메뉴 건너뛰기




Volumn , Issue , 2006, Pages 443-478

Cytochromes P450

Author keywords

[No Author keywords available]

Indexed keywords


EID: 67650765007     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/0-387-34577-2_16     Document Type: Chapter
Times cited : (3)

References (228)
  • 1
    • 0028942981 scopus 로고
    • Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population
    • Agundez, J. A., Ledesma, M. C., Ladero, J. M. et al., 1995, Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population, Clin. Pharmacol. Ther. 57, 265-269.
    • (1995) Clin. Pharmacol. Ther. , vol.57 , pp. 265-269
    • Agundez, J.A.1    Ledesma, M.C.2    Ladero, J.M.3
  • 2
    • 0032821401 scopus 로고    scopus 로고
    • Failure to respond to treatment with typical antipsychotics is not associated with CYP2D6 ultrarapid hydroxylation
    • Aitchison, K. J., Munro, J., Wright, P. et al., 1999, Failure to respond to treatment with typical antipsychotics is not associated with CYP2D6 ultrarapid hydroxylation, Br. J. Clin. Pharmacol. 48, 388-394.
    • (1999) Br. J. Clin. Pharmacol. , vol.48 , pp. 388-394
    • Aitchison, K.J.1    Munro, J.2    Wright, P.3
  • 3
    • 0014693146 scopus 로고
    • Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapy
    • Alexanderson, B., Evans, D. A., Sjöqvist, F., 1969, Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy, Br. Med. J. 4, 764-768.
    • (1969) Br. Med. J. , vol.4 , pp. 764-768
    • Alexanderson, B.1    Evans, D.A.2    Sjöqvist, F.3
  • 4
    • 0025572192 scopus 로고
    • Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations
    • Alvan, G., Bechtel, P., Iselius, L. et al., 1990, Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations, Eur. J. Clin. Pharmacol. 39, 533-537.
    • (1990) Eur. J. Clin. Pharmacol. , vol.39 , pp. 533-537
    • Alvan, G.1    Bechtel, P.2    Iselius, L.3
  • 5
    • 0030910635 scopus 로고    scopus 로고
    • Nonfunctional CYP2D6 alleles and risk for neuroleptic-induced movement disorders in schizophrenic patients
    • Andreassen, O. A., Macewan, T., Gulbrandsen, A. K., Mccreadie, R. G., Steen, V. M., 1997, Nonfunctional CYP2D6 alleles and risk for neuroleptic-induced movement disorders in schizophrenic patients, Psychopharmacology. 131, 174-179.
    • (1997) Psychopharmacology , vol.131 , pp. 174-179
    • Andreassen, O.A.1    Macewan, T.2    Gulbrandsen, A.K.3    Mccreadie, R.G.4    Steen, V.M.5
  • 6
    • 0030809767 scopus 로고    scopus 로고
    • Antipsychotic druginduced movement disorders in schizophrenics in relation to CYP2D6 genotype
    • Armstrong, M., Daly, A. K., Blennerhassett, R., Ferrier, N., Idle, J., 1997, Antipsychotic druginduced movement disorders in schizophrenics in relation to CYP2D6 genotype, Br. J. Psychiatry. 170, 23-26.
    • (1997) Br. J. Psychiatry , vol.170 , pp. 23-26
    • Armstrong, M.1    Daly, A.K.2    Blennerhassett, R.3    Ferrier, N.4    Idle, J.5
  • 7
    • 0029049844 scopus 로고
    • Polymorphic drug metabolism in schizophrenic patients with tardive dyskinesia
    • Arthur, H., Dahl, M. L., Siwers, B., Sjöqvist, F., 1995, Polymorphic drug metabolism in schizophrenic patients with tardive dyskinesia, J. Clin. Psychopharmacol. 15, 211-216.
    • (1995) J. Clin. Psychopharmacol. , vol.15 , pp. 211-216
    • Arthur, H.1    Dahl, M.L.2    Siwers, B.3    Sjöqvist, F.4
  • 8
    • 0030873010 scopus 로고    scopus 로고
    • Interaction between fluoxetine and haloperidol: Pharmacokinetic and clinical implications
    • Avenoso, A., Spina, E., Campo, G. et al., 1997, Interaction between fluoxetine and haloperidol: pharmacokinetic and clinical implications, Pharmacol. Res. 35, 335-339.
    • (1997) Pharmacol. Res. , vol.35 , pp. 335-339
    • Avenoso, A.1    Spina, E.2    Campo, G.3
  • 9
    • 0029808757 scopus 로고    scopus 로고
    • Single and multiple dose pharmacokinetics of nefazodone in subjects classified as extensive and poor metabolizers of dextromethorphan
    • Barbhaiya, R. H., Buch, A. B., Greene, D. S., 1996, Single and multiple dose pharmacokinetics of nefazodone in subjects classified as extensive and poor metabolizers of dextromethorphan, Br. J. Clin. Pharmacol. 42, 573-581.
    • (1996) Br. J. Clin. Pharmacol. , vol.42 , pp. 573-581
    • Barbhaiya, R.H.1    Buch, A.B.2    Greene, D.S.3
  • 10
    • 0033939932 scopus 로고    scopus 로고
    • A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: Association with tardive dyskinesia in schizophrenia
    • Basile, V. S., Özdemir, V., Masellis, M. et al., 2000, A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia, Mol. Psychiatry 5, 410-417.
    • (2000) Mol. Psychiatry , vol.5 , pp. 410-417
    • Basile, V.S.1    Özdemir, V.2    Masellis, M.3
  • 11
    • 0022692071 scopus 로고
    • Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin
    • Baumann, P., Jonzier Perey, M., Koeb, L., Küpfer, A., Tinguely, D., Schopf, J., 1986, Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin, Int. Clin. Psychopharmacol. 1, 102-112.
    • (1986) Int. Clin. Psychopharmacol. , vol.1 , pp. 102-112
    • Baumann, P.1    Jonzier Perey, M.2    Koeb, L.3    Küpfer, A.4    Tinguely, D.5    Schopf, J.6
  • 12
    • 0038469903 scopus 로고    scopus 로고
    • Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype
    • Berecz, R., De La Rubia, Dorado, A. P., Fernandez-Salguero, P., Dahl, M. L., Llerena, A., 2003, Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype, Eur. J. Clin. Pharmacol. 59(1), 45-50.
    • (2003) Eur. J. Clin. Pharmacol. , vol.59 , Issue.1 , pp. 45-50
    • Berecz, R.1    De La Rubia, D.A.P.2    Fernandez-Salguero, P.3    Dahl, M.L.4    Llerena, A.5
  • 13
    • 0032718495 scopus 로고    scopus 로고
    • Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine
    • Bernal, M. L., Sinues, B., Johansson, I. et al., 1999, Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine, Pharmacogenetics. 9, 657-660.
    • (1999) Pharmacogenetics. , vol.9 , pp. 657-660
    • Bernal, M.L.1    Sinues, B.2    Johansson, I.3
  • 14
    • 0022337949 scopus 로고
    • Extremely rapid hydroxylation of debrisoquine: A case report with implication for treatment with nortriptyline and other tricyclic antidepressants
    • Bertilsson, L., Åberg-Wistedt, A., Gustafsson, L. L., Nordin, C., 1985, Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants, Ther. Drug Monit. 7, 478-480.
    • (1985) Ther. Drug Monit. , vol.7 , pp. 478-480
    • Bertilsson, L.1    Åberg-Wistedt, A.2    Gustafsson, L.L.3    Nordin, C.4
  • 15
    • 0027985726 scopus 로고
    • Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test
    • Bertilsson, L., Carrillo, J. A., Dahl, M. L. et al., 1994, Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test, Br. J. Clin. Pharmacol. 38, 471-473.
    • (1994) Br. J. Clin. Pharmacol. , vol.38 , pp. 471-473
    • Bertilsson, L.1    Carrillo, J.A.2    Dahl, M.L.3
  • 17
    • 0036204756 scopus 로고    scopus 로고
    • Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs
    • Bertilsson, L., Dahl, M.-L., Dalén, P., Al-Shurbaji, A., 2002, Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs, Br. J. Clin. Pharmacol. 53, 111-122.
    • (2002) Br. J. Clin. Pharmacol. , vol.53 , pp. 111-122
    • Bertilsson, L.1    Dahl, M.-L.2    Dalén, P.3    Al-Shurbaji, A.4
  • 18
    • 0026506140 scopus 로고
    • Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquine and S-mephenytoin
    • Bertilsson, L., Lou, Y., Q., Du, Y. L. et al., 1992, Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquine and S-mephenytoin, Clin. Pharmacol. Ther. 51, 388-397.
    • (1992) Clin. Pharmacol. Ther. , vol.51 , pp. 388-397
    • Bertilsson, L.1    Lou, Y.Q.2    Du, Y.L.3
  • 19
    • 0019450472 scopus 로고
    • Slow hydroxylation of nortriptyline and concomitant poor debrisoquine hydroxylation: Clinical implications [letter]
    • Bertilsson, L., Mellström, B., Sjöqvist, F., Martenson, B., Åsberg, M., 1981, Slow hydroxylation of nortriptyline and concomitant poor debrisoquine hydroxylation: clinical implications [letter], Lancet. 1, 560-561.
    • (1981) Lancet. , vol.1 , pp. 560-561
    • Bertilsson, L.1    Mellström, B.2    Sjöqvist, F.3    Martenson, B.4    Åsberg, M.5
  • 20
    • 0026568846 scopus 로고
    • The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes
    • Bloomer, J. C., Woods, F. R., Haddock, R. E., Lennard, M. S., Tucker, G. T., 1992, The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes, Br. J. Clin. Pharmacol. 33, 521-523.
    • (1992) Br. J. Clin. Pharmacol. , vol.33 , pp. 521-523
    • Bloomer, J.C.1    Woods, F.R.2    Haddock, R.E.3    Lennard, M.S.4    Tucker, G.T.5
  • 21
    • 0032776927 scopus 로고    scopus 로고
    • A pilot study on risperidone metabolism: The role of cytochromes P450 2D6 and 3A
    • Bork, J. A., Rogers, T., Wedlund, P. J. et al., 1999, A pilot study on risperidone metabolism: the role of cytochromes P450 2D6 and 3A, J. Clin. Psychiatry. 60, 469-476.
    • (1999) J. Clin. Psychiatry , vol.60 , pp. 469-476
    • Bork, J.A.1    Rogers, T.2    Wedlund, P.J.3
  • 25
    • 0025950370 scopus 로고
    • Debrisoquine/sparteine hydroxylation genotype and phenotype: Analysis of common mutations and alleles of CYP2D6 in a European population
    • Broly, F., Gaedigk, A., Heim, M., Eichelbaum, M., Morike, K., Meyer, U. A., 1991, Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population, DNA Cell. Biol. 10, 545-558.
    • (1991) DNA Cell. Biol. , vol.10 , pp. 545-558
    • Broly, F.1    Gaedigk, A.2    Heim, M.3    Eichelbaum, M.4    Morike, K.5    Meyer, U.A.6
  • 26
    • 0022647723 scopus 로고
    • Steady-state levels of imipramine and its metabolites: Significance of dose-dependent kinetics
    • Brøsen, K., Gram, L. F., Klysner, R., Bech, P., 1986, Steady-state levels of imipramine and its metabolites: significance of dose-dependent kinetics, Eur. J. Clin. Pharmacol. 30, 43-49.
    • (1986) Eur. J. Clin. Pharmacol. , vol.30 , pp. 43-49
    • Brøsen, K.1    Gram, L.F.2    Klysner, R.3    Bech, P.4
  • 27
    • 0022510805 scopus 로고
    • Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism
    • Brøsen, K., Klysner, R., Gram, L. F., Otton, S. V., Bech, P., Bertilsson, L., 1986, Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism, Eur. J. Clin. Pharmacol. 30, 679-684.
    • (1986) Eur. J. Clin. Pharmacol. , vol.30 , pp. 679-684
    • Brøsen, K.1    Klysner, R.2    Gram, L.F.3    Otton, S.V.4    Bech, P.5    Bertilsson, L.6
  • 28
    • 0031979755 scopus 로고    scopus 로고
    • Metabolism of the newer antidepressants. An overview of the pharmacological and pharmacokinetic implications
    • Caccia, S., 1998, Metabolism of the newer antidepressants. An overview of the pharmacological and pharmacokinetic implications, Clin. Pharmacokinet. 34, 281-302.
