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Volumn 45, Issue 5, 2007, Pages 483-493

Transient viremia, plasma viral load, and reservoir replenishment in HIV-infected patients on antiretroviral therapy

Author keywords

HIV; Latent reservoir; Transient viremia; Viral blips

Indexed keywords

ANTIRETROVIRUS AGENT; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR;

EID: 34548088101     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3180654836     Document Type: Article
Times cited : (96)

References (59)
  • 1
    • 0035477944 scopus 로고    scopus 로고
    • Transient relapses (blips) of plasma HIV RNA levels during HAART are associated with drug resistance
    • Cohen Stuart JWT, Wensing AMJ, Kovacs C, et al. Transient relapses (blips) of plasma HIV RNA levels during HAART are associated with drug resistance. J Acquir Immune Defic Syndr. 2001;28:105-113.
    • (2001) J Acquir Immune Defic Syndr , vol.28 , pp. 105-113
    • Cohen Stuart, J.W.T.1    Wensing, A.M.J.2    Kovacs, C.3
  • 2
    • 0034943570 scopus 로고    scopus 로고
    • Prevalence and predictive value of intermittent viremia with combination HIV therapy
    • Havlir DV, Bassett R, Levitan D, et al. Prevalence and predictive value of intermittent viremia with combination HIV therapy. JAMA. 2001;286:171-179.
    • (2001) JAMA , vol.286 , pp. 171-179
    • Havlir, D.V.1    Bassett, R.2    Levitan, D.3
  • 3
    • 0242300180 scopus 로고    scopus 로고
    • Viral blip dynamics during highly active antiretroviral therapy
    • Di Mascio M, Markowitz M, Louie M, et al. Viral blip dynamics during highly active antiretroviral therapy. J Virol. 2003;77:12165-12172.
    • (2003) J Virol , vol.77 , pp. 12165-12172
    • Di Mascio, M.1    Markowitz, M.2    Louie, M.3
  • 4
    • 22544461340 scopus 로고    scopus 로고
    • Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: Expression of archival virus and replication of virus
    • Tobin NH, Learn GH, Holte SE, et al. Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: expression of archival virus and replication of virus. J Virol. 2005;79:9625-9634.
    • (2005) J Virol , vol.79 , pp. 9625-9634
    • Tobin, N.H.1    Learn, G.H.2    Holte, S.E.3
  • 5
    • 13844274980 scopus 로고    scopus 로고
    • Intermittent HIV-1 viremia (blips) and drug resistance in patients receiving HAART
    • Nettles RE, Kieffer TL, Kwon P, et al. Intermittent HIV-1 viremia (blips) and drug resistance in patients receiving HAART. JAMA. 2005;293:817-829.
    • (2005) JAMA , vol.293 , pp. 817-829
    • Nettles, R.E.1    Kieffer, T.L.2    Kwon, P.3
  • 6
    • 0034092682 scopus 로고    scopus 로고
    • Effect of influenza vaccination on viral replication and immune response on persons infected with human immunodeficiency virus receiving potent antiretroviral therapy
    • Gunthard HF, Wong JK, Spina CA, et al. Effect of influenza vaccination on viral replication and immune response on persons infected with human immunodeficiency virus receiving potent antiretroviral therapy. J Infect Dis. 2000;181:47-62.
    • (2000) J Infect Dis , vol.181 , pp. 47-62
    • Gunthard, H.F.1    Wong, J.K.2    Spina, C.A.3
  • 7
    • 0036892645 scopus 로고    scopus 로고
    • Modeling the effects of vaccination on chronically infected HIV-positive patients
    • Jones LE, Perelson AS. Modeling the effects of vaccination on chronically infected HIV-positive patients. J Acquir Immune Defic Syndr. 2002;31:369-377.
    • (2002) J Acquir Immune Defic Syndr , vol.31 , pp. 369-377
    • Jones, L.E.1    Perelson, A.S.2
  • 8
    • 0037040359 scopus 로고    scopus 로고
    • Genotypic analysis of plasma HIV-1 RNA after influenza vaccination of patients with previously undetectable viral loads
    • Kolber MA, Gabr AH, De La RA, et al. Genotypic analysis of plasma HIV-1 RNA after influenza vaccination of patients with previously undetectable viral loads. AIDS. 2002;16:537-542.
