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Volumn 4, Issue 8, 2009, Pages

Apoptosis of CD4+CD25high T cells in type 1 diabetes may be partially mediated by IL-2 deprivation

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; HLA ANTIGEN; INTERLEUKIN 2; PROTEIN KINASE B; PROTEIN P53; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA;

EID: 68349127013     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006527     Document Type: Article
Times cited : (73)

References (81)
  • 1
    • 0029954214 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus
    • Tisch R, McDevitt H (1996) Insulin-dependent diabetes mellitus. Cell 85: 291-297.
    • (1996) Cell , vol.85 , pp. 291-297
    • Tisch, R.1    McDevitt, H.2
  • 2
    • 0041828484 scopus 로고    scopus 로고
    • Inflammatory mediators and islet beta-cell failure: A link between type 1 and type 2 diabetes
    • Donath MY, Storling J, Maedler K, Mandrup-Poulsen T (2003) Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med 81: 455-470.
    • (2003) J Mol Med , vol.81 , pp. 455-470
    • Donath, M.Y.1    Storling, J.2    Maedler, K.3    Mandrup-Poulsen, T.4
  • 3
    • 34547138154 scopus 로고    scopus 로고
    • Role of regulatory T cells and FOXP3 in human diseases
    • quiz 236-227
    • Bacchetta R, Gambineri E, Roncarolo MG (2007) Role of regulatory T cells and FOXP3 in human diseases. J Allergy Clin Immunol 120: 227-235; quiz 236-227.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 227-235
    • Bacchetta, R.1    Gambineri, E.2    Roncarolo, M.G.3
  • 4
    • 13944270218 scopus 로고    scopus 로고
    • CD4+CD25high regulatory T cells in human autoimmune diabetes
    • Putnam AL, Vendrame F, Dotta F, Gottlieb PA (2005) CD4+CD25high regulatory T cells in human autoimmune diabetes. J Autoimmun 24: 55-62.
    • (2005) J Autoimmun , vol.24 , pp. 55-62
    • Putnam, A.L.1    Vendrame, F.2    Dotta, F.3    Gottlieb, P.A.4
  • 5
    • 0036141438 scopus 로고    scopus 로고
    • Multiple immunoregulatory defects in type-1 diabetes
    • Kukreja A, Cost G, Marker J, Zhang C, Sun Z, et al. (2002) Multiple immunoregulatory defects in type-1 diabetes. J Clin Invest 109: 131-140.
    • (2002) J Clin Invest , vol.109 , pp. 131-140
    • Kukreja, A.1    Cost, G.2    Marker, J.3    Zhang, C.4    Sun, Z.5
  • 6
    • 12144249838 scopus 로고    scopus 로고
    • Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
    • Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, et al. (2005) Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 54: 92-99.
    • (2005) Diabetes , vol.54 , pp. 92-99
    • Lindley, S.1    Dayan, C.M.2    Bishop, A.3    Roep, B.O.4    Peakman, M.5
  • 7
    • 17844364504 scopus 로고    scopus 로고
    • Functional defects and the influence of age on the frequency of CD4+ CD25+ Tcells in type 1 diabetes
    • Brusko TM, Wasserfall CH, Clare-Salzler MJ, Schatz DA, Atkinson MA (2005) Functional defects and the influence of age on the frequency of CD4+ CD25+ Tcells in type 1 diabetes. Diabetes 54: 1407-1414.
    • (2005) Diabetes , vol.54 , pp. 1407-1414
    • Brusko, T.M.1    Wasserfall, C.H.2    Clare-Salzler, M.J.3    Schatz, D.A.4    Atkinson, M.A.5
  • 8
    • 33645821472 scopus 로고    scopus 로고
    • The honeymoon phase' in children with type 1 diabetes mellitus: Frequency, duration, and influential factors
    • Abdul-Rasoul M, Habib H, Al-Khouly M (2006) 'The honeymoon phase' in children with type 1 diabetes mellitus: frequency, duration, and influential factors. Pediatr Diabetes 7: 101-107.