    • (1998) Clin. Pharmacokinet. , vol.34 , pp. 281-302
    • Caccia, S.1
  • 29
    • 0034062749 scopus 로고    scopus 로고
    • Biotransformation of post-clozapine antipsychotics: Pharmacological implications
    • Caccia, S., 2000, Biotransformation of post-clozapine antipsychotics: pharmacological implications, Clin. Pharmacokinet. 38, 393-414.
    • (2000) Clin. Pharmacokinet. , vol.38 , pp. 393-414
    • Caccia, S.1
  • 31
    • 0029860967 scopus 로고    scopus 로고
    • Disposition of fluvoxamine in humans is determined by the polymorphic CYP2D6 and also by the CYP1A2 activity
    • Carrillo, J. A., Dahl, M. L., Svensson, J. O., Alm, C., Rodriguez, I., Bertilsson, L., 1996, Disposition of fluvoxamine in humans is determined by the polymorphic CYP2D6 and also by the CYP1A2 activity, Clin. Pharmacol. Ther. 60, 183-190.
    • (1996) Clin. Pharmacol. Ther. , vol.60 , pp. 183-190
    • Carrillo, J.A.1    Dahl, M.L.2    Svensson, J.O.3    Alm, C.4    Rodriguez, I.5    Bertilsson, L.6
  • 32
    • 0032699804 scopus 로고    scopus 로고
    • Pharmacokinetic interaction of fluvoxamine and thioridazine in schizophrenic patients
    • Carrillo, J. A., Ramos, S. I., Herraiz, A. G. et al., 1999, Pharmacokinetic interaction of fluvoxamine and thioridazine in schizophrenic patients, J. Clin. Psychopharmacol. 19, 494-499.
    • (1999) J. Clin. Psychopharmacol. , vol.19 , pp. 494-499
    • Carrillo, J.A.1    Ramos, S.I.2    Herraiz, A.G.3
  • 33
    • 0029953653 scopus 로고    scopus 로고
    • Serum levels of clozapine and norclozapine in patients treated with selective serotonin re-uptake inhibitors
    • Centorrino, F., Baldessarini, R. J., Frankenburg, F. et al., 1996, Serum levels of clozapine and norclozapine in patients treated with selective serotonin re-uptake inhibitors, Am. J. Psychiatry. 153, 820-822.
    • (1996) Am. J. Psychiatry , vol.153 , pp. 820-822
    • Centorrino, F.1    Baldessarini, R.J.2    Frankenburg, F.3
  • 35
    • 0029587180 scopus 로고
    • Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians: Comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype
    • Chang, M., Dahl, M. L., Tybring, G., Gotharson, E., Bertilsson, L., 1995, Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians: comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype, Pharmacogenetics. 5, 358-363.
    • (1995) Pharmacogenetics. , vol.5 , pp. 358-363
    • Chang, M.1    Dahl, M.L.2    Tybring, G.3    Gotharson, E.4    Bertilsson, L.5
  • 36
    • 0028214359 scopus 로고
    • The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: A two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation
    • Chiba, K., Saitoh, A., Koyama, E., Tani, M., Hayashi, M., Ishizaki, T., 1994, The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation, Br. J. Clin. Pharmacol. 37, 237-242.
    • (1994) Br. J. Clin. Pharmacol. , vol.37 , pp. 237-242
    • Chiba, K.1    Saitoh, A.2    Koyama, E.3    Tani, M.4    Hayashi, M.5    Ishizaki, T.6
  • 37
    • 0032751791 scopus 로고    scopus 로고
    • Detection of three genetic polymorphisms in the 5'-flanking region and intron 1 of human CYP1A2 in the Japanese population
    • Chida, M., Yokoi, T., Fukui, T., Kinoshita, M., Yokota, J., Kamataki, T., 1999, Detection of three genetic polymorphisms in the 5'-flanking region and intron 1 of human CYP1A2 in the Japanese population, Jpn. J. Cancer Res. 90, 899-902.
    • (1999) Jpn. J. Cancer Res. , vol.90 , pp. 899-902
    • Chida, M.1    Yokoi, T.2    Fukui, T.3    Kinoshita, M.4    Yokota, J.5    Kamataki, T.6
  • 38
    • 0001697297 scopus 로고    scopus 로고
    • Extension of a pilot study: Impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness
    • Chou, W. H., Yan, F. X., De Leon, J. et al., 2000, Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness, J. Clin. Psychopharmacol. 20, 246-251.
    • (2000) J. Clin. Psychopharmacol. , vol.20 , pp. 246-251
    • Chou, W.H.1    Yan, F.X.2    De Leon, J.3
  • 40
    • 0029926315 scopus 로고    scopus 로고
    • Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite: Relationship to the CYP2D6 genotype
    • Dahl, M. L., Bertilsson, L., Nordin, C., 1996, Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite: relationship to the CYP2D6 genotype, Psychopharmacology (Berl). 123, 315-319.
    • (1996) Psychopharmacology (Berl) , vol.123 , pp. 315-319
    • Dahl, M.L.1    Bertilsson, L.2    Nordin, C.3
  • 41
    • 0025824216 scopus 로고
    • Disposition of the neuroleptic zuclopenthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humans
    • Dahl, M. L., Ekqvist B., Widen, J., Bertilsson, L., 1991, Disposition of the neuroleptic zuclopenthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humans, Acta Psychiatr. Scand. 84, 99-102.
    • (1991) Acta Psychiatr. Scand. , vol.84 , pp. 99-102
    • Dahl, M.L.1    Ekqvist, B.2    Widen, J.3    Bertilsson, L.4
  • 43
    • 0029064096 scopus 로고
    • Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis
    • Dahl, M. L., Johansson, I., Bertilsson, L. et al, 1995, Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis, J. Pharmacol. Exp. Ther. 274, 516-520.
    • (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 516-520
    • Dahl, M.L.1    Johansson, I.2    Bertilsson, L.3
  • 44
    • 0026610576 scopus 로고
    • Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population
    • Dahl, M. L., Johansson, I., Palmertz, M. P., Ingelman-Sundberg, M., Sjöqvist, F., 1992, Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population, Clin. Pharmacol. Ther. 51, 12-17.
    • (1992) Clin. Pharmacol. Ther. , vol.51 , pp. 12-17
    • Dahl, M.L.1    Johansson, I.2    Palmertz, M.P.3    Ingelman-Sundberg, M.4    Sjöqvist, F.5
  • 45
    • 0028307888 scopus 로고
    • Disposition of clozapine in man: Lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms
    • Dahl, M. L., Llerena, A., Bondesson, U. et al., 1994, Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphisms, Br. J. Clin. Pharmacol. 37, 71-74.
    • (1994) Br. J. Clin. Pharmacol. , vol.37 , pp. 71-74
    • Dahl, M.L.1    Llerena, A.2    Bondesson, U.3
  • 48
    • 0036073564 scopus 로고    scopus 로고
    • Cytochrome P450 phenotyping/genotyping in patients receiving antipsychotics. Useful aid to prescribing?
    • Dahl, M.-L., 2002, Cytochrome P450 phenotyping/genotyping in patients receiving antipsychotics. Useful aid to prescribing? Clin. Pharmacokinet. 41(7), 453-470.
    • (2002) Clin. Pharmacokinet. , vol.41 , Issue.7 , pp. 453-470
    • Dahl, M.-L.1
  • 49
    • 0020071485 scopus 로고
    • Active metabolites of neuroleptic drugs: Possible contribution to therapeutic and toxic effects
    • Dahl, S. G., 1982, Active metabolites of neuroleptic drugs: possible contribution to therapeutic and toxic effects, Ther. Drug Monit. 4, 33-40.
    • (1982) Ther. Drug Monit. , vol.4 , pp. 33-40
    • Dahl, S.G.1
  • 50
    • 0024333471 scopus 로고
    • Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings
    • Dahl-Puustinen, M. L., Liden, A. Alm, C., Nordin, C., Bertilsson, L., 1989, Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings, Clin. Pharmacol. Ther. 46, 78-81.
    • (1989) Clin. Pharmacol. Ther. , vol.46 , pp. 78-81
    • Dahl-Puustinen, M.L.1    Liden, A.2    Alm, C.3    Nordin, C.4    Bertilsson, L.5
  • 51
    • 0031949132 scopus 로고    scopus 로고
    • 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes
    • Dalén, P., Dahl, M. L., Ruiz, M. L., Nordin, J., Bertilsson, L., 1998, 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes, Clin. Pharmacol. Ther. 63, 444-452.
    • (1998) Clin. Pharmacol. Ther. , vol.63 , pp. 444-452
    • Dalén, P.1    Dahl, M.L.2    Ruiz, M.L.3    Nordin, J.4    Bertilsson, L.5
  • 52
    • 0028150994 scopus 로고
    • Coadministration of fluvoxamine increases serum concentrations of haloperidol
    • Daniel, D. G., Randolph, C., Jaskiw, G. et al., 1994, Coadministration of fluvoxamine increases serum concentrations of haloperidol, J. Clin. Psychopharmacol. 14, 340-343.
    • (1994) J. Clin. Psychopharmacol. , vol.14 , pp. 340-343
    • Daniel, D.G.1    Randolph, C.2    Jaskiw, G.3
  • 54
    • 0028044085 scopus 로고
    • Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese
    • De Morais, S. M., Wilkinson, G. R., Blaisdell, J. et al., 1994, Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese, Mol. Pharmacol 46, 594-598.
    • (1994) Mol. Pharmacol , vol.46 , pp. 594-598
    • De Morais, S.M.1    Wilkinson, G.R.2    Blaisdell, J.3
  • 55
    • 0028260641 scopus 로고
    • The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
    • De Morais, S. M., Wilkinson, G. R., Blaisdell, J. et al., 1994, The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans, J. Biol. Chem. 269, 15419-15422.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15419-15422
    • De Morais, S.M.1    Wilkinson, G.R.2    Blaisdell, J.3
  • 56
    • 0030906584 scopus 로고    scopus 로고
    • The clinical relevance of preclinical data: Mirtazapine, a model compound
    • Delbressine, L. P., Vos, R. M., 1997, The clinical relevance of preclinical data: Mirtazapine, a model compound, J. Clin. Psychopharmacol. 17, 29S-33S.
    • (1997) J. Clin. Psychopharmacol. , vol.17
    • Delbressine, L.P.1    Vos, R.M.2
  • 57
    • 0034958715 scopus 로고    scopus 로고
    • Smoking in patients receiving psychotropic medications: A pharmacokinetic perspective
    • Desai, H. D., Seabolt, J., Jann, M. W., 2001, Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective, CNS Drugs. 15, 469-494.
    • (2001) CNS Drugs. , vol.15 , pp. 469-494
    • Desai, H.D.1    Seabolt, J.2    Jann, M.W.3
  • 58
    • 0033782694 scopus 로고    scopus 로고
    • Quetiapine: A review of its safety in the management of schizophrenia
    • Dev, V., Raniwalla, J., 2000, Quetiapine: a review of its safety in the management of schizophrenia, Drug Saf 23, 295-307.
    • (2000) Drug Saf , vol.23 , pp. 295-307
    • Dev, V.1    Raniwalla, J.2
  • 59
    • 17844379465 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of quetiapine: An atypical antipsychotic
    • Devane, C. L., Nemeroff, C. B., 2001, Clinical pharmacokinetics of quetiapine: an atypical antipsychotic, Clin. Pharmacokinet. 40, 509-522.
    • (2001) Clin. Pharmacokinet. , vol.40 , pp. 509-522
    • Devane, C.L.1    Nemeroff, C.B.2
  • 61
    • 0035018421 scopus 로고    scopus 로고
    • Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizers
    • Eap, C. B., Bondolfi, G., Zullino, D., Savary-Cosendai, L., Powell-Golay, K., Kosel, M., Baumann, P., 2001, Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizers, J. Clin. Psychopharmacol. 21, 330-334.
