Reduced CD4+ T-cell-specific gene expression in human type 1 diabetes mellitus

Journal of Autoimmunity

Volumn 28, Issue 4, 2007, Pages 177-187

  Orban, Tihamer ^a   Kis, Janos ^a,b   Szereday, Laszlo ^a,c   Engelmann, Peter ^a,d   Farkas, Klara ^a,e   Jalahej, Heyam ^a   Treszl, Andras ^a,f  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Polyclinic of the Hospitaller Brothers ^*  (Hungary)

^c Reproductive and Tumor Immunology Research Group Hungarian Academy of Science   (Hungary)

^d UNIVERSITY OF PÉCS   (Hungary)

^e BAJCSY ZSILINSZKY HOSPITAL   (Hungary)

^f SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

CD4+ cells; DNA microarray; Type 1 diabetes mellitus

Indexed keywords

DNA;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELL CYCLE REGULATION; CELL ISOLATION; CLINICAL ARTICLE; DNA MICROARRAY; DNA MODIFICATION; DOWN REGULATION; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE FUNCTION; GLUCOSE HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

CD4-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DOWN-REGULATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HISTONE DEACETYLASES; HUMANS; IMMUNE TOLERANCE; INSULIN-SECRETING CELLS; MALE;

EID: 34248585113     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2007.01.002     Document Type: Article

References (48)

