Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy

Journal of Virology

Volumn 72, Issue 3, 1998, Pages 2422-2428

  Günthard, Huldrych F ^a,c   Wong, Joseph K ^a   Ignacio, Caroline C ^a   Guatelli, John C ^a,b   Riggs, Nanette L ^a,b   Havlir, Diane V ^a,c   Richman, Douglas D ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; INDINAVIR; VIRUS RNA; ZIDOVUDINE;

ARTICLE; BLOOD; CLINICAL ARTICLE; DRUG RESISTANCE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; LYMPH NODE; PRIORITY JOURNAL; VIRUS LOAD; VIRUS REPLICATION;

EID: 2642704250     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.3.2422-2428.1998     Document Type: Article

References (29)

1. Boucher, C. A., N. Cammack, P. Schipper, R. Schuurman, P. Rouse, M. A. Wainberg, and J. M. Cameron. 1993. High-level resistance to (-) enantiomeric 2′-deoxy-3′-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase. Animicrob. Agents Chemother. 37:2231-2234.
2. Cavert, W., D. W. Notermans, K. Staskus, S. W. Wietgrefe, M. Zupancic, K. Gebhard, K. Henry, Z. Zhi-Qiang, R. Mills, H. McDade, J. Goudsmit, S. V. Danner, and A. T. Haase. 1997. Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science 276:960-963.
3. Chun, T. W., L. Carruth, D. Finzi, S. Xuefei, J. A. DiGiuseppe, H. Taylor, M. Hermankova, K. Chadwick, J. Margolick, T. C. Quinn, Y. H. Kuo, R. Brookmeyer, M. A. Zeiger, P. Barditch-Crovo, and R. F. Siliciano. 1997. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387:183-188.
4. Delassus, S., R. Cheynier, and S. Wain-Hobson. 1991. Evolution of human immunodeficiency virus type 1 nef and long terminal repeat sequences over 4 years in vivo and in vitro. J. Virol. 65:225-231.
5. Embretson, J., M. Zupancic, J. L. Ribas, A. Burke, P. Racz, K. Tenner-Racz, and A. T. Haase. 1993. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362: 359-362.
6. 5a. Finzi, D., M. Hermankova, T. Pierson, et al. 1997. Identification of a reservoir for HIV-1 in patients on highly active antiviral therapy. Science 278: 1295-1300.
7. + T-cell number decline in human immunodeficiency virus type 1-infected individuals. J. Virol. 69:2092-2100.
8. Gulick, R. M., J. W. Mellors, D. Havlir, et al. 1997. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N. Engl. J. Med. 337:734-739.
9. Günthard, H. F., J. K. Wong, C. C. Ignacio, D. V. Havlir, and D. D. Richman. 1997. Comparative performance of high density oligonucleotide sequencing and dideoxynucleotide sequencing of HIV-1 Pol from clinical samples, abstr. 577. In Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections January 1997, Washington, D.C.
10. Haase, A. T., K. Henry, M. Zupancic, G. Sedgewick, R. A. Faust, H. McIroe, W. Cavert, K. Gebhard, K. Staskus, Z. Q. Zhang, P. J. Dailey, H. H. Balfour, Jr., A. P. Erice, and A. S. Perelson. 1996. Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science 274:985-989.
11. Havlir, D. V., S. Eastman, A. Gamst, and D. D. Richman. 1996. Nevirapine-resistant human immunodeficiency virus: kinetics of replication and estimated prevalence in untreated patients. J. Virol. 70:7894-7899.
12. Japour, A. J., D. L. Mayers, V. A. Johnson, D. R. Kuritzkes, L. A. Beckett, J.-M. Arduino, J. Lane, R. J. Black, P. S. Reichelderfer, R. T. D'Aquila, C. S. Crumpacker, The RV-43 Study Group, and The AIDS Clinical Trials Group Virology Committee Resistance Working Group. 1993. Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates. Antimicrob. Agents Chemother. 37:1095-1101.
13. Kim, S. Y., R. Byrn, J. Groopman, and D. Baltimore. 1989. Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression. J. Virol. 63:3708-3713.