    • (2002) AIDS , vol.16 , pp. 537-542
    • Kolber, M.A.1    Gabr, A.H.2    De La, R.A.3
  • 9
    • 24944439857 scopus 로고    scopus 로고
    • Opportunistic infection as a cause of transient viremia in chronically infected HIV patients under treatment with HAART
    • Jones LE, Perelson AS. Opportunistic infection as a cause of transient viremia in chronically infected HIV patients under treatment with HAART. Bull Math Biol. 2005;67:1227-1251.
    • (2005) Bull Math Biol , vol.67 , pp. 1227-1251
    • Jones, L.E.1    Perelson, A.S.2
  • 10
    • 0029133156 scopus 로고
    • Human immunodeficiency virus type 1 replication can be increased in the peripheral blood of seropositive patients after influenza vaccination
    • O'Brien WA, Grovit-Ferbas K, Namazi A, et al. Human immunodeficiency virus type 1 replication can be increased in the peripheral blood of seropositive patients after influenza vaccination. Blood. 1995;86:1082-1089.
    • (1995) Blood , vol.86 , pp. 1082-1089
    • O'Brien, W.A.1    Grovit-Ferbas, K.2    Namazi, A.3
  • 11
    • 0028871397 scopus 로고
    • Activation of virus replication after vaccination of HIV-1 infected individuals
    • Staprans SI, Hamilton B, Follansbee S, et al. Activation of virus replication after vaccination of HIV-1 infected individuals. J Exp Med. 1995;182:1727-1737.
    • (1995) J Exp Med , vol.182 , pp. 1727-1737
    • Staprans, S.I.1    Hamilton, B.2    Follansbee, S.3
  • 12
    • 0029852819 scopus 로고    scopus 로고
    • Increased plasma human immunodeficiency virus type 1 burden following antigenic challenge with pneumococcal vaccine
    • Brichacek B, Swindells S, Janoff EN, et al. Increased plasma human immunodeficiency virus type 1 burden following antigenic challenge with pneumococcal vaccine. J Infect Dis. 1996;174:1191-1199.
    • (1996) J Infect Dis , vol.174 , pp. 1191-1199
    • Brichacek, B.1    Swindells, S.2    Janoff, E.N.3
  • 13
    • 0029979690 scopus 로고    scopus 로고
    • Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1
    • Stanley SK, Ostrowski MA, Justement JS, et al. Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1. N Engl J Med. 1996;334:1222-1230.
    • (1996) N Engl J Med , vol.334 , pp. 1222-1230
    • Stanley, S.K.1    Ostrowski, M.A.2    Justement, J.S.3
  • 14
    • 0030008547 scopus 로고    scopus 로고
    • Changes in virus load markers during AIDS-associated opportunistic diseases in human-immunodeficiency virus-infected persons
    • Donovan RM, Bush CE, Markowitz NP, et al. Changes in virus load markers during AIDS-associated opportunistic diseases in human-immunodeficiency virus-infected persons. J Infect Dis. 1996;174:401-403.
    • (1996) J Infect Dis , vol.174 , pp. 401-403
    • Donovan, R.M.1    Bush, C.E.2    Markowitz, N.P.3
  • 15
    • 0030209725 scopus 로고    scopus 로고
    • Effect of Mycobacterium tuberculosis on HIV replication
    • Goletti D, Weissman D, Jackson RW, et al. Effect of Mycobacterium tuberculosis on HIV replication. J Immunol. 1996;157:1271-1278.
    • (1996) J Immunol , vol.157 , pp. 1271-1278
    • Goletti, D.1    Weissman, D.2    Jackson, R.W.3
  • 16
    • 0030852677 scopus 로고    scopus 로고
    • The impact of active herpes simplex virus infection on human immunodeficiency virus load
    • Mole L, Ripich S, Margolis D, et al. The impact of active herpes simplex virus infection on human immunodeficiency virus load. J Infect Dis. 1997;176:766-770.
    • (1997) J Infect Dis , vol.176 , pp. 766-770
    • Mole, L.1    Ripich, S.2    Margolis, D.3
  • 17
    • 0033786821 scopus 로고    scopus 로고
    • Concurrent infections and HIV pathogenesis
    • Bentwich Z, Maartens G, Torten D, et al. Concurrent infections and HIV pathogenesis. AIDS. 2000;14:2071-2081.
    • (2000) AIDS , vol.14 , pp. 2071-2081
    • Bentwich, Z.1    Maartens, G.2    Torten, D.3
  • 18
    • 0026574212 scopus 로고
    • Models of interactions between HIV and other pathogens
    • McLean AR, Nowak MA. Models of interactions between HIV and other pathogens. J Theor Biol. 1992;155:69-102.