    • (2001) J. Clin. Psychopharmacol. , vol.21 , pp. 330-334
    • Eap, C.B.1    Bondolfi, G.2    Zullino, D.3    Savary-Cosendai, L.4    Powell-Golay, K.5    Kosel, M.6    Baumann, P.7
  • 63
    • 0344404410 scopus 로고    scopus 로고
    • Steady state concentrations of the enantiomers of mianserin and desmethylmianserin in poor and in homozygous and heterozygous extensive metabolizers of debrisoquine
    • Eap, C. B., Lima, C. A., Macciardi, F., Woggon, B., Powell, K., Baumann, P., 1998, Steady state concentrations of the enantiomers of mianserin and desmethylmianserin in poor and in homozygous and heterozygous extensive metabolizers of debrisoquine, Ther. Drug. Monit. 20(1), 7-13.
    • (1998) Ther. Drug. Monit. , vol.20 , Issue.1 , pp. 7-13
    • Eap, C.B.1    Lima, C.A.2    Macciardi, F.3    Woggon, B.4    Powell, K.5    Baumann, P.6
  • 64
    • 0029897864 scopus 로고    scopus 로고
    • Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin
    • Eap, C. B., Guentert, T. W., Schaublin M., Loidl et al., 1996, Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin, Clin. Pharmacol. Ther. 59, 322-331.
    • (1996) Clin. Pharmacol. Ther. , vol.59 , pp. 322-331
    • Eap, C.B.1    Guentert, T.W.2    Schaublin, M.3    Loidl4
  • 65
    • 0018615011 scopus 로고
    • Defective N-oxidation of sparteine in man: A new pharmacogenetic defect
    • Eichelbaum, M., Spannbrucker, N., Steincke, B. et al., 1979, Defective N-oxidation of sparteine in man: a new pharmacogenetic defect, Eur. J. Clin. Pharmacol. 16, 183-187.
    • (1979) Eur. J. Clin. Pharmacol. , vol.16 , pp. 183-187
    • Eichelbaum, M.1    Spannbrucker, N.2    Steincke, B.3
  • 66
    • 0030656425 scopus 로고    scopus 로고
    • The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine
    • Eiermann, B., Engel, G., Johansson, I. et al., 1997, The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine, Br. J. Clin. Pharmacol. 44, 439-446.
    • (1997) Br. J. Clin. Pharmacol. , vol.44 , pp. 439-446
    • Eiermann, B.1    Engel, G.2    Johansson, I.3
  • 67
    • 0018900001 scopus 로고
    • A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population
    • Evans, D. A., Mahgoub, A., Sloan, T. P. et al., 1980, A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population, J. Med. Genet. 17, 102-105.
    • (1980) J. Med. Genet. , vol.17 , pp. 102-105
    • Evans, D.A.1    Mahgoub, A.2    Sloan, T.P.3
  • 68
    • 0030930935 scopus 로고    scopus 로고
    • Involvement of CYP3A4 and CYP2D6 in the metabolism of haloperidol
    • Fang, J., Baker, G. B., Silverstone, P. H. et al., 1997, Involvement of CYP3A4 and CYP2D6 in the metabolism of haloperidol, Cell. Mol. Neurobiology. 17, 227-233.
    • (1997) Cell. Mol. Neurobiology , vol.17 , pp. 227-233
    • Fang, J.1    Baker, G.B.2    Silverstone, P.H.3
  • 69
    • 0033063442 scopus 로고    scopus 로고
    • Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4
    • Fang, J., Bourin, M., Baker, G. B., 1999, Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4, Naunyn- Schmiedeberg's Arch. Pharmacol. 359, 147-151.
    • (1999) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.359 , pp. 147-151
    • Fang, J.1    Bourin, M.2    Baker, G.B.3
  • 70
    • 0032980471 scopus 로고    scopus 로고
    • Metabolism, pharmacogenetics and metabolic drug-drug interactions of antipsychotic drugs
    • Fang, J., Gorrod, J. W., 1999, Metabolism, pharmacogenetics and metabolic drug-drug interactions of antipsychotic drugs, Cell. Mol. Neurobiol. 19, 491-510.
    • (1999) Cell. Mol. Neurobiol. , vol.19 , pp. 491-510
    • Fang, J.1    Gorrod, J.W.2
  • 71
    • 0028282613 scopus 로고
    • Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine
    • Firkusny, L., Gleiter, C. H., 1994, Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine. Br. J. Clin. Pharmacol. 37, 383-388.
    • (1994) Br. J. Clin. Pharmacol. , vol.37 , pp. 383-388
    • Firkusny, L.1    Gleiter, C.H.2
  • 72
    • 0026666976 scopus 로고
    • The antipsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cytochrome P450 2D6
    • Fischer, V., Vogels, B., Maurer, G. et al., 1992, The antipsychotic clozapine is metabolized by the polymorphic human microsomal and recombinant cytochrome P450 2D6, J. Pharmacol. Exp. Ther. 260, 1355-1360.
    • (1992) J. Pharmacol. Exp. Ther. , vol.260 , pp. 1355-1360
    • Fischer, V.1    Vogels, B.2    Maurer, G.3
  • 73
    • 0032891488 scopus 로고    scopus 로고
    • The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine
    • Fjordside, L., Jeppesen, U., Eap, C. B., Powell, K., Baumann, P., Brøsen, K., 1999, The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine, Pharmacogenetics. 9, 55-60.
    • (1999) Pharmacogenetics. , vol.9 , pp. 55-60
    • Fjordside, L.1    Jeppesen, U.2    Eap, C.B.3    Powell, K.4    Baumann, P.5    Brøsen, K.6
  • 74
    • 0033136981 scopus 로고    scopus 로고
    • O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: Effect of metabolic inhibitors and SSRI antidepressants
    • Fogelman, S. M., Schmider, J., Venkatakrishnan, K., Von Moltke, L. L., Harmatz, J. S., Shader, R. I., Greenblatt, D. J., 1999, O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: Effect of metabolic inhibitors and SSRI antidepressants, Neuropsychopharmacol. 20, 480-490.
    • (1999) Neuropsychopharmacol. , vol.20 , pp. 480-490
    • Fogelman, S.M.1    Schmider, J.2    Venkatakrishnan, K.3    Von Moltke, L.L.4    Harmatz, J.S.5    Shader, R.I.6    Greenblatt, D.J.7
  • 75
    • 0034114843 scopus 로고    scopus 로고
    • The impact of the CYP2D6 and CYP2C19 genotypes on venlafaxine pharmacokinetics in a Japanese population
    • Fukuda, T., Nishida, Y., Zhou, Q., Yamamoto, I., Kondo, S., Azuma, J., 2000, The impact of the CYP2D6 and CYP2C19 genotypes on venlafaxine pharmacokinetics in a Japanese population, Eur. J. Clin. Pharmacol. 56, 175-180.
    • (2000) Eur. J. Clin. Pharmacol. , vol.56 , pp. 175-180
    • Fukuda, T.1    Nishida, Y.2    Zhou, Q.3    Yamamoto, I.4    Kondo, S.5    Azuma, J.6
  • 76
    • 0028143954 scopus 로고
    • Seizure following addition of erythromycin to clozapine therapy
    • Funderburg, L. G., Vertrees, J. E., True, J. E., Miller, A. L., 1994, Seizure following addition of erythromycin to clozapine therapy, Am. J. Psychiatry. 151, 1840-1841.
    • (1994) Am. J. Psychiatry , vol.151 , pp. 1840-1841
    • Funderburg, L.G.1    Vertrees, J.E.2    True, J.E.3    Miller, A.L.4
  • 77
    • 0025805934 scopus 로고
    • Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism
    • Gaedigk, A., Blum, M., Gaedigk, R., Eichelbaum, M., Meyer, U. A., 1991, Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism, Am. J. Hum. Genet. 48, 943-950.
    • (1991) Am. J. Hum. Genet. , vol.48 , pp. 943-950
    • Gaedigk, A.1    Blum, M.2    Gaedigk, R.3    Eichelbaum, M.4    Meyer, U.A.5
  • 78
    • 0034792584 scopus 로고    scopus 로고
    • Clinical relevance of genetic polymorphisms in the human CYP2C subfamily
    • Goldstein, J. A., 2001, Clinical relevance of genetic polymorphisms in the human CYP2C subfamily, Br. J. Clin. Pharmacol. 52, 349-355.
    • (2001) Br. J. Clin. Pharmacol. , vol.52 , pp. 349-355
    • Goldstein, J.A.1
  • 79
    • 0026651273 scopus 로고
    • Human cytochrome P450: Problems and prospects
    • Gonzales, F. J., 1992, Human cytochrome P450: problems and prospects, Trends Pharmacol. Sci. 13, 346-352.
    • (1992) Trends Pharmacol. Sci. , vol.13 , pp. 346-352
    • Gonzales, F.J.1
  • 80
    • 0017641799 scopus 로고
    • Plasma level monitoring of tricyclic antidepressant therapy
    • Gram, L. F., 1977, Plasma level monitoring of tricyclic antidepressant therapy, Clin. Pharmacokinet. 2, 237-251.
    • (1977) Clin. Pharmacokinet. , vol.2 , pp. 237-251
    • Gram, L.F.1
  • 81
    • 0029016328 scopus 로고
    • Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study
    • Gram, L. F., Guentert, T. W., Grange, S., Vistisen, K., Brøsen, K., 1995, Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: a panel study. Clin. Pharmacol. Ther. 57, 670-677.
    • (1995) Clin. Pharmacol. Ther. , vol.57 , pp. 670-677
    • Gram, L.F.1    Guentert, T.W.2    Grange, S.3    Vistisen, K.4    Brøsen, K.5
  • 82
    • 0002888510 scopus 로고
    • Human cytochrome P450 enzymes
    • Ortiz De La Montellano PR Ed., Plenum Press, New York
    • Guengerich, F. P., 1995, Human cytochrome P450 enzymes. In: Cytochrome P450: structure, mechanism, and biochemistry, Ortiz De La Montellano PR (Ed.), Plenum Press, New York, 473-535.
    • (1995) Cytochrome P450: Structure, Mechanism, and Biochemistry , pp. 473-535
    • Guengerich, F.P.1
  • 83
    • 0033849669 scopus 로고    scopus 로고
    • Risperidone metabolism and the impact of being a cytochrome P450 2D6 ultrarapid metabolizer
    • Güsey, C., Aamo, T., Spigset, O., 2000, Risperidone metabolism and the impact of being a cytochrome P450 2D6 ultrarapid metabolizer, J. Clin. Psychiatry. 61, 600-601.
    • (2000) J. Clin. Psychiatry , vol.61 , pp. 600-601
    • Güsey, C.1    Aamo, T.2    Spigset, O.3
  • 86
    • 0029827303 scopus 로고    scopus 로고
    • The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin
    • Hamelin, B. A., Turgeon, J., Vallee, F., Belanger, P. M., Paquet, F., LeBel, M., 1996, The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin. Clin. Pharmacol. Ther. 60, 512-521.
    • (1996) Clin. Pharmacol. Ther. , vol.60 , pp. 512-521
    • Hamelin, B.A.1    Turgeon, J.2    Vallee, F.3    Belanger, P.M.4    Paquet, F.5    Le Bel, M.6
  • 87
    • 0014128388 scopus 로고
    • Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds
    • Hammer, W., Sjöqvist, F., 1967, Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds, Life Sci. 6, 1895-1903.
    • (1967) Life Sci. , vol.6 , pp. 1895-1903
    • Hammer, W.1    Sjöqvist, F.2
  • 88
    • 0025104037 scopus 로고
    • Influence of plasma related variables on clozapine levels
    • Haring, C., Fleischhacker, W., Schett, P., Humpel, C., 1990, Influence of plasma related variables on clozapine levels, Am. J. Psychiatry. 147, 1471-1475.
    • (1990) Am. J. Psychiatry , vol.147 , pp. 1471-1475
    • Haring, C.1    Fleischhacker, W.2    Schett, P.3    Humpel, C.4
  • 90
    • 0027740188 scopus 로고
    • Relationship between clinical efficacy and clozapine concentration in plasma in schizophrenia: Effect of smoking
    • Hasegawa, M., Guiterrez, R., Way, L., Meltzer, H. Y., 1993, Relationship between clinical efficacy and clozapine concentration in plasma in schizophrenia: effect of smoking, J. Clin. Psychopharmacol. 13, 383-390.