    • (2006) Pediatr Diabetes , vol.7 , pp. 101-107
    • Abdul-Rasoul, M.1    Habib, H.2    Al-Khouly, M.3
  • 9
    • 0031669576 scopus 로고    scopus 로고
    • Residual beta-cell function and spontaneous clinical remission in type 1 diabetes mellitus: The role of puberty
    • Bonfanti R, Bognetti E, Meschi F, Brunelli A, Riva MC, et al. (1998) Residual beta-cell function and spontaneous clinical remission in type 1 diabetes mellitus: the role of puberty. Acta Diabetol 35: 91-95.
    • (1998) Acta Diabetol , vol.35 , pp. 91-95
    • Bonfanti, R.1    Bognetti, E.2    Meschi, F.3    Brunelli, A.4    Riva, M.C.5
  • 11
    • 33646881121 scopus 로고    scopus 로고
    • Functional and molecular comparison of anergic and regulatory T lymphocytes
    • Knoechel B, Lohr J, Zhu S, Wong L, Hu D, et al. (2006) Functional and molecular comparison of anergic and regulatory T lymphocytes. J Immunol 176: 6473-6483.
    • (2006) J Immunol , vol.176 , pp. 6473-6483
    • Knoechel, B.1    Lohr, J.2    Zhu, S.3    Wong, L.4    Hu, D.5
  • 12
    • 33747303831 scopus 로고    scopus 로고
    • Signatures of human regulatory T cells: An encounter with old friends and new players
    • Pfoertner S, Jeron A, Probst-Kepper M, Guzman CA, Hansen W, et al. (2006) Signatures of human regulatory T cells: an encounter with old friends and new players. Genome Biol 7: R54.
    • (2006) Genome Biol , vol.7
    • Pfoertner, S.1    Jeron, A.2    Probst-Kepper, M.3    Guzman, C.A.4    Hansen, W.5
  • 13
    • 33748460087 scopus 로고    scopus 로고
    • Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis
    • Sugimoto N, Oida T, Hirota K, Nakamura K, Nomura T, et al. (2006) Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int Immunol 18: 1197-1209.
    • (2006) Int Immunol , vol.18 , pp. 1197-1209
    • Sugimoto, N.1    Oida, T.2    Hirota, K.3    Nakamura, K.4    Nomura, T.5
  • 14
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4: 330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 16
    • 33745335278 scopus 로고    scopus 로고
    • Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen-specific tolerance
    • Anderson PO, Manzo BA, Sundstedt A, Minaee S, Symonds A, et al. (2006) Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen-specific tolerance. Eur J Immunol 36: 1374-1385.
    • (2006) Eur J Immunol , vol.36 , pp. 1374-1385
    • Anderson, P.O.1    Manzo, B.A.2    Sundstedt, A.3    Minaee, S.4    Symonds, A.5
  • 17
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    • Hill JA, Feuerer M, Tash K, Haxhinasto S, Perez J, et al. (2007) Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 27: 786-800.
    • (2007) Immunity , vol.27 , pp. 786-800
    • Hill, J.A.1    Feuerer, M.2    Tash, K.3    Haxhinasto, S.4    Perez, J.5
  • 18
    • 2942692037 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion
    • Herman AE, Freeman GJ, Mathis D, Benoist C (2004) CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med 199: 1479-1489.
    • (2004) J Exp Med , vol.199 , pp. 1479-1489
    • Herman, A.E.1    Freeman, G.J.2    Mathis, D.3    Benoist, C.4
  • 19
    • 27944454429 scopus 로고    scopus 로고
    • Where CD4+CD25+ T reg cells impinge on autoimmune diabetes
    • Chen Z, Herman AE, Matos M, Mathis D, Benoist C (2005) Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med 202: 1387-1397.