    • (1992) J Theor Biol , vol.155 , pp. 69-102
    • McLean, A.R.1    Nowak, M.A.2
  • 19
    • 0033592913 scopus 로고    scopus 로고
    • Antigen-driven CD4+ T-cell and HIV-1 dynamics: Residual viral replication under highly active antiretroviral therapy
    • Ferguson NM, deWolf F, Ghani AC, et al. Antigen-driven CD4+ T-cell and HIV-1 dynamics: residual viral replication under highly active antiretroviral therapy. Proc Natl Acad Sci USA. 1999;96:15167-15172.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 15167-15172
    • Ferguson, N.M.1    deWolf, F.2    Ghani, A.C.3
  • 20
    • 0035934874 scopus 로고    scopus 로고
    • The role of antigenic stimulation and cytotoxic T cell activity in regulating long-term immunopathogenesis of HIV: Mechanisms and clinical implications
    • Fraser C, Ferguson NM, de Wolf F, et al. The role of antigenic stimulation and cytotoxic T cell activity in regulating long-term immunopathogenesis of HIV: mechanisms and clinical implications. Proc R Soc Lond B Biol Sci. 2001;268:2085-2095.
    • (2001) Proc R Soc Lond B Biol Sci , vol.268 , pp. 2085-2095
    • Fraser, C.1    Ferguson, N.M.2    de Wolf, F.3
  • 21
    • 0035909915 scopus 로고    scopus 로고
    • Quantification of intrinsic residual viral replication in treated HIV-infected patients
    • Fraser C, Ferguson NM, Anderson RM. Quantification of intrinsic residual viral replication in treated HIV-infected patients. Proc Natl Acad Sci USA. 2001;98:15167-15172.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 15167-15172
    • Fraser, C.1    Ferguson, N.M.2    Anderson, R.M.3
  • 22
    • 19044378629 scopus 로고    scopus 로고
    • Duration of an intermittent episode of viremia
    • Di Mascio M, Percus JK, Percus OE, et al. Duration of an intermittent episode of viremia. Bull Math Biol. 2005;67:885-900.
    • (2005) Bull Math Biol , vol.67 , pp. 885-900
    • Di Mascio, M.1    Percus, J.K.2    Percus, O.E.3
  • 23
    • 4544262243 scopus 로고    scopus 로고
    • Dynamics of intermittent viremia during highly active antiretroviral therapy in patients who initiate therapy during chronic versus acute and early human immunodeficiency virus type 1 infection
    • Di Mascio M, Markowitz M, Louie M, et al. Dynamics of intermittent viremia during highly active antiretroviral therapy in patients who initiate therapy during chronic versus acute and early human immunodeficiency virus type 1 infection. J Virol. 2004;78:10566-10573.
    • (2004) J Virol , vol.78 , pp. 10566-10573
    • Di Mascio, M.1    Markowitz, M.2    Louie, M.3
  • 24
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell lifespan, and viral generation time
    • Perelson AS, Neumann AU, Markowitz M, et al. HIV-1 dynamics in vivo: virion clearance rate, infected cell lifespan, and viral generation time. Science. 1996;271:1582-1586.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3
  • 25
    • 24944462671 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1 infected compartments during combination therapy
    • Perelson AS, Essunger P, Cao Y, et al. Decay characteristics of HIV-1 infected compartments during combination therapy. Nature. 1997;271:1582-1586.
    • (1997) Nature , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Essunger, P.2    Cao, Y.3
  • 26
    • 0036371443 scopus 로고    scopus 로고
    • Modelling viral and immune system dynamics
    • Perelson AS. Modelling viral and immune system dynamics. Nat Rev Immunol. 2002;2:28-36.
    • (2002) Nat Rev Immunol , vol.2 , pp. 28-36
    • Perelson, A.S.1
  • 27
    • 0842346379 scopus 로고    scopus 로고
    • Modeling the long-term control of viremia in HIV-1 infected patients treated with antiretroviral therapy
    • Di Mascio M, Ribeiro RM, Markowitz M, et al. Modeling the long-term control of viremia in HIV-1 infected patients treated with antiretroviral therapy. Math Biosci. 2004;188:47-62.