    • (1993) J. Clin. Psychopharmacol. , vol.13 , pp. 383-390
    • Hasegawa, M.1    Guiterrez, R.2    Way, L.3    Meltzer, H.Y.4
  • 91
    • 0028016505 scopus 로고
    • Elevated levels of clozapine in serum after addition of fluvoxamine
    • Hiemke, C., Weigmann, H., Härtter, S. et al., 1994, Elevated levels of clozapine in serum after addition of fluvoxamine, J. Clin. Psychopharmacol. 14, 279-281.
    • (1994) J. Clin. Psychopharmacol. , vol.14 , pp. 279-281
    • Hiemke, C.1    Weigmann, H.2    Härtter, S.3
  • 92
    • 0028801952 scopus 로고
    • Venlafaxine - A review of its pharmacology and therapeutic potential in depression
    • Holliday, S. M., Benfield, P., 1995, Venlafaxine - a review of its pharmacology and therapeutic potential in depression, Drugs. 49, 280-294.
    • (1995) Drugs. , vol.49 , pp. 280-294
    • Holliday, S.M.1    Benfield, P.2
  • 93
    • 0034885445 scopus 로고    scopus 로고
    • Characterization of moclobemide N-oxidation in human liver microsomes
    • Hoskins, J., Shenfield, G., Murray, M., Gross, A., 2001, Characterization of moclobemide N-oxidation in human liver microsomes, Xenobiotica. 31(7), 387-397.
    • (2001) Xenobiotica. , vol.31 , Issue.7 , pp. 387-397
    • Hoskins, J.1    Shenfield, G.2    Murray, M.3    Gross, A.4
  • 94
    • 0027436269 scopus 로고
    • Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects
    • Huang, M. L., Van Peer, A., Woestenborghs, R. et al., 1993, Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects, Clin. Pharmacol. Ther. 54, 257-268.
    • (1993) Clin. Pharmacol. Ther. , vol.54 , pp. 257-268
    • Huang, M.L.1    Van Peer, A.2    Woestenborghs, R.3
  • 95
    • 0027420937 scopus 로고
    • Metabolism of phenothiazine and butyrophenone antipsychotic drugs: A review of some recent research findings and clinical implications
    • Hubbard, J. W., Midha, K. K., Hawe, E. M. et al., 1993, Metabolism of phenothiazine and butyrophenone antipsychotic drugs: a review of some recent research findings and clinical implications, Br. J. Psychiatry. 163, 19-24.
    • (1993) Br. J. Psychiatry , vol.163 , pp. 19-24
    • Hubbard, J.W.1    Midha, K.K.2    Hawe, E.M.3
  • 96
    • 0032793249 scopus 로고    scopus 로고
    • Polymorphic human cytochrome P450 enzymes: An opportunity for individualized drug treatment
    • Ingelman-Sundberg, M., Oscarsson, M., McLellan, R. A., 1999, Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment, Trends Pharmacol. Sci. 20, 342-349 (1999).
    • (1999) Trends Pharmacol. Sci. , vol.20 , pp. 342-349
    • Ingelman-Sundberg, M.1    Oscarsson, M.2    McLellan, R.A.3
  • 98
    • 0035987391 scopus 로고    scopus 로고
    • Maintenance therapy with zuclopenthixol decanoate: Associations between plasma concentrations, neurological side effects and CYP2D6 genotype
    • Jaanson, P., Marandi, T., Kiivet, R. A., Vasar, V., Vään, S., Svensson, J. O., Dahl, M. L., 2002, Maintenance therapy with zuclopenthixol decanoate: associations between plasma concentrations, neurological side effects and CYP2D6 genotype, Psychopharmacol. 162, 67-73.
    • (2002) Psychopharmacol. , vol.162 , pp. 67-73
    • Jaanson, P.1    Marandi, T.2    Kiivet, R.A.3    Vasar, V.4    Vään, S.5    Svensson, J.O.6    Dahl, M.L.7
  • 100
    • 0029930015 scopus 로고    scopus 로고
    • The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclopenthixol
    • Jerling, M., Dahl, M. L., Åberg-Wistedt, A. et al., 1996, The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclopenthixol, Clin. Pharmacol. Ther. 59, 423-428.
    • (1996) Clin. Pharmacol. Ther. , vol.59 , pp. 423-428
    • Jerling, M.1    Dahl, M.L.2    Åberg-Wistedt, A.3
  • 101
    • 0001703176 scopus 로고
    • Metabolism and pharmacokinetics of antipsychotic drugs
    • Joergensen, A., 1986, Metabolism and pharmacokinetics of antipsychotic drugs, Prog. Drug Metabolism. 9, 111-174.
    • (1986) Prog. Drug Metabolism. , vol.9 , pp. 111-174
    • Joergensen, A.1
  • 102
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson, I., Lundqvist, E., Bertilsson, L. et al., 1993, Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine, Proc. Natl. Acad. Sci. USA. 90, 11825-11829.
    • (1993) Proc. Natl. Acad. Sci. USA. , vol.90 , pp. 11825-11829
    • Johansson, I.1    Lundqvist, E.2    Bertilsson, L.3
  • 103
    • 0027965620 scopus 로고
    • Genetic analysis of the Chinese cytochrome P4502D locus: Characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
    • Johansson, I., Oscarson, M., Yue, Q. Y. et al., 1994, Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation, Mol. Pharmacol. 46, 452-459.
    • (1994) Mol. Pharmacol. , vol.46 , pp. 452-459
    • Johansson, I.1    Oscarson, M.2    Yue, Q.Y.3
  • 104
    • 0025036544 scopus 로고
    • Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes
    • Kagimoto, M., Heim, M., Kagimoto, K., Zeugin, T., Meyer, U. A., 1990, Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes, J. Biol. Chem. 265, 17209-17214.
    • (1990) J. Biol. Chem. , vol.265 , pp. 17209-17214
    • Kagimoto, M.1    Heim, M.2    Kagimoto, K.3    Zeugin, T.4    Meyer, U.A.5
  • 105
    • 0031030609 scopus 로고    scopus 로고
    • Disposition and biotransformation of the antipsychotic agent olanzapine in humans
    • Kassahun, K., Mattiuz, E., Nyhart, E. et al., 1997, Disposition and biotransformation of the antipsychotic agent olanzapine in humans, Drug Metab. Dispos. 25, 81-93.
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 81-93
    • Kassahun, K.1    Mattiuz, E.2    Nyhart, E.3
  • 108
    • 0344517077 scopus 로고    scopus 로고
    • Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro
    • Kobayashi, K., Ishizuka, T., Shimada, N., Yoshimura, Y., Kamijima, K., Chiba, K., 1999, Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro, Drug Metab. Dispos. 27, 763-766.
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 763-766
    • Kobayashi, K.1    Ishizuka, T.2    Shimada, N.3    Yoshimura, Y.4    Kamijima, K.5    Chiba, K.6
  • 109
    • 0030434501 scopus 로고    scopus 로고
    • Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers
    • Koyama, E., Chiba, K., Tani, M., Ishizaki, T., 1996, Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers, J. Pharmacol. Exp. Ther. 278, 21-30.
    • (1996) J. Pharmacol. Exp. Ther. , vol.278 , pp. 21-30
    • Koyama, E.1    Chiba, K.2    Tani, M.3    Ishizaki, T.4
  • 110
    • 0030055999 scopus 로고    scopus 로고
    • Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4'-hydroxylation status in Japanese depressive patients
    • Koyama, E., Tanaka, T., Chiba, K., Kawakatsu, S., Morinobu, S., Totsuka, S., Ishizaki, T., 1996, Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4'-hydroxylation status in Japanese depressive patients, J. Clin. Psychopharmacol. 16, 286-293.
    • (1996) J. Clin. Psychopharmacol. , vol.16 , pp. 286-293
    • Koyama, E.1    Tanaka, T.2    Chiba, K.3    Kawakatsu, S.4    Morinobu, S.5    Totsuka, S.6    Ishizaki, T.7
  • 111
    • 0031761931 scopus 로고    scopus 로고
    • Extrapyramidal symptoms after addition of fluvoxamine to clozapine
    • Kuo, F. J., Lane, H. Y., Chang, W. H., 1998, Extrapyramidal symptoms after addition of fluvoxamine to clozapine, J. Clin. Psychopharmacol. 53, 483-484.
    • (1998) J. Clin. Psychopharmacol. , vol.53 , pp. 483-484
    • Kuo, F.J.1    Lane, H.Y.2    Chang, W.H.3
  • 113
    • 0030903753 scopus 로고    scopus 로고
    • Dextromethorphan phenotyping and haloperidol disposition in schizophrenic patients
    • Lane, H. Y., Hu, O. Y. P., Jann, M. W. et al., 1997, Dextromethorphan phenotyping and haloperidol disposition in schizophrenic patients, Psychiatry Res. 69, 105-111.
    • (1997) Psychiatry Res. , vol.69 , pp. 105-111
    • Lane, H.Y.1    Hu, O.Y.P.2    Jann, M.W.3
  • 114
    • 0036263813 scopus 로고    scopus 로고
    • Cytochrome P450 2C9 polymorphisms: A comprehensive review of the in vitro and human data
    • Lee, C. R., Goldstein, J. A., Pieper, J. A., 2002, Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in vitro and human data, Pharmacogenetics. 12, 251-263.
    • (2002) Pharmacogenetics. , vol.12 , pp. 251-263
    • Lee, C.R.1    Goldstein, J.A.2    Pieper, J.A.3
  • 116
    • 0032847231 scopus 로고    scopus 로고
    • Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans
    • Lessard, E., Yessine, M. A., Hamelin, B. A., O'Hara, G., LeBlanc, J., Turgeon, J., 1999, Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans, Pharmacogenetics. 9, 435-443.
    • (1999) Pharmacogenetics. , vol.9 , pp. 435-443
    • Lessard, E.1    Yessine, M.A.2    Hamelin, B.A.3    O'Hara, G.4    Le Blanc, J.5    Turgeon, J.6
  • 117
    • 0031434742 scopus 로고    scopus 로고
    • Metabolism of clozapine by cDNA expressed human cytochrome P450 enzymes
    • Linnet, K., Olesen O. V., 1997, Metabolism of clozapine by cDNA expressed human cytochrome P450 enzymes, Drug Metab. Dispos. 25, 1379-1382.
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 1379-1382
    • Linnet, K.1    Olesen, O.V.2
  • 118
    • 0029738332 scopus 로고    scopus 로고
    • Steady-state serum concentrations of the neuroleptic perphenazine in relation to CYP2D6 genetic polymorphism
    • Linnet, K., Wiborg, O., 1996, Steady-state serum concentrations of the neuroleptic perphenazine in relation to CYP2D6 genetic polymorphism, Clin. Pharmacol. Ther. 60, 41-47.
    • (1996) Clin. Pharmacol. Ther. , vol.60 , pp. 41-47
    • Linnet, K.1    Wiborg, O.2
  • 119
    • 0029805032 scopus 로고    scopus 로고
    • Influence of CYP2D6 genetic polymorphism on ratios of steady-state serum concentrations to dose of the neuroleptic zuclopenthixol
    • Linnet, K., Wiborg, O., 1996, Influence of CYP2D6 genetic polymorphism on ratios of steady-state serum concentrations to dose of the neuroleptic zuclopenthixol. Ther. Drug. Monit. 18, 629-634.
    • (1996) Ther. Drug. Monit. , vol.18 , pp. 629-634
    • Linnet, K.1    Wiborg, O.2
  • 121
    • 0035132770 scopus 로고    scopus 로고
    • Effects of CYP2C19 genotype and CYP2C9 on fluoxetine N-demethylation in human liver microsomes
    • Liu, Z.-Q., Shu, Y., Huang, S.-L., Wang, L.-S., He, N., Zhou, H.-H., 2001, Effects of CYP2C19 genotype and CYP2C9 on fluoxetine N-demethylation in human liver microsomes, Acta. Pharmacol. Sin. 22(1), 85-90.
    • (2001) Acta. Pharmacol. Sin. , vol.22 , Issue.1 , pp. 85-90
    • Liu, Z.-Q.1    Shu, Y.2    Huang, S.-L.3    Wang, L.-S.4    He, N.5    Zhou, H.-H.6
  • 122
    • 0036138239 scopus 로고    scopus 로고
    • O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes
    • Liu, Z.-Q., Zhu, B., Tan, Y.-F., Tan, Z.-R., Wang, L.-S., Huang, S.-L., Shu, Y., Zhou, H.-H., 2001, O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes, J. Pharmacol. Exp. Ther. 299, 105-111.