    • (2005) J Exp Med , vol.202 , pp. 1387-1397
    • Chen, Z.1    Herman, A.E.2    Matos, M.3    Mathis, D.4    Benoist, C.5
  • 21
    • 34248585113 scopus 로고    scopus 로고
    • Reduced CD4+ T-cell-specific gene expression in human type 1 diabetes mellitus
    • Orban T, Kis J, Szereday L, Engelmann P, Farkas K, et al. (2007) Reduced CD4+ T-cell-specific gene expression in human type 1 diabetes mellitus. J Autoimmun 28: 177-187.
    • (2007) J Autoimmun , vol.28 , pp. 177-187
    • Orban, T.1    Kis, J.2    Szereday, L.3    Engelmann, P.4    Farkas, K.5
  • 23
    • 15444374646 scopus 로고    scopus 로고
    • Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    • Setoguchi R, Hori S, Takahashi T, Sakaguchi S (2005) Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 201: 723-735.
    • (2005) J Exp Med , vol.201 , pp. 723-735
    • Setoguchi, R.1    Hori, S.2    Takahashi, T.3    Sakaguchi, S.4
  • 24
    • 0034965185 scopus 로고    scopus 로고
    • Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: Evidence for two distinct regulatory mechanisms
    • Wolf M, Schimpl A, Hunig T (2001) Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: evidence for two distinct regulatory mechanisms. Eur J Immunol 31: 1637-1645.
    • (2001) Eur J Immunol , vol.31 , pp. 1637-1645
    • Wolf, M.1    Schimpl, A.2    Hunig, T.3
  • 25
    • 0036839102 scopus 로고    scopus 로고
    • Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
    • Almeida AR, Legrand N, Papiernik M, Freitas AA (2002) Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 169: 4850-4860.
    • (2002) J Immunol , vol.169 , pp. 4850-4860
    • Almeida, A.R.1    Legrand, N.2    Papiernik, M.3    Freitas, A.A.4
  • 26
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    • Malek TR, Yu A, Vincek V, Scibelli P, Kong L (2002) CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17: 167-178.
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 27
    • 2442637772 scopus 로고    scopus 로고
    • Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function
    • Thornton AM, Donovan EE, Piccirillo CA, Shevach EM (2004) Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol 172: 6519-6523.
    • (2004) J Immunol , vol.172 , pp. 6519-6523
    • Thornton, A.M.1    Donovan, E.E.2    Piccirillo, C.A.3    Shevach, E.M.4
  • 28
    • 4644369302 scopus 로고    scopus 로고
    • Interleukin-2 is essential for CD4+CD25+ regulatory T cell function
    • de la Rosa M, Rutz S, Dorninger H, Scheffold A (2004) Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. Eur J Immunol 34: 2480-2488.
    • (2004) Eur J Immunol , vol.34 , pp. 2480-2488
    • de la Rosa, M.1    Rutz, S.2    Dorninger, H.3    Scheffold, A.4
  • 29
    • 15544384475 scopus 로고    scopus 로고
    • Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period
    • Bayer AL, Yu A, Adeegbe D, Malek TR (2005) Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period. J Exp Med 201: 769-777.
    • (2005) J Exp Med , vol.201 , pp. 769-777
    • Bayer, A.L.1    Yu, A.2    Adeegbe, D.3    Malek, T.R.4
  • 30
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, et al. (2008) Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 28: 687-697.
    • (2008) Immunity , vol.28 , pp. 687-697
    • Tang, Q.1    Adams, J.Y.2    Penaranda, C.3    Melli, K.4    Piaggio, E.5
  • 31
    • 33847246293 scopus 로고    scopus 로고
    • Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
    • Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, et al. (2007) Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet 39: 329-337.
