MHC class II expression identifies functionally distinct human regulatory T cells

Journal of Immunology

Volumn 176, Issue 8, 2006, Pages 4622-4631

  Baecher Allan, Clare ^a,b   Wolf, Elizabeth ^a   Hafter, David A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA;

ANTIGEN EXPRESSION; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 33645778289     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.8.4622     Document Type: Article

References (45)

1. Ko, H. S., S. M. Fu, R. J. Winchester, D. T. Yu, and H. G. Kunkel. 1979. Ia determinants on stimulated human T lymphocytes: occurrence on mitogen- and antigen-activated T cells. J. Exp. Med. 150: 246-255.
2. Evans, R. L., T. J. Faldetta, R. E. Humphreys, D. M. Pratt, E. J. Yunis, and S. F. Schlossman. 1978. Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens. J. Exp. Med. 148: 1440-1445.
3. Chang, C. H., S. C. Hong, C. C. Hughes, C. A. Janeway, Jr., and R. A. Flavell. 1995. CIITA activates the expression of MHC class II genes in mouse T cells. Int. Immunol. 7: 1515-1518.
4. Holling, T. M., N. van der Stoep, E. Quinten, and P. J. van den Elsen. 2002. Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III. J. Immunol. 168: 763-770.
5. Lamb, J. R., and M. Fledmann. 1982. A human suppressor T cell clone which recognizes an autologous helper T cell clone. Nature 300: 456-458.
6. LaSalle, J. M., K. Ota, and D. A. Hafler. 1991. Presentation of autoantigen by human T cells. J. Immunol. 147: 774-780.
7. LaSalle, J. M., P. J. Tolentino, G. J. Freeman, L. M. Nadler, and D. A. Hafler. 1992. Early signaling defects in human T cells anergized by T cell presentation of autoantigen. J. Exp. Med. 176: 177-186.
8. Hollsberg, P., K. W. Wucherpfennig, L. J. Ausubel, V. Calvo, B. E. Bierer, and D. A. Hafler. 1992. Characterization of HTLV-I in vivo infected T cell clones: IL-2-independent growth of nontransformed T cells. J. Immunol. 148: 3256-3263.
9. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184: 387-396.
10. + immunoregulatory T cells in the induction of autoimmune gastritis. Immunol. Cell Biol. 80: 567-573.
11. Suri-Payer, E., A. Z. Amar, R. McHugh, K. Natarajan, D. H. Margulies, and E. M. Shevach. 1999. Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells. Eur. J. Immunol. 29: 669-677.
12. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190: 995-1004.
13. + regulatory T cells cure murine colitis: the role of IL-10, TGF-β, and CTLA4. J. Immunol. 171: 5012-5017.
14. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
15. high regulatory cells in human peripheral blood. J. Immunol. 167: 1245-1253.
16. + T cells in thymus, cord and adult blood. Immunology 106: 190-199.
17. high regulatory T cell function. J. Immunol. 169: 6210-6217.
18. + regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 199: 971-979.
19. + T cells from the target organ of patients with rheumatoid arthritis. Eur. J. Immunol. 33: 215-223.
20. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166: 3008-3018.
21. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2: 389-400.
22. + regulatory T cells protects from lethal acute GVHD. Blood. 105: 2220-2226.
23. Chatenoud, L., B. Salomon, and J. A. Bluestone. 2001. Suppressor T cells: they're back and critical for regulation of autoimmunity! Immunol. Rev. 182: 149-163.
24. Baecher-Allan, C., and D. A. Hafler. 2004. Suppressor T cells in human diseases. J. Exp. Med. 200: 273-276.
25. + regulatory T cells at the single-cell level. Eur. J. Immunol. 35: 1681-1691.
26. Parish, C. R. 1999. Fluorescent dyes for lymphocyte migration and proliferation studies. Immunol. Cell Biol. 77: 499-508.
27. + T suppressor cell clones produce transforming growth factor β, but not interleukin 10, and are distinct from type 1 T regulatory cells. J. Exp. Med. 196: 1335-1346.
28. McFarland, R. D., D. C. Douek, R. A. Koup, and L. J. Picker. 2000. Identification of a human recent thymic emigrant phenotype. Proc. Natl. Acad. Sci. USA 97: 4215-4220.
29. + regulatory T cells. Int. Immunol. 16: 1643-1656.
30. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
31. + regulatory T cells. Nat. Immunol. 4: 330-336.
32. Rao, P. E., A. L. Petrone, and P. D. Ponath. 2005. Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-β. J. Immunol. 174: 1446-1455.
33. Brod, S. A., M. Purvee, D. Benjamin, and D. A. Hafler. 1990. T-T cell interactions are mediated by adhesion molecules. Eur. J. Immunol. 20: 2259-2268.
34. Wucherpfennig, K. W., P. Hollsberg, J. H. Richardson, D. Benjamin, and D. A. Hafler. 1992. T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. Proc. Natl. Acad. Sci. USA 89: 2110-2114.
35. + T regulatory cells in humans. Hum. Immunol. 66: 13-20.
36. + T cells: evidence from a lymphopenic T cell model. Immunity 17: 425-436.
37. + regulatory T cells. J. Immunol. 171: 5678-5682.
38. + regulatory T cell function. J. Exp. Med. 196: 851-857.
39. + T regulatory cells. Nat. Immunol. 4: 337-342.
40. high-induced colitis by a TGF-β-dependent mechanism. J. Immunol. 170: 2516-2522.
41. + T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp. Med. 197: 111-119.
42. + T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. 195: 603-616.
43. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192: 295-302.
44. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J. Exp. Med. 196: 237-246.
45. + regulatory T cells. Semin. Immunol. 16: 89-98.