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 105-111
    • Liu, Z.-Q.1    Zhu, B.2    Tan, Y.-F.3    Tan, Z.-R.4    Wang, L.-S.5    Huang, S.-L.6    Shu, Y.7    Zhou, H.-H.8
  • 123
    • 0026692983 scopus 로고
    • Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype
    • Llerena, A., Alm, C., Dahl, M. L. et al., 1992, Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype, Ther. Drug Monit. 14, 92-97.
    • (1992) Ther. Drug Monit. , vol.14 , pp. 92-97
    • Llerena, A.1    Alm, C.2    Dahl, M.L.3
  • 124
    • 0026780430 scopus 로고
    • Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: Increased plasma levels of the reduced metabolite in poor metabolizers
    • Llerena, A., Dahl, M. L., Ekqvist, B. et al., 1992, Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers, Ther. Drug Monit. 14, 261-264.
    • (1992) Ther. Drug Monit. , vol.14 , pp. 261-264
    • Llerena, A.1    Dahl, M.L.2    Ekqvist, B.3
  • 125
    • 84890193119 scopus 로고    scopus 로고
    • Influence of CYP2D6 and CYP2C9 genotypes on fluoxetine plasma concentrations in psychiatric patients: European Collaboration: Towards Drug Development and Rational Drug Therapy
    • F. C. Tulunay, M. Orme, Istanbul, June 24-28
    • Llerena, A., Dorado, P., Berecz, R., González, A. P., Cáceres, M. C., 2003, Influence of CYP2D6 and CYP2C9 genotypes on fluoxetine plasma concentrations in psychiatric patients: European Collaboration: Towards Drug Development and Rational Drug Therapy, eds. F. C. Tulunay, M. Orme, Proceedings of the Sixth Congress of the European Association for Clinical Pharmacology and Therapeutics, Istanbul, June 24-28.
    • (2003) Proceedings of the Sixth Congress of the European Association for Clinical Pharmacology and Therapeutics
    • Llerena, A.1    Dorado, P.2    Berecz, R.3    González, A.P.4    Cáceres, M.C.5
  • 126
    • 0031770968 scopus 로고    scopus 로고
    • A pharmacokinetic interaction between carbamazepine and olanzapine: Observations on possible mechanisms
    • Lucas, R. A., Gilfillan, D. J., Bergstrom, R. F., 1998, A pharmacokinetic interaction between carbamazepine and olanzapine: observations on possible mechanisms, Eur. J. Clin. Pharmacol. 54, 639-643.
    • (1998) Eur. J. Clin. Pharmacol. , vol.54 , pp. 639-643
    • Lucas, R.A.1    Gilfillan, D.J.2    Bergstrom, R.F.3
  • 127
    • 14444283041 scopus 로고    scopus 로고
    • Pharmacokinetic (Pk) and pharmacodynamic (Pd) interactions between fluvoxamine and olanzapine
    • Mäenpää, J., Wrightson, S., Bergstrom, R. et al., 1997, Pharmacokinetic (Pk) and pharmacodynamic (Pd) interactions between fluvoxamine and olanzapine, Clin. Pharmacol. Ther. 61, 225.
    • (1997) Clin. Pharmacol. Ther. , vol.61 , pp. 225
    • Mäenpää, J.1    Wrightson, S.2    Bergstrom, R.3
  • 128
    • 0017695082 scopus 로고
    • Polymorphic hydroxylation of debrisoquine in man
    • Mahgoub, A., Idle, J. R., Dring, L. G., et al., 1977, Polymorphic hydroxylation of debrisoquine in man, Lancet 2, 584-586.
    • (1977) Lancet , vol.2 , pp. 584-586
    • Mahgoub, A.1    Idle, J.R.2    Dring, L.G.3
  • 129
    • 0027433081 scopus 로고
    • Absorption, metabolism, and excretion of risperidone in humans
    • Mannens, G., Huang, M. L., Meuldermans, W. et al., 1993, Absorption, metabolism, and excretion of risperidone in humans, Drug Metab. Dispos. 21, 1134-1141.
    • (1993) Drug Metab. Dispos. , vol.21 , pp. 1134-1141
    • Mannens, G.1    Huang, M.L.2    Meuldermans, W.3
  • 130
  • 131
    • 0032902281 scopus 로고    scopus 로고
    • Suspected ciprofloxacin inhibition of olanzapine resulting in increased plasma concentrations
    • Markowitz, J. S., Devane, C. L., 1999, Suspected ciprofloxacin inhibition of olanzapine resulting in increased plasma concentrations, J. Clin. Psychopharmacol. 19, 289-291.
    • (1999) J. Clin. Psychopharmacol. , vol.19 , pp. 289-291
    • Markowitz, J.S.1    Devane, C.L.2
  • 133
    • 0022481136 scopus 로고
    • Amitriptyline metabolism: Association with debrisoquin hydroxylation in nonsmokers
    • Mellström, B., Säwe, J., Bertilsson, L., Sjöqvist, F., 1986, Amitriptyline metabolism: association with debrisoquin hydroxylation in nonsmokers, Clin. Pharmacol. Ther. 39, 369-371.
    • (1986) Clin. Pharmacol. Ther. , vol.39 , pp. 369-371
    • Mellström, B.1    Säwe, J.2    Bertilsson, L.3    Sjöqvist, F.4
  • 134
    • 0025602984 scopus 로고
    • Clinical implications of slow sulphoxidation of thioridazine in a poor metabolizer of the debrisoquine type
    • Meyer, J. W., Woggon, B., Baumann, P. et al., 1990, Clinical implications of slow sulphoxidation of thioridazine in a poor metabolizer of the debrisoquine type, Eur. J. Clin. Pharmacol. 39, 613-614.
    • (1990) Eur. J. Clin. Pharmacol. , vol.39 , pp. 613-614
    • Meyer, J.W.1    Woggon, B.2    Baumann, P.3
  • 135
    • 0034015675 scopus 로고    scopus 로고
    • The effect of carbamazepine on the steady-state pharmacokinetics of ziprasidone in healthy volunteers
    • Miceli, J. J., Anziano, R. J., Robarge, L., Hansen, R. A., Laurent, A., 2000, The effect of carbamazepine on the steady-state pharmacokinetics of ziprasidone in healthy volunteers, Br. J. Clin. Pharmacol. 49(Suppl. 1), 65s-70s.
    • (2000) Br. J. Clin. Pharmacol. , vol.49 , Issue.SUPPL. 1
    • Miceli, J.J.1    Anziano, R.J.2    Robarge, L.3    Hansen, R.A.4    Laurent, A.5
  • 136
    • 0034059620 scopus 로고    scopus 로고
    • The effects of ketoconazole on ziprasidone pharmacokinetics: A placebo-controlled crossover study in healthy volunteers
    • Miceli, J. J., Smith, M., Robarge, L., Morse, T., Laurent, A., 2000, The effects of ketoconazole on ziprasidone pharmacokinetics: a placebo-controlled crossover study in healthy volunteers, Br. J. Clin. Pharmacol. 49(Suppl. 1), 71s-76s.
    • (2000) Br. J. Clin. Pharmacol. , vol.49 , Issue.SUPPL. 1
    • Miceli, J.J.1    Smith, M.2    Robarge, L.3    Morse, T.4    Laurent, A.5
  • 138
    • 0031400024 scopus 로고    scopus 로고
    • The CYP2D6 genotype and plasma concentrations of mianserin enantiomers in relation to therapeutic response to mianserin in depressed Japanese patients
    • Mihara, K., Otani, K., Tybring, G., Dahl, M. L., Bertilsson, L., Kaneko, S., 1997, The CYP2D6 genotype and plasma concentrations of mianserin enantiomers in relation to therapeutic response to mianserin in depressed Japanese patients, J. Clin. Psychopharmacol. 17, 467-471.
    • (1997) J. Clin. Psychopharmacol. , vol.17 , pp. 467-471
    • Mihara, K.1    Otani, K.2    Tybring, G.3    Dahl, M.L.4    Bertilsson, L.5    Kaneko, S.6
  • 139
    • 0032588999 scopus 로고    scopus 로고
    • *10 allele on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia
    • *10 allele on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia, Clin. Pharmacol. Ther. 65, 291-294.
    • (1999) Clin. Pharmacol. Ther. , vol.65 , pp. 291-294
    • Mihara, K.1    Suzuki, A.2    Kondo, T.3
  • 140
    • 0034048082 scopus 로고    scopus 로고
    • Effect of a genetic polymorphism of CYP1A2 inducibility on the steady state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia
    • Mihara, K., Suzuki, A., Kondo, T. et al., 2000, Effect of a genetic polymorphism of CYP1A2 inducibility on the steady state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia, Ther. Drug Monit. 22, 245-249.
    • (2000) Ther. Drug Monit. , vol.22 , pp. 245-249
    • Mihara, K.1    Suzuki, A.2    Kondo, T.3
  • 141
    • 0031841377 scopus 로고    scopus 로고
    • Cytochrome P4502C9: An enzyme of major importance in human drug metabolism
    • Miners, J. O., Birkett, D. J., 1998, Cytochrome P4502C9: an enzyme of major importance in human drug metabolism, Br. J. Clin. Pharmacol. 45, 525-538.
    • (1998) Br. J. Clin. Pharmacol. , vol.45 , pp. 525-538
    • Miners, J.O.1    Birkett, D.J.2
  • 142
    • 0030872484 scopus 로고    scopus 로고
    • Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy
    • Morinobu, S., Tanaka, T., Kawakatsu, S., Totsuka, S., Koyama, E., Chiba, K., Ishizaki, T., Kubota, T., 1997, Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy, Psychiatry. Clin. Neurosci. 51, 253-257.
    • (1997) Psychiatry. Clin. Neurosci. , vol.51 , pp. 253-257
    • Morinobu, S.1    Tanaka, T.2    Kawakatsu, S.3    Totsuka, S.4    Koyama, E.5    Chiba, K.6    Ishizaki, T.7    Kubota, T.8
  • 143
    • 0034115770 scopus 로고    scopus 로고
    • Steady-state plasma levels of nortriptyline and its hydroxylated metabolites in Japanese patients: Impact of CYP2D6 genotype on the hydroxylation of nortriptyline
    • Morita, S., Shimoda, K., Someya, T., Yoshimura, Y., Kamijima, K., Kato, N., 2000, Steady-state plasma levels of nortriptyline and its hydroxylated metabolites in Japanese patients: Impact of CYP2D6 genotype on the hydroxylation of nortriptyline, J. Clin. Psychopharmacol. 20, 141-149.
    • (2000) J. Clin. Psychopharmacol. , vol.20 , pp. 141-149
    • Morita, S.1    Shimoda, K.2    Someya, T.3    Yoshimura, Y.4    Kamijima, K.5    Kato, N.6
  • 144
    • 0032929010 scopus 로고    scopus 로고
    • Genetic polymorphism in the 5'-Flanking region of human CYP1A2 gene: Effect on the CYP1A2 inducibility in humans
    • Nakajima, M., Yokoi, T., Mizutani, M. et al., 1999, Genetic polymorphism in the 5'-Flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans, J. Biochem. 125, 803-808.
    • (1999) J. Biochem. , vol.125 , pp. 803-808
    • Nakajima, M.1    Yokoi, T.2    Mizutani, M.3
  • 145
    • 9044254525 scopus 로고    scopus 로고
    • P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
    • Nelson, D. R., Koymans, L., Kamataki, T. et al., 1996, P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature, Pharmacogenetics 6, 1-42.
    • (1996) Pharmacogenetics , vol.6 , pp. 1-42
    • Nelson, D.R.1    Koymans, L.2    Kamataki, T.3
  • 146
    • 0028813788 scopus 로고
    • Active hydroxymetabolites of antidepressants. Emphasis on E-10-hydroxy-nortriptyline
    • Nordin, C., Bertilsson, L., 1995, Active hydroxymetabolites of antidepressants. Emphasis on E-10-hydroxy-nortriptyline, Clin. Pharmacokinet. 28, 26-40.