    • (2007) Nat Genet , vol.39 , pp. 329-337
    • Yamanouchi, J.1    Rainbow, D.2    Serra, P.3    Howlett, S.4    Hunter, K.5
  • 32
    • 33748296240 scopus 로고    scopus 로고
    • Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo
    • Vukmanovic-Stejic M, Zhang Y, Cook JE, Fletcher JM, McQuaid A, et al. (2006) Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J Clin Invest 116: 2423-2433.
    • (2006) J Clin Invest , vol.116 , pp. 2423-2433
    • Vukmanovic-Stejic, M.1    Zhang, Y.2    Cook, J.E.3    Fletcher, J.M.4    McQuaid, A.5
  • 33
    • 23844435586 scopus 로고    scopus 로고
    • High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: A role for P2X7 receptors
    • Aswad F, Kawamura H, Dennert G (2005) High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors. J Immunol 175: 3075-3083.
    • (2005) J Immunol , vol.175 , pp. 3075-3083
    • Aswad, F.1    Kawamura, H.2    Dennert, G.3
  • 34
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, et al. (2003) PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34: 267-273.
    • (2003) Nat Genet , vol.34 , pp. 267-273
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.F.3    Subramanian, A.4    Sihag, S.5
  • 36
    • 0036658731 scopus 로고    scopus 로고
    • Increased susceptibility to apoptosis and attenuated Bcl-2 expression in T lymphocytes and monocytes from patients with advanced chronic hepatitis C
    • Nakamoto Y, Kaneko S, Kobayashi K (2002) Increased susceptibility to apoptosis and attenuated Bcl-2 expression in T lymphocytes and monocytes from patients with advanced chronic hepatitis C. J Leukoc Biol 72: 49-55.
    • (2002) J Leukoc Biol , vol.72 , pp. 49-55
    • Nakamoto, Y.1    Kaneko, S.2    Kobayashi, K.3
  • 38
    • 34047111769 scopus 로고    scopus 로고
    • Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells
    • Dalberg U, Markholst H, Hornum L (2007) Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells. Int Immunol 19: 447-453.
    • (2007) Int Immunol , vol.19 , pp. 447-453
    • Dalberg, U.1    Markholst, H.2    Hornum, L.3
  • 39
    • 33846172748 scopus 로고    scopus 로고
    • IAN family critically regulates survival and development of T lymphocytes
    • Nitta T, Nasreen M, Seike T, Goji A, Ohigashi I, et al. (2006) IAN family critically regulates survival and development of T lymphocytes. PLoS Biol 4: e103.
    • (2006) PLoS Biol , vol.4
    • Nitta, T.1    Nasreen, M.2    Seike, T.3    Goji, A.4    Ohigashi, I.5
  • 40
    • 24144499959 scopus 로고    scopus 로고
    • Expression of the Ian family of putative GTPases during T cell development and description of an Ian with three sets of GTP/GDP-binding motifs
    • Dion C, Carter C, Hepburn L, Coadwell WJ, Morgan G, et al. (2005) Expression of the Ian family of putative GTPases during T cell development and description of an Ian with three sets of GTP/GDP-binding motifs. Int Immunol 17: 1257-1268.
    • (2005) Int Immunol , vol.17 , pp. 1257-1268
    • Dion, C.1    Carter, C.2    Hepburn, L.3    Coadwell, W.J.4    Morgan, G.5
  • 41
    • 0032143524 scopus 로고    scopus 로고
    • Chemokines: Understanding their role in T-lymphocyte biology
    • Ward SG, Westwick J (1998) Chemokines: understanding their role in T-lymphocyte biology. Biochem J 333 (Pt3): 457-470.
    • (1998) Biochem J , vol.333 , Issue.PT3 , pp. 457-470
    • Ward, S.G.1    Westwick, J.2
  • 42
    • 0020001136 scopus 로고
    • Mechanism of T cell activation: Role and functional relationship of HLA-DR antigens and interleukins
    • Palacios R (1982) Mechanism of T cell activation: role and functional relationship of HLA-DR antigens and interleukins. Immunol Rev 63: 73-110.