    • (2004) Math Biosci , vol.188 , pp. 47-62
    • Di Mascio, M.1    Ribeiro, R.M.2    Markowitz, M.3
  • 28
    • 0037302345 scopus 로고    scopus 로고
    • In a subset of patients on highly active antiretroviral therapy plasma HIV-1 RNA can decay from 50 copies/ml to <5 copies/ml with a half-life of six months
    • Di Mascio M, Dornadula G, Zhang H, et al. In a subset of patients on highly active antiretroviral therapy plasma HIV-1 RNA can decay from 50 copies/ml to <5 copies/ml with a half-life of six months. J Virol. 2003;77:2271-2275.
    • (2003) J Virol , vol.77 , pp. 2271-2275
    • Di Mascio, M.1    Dornadula, G.2    Zhang, H.3
  • 29
    • 0035348175 scopus 로고    scopus 로고
    • Memory CD8+ T cell differentiation: Initial antigen encounter triggers a developmental program in naive cells
    • Kaech SM, Ahmed R. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat Immunol. 2001;2:415-422.
    • (2001) Nat Immunol , vol.2 , pp. 415-422
    • Kaech, S.M.1    Ahmed, R.2
  • 30
    • 24944454937 scopus 로고    scopus 로고
    • Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
    • Van Stipdonk MJ, Lemmons EE, Schoenberger SP. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat Immunol. 2001;21:29-70.
    • (2001) Nat Immunol , vol.21 , pp. 29-70
    • Van Stipdonk, M.J.1    Lemmons, E.E.2    Schoenberger, S.P.3
  • 31
    • 0035873191 scopus 로고    scopus 로고
    • Antigen-independent CD8 T cell proliferation
    • Wong P, Pamer EG. Antigen-independent CD8 T cell proliferation. J Immunol. 2001;166:5864-5869.
    • (2001) J Immunol , vol.166 , pp. 5864-5869
    • Wong, P.1    Pamer, E.G.2
  • 32
    • 23344445378 scopus 로고    scopus 로고
    • Estimating division and death rates from CFSE data
    • De Boer RJ, Perelson AS. Estimating division and death rates from CFSE data. J Comp Appl Math. 2005;184:140-164.
    • (2005) J Comp Appl Math , vol.184 , pp. 140-164
    • De Boer, R.J.1    Perelson, A.S.2
  • 33
    • 33746869245 scopus 로고    scopus 로고
    • Estimating lymphocyte division and death rates from CFSE data
    • De Boer RJ, Ganusov VV, Milutinovic D, et al. Estimating lymphocyte division and death rates from CFSE data. Bull Math Biol. 2006;68:1011-1031.
    • (2006) Bull Math Biol , vol.68 , pp. 1011-1031
    • De Boer, R.J.1    Ganusov, V.V.2    Milutinovic, D.3
  • 34
    • 0032518290 scopus 로고    scopus 로고
    • The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
    • Kim RB, Fromm MF, Wandel C, et al. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest. 1998;101:289-294.
    • (1998) J Clin Invest , vol.101 , pp. 289-294
    • Kim, R.B.1    Fromm, M.F.2    Wandel, C.3
  • 35
    • 0036796994 scopus 로고    scopus 로고
    • P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals
    • Meaden ER, Hoggard PG, Newton P, et al. P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals. J Antimicrob Chemother. 2002;50:583-588.
    • (2002) J Antimicrob Chemother , vol.50 , pp. 583-588
    • Meaden, E.R.1    Hoggard, P.G.2    Newton, P.3
  • 36
    • 0031848314 scopus 로고    scopus 로고
    • Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus
    • Perno C, Newcombe FM, Davis D, et al. Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus. J Infect Dis. 1998;178:413-422.
    • (1998) J Infect Dis , vol.178 , pp. 413-422
    • Perno, C.1    Newcombe, F.M.2    Davis, D.3
  • 37
    • 0032834195 scopus 로고    scopus 로고
    • Interferon-γ up-regulates expression and activity of P-glycoprotein in human peripheral blood monocyte-derived macrophages
    • Puddu P, Fais S, Luciani F, et al. Interferon-γ up-regulates expression and activity of P-glycoprotein in human peripheral blood monocyte-derived macrophages. Lab Invest. 1999;79:1299-1309.
    • (1999) Lab Invest , vol.79 , pp. 1299-1309
    • Puddu, P.1    Fais, S.2    Luciani, F.3
  • 38
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi D, Hermankova M, Pierson T, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science. 1997;278:1295-1300.
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1    Hermankova, M.2    Pierson, T.3
  • 39
    • 0032953920 scopus 로고    scopus 로고
    • Latent infection of CD4+ T-cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • Finzi D, Blankson J, Siliciano JD, et al. Latent infection of CD4+ T-cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med. 1999;5:512-517.