    • (1995) Clin. Pharmacokinet. , vol.28 , pp. 26-40
    • Nordin, C.1    Bertilsson, L.2
  • 147
    • 0021933958 scopus 로고
    • Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients-relationship to the debrisoquine hydroxylation metabolic ratio
    • Nordin, C., Siwers, B., Benitez, J., Bertilsson, L., 1985, Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients-relationship to the debrisoquine hydroxylation metabolic ratio, Br. J. Clin. Pharmacol. 19, 832-835.
    • (1985) Br. J. Clin. Pharmacol. , vol.19 , pp. 832-835
    • Nordin, C.1    Siwers, B.2    Benitez, J.3    Bertilsson, L.4
  • 148
    • 0028982509 scopus 로고
    • D2 Dopamine receptor occupancy during low-dose treatment with haloperidol decanoate
    • Nyberg, S., Farde, L., Halldin, C. et al., 1995, D2 Dopamine receptor occupancy during low-dose treatment with haloperidol decanoate, Am. J.
    • (1995) Am. J. Psychiatry , vol.152 , pp. 173-178
    • Nyberg, S.1    Farde, L.2    Halldin, C.3
  • 149
    • 0032572599 scopus 로고    scopus 로고
    • Tardive dyskinesia and debrisoquine 4-hydroxylase (CYP2D6) genotype in Japanese schizophrenics
    • Ohmori, O., Suzuki, T., Kojima, H. et al., 1998, Tardive dyskinesia and debrisoquine 4-hydroxylase (CYP2D6) genotype in Japanese schizophrenics, Schizophr. Res. 32, 107-113.
    • (1998) Schizophr. Res. , vol.32 , pp. 107-113
    • Ohmori, O.1    Suzuki, T.2    Kojima, H.3
  • 150
    • 0031828859 scopus 로고    scopus 로고
    • Serum concentrations and side effects in psychiatric patients during risperidone therapy
    • Olesen, O. V., Licht, R. W., Thomsen, E. et al., 1998, Serum concentrations and side effects in psychiatric patients during risperidone therapy, Ther. Drug Monit. 20, 380-384.
    • (1998) Ther. Drug Monit. , vol.20 , pp. 380-384
    • Olesen, O.V.1    Licht, R.W.2    Thomsen, E.3
  • 151
    • 0033055756 scopus 로고    scopus 로고
    • Olanzapine serum concentrations in psychiatric patients given standard doses: The influence of comedication
    • Olesen, O. V., Linnet, K., 1999, Olanzapine serum concentrations in psychiatric patients given standard doses: the influence of comedication, Ther. Drug Monit. 21, 87-90.
    • (1999) Ther. Drug Monit. , vol.21 , pp. 87-90
    • Olesen, O.V.1    Linnet, K.2
  • 152
    • 0034530735 scopus 로고    scopus 로고
    • Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine
    • Olesen, O. V., Linnet, K., 2000, Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine, Br. J. Clin. Pharmacol. 50, 563-571.
    • (2000) Br. J. Clin. Pharmacol. , vol.50 , pp. 563-571
    • Olesen, O.V.1    Linnet, K.2
  • 153
    • 0029964624 scopus 로고    scopus 로고
    • Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine
    • Otani, K., Ishida M., Kaneko, S., Mihara, K., Ohkubo, T., Osanai, T., Sugawara, K., 1996, Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, Ther. Drug Monit. 18, 164-167.
    • (1996) Ther. Drug Monit. , vol.18 , pp. 164-167
    • Otani, K.1    Ishida, M.2    Kaneko, S.3    Mihara, K.4    Ohkubo, T.5    Osanai, T.6    Sugawara, K.7
  • 155
    • 18244426328 scopus 로고    scopus 로고
    • Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C? A polymorphism in intron 1 of the CYP1A2 gene: Effect of grapefruit juice and low-dose fluvoxamine
    • Özdemir, V., Kalow, W., Okey, A. B. et al., 2001, Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C? A polymorphism in intron 1 of the CYP1A2 gene: effect of grapefruit juice and low-dose fluvoxamine, J. Clin. Psychopharmacol. 21, 603-607.
    • (2001) J. Clin. Psychopharmacol. , vol.21 , pp. 603-607
    • Özdemir, V.1    Kalow, W.2    Okey, A.B.3
  • 156
    • 0031225744 scopus 로고    scopus 로고
    • Paroxetine potentiates the central nervous system side effects of perphenazine: Contribution of cytochrome P4502D6 inhibition in vivo
    • Özdemir, V., Naranjo, C. A., Herrmann, N., Reed, K., Sellers, E. M., Kalow, W., 1997, Paroxetine potentiates the central nervous system side effects of perphenazine: contribution of cytochrome P4502D6 inhibition in vivo, Clin. Pharmacol. Ther. 62, 334-347.
    • (1997) Clin. Pharmacol. Ther. , vol.62 , pp. 334-347
    • Özdemir, V.1    Naranjo, C.A.2    Herrmann, N.3    Reed, K.4    Sellers, E.M.5    Kalow, W.6
  • 158
    • 0032860134 scopus 로고    scopus 로고
    • In vitro study on the involvement of CYP1A2, CYP2D6 and CYP3A4 in the metabolism of haloperidol and reduced haloperidol
    • Pan, L., Belpaire, F. M., 1999, In vitro study on the involvement of CYP1A2, CYP2D6 and CYP3A4 in the metabolism of haloperidol and reduced haloperidol, Eur. J. Clin. Pharmacol. 55, 599-604.
    • (1999) Eur. J. Clin. Pharmacol. , vol.55 , pp. 599-604
    • Pan, L.1    Belpaire, F.M.2
  • 159
    • 0032852407 scopus 로고    scopus 로고
    • Effects of smoking, CYP2D6 genotype, and concomitant drug intake on the steady state plasma concentrations of haloperidol and reduced haloperidol in schizophrenic inpatients
    • Pan, L., Vander Stichele, R., Rosseel, M. T. et al., 1999, Effects of smoking, CYP2D6 genotype, and concomitant drug intake on the steady state plasma concentrations of haloperidol and reduced haloperidol in schizophrenic inpatients, Ther. Drug Monit. 21, 489-497.
    • (1999) Ther. Drug Monit. , vol.21 , pp. 489-497
    • Pan, L.1    Vander Stichele, R.2    Rosseel, M.T.3
  • 160
    • 0028944753 scopus 로고
    • Metabolism and bioactivation of clozapine by human liver in vitro
    • Pirmohamed, M., Williams, D., Madden, S. et al., 1995, Metabolism and bioactivation of clozapine by human liver in vitro, J. Pharmacol. Exp. Ther. 272, 984-990.
    • (1995) J. Pharmacol. Exp. Ther. , vol.272 , pp. 984-990
    • Pirmohamed, M.1    Williams, D.2    Madden, S.3
  • 161
    • 0028822641 scopus 로고
    • Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia
    • Pollock, B. G., Mulsant, B. H., Sweet, R. A. et al., 1995, Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia, Psychopharmacol. Bulletin 31, 327-331.
    • (1995) Psychopharmacol. Bulletin , vol.31 , pp. 327-331
    • Pollock, B.G.1    Mulsant, B.H.2    Sweet, R.A.3
  • 162
    • 0034014925 scopus 로고    scopus 로고
    • Identification of the major human liver cytochrome P450 isoform (s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions
    • Prakash, C., Kamel, A., Cui, D. et al., 2000, Identification of the major human liver cytochrome P450 isoform (s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions, Br. J. Clin. Pharmacol. 49(Suppl I), 35s-42s.
    • (2000) Br. J. Clin. Pharmacol. , vol.49 , Issue.SUPPL. I
    • Prakash, C.1    Kamel, A.2    Cui, D.3
  • 163
    • 0027375143 scopus 로고
    • Pharmacokinetics of antidepressants: Why and how they are relevant to treatment
    • Preskorn, S. H., 1993, Pharmacokinetics of antidepressants: Why and how they are relevant to treatment, J. Clin. Psychiatry. 54(9), 14-34.
    • (1993) J. Clin. Psychiatry , vol.54 , Issue.9 , pp. 14-34
    • Preskorn, S.H.1
  • 164
    • 0031948562 scopus 로고    scopus 로고
    • Serum concentrations of clozapine and N-desmethylclozapine are unaffected by the potent CYP3A4 inhibitor itraconazole
    • Raaska, K., Neuvonen, P. J., 1998, Serum concentrations of clozapine and N-desmethylclozapine are unaffected by the potent CYP3A4 inhibitor itraconazole, Eur. J. Clin. Pharmacol. 54, 167-170.
    • (1998) Eur. J. Clin. Pharmacol. , vol.54 , pp. 167-170
    • Raaska, K.1    Neuvonen, P.J.2
  • 165
    • 0034075099 scopus 로고    scopus 로고
    • Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors?
    • Rasmussen, B. B., Brøsen, K., 2000, Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors?, Ther. Drug. Monit. 22(2), 143-154.
    • (2000) Ther. Drug. Monit. , vol.22 , Issue.2 , pp. 143-154
    • Rasmussen, B.B.1    Brøsen, K.2
  • 166
    • 0026621673 scopus 로고
    • Racial and gender differences in N-acetyltransferase, xanthine oxidase and CYP1A2 activities
    • Relling, M. V., Lin, J. S., Ayers, G. D., Evans, W. E., 1992, Racial and gender differences in N-acetyltransferase, xanthine oxidase and CYP1A2 activities, Clin. Pharmacol. Ther. 52, 643-658.
    • (1992) Clin. Pharmacol. Ther. , vol.52 , pp. 643-658
    • Relling, M.V.1    Lin, J.S.2    Ayers, G.D.3    Evans, W.E.4
  • 168
    • 0030077735 scopus 로고    scopus 로고
    • Identification of the human cytochrome P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine
    • Ring, B. J., Catlow, J., Lindsay, T. J. et al., 1996, Identification of the human cytochrome P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine, J. Pharmacol. Exp. Ther. 276, 658-666.
    • (1996) J. Pharmacol. Exp. Ther. , vol.276 , pp. 658-666
    • Ring, B.J.1    Catlow, J.2    Lindsay, T.J.3
  • 169
    • 0030957623 scopus 로고    scopus 로고
    • Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes
    • Rochat, B., Amey, M., Gillet, M., Meyer, U. A., Baumann, P., 1997, Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes, Pharmacogenetics 7, 1-10.
    • (1997) Pharmacogenetics , vol.7 , pp. 1-10
    • Rochat, B.1    Amey, M.2    Gillet, M.3    Meyer, U.A.4    Baumann, P.5
  • 170
    • 0035464647 scopus 로고    scopus 로고
    • Plasma concentrations of haloperidol and its reduced metabolite are related to the CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients
    • Roh, H. K., Chung, J. Y., Oh, D. Y. et al., 2001, Plasma concentrations of haloperidol and its reduced metabolite are related to the CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients, Br. J. Clin. Pharmacol. 52, 265-271.
    • (2001) Br. J. Clin. Pharmacol. , vol.52 , pp. 265-271
    • Roh, H.K.1    Chung, J.Y.2    Oh, D.Y.3
  • 171
    • 0032402384 scopus 로고    scopus 로고
    • Human CYP2D6 and metabolism of m-chlorophenylpiperazine
    • Rotzinger, S., Fang, J., Coutts, RT., Baker, G. B., 1998, Human CYP2D6 and metabolism of m-chlorophenylpiperazine, Biol. Psychiatry 44, 1185-1191.
    • (1998) Biol. Psychiatry , vol.44 , pp. 1185-1191
    • Rotzinger, S.1    Fang, J.2    Coutts, R.T.3    Baker, G.B.4
  • 172
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • Sachse, C., Brockmöller, J., Bauer, S., Roots, I., 1997, Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences, Am. J. Hum. Genet. 60, 284-295.
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 284-295
    • Sachse, C.1    Brockmöller, J.2    Bauer, S.3    Roots, I.4
  • 173
    • 0032908778 scopus 로고    scopus 로고
    • Functional significance of a C? A polymorphism in Intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine
    • Sachse, C., Brockmöller, J., Bauer, S. et al., 1999, Functional significance of a C? A polymorphism in Intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine, Br. J. Clin. Pharmacol. 47, 445-449.