    • (1982) Immunol Rev , vol.63 , pp. 73-110
    • Palacios, R.1
  • 43
    • 7144259082 scopus 로고    scopus 로고
    • Regulatory CD4 T cells: Expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
    • Papiernik M, de Moraes ML, Pontoux C, Vasseur F, Penit C (1998) Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int Immunol 10: 371-378.
    • (1998) Int Immunol , vol.10 , pp. 371-378
    • Papiernik, M.1    de Moraes, M.L.2    Pontoux, C.3    Vasseur, F.4    Penit, C.5
  • 44
    • 34548361965 scopus 로고    scopus 로고
    • Roles of cytokines in the pathogenesis and therapy of type 1 diabetes
    • Rabinovitch A, Suarez-Pinzon WL (2007) Roles of cytokines in the pathogenesis and therapy of type 1 diabetes. Cell Biochem Biophys 48: 159-163.
    • (2007) Cell Biochem Biophys , vol.48 , pp. 159-163
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2
  • 45
    • 34548210927 scopus 로고    scopus 로고
    • Cascade of transcriptional induction and repression during IL-2 deprivation-induced apoptosis
    • Fleischer A, Duhamel M, Lopez-Fernandez LA, Munoz M, Rebollo MP, et al. (2007) Cascade of transcriptional induction and repression during IL-2 deprivation-induced apoptosis. Immunol Lett 112: 9-29.
    • (2007) Immunol Lett , vol.112 , pp. 9-29
    • Fleischer, A.1    Duhamel, M.2    Lopez-Fernandez, L.A.3    Munoz, M.4    Rebollo, M.P.5
  • 46
    • 0022472851 scopus 로고
    • Acquired defect in interleukin-2 production in patients with type I diabetes mellitus
    • Kaye WA, Adri MN, Soeldner JS, Rabinowe SL, Kaldany A, et al. (1986) Acquired defect in interleukin-2 production in patients with type I diabetes mellitus. N Engl J Med 315: 920-924.
    • (1986) N Engl J Med , vol.315 , pp. 920-924
    • Kaye, W.A.1    Adri, M.N.2    Soeldner, J.S.3    Rabinowe, S.L.4    Kaldany, A.5
  • 47
    • 0024565494 scopus 로고
    • Interleukin 2 and soluble interleukin 2-receptor secretion defect in vitro in newly diagnosed type I diabetic patients
    • Giordano C, Panto F, Caruso C, Modica MA, Zambito AM, et al. (1989) Interleukin 2 and soluble interleukin 2-receptor secretion defect in vitro in newly diagnosed type I diabetic patients. Diabetes 38: 310-315.
    • (1989) Diabetes , vol.38 , pp. 310-315
    • Giordano, C.1    Panto, F.2    Caruso, C.3    Modica, M.A.4    Zambito, A.M.5
  • 48
    • 33748789594 scopus 로고    scopus 로고
    • Apoptosis by IL-2 deprivation in human CD8+ T cell blasts predominates over death receptor ligation, requires Bim expression and is associated with Mcl-1 loss
    • Bosque A, Marzo I, Naval J, Anel A (2007) Apoptosis by IL-2 deprivation in human CD8+ T cell blasts predominates over death receptor ligation, requires Bim expression and is associated with Mcl-1 loss. Mol Immunol 44: 1446-1453.
    • (2007) Mol Immunol , vol.44 , pp. 1446-1453
    • Bosque, A.1    Marzo, I.2    Naval, J.3    Anel, A.4
  • 49
    • 0038383027 scopus 로고    scopus 로고
    • Transcriptional program of apoptosis induction following interleukin 2 deprivation: Identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor
    • Devireddy LR, Green MR (2003) Transcriptional program of apoptosis induction following interleukin 2 deprivation: identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor. Mol Cell Biol 23: 4532-4541.
