINI, E. A., DEUTSCH, P., et al. (1995). Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373, 117-122.
71. WEISS, R. A. (1993). How does HIV cause AIDS? Science 260, 1273-1279.
72. WENG, N. P., LEVINE, B. L., JUNE, C. H. & HODES, R. J. (1995). Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc. Natl. Acad. Sci. U.S.A. 92, 11091-11094.
73. WOLINSKY, S. M., KORBER, B. T., NEUMANN, A. U., DANIELS, M., KUNSTMAN, K. J., WHETSELL, A. J., et al. (1996). Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection. Science 272, 537-542.
74. + T cell turnover. Science 274, 1543-1547.