    • (1999) Br. J. Clin. Pharmacol. , vol.47 , pp. 445-449
    • Sachse, C.1    Brockmöller, J.2    Bauer, S.3
  • 174
    • 84890229857 scopus 로고    scopus 로고
    • Frequency of CYP2D6 genotypes in schizophrenic patients and relation to antipsychotic therapy. Proceedings of the VII World Conference on Clinical Pharmacology and Therapeutics & 4th Congress of the European Association for Clinical Pharmacology and Therapeutics. Florence
    • Sachse, C., Schmider, J., Kanitz, P. et al., 2000, Frequency of CYP2D6 genotypes in schizophrenic patients and relation to antipsychotic therapy. Proceedings of the VII World Conference on Clinical Pharmacology and Therapeutics & 4th Congress of the European Association for Clinical Pharmacology and Therapeutics. Florence, Italy.
    • (2000) Italy
    • Sachse, C.1    Schmider, J.2    Kanitz, P.3
  • 175
    • 0033632228 scopus 로고    scopus 로고
    • CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: Evidence for an allelic variant with altered catalytic activity
    • Sata, F., Sapone, A., Elizondo, G. et al., 2000, CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity, Clin. Pharmacol. Ther. 67, 48-56.
    • (2000) Clin. Pharmacol. Ther. , vol.67 , pp. 48-56
    • Sata, F.1    Sapone, A.2    Elizondo, G.3
  • 176
    • 0035828077 scopus 로고    scopus 로고
    • Lack of association between a functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene and tardive dyskinesia in schizophrenia
    • Schulze, T. G., Schumacher, J., Muller, D. J. et al., 2001, Lack of association between a functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene and tardive dyskinesia in schizophrenia, Am. J. Med. Genet. 105, 498-501.
    • (2001) Am. J. Med. Genet. , vol.105 , pp. 498-501
    • Schulze, T.G.1    Schumacher, J.2    Muller, D.J.3
  • 177
    • 84890168172 scopus 로고    scopus 로고
    • Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on plasma levels of fluoxetine and norfluoxetine enantiomers: European Collaboration: Towards Drug Development and Rational Drug Therapy
    • F. C. Tulunay, M. Orme, Istanbul, June 24-28
    • Scordo, M. G., Spina, E. Dahl, M-L., Gatti, G., Perucca, E., 2003, Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on plasma levels of fluoxetine and norfluoxetine enantiomers: European Collaboration: Towards Drug Development and Rational Drug Therapy, eds. F. C. Tulunay, M. Orme, Proceedings of the Sixth Congress of the European Association for Clinical Pharmacology and Therapeutics, Istanbul, June 24-28.
    • (2003) Proceedings of the Sixth Congress of the European Association for Clinical Pharmacology and Therapeutics
    • Scordo, M.G.1    Spina, E.2    Dahl, M.-L.3    Gatti, G.4    Perucca, E.5
  • 179
    • 0036914221 scopus 로고    scopus 로고
    • Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance
    • Scordo, M. G., Pengo, V. Spina, E. Dahl, M. L. Gusella, M. Padrini, R., 2002, Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance, Clin. Pharmacol. Ther. 72, 702-710.
    • (2002) Clin. Pharmacol. Ther. , vol.72 , pp. 702-710
    • Scordo, M.G.1    Pengo, V.S.2    Dahl, E.3    Gusella, M.L.4    Padrini, M.R.5
  • 180
    • 0033987060 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone
    • Scordo, M. G., Spina, E., Facciolà, G. et al., 1999, Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone, Psychopharmacology 147, 300-305.
    • (1999) Psychopharmacology , vol.147 , pp. 300-305
    • Scordo, M.G.1    Spina, E.2    Facciolà, G.3
  • 181
    • 0034467571 scopus 로고    scopus 로고
    • CYP2D6 genotype and antipsychotic-induced extrapyramidal side-effecs in schizophrenic patients
    • Scordo, M. G., Spina, E., Romeo, P. et al., 2000, CYP2D6 genotype and antipsychotic-induced extrapyramidal side-effecs in schizophrenic patients, Eur. J. Clin. Pharmacol. 56, 679-683.
    • (2000) Eur. J. Clin. Pharmacol. , vol.56 , pp. 679-683
    • Scordo, M.G.1    Spina, E.2    Romeo, P.3
  • 182
    • 0036119445 scopus 로고    scopus 로고
    • Cytochrome P450 polymorphisms and response to antipsychotic therapy
    • Scordo, M. G., Spina, E., 2002, Cytochrome P450 polymorphisms and response to antipsychotic therapy, Pharmacogenomics 3, 201-218.
    • (2002) Pharmacogenomics , vol.3 , pp. 201-218
    • Scordo, M.G.1    Spina, E.2
  • 183
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada, T., Yamazaki, H., Mimura, M. et al., 1994, Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians, J. Pharmacol. Exp. Ther. 270, 414-423.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3
  • 184
    • 0033624471 scopus 로고    scopus 로고
    • *10 alleles are not the determinant of the plasma haloperidol concentrations in Asian patients
    • *10 alleles are not the determinant of the plasma haloperidol concentrations in Asian patients, Ther. Drug Monit. 122, 392-396.
    • (2000) Ther. Drug Monit. , vol.122 , pp. 392-396
    • Shimoda, K.1    Morita, S.2    Someya, T.3
  • 185
    • 0033007984 scopus 로고    scopus 로고
    • Lower plasma levels of haloperidol in smoking than in nonsmoking schizophrenic patients
    • Shimoda, K., Someya, T., Morita, S. et al., 1999, Lower plasma levels of haloperidol in smoking than in nonsmoking schizophrenic patients, Ther. Drug Monit. 21, 293-296.
    • (1999) Ther. Drug Monit. , vol.21 , pp. 293-296
    • Shimoda, K.1    Someya, T.2    Morita, S.3
  • 186
    • 0026576928 scopus 로고
    • Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: Nonlinearity and relation to the sparteine oxidation polymorphism
    • Sindrup, S. H., Brøsen, K., Gram, L. F., 1992, Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: nonlinearity and relation to the sparteine oxidation polymorphism, Clin. Pharmacol. Ther. 51, 288-295.
    • (1992) Clin. Pharmacol. Ther. , vol.51 , pp. 288-295
    • Sindrup, S.H.1    Brøsen, K.2    Gram, L.F.3
  • 188
    • 0027472058 scopus 로고
    • Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms
    • Sindrup, S. H., Brøsen, K., Hansen, M. G., Aaes-Jorgensen, T., Overo, K. F., Gram, L. F., 1993, Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms, Ther. Drug. Monit. 15, 11-17.
    • (1993) Ther. Drug. Monit. , vol.15 , pp. 11-17
    • Sindrup, S.H.1    Brøsen, K.2    Hansen, M.G.3    Aaes-Jorgensen, T.4    Overo, K.F.5    Gram, L.F.6
  • 189
    • 0025964524 scopus 로고
    • The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine
    • Skjelbo, E., Brøsen, K., Hallas, J., Gram, L. F., 1991, The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine, Clin. Pharmacol. Ther. 49, 18-23.
    • (1991) Clin. Pharmacol. Ther. , vol.49 , pp. 18-23
    • Skjelbo, E.1    Brøsen, K.2    Hallas, J.3    Gram, L.F.4
  • 190
    • 0032752546 scopus 로고    scopus 로고
    • The effect of cytochrome P450 2D6 genotypes on haloperidol metabolism: A preliminary study in a psychiatric population
    • Someya, T., Suzuki, Y., Shimoda, K. et al., 1999, The effect of cytochrome P450 2D6 genotypes on haloperidol metabolism: a preliminary study in a psychiatric population, Psychiatry and Clinical Neurosciences 53, 593-597.
    • (1999) Psychiatry and Clinical Neurosciences , vol.53 , pp. 593-597
    • Someya, T.1    Suzuki, Y.2    Shimoda, K.3
  • 193
    • 0030957166 scopus 로고    scopus 로고
    • Relationship between fluvoxamine pharmacokinetics and CYP2D6/CYP2C19 phenotype polymorphisms
    • Spigset, O., Granberg, K., Hagg, S., Norstrom, A., Dahlqvist, R., 1997, Relationship between fluvoxamine pharmacokinetics and CYP2D6/CYP2C19 phenotype polymorphisms, Eur. J. Clin. Pharmacol. 52, 129-133.
    • (1997) Eur. J. Clin. Pharmacol. , vol.52 , pp. 129-133
    • Spigset, O.1    Granberg, K.2    Hagg, S.3    Norstrom, A.4    Dahlqvist, R.5
  • 194
    • 0033044370 scopus 로고    scopus 로고
    • Lack of correlation between fluvoxamine clearance and CYP1A2 activity as measured by systemic caffeine clearance
    • Spigset, O., Hägg, S., Söderström, E., Dahlqvist, R., 1999, Lack of correlation between fluvoxamine clearance and CYP1A2 activity as measured by systemic caffeine clearance, Eur. J. Clin. Pharmacol. 54, 943-946.
    • (1999) Eur. J. Clin. Pharmacol. , vol.54 , pp. 943-946
    • Spigset, O.1    Hägg, S.2    Söderström, E.3    Dahlqvist, R.4
  • 195
    • 0030659112 scopus 로고    scopus 로고
    • Seizures and myoclonus, associated with antidepressant treatment: Assessment of potential risk factors, including CYP2D6 and CYP2C19 polymorphisms, and treatment with CYP2D6 inhibitors
    • Spigset, O., Hedenmalm, K., Dahl, M.-L., Wiholm, B.-E., Dahlqvist, R., 1997, Seizures and myoclonus, associated with antidepressant treatment: assessment of potential risk factors, including CYP2D6 and CYP2C19 polymorphisms, and treatment with CYP2D6 inhibitors, Acta. Psychiatr. Scand. 96, 379-384.
    • (1997) Acta. Psychiatr. Scand. , vol.96 , pp. 379-384
    • Spigset, O.1    Hedenmalm, K.2    Dahl, M.-L.3    Wiholm, B.-E.4    Dahlqvist, R.5
  • 196
    • 0026501881 scopus 로고
    • Polymorphic debrisoquine oxidation and acute neuroleptic-induced adverse effects
    • Spina, E., Ancione, M., Di Rosa, A. E. et al., 1992, Polymorphic debrisoquine oxidation and acute neuroleptic-induced adverse effects, Eur. J. Clin. Pharmacol. 42, 347-348.
    • (1992) Eur. J. Clin. Pharmacol. , vol.42 , pp. 347-348
    • Spina, E.1    Ancione, M.2    Di Rosa, A.E.3
  • 197
    • 0033853419 scopus 로고    scopus 로고
    • Plasma concentrations of risperidone and 9-hydroxyrisperidone: Effect of comedication with carbamazepine or valproate
    • Spina, E., Avenoso, A., Facciolà, G. et al., 2000, Plasma concentrations of risperidone and 9-hydroxyrisperidone: effect of comedication with carbamazepine or valproate, Ther. Drug Monit. 22, 481-485.
    • (2000) Ther. Drug Monit. , vol.22 , pp. 481-485
    • Spina, E.1    Avenoso, A.2    Facciolà, G.3
  • 198
    • 0035140878 scopus 로고    scopus 로고
    • Relationship between plasma risperidone and 9-hydroxyrisperidone concentrations and clinical response in patients with schizophrenia
    • Spina, E., Avenoso, A., Facciolà, G. et al., 2001, Relationship between plasma risperidone and 9-hydroxyrisperidone concentrations and clinical response in patients with schizophrenia, Psychopharmacology 153, 238-243.
    • (2001) Psychopharmacology , vol.153 , pp. 238-243
    • Spina, E.1    Avenoso, A.2    Facciolà, G.3
  • 199
    • 0031852710 scopus 로고    scopus 로고
    • Effect of fluoxetine on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenia
    • Spina, E., Avenoso, A., Facciolà, G. et al., 1998, Effect of fluoxetine on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenia, Int. Clin. Psychopharmacol. 13, 141-145.
    • (1998) Int. Clin. Psychopharmacol. , vol.13 , pp. 141-145
    • Spina, E.1    Avenoso, A.2    Facciolà, G.3
  • 200
    • 0035012610 scopus 로고    scopus 로고
    • Plasma concentrations of risperidone and 9-hydroxyrisperidone during combined treatment with paroxetine
    • Spina, E., Avenoso, A., Facciolà, G., Scordo, M. G., Ancione, M., Madia, A., 2001, Plasma concentrations of risperidone and 9-hydroxyrisperidone during combined treatment with paroxetine, Ther. Drug Monit. 23, 223-227.