14. Kozal, M. J., N. Shah, N. Shen, R. Yang, R. Fucini, T. C. Merigan, D. D. Richman, D. Morris, E. Hubbell, M. Chee, and T. R. Gingeras. 1996. Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays. Nat. Med. 2:753-759.
15. Kusumi, K., B. Conway, S. Cunningham, A. Berson, C. Evans, A. K. N. Iversen, D. Colvin, M. V. Gallo, S. Coutre, E. G. Shpaer, D. V. Faulkner, A. deRonde, S. Volkman, C. Williams, M. S. Hirsch, and J. I. Mullins. 1992. Human immunodeficiency virus type 1 envelope gene structure and diversity in vivo and after cocultivation in vitro. J. Virol. 66:875-885.
16. Markowitz, M., Y. Cao, M. Vesanen, A. Talal, D. Nixon, A. Hurley, R. O'Donovan, P. Racz, K. Tenner-Racz, and D. D. Ho. Recent HIV infection treated with AZT, 32TC, and a potent protease inhibitor, abstr. LB 8. In Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections January 1997, Washington, D.C.
17. Michael, N. L., G. Chang, P. K. Ehrenberg, M. T. Vahey, and R. R. Redfield. 1993. HIV-1 proviral genotypes from the peripheral blood mononuclear cells of an infected patient are differentially represented in expressed sequences. J. Acquired Immune Defic. Syndr. 6:1073-1085.
18. Mulder, J., R. Resnick, B. Saget, S. Scheibel, H. Herman, H. Payne, R. Harrigan, and S. Kwok. 1997. A rapid and simple method for extracting human immunodeficiency virus type 1 RNA from plasma: enhanced sensitivity. J. Clin. Microbiol. 35:1278-1280.
19. Pantaleo, G., C. Graziosi, L. Butini, P. A. Pizzo, S. M. Schnittmann, D. P. Kotler, and A. S. Fauci. 1991. Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 88:9838-9842.
20. Pantaleo, G. 1997. How immune-based interventions can change HIV therapy. Nat. Med. 3:483-486.
21. Riggs, N. L., S. Little, and J. C. Guatelli. 1997. Unpublished data.
22. Saksela, K., E. Muchmore, M. Girard, P. Fultz, and D. Baltimore. 1993. High viral load in lymph nodes and latent human immunodeficiency virus (HIV) in peripheral blood cells of HIV-1 infected chimpanzees. J. Virol. 67:7423-7427.
23. Schinazi, R. F., B. A. Larder, and J. W. Mellors. 1997. Mutations in HIV-1 reverse transcriptase and protease associated with drug resistance. Int. Antiviral News 5:129-134.
24. Schuurman, R., M. Nijhuis, R. van Leeuwen, P. Schipper, D. de Jong, P. Collis, S. A. Danner, J. Mulder, C. Loveday, C. Christoperson, S. Kwok, J. Sninsky, and C. A. B. Boucher. 1995. Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC). J. Infect. Dis. 171:1411-1419.
25. Simmonds, P., L. Q. Zhang, F. McOmish, P. Balfe, C. A. Ludlam, and A. J. L. Brown. 1991. Discontinuous sequence change of human immunodeficiency virus (HIV) type 1 env sequences in plasma viral and lymphocyte-associated proviral populations in vivo: implications for models of HIV pathogenesis. J. Virol. 65:6266-6276.
26. Tisdale, M., S. D. Kemp, N. R. Parry, and B. A. Larder. 1993. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc Natl. Acad. Sci. USA 90:5653-5656.
27. Wei, X., S. K. Ghosh, M. E. Taylor, V. A. Johnson, E. A. Emini, P. Deutsch, J. D. Lifson, S. Bonhoeffer, M. A. Nowak, B. H. Hahn, M. S. Saag, and G. M. Shaw. 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373:117-122.
28. Wong, J. K., H. F. Günthard, D. V. Havlir, Z. Zhang, A. T. Haase, C. C. Ignacio, S. Kwok, E. Emini, and D. D. Richman. 1997. Reduction of HIV-1 in blood and lymph nodes following potent anti-retroviral therapy and the virologie correlates of treatment failure. Proc. Natl. Acad. Sci. USA 95:12574-12579.
29. Wong, J. K., M. Hezareh, H. F. Günthard, D. V. Havlir, C. C. Ignacio, C. A. Spina, and D. D. Richman. 1997. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 278:1291-1295.