1. Bottazzo G.F., Dean B.M., McNally J.M., Mackay E.H., Swift P.G.F., and Gamble D.R. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 313 (1985) 353-360
2. Sibley R.K., Sutherland D.E., Goetz F., and Michael A.F. Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab Invest 53 (1985) 132-144
3. Lampeter E.F., Homberg M., Quabeck K., Schaefer U.W., Wernet P., Bertrams J., et al. Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation. Lancet 341 (1993) 1243-1244
4. Wong F.S., and Janeway Jr. C.A. Insulin-dependent diabetes mellitus and its animal models. Curr Opin Immunol 11 (1999) 643-647
5. Pinkse G.G., Tysma O.H., Bergen C.A., Kester M.G., Ossendorp F., van Veelen P.A., et al. Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci USA 102 (2005) 18425-18430
6. Yamanouchi J., Verdaguer J., Han B., Amrani A., Serra P., and Santamaria P. Cross-priming of diabetogenic T cells dissociated from CTL-induced shedding of beta cell autoantigens. J Immunol 171 (2003) 6900-6909
7. Ejrnaes M., Videbaek N., Christen U., Cooke A., Michelsen B.K., and von Herrath M. Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics. J Immunol 174 (2005) 2746-2755
8. Moore A., Grimm J., Han B., and Santamaria P. Tracking the recruitment of diabetogenic CD8+ T-cells to the pancreas in real time. Diabetes 53 (2004) 1459-1466
9. Peterson J.D., and Haskins K. Transfer of diabetes in the NOD-scid mouse by CD4 T-cell clones. Differential requirement for CD8 T-cells. Diabetes 45 (1996) 328-336
10. Wong F.S., Visintin I., Wen L., Flavell R.A., and Janeway Jr. C.A. CD8 T-cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J Exp Med 183 (1996) 67-76
11. Haskins K. Pathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse. Adv Immunol 87 (2005) 123-162
12. Shizuru J.A., Taylor-Edwards C., Banks B.A., Gregory A.K., and Fathman C.G. Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes. Science 240 (1988) 659-662
13. Eibl N., Spatz M., Fischer G.F., Mayr W.R., Samstag A., Wolf H.M., et al. Impaired primary immune response in type-1 diabetes: results from a controlled vaccination study. Clin Immunol 103 (2002) 249-259
14. Spatz M., Eibl N., Hink S., Wolf H.M., Fischer G.F., Mayr W.R., et al. Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. Cell Immunol 221 (2003) 15-26
15. Abbas A.K., Murphy K.M., and Sher A. Functional diversity of helper T lymphocytes. Nature 383 (1996) 787-793
16. Foulis A.K., McGill M., and Farquharson M.A. Insulitis in type 1 (insulin-dependent) diabetes mellitus in man-macrophages, lymphocytes, and interferon-gamma containing cells. J Pathol 165 (1991) 97-103
17. Huang X., Yuang J., Goddard A., Foulis A., James R.F., Lernmark A., et al. Interferon expression in the pancreases of patients with type I diabetes. Diabetes 44 (1995) 658-664
18. Pop S.M., Wong C.P., Culton D.A., Clarke S.H., and Tisch R. Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med 201 (2005) 1333-1346
19. Lundsgaard D., Holm T.L., Hornum L., and Markholst H. In vivo control of diabetogenic T-cells by regulatory CD4+CD25+ T-cells expressing Foxp3. Diabetes 54 (2005) 1040-1047
20. Jaeckel E., von Boehmer H., and Manns M.P. Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes 54 (2005) 306-310
21. Cain J.A., Smith J.A., Ondr J.K., Wang B., and Katz J.D. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176 (2006) 1645-1654
22. de Ruijter A.J., van Gennip A.H., Caron H.N., Kemp S., and van Kuilenburg A.B. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370 (2003) 737-749
23. Christianson S.W., Shultz L.D., and Leiter E.H. Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors. Diabetes 42 (1993) 44-55
24. Ballestar E., Paz M.F., Valle L., Wei S., Fraga M.F., Espada J., et al. Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. EMBO J 22 (2003) 6335-6345
25. Ren Q., Robertson S.J., Howe D., Barrows L.F., and Heinzen R.A. Comparative DNA microarray analysis of host cell transcriptional responses to infection by Coxiella burnetii or Chlamydia trachomatis. Ann N Y Acad Sci 990 (2003) 701-713
26. An H.J., Cho N.H., Lee S.Y., Kim I.H., Lee C., Kim S.J., et al. Correlation of cervical carcinoma and precancerous lesions with human papillomavirus (HPV) genotypes detected with the HPV DNA chip microarray method. Cancer 97 (2003) 1672-1680
27. Firneisz G., Zehavi I., Vermes C., Hanyecz A., Frieman J.A., and Glant T.T. Identification and quantification of disease-related gene clusters. Bioinformatics 19 (2003) 1781-1786
28. Carroll J.M., McElwee K.J., King E., Byrne M.C., and Sundberg J.P. Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans. J Invest Dermatol 119 (2002) 392-402
29. Bach J.F., and Chatenoud L. Tolerance to islet autoantigens in type 1 diabetes. Annu Rev Immunol 19 (2001) 131-161
30. Coyle A.J., and Gutierrez-Ramos J.C. The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T-cell function. Nat Immunol 2 (2001) 203-209
31. Alegre M.L., Shiels H., Thompson C.B., and Gajewski T.F. Expression and function of CTLA-4 in Th1 and Th2 cells. J Immunol 161 (1998) 3347-3356
32. Kondo M., Akashi K., Domen J., Sugamura K., and Weissman I.L. Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice. Immunity 7 (1997) 155-162
33. Sugamura K., Asao H., Kondo M., Tanaka N., Ishii N., Ohbo K., et al. The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T-cell development in XSCID. Annu Rev Immunol 14 (1996) 179-205
34. Nakajima H., Noguchi M., and Leonard W.J. Role of the common cytokine receptor gamma chain (gammac) in thymocyte selection. Immunol Today 21 (2000) 88-94
35. Noguchi M., Sarin A., Aman M.J., Nakajima H., Shores E.W., Henkart P.A., et al. Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain. Proc Natl Acad Sci USA 94 (1997) 11534-11539
36. Nakajima H., Shores E.W., Noguchi M., and Leonard W.J. The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis. J Exp Med 185 (1997) 189-195
37. Camacho S.A., Heath W.R., Carbone F.R., Sarvetnick N., LeBon A., Karlsson L., et al. A key role for ICAM-1 in generating effector cells mediating inflammatory responses. Nat Immunol 2 (2001) 523-529
38. Ludwig R., Kretschmer M., Caspar G., Bojunga J., Oldenburg A., Schumm-Draeger P., et al. In vivo microscopy of murine islets of Langerhans: increased adhesion of transferred lymphocytes to islets depends on macrophage-derived cytokines in a model of organ-specific insulitis. Immunology 98 (1999) 111-115
39. Kallan A.A., Duinkerken G., de Jong R., van den E.P., Hutton J.C., Martin S., et al. Th1-like cytokine production profile and individual specific alterations in TCRBV-gene usage of T cells from newly diagnosed type 1 diabetes patients after stimulation with beta-cell antigens. J Autoimmun 10 (1997) 589-598
40. Wilson S.B., Kent S.C., Patton K.T., Orban T., Jackson R.A., Exley M., et al. Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature 391 (1998) 177-181
41. Karlsson M.G., Lawesson S.S., and Ludvigsson J. Th1-like dominance in high-risk first-degree relatives of type I diabetic patients. Diabetologia 43 (2000) 742-749
42. Ciampolillo A., Guastamacchia E., Caragiulo L., Lollino G., De Robertis O., Lattanzi V., et al. In vitro secretion of interleukin-1 beta and interferon-gamma by peripheral blood lymphomononuclear cells in diabetic patients. Diabetes Res Clin Pract 21 (1993) 87-93
43. Durinovic-Bello I., Boehm B.O., and Ziegler A.G. Predominantly recognized proinsulin T helper cell epitopes in individuals with and without islet cell autoimmunity. J Autoimmun 18 (2002) 55-66
44. Huebert D.J., and Bernstein B.E. Genomic views of chromatin. Curr Opin Genet Dev 15 (2005) 476-481
45. Bernstein B.E., Kamal M., Lindblad-Toh K., Bekiranov S., Bailey D.K., Huebert D.J., et al. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell 120 (2005) 169-181
46. Roh T.Y., Cuddapah S., and Zhao K. Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping. Genes Dev 19 (2005) 542-552
47. Wang A.G., Kim S.U., Lee S.H., Kim S.K., Seo S.B., Yu D.Y., et al. Histone deacetylase 1 contributes to cell cycle and apoptosis. Biol Pharm Bull 28 (2005) 1966-1970
48. Moreira J.M., Scheipers P., and Sorensen P. The histone deacetylase inhibitor Trichostatin A modulates CD4+ T-cell responses. BMC Cancer 3 (2003) 30