    • (2003) Mol Cell Biol , vol.23 , pp. 4532-4541
    • Devireddy, L.R.1    Green, M.R.2
  • 50
    • 0037094096 scopus 로고    scopus 로고
    • The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2
    • Stahl M, Dijkers PF, Kops GJ, Lens SM, Coffer PJ, et al. (2002) The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol 168: 5024-5031.
    • (2002) J Immunol , vol.168 , pp. 5024-5031
    • Stahl, M.1    Dijkers, P.F.2    Kops, G.J.3    Lens, S.M.4    Coffer, P.J.5
  • 51
  • 52
    • 33745841375 scopus 로고    scopus 로고
    • FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
    • You H, Pellegrini M, Tsuchihara K, Yamamoto K, Hacker G, et al. (2006) FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med 203: 1657-1663.
    • (2006) J Exp Med , vol.203 , pp. 1657-1663
    • You, H.1    Pellegrini, M.2    Tsuchihara, K.3    Yamamoto, K.4    Hacker, G.5
  • 53
    • 33745163907 scopus 로고    scopus 로고
    • Regulation of transactivationindependent proapoptotic activity of p53 by FOXO3a
    • You H, Yamamoto K, Mak TW (2006) Regulation of transactivationindependent proapoptotic activity of p53 by FOXO3a. Proc Natl Acad Sci U S A 103: 9051-9056.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 9051-9056
    • You, H.1    Yamamoto, K.2    Mak, T.W.3
  • 54
    • 0037134040 scopus 로고    scopus 로고
    • Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, et al. (2002) DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296: 530-534.
    • Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, et al. (2002) DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296: 530-534.
  • 55
    • 17644379936 scopus 로고    scopus 로고
    • FOXO transcription factors in cell-cycle regulation and the response to oxidative stress
    • Furukawa-Hibi Y, Kobayashi Y, Chen C, Motoyama N (2005) FOXO transcription factors in cell-cycle regulation and the response to oxidative stress. Antioxid Redox Signal 7: 752-760.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 752-760
    • Furukawa-Hibi, Y.1    Kobayashi, Y.2    Chen, C.3    Motoyama, N.4
  • 56
    • 0026321504 scopus 로고
    • Linkage of faulty major histocompatibility complex class I to autoimmune diabetes
    • Faustman D, Li XP, Lin HY, Fu YE, Eisenbarth G, et al. (1991) Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Science 254: 1756-1761.
    • (1991) Science , vol.254 , pp. 1756-1761
    • Faustman, D.1    Li, X.P.2    Lin, H.Y.3    Fu, Y.E.4    Eisenbarth, G.5
  • 57
    • 0029818658 scopus 로고    scopus 로고
    • Major histocompatibility complex class I molecule expression is normal on peripheral blood lymphocytes from patients with insulin-dependent diabetes mellitus
    • Hao W, Gladstone P, Engardt S, Greenbaum C, Palmer JP (1996) Major histocompatibility complex class I molecule expression is normal on peripheral blood lymphocytes from patients with insulin-dependent diabetes mellitus. J Clin Invest 98: 1613-1618.
    • (1996) J Clin Invest , vol.98 , pp. 1613-1618
    • Hao, W.1    Gladstone, P.2    Engardt, S.3    Greenbaum, C.4    Palmer, J.P.5
  • 58
    • 0030858167 scopus 로고    scopus 로고
    • MHC class I antigen expression in patients with IDDM and their siblings
    • Anal O, Akkoc N, Sen A, Yesil S, Yuksel F, et al. (1997) MHC class I antigen expression in patients with IDDM and their siblings. J Pediatr Endocrinol Metab 10: 391-394.
    • (1997) J Pediatr Endocrinol Metab , vol.10 , pp. 391-394
    • Anal, O.1    Akkoc, N.2    Sen, A.3    Yesil, S.4    Yuksel, F.5
  • 59
    • 33645778289 scopus 로고    scopus 로고
    • MHC class II expression identifies functionally distinct human regulatory T cells
    • Baecher-Allan C, Wolf E, Hafler DA (2006) MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol 176: 4622-4631.