    • (1999) Nat Med , vol.5 , pp. 512-517
    • Finzi, D.1    Blankson, J.2    Siliciano, J.D.3
  • 40
    • 0034887110 scopus 로고    scopus 로고
    • Differential regulation of antiviral immunity results in stable CD8+ and declining CD4+ memory
    • Homann D, Teyton L, Oldstone MBA. Differential regulation of antiviral immunity results in stable CD8+ and declining CD4+ memory. Nat Med. 2001;7:913-919.
    • (2001) Nat Med , vol.7 , pp. 913-919
    • Homann, D.1    Teyton, L.2    Oldstone, M.B.A.3
  • 41
    • 0033681160 scopus 로고    scopus 로고
    • Biphasic decay of latently infected CD4+ cells in acute human immunodeficiency virus type I infection
    • Blankson JN, Finzi D, Pierson TC, et al. Biphasic decay of latently infected CD4+ cells in acute human immunodeficiency virus type I infection. J Infect Dis. 2000;182:1636-1642.
    • (2000) J Infect Dis , vol.182 , pp. 1636-1642
    • Blankson, J.N.1    Finzi, D.2    Pierson, T.C.3
  • 42
    • 0037040366 scopus 로고    scopus 로고
    • Raised viral load in patients with viral suppression on highly active antiretroviral therapy: Transient increase or treatment failure?
    • Moore AL, Youle M, Lipman M, et al. Raised viral load in patients with viral suppression on highly active antiretroviral therapy: transient increase or treatment failure? AIDS. 2002;16:615-618.
    • (2002) AIDS , vol.16 , pp. 615-618
    • Moore, A.L.1    Youle, M.2    Lipman, M.3
  • 43
    • 0037131203 scopus 로고    scopus 로고
    • Prevalence and clinical correlates of HIV viremia ('blips') in patients with previous suppression below the limits of quantification
    • Sklar PA, Ward DJ, Baker RK, et al. Prevalence and clinical correlates of HIV viremia ('blips') in patients with previous suppression below the limits of quantification. AIDS. 2002;16:2035-2041.
    • (2002) AIDS , vol.16 , pp. 2035-2041
    • Sklar, P.A.1    Ward, D.J.2    Baker, R.K.3
  • 44
    • 0037183958 scopus 로고    scopus 로고
    • Intermittent and sustained low level HIV viral rebound in patients receiving potent antiretroviral therapy
    • Grueb G, Cozzi-Lepri A, Ledergerber B, et al. Intermittent and sustained low level HIV viral rebound in patients receiving potent antiretroviral therapy. AIDS. 2002;16:1967-1969.
    • (2002) AIDS , vol.16 , pp. 1967-1969
    • Grueb, G.1    Cozzi-Lepri, A.2    Ledergerber, B.3
  • 45
    • 0033609374 scopus 로고    scopus 로고
    • Persistence of HIV-1 transcription in peripheral blood mononuclear cells in patients receiving potent antiretroviral therapy
    • Furtado MR, Callaway DS, Phair JP, et al. Persistence of HIV-1 transcription in peripheral blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med. 1999;340:1614-1622.
    • (1999) N Engl J Med , vol.340 , pp. 1614-1622
    • Furtado, M.R.1    Callaway, D.S.2    Phair, J.P.3
  • 46
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in persons receiving combination antiretroviral therapy
    • Zhang L, Ramratnam B, Tenner-Racz K, et al. Quantifying residual HIV-1 replication in persons receiving combination antiretroviral therapy. N Engl J Med. 1999;340:1605-1613.
    • (1999) N Engl J Med , vol.340 , pp. 1605-1613
    • Zhang, L.1    Ramratnam, B.2    Tenner-Racz, K.3
  • 47
    • 0033520673 scopus 로고    scopus 로고
    • Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy
    • Dornadula G, Zhang H, Van Uitert B, et al. Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy. JAMA. 1999;282:1627-1632.
    • (1999) JAMA , vol.282 , pp. 1627-1632
    • Dornadula, G.1    Zhang, H.2    Van Uitert, B.3
  • 48
    • 10744228049 scopus 로고    scopus 로고
    • New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma
    • Palmer S, Wiegand AP, Maldarelli F, et al. New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma. J Clin Microbiol. 2003;41:4531-4536.
    • (2003) J Clin Microbiol , vol.41 , pp. 4531-4536
    • Palmer, S.1    Wiegand, A.P.2    Maldarelli, F.3
  • 49
    • 0038579210 scopus 로고    scopus 로고
    • Long term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ cells
    • Siliciano JD, Kajdas J, Finzi D, et al. Long term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ cells. Nat Med. 2003;9:727-728.