    • (2006) J Immunol , vol.176 , pp. 4622-4631
    • Baecher-Allan, C.1    Wolf, E.2    Hafler, D.A.3
  • 60
    • 33846645383 scopus 로고    scopus 로고
    • The lymphocyte guard-IANs: Regulation of lymphocyte survival by IAN/GIMAP family proteins
    • Nitta T, Takahama Y (2007) The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins. Trends Immunol 28: 58-65.
    • (2007) Trends Immunol , vol.28 , pp. 58-65
    • Nitta, T.1    Takahama, Y.2
  • 61
    • 33747816472 scopus 로고    scopus 로고
    • Loss of a gimap/ian gene leads to activation of NF-kappaB through a MAPK-dependent pathway
    • Kupfer R, Lang J, Williams-Skipp C, Nelson M, Bellgrau D, et al. (2007) Loss of a gimap/ian gene leads to activation of NF-kappaB through a MAPK-dependent pathway. Mol Immunol 44: 479-487.
    • (2007) Mol Immunol , vol.44 , pp. 479-487
    • Kupfer, R.1    Lang, J.2    Williams-Skipp, C.3    Nelson, M.4    Bellgrau, D.5
  • 62
    • 0036062788 scopus 로고    scopus 로고
    • Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene
    • MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, et al. (2002) Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res 12: 1029-1039.
    • (2002) Genome Res , vol.12 , pp. 1029-1039
    • MacMurray, A.J.1    Moralejo, D.H.2    Kwitek, A.E.3    Rutledge, E.A.4    Van Yserloo, B.5
  • 63
    • 0036263450 scopus 로고    scopus 로고
    • The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1
    • Hornum L, Romer J, Markholst H (2002) The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1. Diabetes 51: 1972-1979.
    • (2002) Diabetes , vol.51 , pp. 1972-1979
    • Hornum, L.1    Romer, J.2    Markholst, H.3
  • 64
    • 33847242598 scopus 로고    scopus 로고
    • Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    • Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, et al. (2007) Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 445: 931-935.
    • (2007) Nature , vol.445 , pp. 931-935
    • Marson, A.1    Kretschmer, K.2    Frampton, G.M.3    Jacobsen, E.S.4    Polansky, J.K.5
  • 65
    • 34548534993 scopus 로고    scopus 로고
    • Dynamic changes in CD4+ CD25+(high) T cell apoptosis after the diagnosis of type 1 diabetes
    • Glisic-Milosavljevic S, Wang T, Koppen M, Kramer J, Ehlenbach S, et al. (2007) Dynamic changes in CD4+ CD25+(high) T cell apoptosis after the diagnosis of type 1 diabetes. Clin Exp Immunol 150: 75-82.
    • (2007) Clin Exp Immunol , vol.150 , pp. 75-82
    • Glisic-Milosavljevic, S.1    Wang, T.2    Koppen, M.3    Kramer, J.4    Ehlenbach, S.5
  • 66
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
    • Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15: 539-553.
    • (1998) Diabet Med , vol.15 , pp. 539-553
    • Alberti, K.G.1    Zimmet, P.Z.2
  • 67
    • 0037099613 scopus 로고    scopus 로고
    • CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness
    • Piccirillo CA, Letterio JJ, Thornton AM, McHugh RS, Mamura M, et al. (2002) CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med 196: 237-246.
    • (2002) J Exp Med , vol.196 , pp. 237-246
    • Piccirillo, C.A.1    Letterio, J.J.2    Thornton, A.M.3    McHugh, R.S.4    Mamura, M.5
  • 68
    • 0037099719 scopus 로고    scopus 로고
    • Infectious tolerance: Human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells
    • Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J, et al. (2002) Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med 196: 255-260.