    • (2003) Nat Med , vol.9 , pp. 727-728
    • Siliciano, J.D.1    Kajdas, J.2    Finzi, D.3
  • 50
    • 0033984045 scopus 로고    scopus 로고
    • The decay of the latent reservoir of replication competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy
    • Ramratnam B, Mittler JE, Zhang L, et al. The decay of the latent reservoir of replication competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat Med. 2000;6:82-85.
    • (2000) Nat Med , vol.6 , pp. 82-85
    • Ramratnam, B.1    Mittler, J.E.2    Zhang, L.3
  • 51
    • 0141676556 scopus 로고    scopus 로고
    • Productive infection maintains a dynamic steady state of residual viremia in human immunodeficiency virus type-1 infected patients treated with suppressive antiretroviral therapy for five years
    • Havlir DV, Strain MC, Clerici M, et al. Productive infection maintains a dynamic steady state of residual viremia in human immunodeficiency virus type-1 infected patients treated with suppressive antiretroviral therapy for five years. J Virol. 2003;77:11212-11219.
    • (2003) J Virol , vol.77 , pp. 11212-11219
    • Havlir, D.V.1    Strain, M.C.2    Clerici, M.3
  • 52
    • 27644524761 scopus 로고    scopus 로고
    • HIV-infected individuals receiving effective antiretroviral therapy for extended periods of time continuously replenish their viral reservoir
    • Chun T-W, Nickle DC, Justement JS, et al. HIV-infected individuals receiving effective antiretroviral therapy for extended periods of time continuously replenish their viral reservoir. J Clin Invest. 2005;115:3250-3255.
    • (2005) J Clin Invest , vol.115 , pp. 3250-3255
    • Chun, T.-W.1    Nickle, D.C.2    Justement, J.S.3
  • 53
    • 0034280834 scopus 로고    scopus 로고
    • A cellular calculus for signal integration by T cells
    • Gett AV, Hodgkin PD. A cellular calculus for signal integration by T cells. Nat Immunol. 2000;1:239-244.
    • (2000) Nat Immunol , vol.1 , pp. 239-244
    • Gett, A.V.1    Hodgkin, P.D.2
  • 54
    • 0034765725 scopus 로고    scopus 로고
    • Recruitment times, proliferation, and apoptosis rates during the CD8+ T cell response to LCMV
    • De Boer RJ, Oprea M, Antia R, et al. Recruitment times, proliferation, and apoptosis rates during the CD8+ T cell response to LCMV. J Virol. 2001;75:10663-10669.
    • (2001) J Virol , vol.75 , pp. 10663-10669
    • De Boer, R.J.1    Oprea, M.2    Antia, R.3
  • 55
    • 0033589745 scopus 로고    scopus 로고
    • Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis
    • Ramratnam B, Bonhoeffer S, Binley J, et al. Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet. 1999;354:1782-1785.
    • (1999) Lancet , vol.354 , pp. 1782-1785
    • Ramratnam, B.1    Bonhoeffer, S.2    Binley, J.3
  • 56
    • 0141958258 scopus 로고    scopus 로고
    • Different dynamics of CD4+ and CD8+ T cell responses during and after acute lymphocytic choriomeningitis virus infection
    • De Boer RJ, Homann D, Perelson AS. Different dynamics of CD4+ and CD8+ T cell responses during and after acute lymphocytic choriomeningitis virus infection. J Immunol. 2003;171:3928-3935.
    • (2003) J Immunol , vol.171 , pp. 3928-3935
    • De Boer, R.J.1    Homann, D.2    Perelson, A.S.3
  • 57
    • 0036381110 scopus 로고    scopus 로고
    • HIV-1 infection and low steady state viral loads
    • Callaway DS, Perelson AS. HIV-1 infection and low steady state viral loads. Bull Math Biol. 2002;64:29-64.
    • (2002) Bull Math Biol , vol.64 , pp. 29-64
    • Callaway, D.S.1    Perelson, A.S.2
  • 58
    • 1842782773 scopus 로고    scopus 로고
    • Roles of substrate activity and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection
    • Zhang ZQ, Wietgrefe SW, Li Q, et al. Roles of substrate activity and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection. Proc Natl Acad Sci USA. 2004;101:5640-5645.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 5640-5645
    • Zhang, Z.Q.1    Wietgrefe, S.W.2    Li, Q.3


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