    • (2002) J Exp Med , vol.196 , pp. 255-260
    • Jonuleit, H.1    Schmitt, E.2    Kakirman, H.3    Stassen, M.4    Knop, J.5
  • 70
    • 33846283803 scopus 로고    scopus 로고
    • Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells
    • Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM (2007) Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods 319: 41-52.
    • (2007) J Immunol Methods , vol.319 , pp. 41-52
    • Hartigan-O'Connor, D.J.1    Poon, C.2    Sinclair, E.3    McCune, J.M.4
  • 71
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    • Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, et al. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 203: 1701-1711.
    • (2006) J Exp Med , vol.203 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3    Szot, G.L.4    Lee, M.R.5
  • 72
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: Open software development for computational biology and bioinformatics
    • Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, et al. (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80.
    • (2004) Genome Biol , vol.5
    • Gentleman, R.C.1    Carey, V.J.2    Bates, D.M.3    Bolstad, B.4    Dettling, M.5
  • 73
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher VG, Tibshirani R, Chu G (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 98: 5116-5121.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 74
    • 0034948896 scopus 로고    scopus 로고
    • A Bayesian framework for the analysis of microarray expression data: Regularized t -test and statistical inferences of gene changes
    • Baldi P, Long AD (2001) A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes. Bioinformatics 17: 509-519.
    • (2001) Bioinformatics , vol.17 , pp. 509-519
    • Baldi, P.1    Long, A.D.2
  • 77
    • 24644473482 scopus 로고    scopus 로고
    • BGX: A fully Bayesian integrated approach to the analysis of Affymetrix GeneChip data
    • Hein AM, Richardson S, Causton HC, Ambler GK, Green PJ (2005) BGX: a fully Bayesian integrated approach to the analysis of Affymetrix GeneChip data. Biostatistics 6: 349-373.
    • (2005) Biostatistics , vol.6 , pp. 349-373
    • Hein, A.M.1    Richardson, S.2    Causton, H.C.3    Ambler, G.K.4    Green, P.J.5
  • 78
    • 33749386597 scopus 로고    scopus 로고
    • A powerful method for detecting differentially expressed genes from GeneChip arrays that does not require replicates
    • Hein AM, Richardson S (2006) A powerful method for detecting differentially expressed genes from GeneChip arrays that does not require replicates. BMC Bioinformatics 7: 353.
    • (2006) BMC Bioinformatics , vol.7 , pp. 353
    • Hein, A.M.1    Richardson, S.2
  • 79
    • 68349164982 scopus 로고    scopus 로고
    • Large-scale simultaneous hypothesis testing: The choice of a null hypothesis
    • Efron B (2003) Large-scale simultaneous hypothesis testing: the choice of a null hypothesis. J Am Statist Assoc: 96: 99.
    • (2003) J Am Statist Assoc , vol.96 , pp. 99
    • Efron, B.1
  • 80
    • 0034069495 scopus 로고    scopus 로고
    • Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium
    • Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, et al. (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25: 25-29.
    • (2000) Nat Genet , vol.25 , pp. 25-29
    • Ashburner, M.1    Ball, C.A.2    Blake, J.A.3    Botstein, D.4    Butler, H.5
  • 81
    • 27144482127 scopus 로고    scopus 로고
    • Comparison of apoptosis and mortality measurements in peripheral blood mononuclear cells (PBMCs) using multiple methods
    • Glisic-Milosavljevic S, Waukau J, Jana S, Jailwala P, Rovensky J, et al. (2005) Comparison of apoptosis and mortality measurements in peripheral blood mononuclear cells (PBMCs) using multiple methods. Cell Prolif 38: 301-311.
    • (2005) Cell Prolif , vol.38 , pp. 301-311
    • Glisic-Milosavljevic, S.1    Waukau, J.2    Jana, S.3    Jailwala, P.4    Rovensky, J.5


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