    • (2001) Ther. Drug Monit. , vol.23 , pp. 223-227
    • Spina, E.1    Avenoso, A.2    Facciolà, G.3    Scordo, M.G.4    Ancione, M.5    Madia, A.6
  • 201
    • 0033670739 scopus 로고    scopus 로고
    • Plasma concentrations of clozapine and its major metabolites during combined treatment with paroxetine or sertraline
    • Spina, E., Avenoso, A., Salemi, M. et al., 2000, Plasma concentrations of clozapine and its major metabolites during combined treatment with paroxetine or sertraline, Pharmacopsychiatry 33, 213-217.
    • (2000) Pharmacopsychiatry , vol.33 , pp. 213-217
    • Spina, E.1    Avenoso, A.2    Salemi, M.3
  • 202
    • 0036328632 scopus 로고    scopus 로고
    • Inhibition of risperidone metabolism by fluoxetine in patients with schizophrenia: A clinically relevant pharmacokinetic drug interaction
    • Spina, E., Avenoso, A., Scordo, M. G. et al., 2002, Inhibition of risperidone metabolism by fluoxetine in patients with schizophrenia: a clinically relevant pharmacokinetic drug interaction, J. Clin. Psychopharmacol. 22, 419-423.
    • (2002) J. Clin. Psychopharmacol. , vol.22 , pp. 419-423
    • Spina, E.1    Avenoso, A.2    Scordo, M.G.3
  • 203
    • 0031028101 scopus 로고    scopus 로고
    • Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: A prospective study
    • Spina, E., Gitto, C., Avenoso, A., Campo, G. M., Caputi, A. P., Perucca, E., 1997, Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: a prospective study, Eur. J. Clin. Pharmacol. 51, 395-398.
    • (1997) Eur. J. Clin. Pharmacol. , vol.51 , pp. 395-398
    • Spina, E.1    Gitto, C.2    Avenoso, A.3    Campo, G.M.4    Caputi, A.P.5    Perucca, E.6
  • 204
    • 0035139726 scopus 로고    scopus 로고
    • Adverse drug interaction between risperidone and carbamazepine in a patient with chronic schizophrenia and deficient CYP2D6 activity
    • Spina, E., Scordo, M. G., Avenoso, A., Perucca, E., 2001, Adverse drug interaction between risperidone and carbamazepine in a patient with chronic schizophrenia and deficient CYP2D6 activity, J. Clin. Psychopharmacol. 21, 108-109.
    • (2001) J. Clin. Psychopharmacol. , vol.21 , pp. 108-109
    • Spina, E.1    Scordo, M.G.2    Avenoso, A.3    Perucca, E.4
  • 205
    • 0023139103 scopus 로고
    • Hydroxylation of desmethylimipramine: Dependence on the debrisoquin hydroxylation phenotype
    • Spina, E., Steiner, E., Ericsson, O., Sjöqvist, F., 1987, Hydroxylation of desmethylimipramine: dependence on the debrisoquin hydroxylation phenotype, Clin Pharmacol Ther 41, 314-319.
    • (1987) Clin Pharmacol Ther , vol.41 , pp. 314-319
    • Spina, E.1    Steiner, E.2    Ericsson, O.3    Sjöqvist, F.4
  • 206
    • 0026472588 scopus 로고
    • Debrisoquine oxidation phenotype and neurolepticinduced dystonic reactions
    • Spina, E., Sturiale, V., Valvo, S. et al., 1992, Debrisoquine oxidation phenotype and neurolepticinduced dystonic reactions, Acta Psychiatr. Scand. 86, 364-366.
    • (1992) Acta Psychiatr. Scand. , vol.86 , pp. 364-366
    • Spina, E.1    Sturiale, V.2    Valvo, S.3
  • 207
    • 0033810675 scopus 로고    scopus 로고
    • Metabolism of the antidepressant mirtazapine in vitro: Contribution of cytochromes P-450 1A2, 2D6, and 3A4
    • Störmer, E., Von Moltke, L. L., Shader, R. I., Greenblatt, D. J., 2000, Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4, Drug. Metab. Dispos. 28, 1168-1175.
    • (2000) Drug. Metab. Dispos. , vol.28 , pp. 1168-1175
    • Störmer, E.1    Von Moltke, L.L.2    Shader, R.I.3    Greenblatt, D.J.4
  • 208
    • 0030826785 scopus 로고    scopus 로고
    • Effects of the CYP2D6 genotype on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients
    • Suzuki, A., Otani, K., Mihara, K. et al., 1997, Effects of the CYP2D6 genotype on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients, Pharmacogenetics 7, 415-418.
    • (1997) Pharmacogenetics , vol.7 , pp. 415-418
    • Suzuki, A.1    Otani, K.2    Mihara, K.3
  • 210
    • 0021923893 scopus 로고
    • Tricyclic antidepressants-blood level measurements and clinical outcome: An APA Task Force report. Task Force on the Use of Laboratory Tests in Psychiatry
    • Task Force Laboratory Tests in Psychiatry
    • Task Force Laboratory Tests in Psychiatry, 1985, Tricyclic antidepressants-blood level measurements and clinical outcome: an APA Task Force report. Task Force on the Use of Laboratory Tests in Psychiatry, Am. J. Psychiatry. 142, 155-162.
    • (1985) Am. J. Psychiatry , vol.142 , pp. 155-162
  • 212
    • 0017667456 scopus 로고
    • Polymorphic hydroxylation of debrisoquine
    • Tucker, G. T., Silas, J. H., Iyun, A. O. et al., 1977, Polymorphic hydroxylation of debrisoquine, Lancet 2, 718.
    • (1977) Lancet , vol.2 , pp. 718
    • Tucker, G.T.1    Silas, J.H.2    Iyun, A.O.3
  • 213
    • 0028333931 scopus 로고
    • The regional brain distribution of risperidone and its active metabolite 9-hydroxyrisperidone in the rat
    • Van Beijsterveldt, L. E. C., Geerts, R. J. F., Leysen, J. E. et al., 1994, The regional brain distribution of risperidone and its active metabolite 9-hydroxyrisperidone in the rat, Psychopharmacology 114, 53-62.
    • (1994) Psychopharmacology , vol.114 , pp. 53-62
    • Van Beijsterveldt, L.E.C.1    Geerts, R.J.F.2    Leysen, J.E.3
  • 214
    • 0037339287 scopus 로고    scopus 로고
    • The effect of smoking and cytochrome P450 CYP1A2 genetic polymorphism on clozapine clearance and dose requirement
    • Van Der Weide, J., Steijns, L. S., Van Weelden, M. J., 2003, The effect of smoking and cytochrome P450 CYP1A2 genetic polymorphism on clozapine clearance and dose requirement, Pharmacogenetics 13, 169-172.
    • (2003) Pharmacogenetics , vol.13 , pp. 169-172
    • Van Der Weide, J.1    Steijns, L.S.2    Van Weelden, M.J.3
  • 216
    • 0026086815 scopus 로고
    • Plasma levels of thioridazine and metabolites are influenced by the debrisoquine hydroxylation phenotype
    • Von Bahr, C., Movin, G., Nordin, C. et al., 1991, Plasma levels of thioridazine and metabolites are influenced by the debrisoquine hydroxylation phenotype, Clin. Pharmacol. Ther. 49, 234-240.
    • (1991) Clin. Pharmacol. Ther. , vol.49 , pp. 234-240
    • Von Bahr, C.1    Movin, G.2    Nordin, C.3
  • 217
    • 0034936466 scopus 로고    scopus 로고
    • Escitalopram (S-citalopram) and its metabolites in vitro: Cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram
    • Von Moltke, L. L., Greenblatt, D. J., Giancarlo, G. M., Granda, B. W., Harmatz, J. S., Shader, R. I., 2001, Escitalopram (S-citalopram) and its metabolites in vitro: Cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram, Drug Metab. Dispos. 29, 1102-1109.
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 1102-1109
    • Von Moltke, L.L.1    Greenblatt, D.J.2    Giancarlo, G.M.3    Granda, B.W.4    Harmatz, J.S.5    Shader, R.I.6
  • 219
    • 0031963522 scopus 로고    scopus 로고
    • Pharmacokinetic interaction of clozapine with selective serotonin re-uptake inhibitors: Differential effects of fluvoxamine and paroxetine in a prospective study
    • Wetzel, H., Anghelescu, I., Szegedi, A. et al., 1998, Pharmacokinetic interaction of clozapine with selective serotonin re-uptake inhibitors: differential effects of fluvoxamine and paroxetine in a prospective study, J. Clin. Psychopharmacol. 18, 2-9.
    • (1998) J. Clin. Psychopharmacol. , vol.18 , pp. 2-9
    • Wetzel, H.1    Anghelescu, I.2    Szegedi, A.3
  • 220
    • 0032750751 scopus 로고    scopus 로고
    • Cytochrome P-450-mediated metabolism of the individual enantiomers of the antidepressant agent reboxetine in human liver microsomes
    • Wienkers, L. C., Allievi, C., Hauer, M. J., Wynalda, M. A., 1999, Cytochrome P-450-mediated metabolism of the individual enantiomers of the antidepressant agent reboxetine in human liver microsomes, Drug. Metab. Dispos. 27, 1334-1340.
    • (1999) Drug. Metab. Dispos. , vol.27 , pp. 1334-1340
    • Wienkers, L.C.1    Allievi, C.2    Hauer, M.J.3    Wynalda, M.A.4
  • 221
    • 0032840038 scopus 로고    scopus 로고
    • Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes
    • Xu, Z.-H., Wang, W., Zhao, X.-J., Huang, S.-L., Zhu, B., He, N., Shu, Y., Liu, Z.-Q., Zhou, H.-H., 1999, Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes, J. Clin. Pharmacol. 48, 416-423.
    • (1999) J. Clin. Pharmacol. , vol.48 , pp. 416-423
    • Xu, Z.-H.1    Wang, W.2    Zhao, X.-J.3    Huang, S.-L.4    Zhu, B.5    He, N.6    Shu, Y.7    Liu, Z.-Q.8    Zhou, H.-H.9
  • 222
    • 0036161753 scopus 로고    scopus 로고
    • Pharmacokinetics of losartan and its metabolite E-3174 in relation to the CYP2C9 genotype
    • Yasar, U., Forslund-Bergengren, C., Tybring, G. et al., 2002, Pharmacokinetics of losartan and its metabolite E-3174 in relation to the CYP2C9 genotype, Clin. Pharmacol. Ther. 71, 89-98.
    • (2002) Clin. Pharmacol. Ther. , vol.71 , pp. 89-98
    • Yasar, U.1    Forslund-Bergengren, C.2    Tybring, G.3
  • 223
    • 0032929998 scopus 로고    scopus 로고
    • Effects of itraconazole on the steady-state plasma concentrations of haloperidol and its reduced metabolite in schizophrenic patients: In vivo evidence of the involvement of CYP3A4 for haloperidol metabolism
    • Yasui, N., Kondo, T., Otani K. et al., 1999, Effects of itraconazole on the steady-state plasma concentrations of haloperidol and its reduced metabolite in schizophrenic patients: in vivo evidence of the involvement of CYP3A4 for haloperidol metabolism, J. Clin. Psychopharmacol. 19, 149-154.
    • (1999) J. Clin. Psychopharmacol. , vol.19 , pp. 149-154
    • Yasui, N.1    Kondo, T.2    Otani, K.3
  • 225
    • 0034829228 scopus 로고    scopus 로고
    • Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes
    • Yasui-Furukori, N., Hidestrand, M., Spina E. et al., 2001, Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes, Drug Metab. Dispos. 29, 1263-1268.
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 1263-1268
    • Yasui-Furukori, N.1    Hidestrand, M.2    Spina, E.3
  • 227
    • 0034595672 scopus 로고    scopus 로고
    • Identification of human cytochrome P450 isoforms involved in the 7-hydroxylation of chlorpromazine by human liver microsomes
    • Yoshii, K., Kobayashi K., Tsumuji, M. et al., 2000, Identification of human cytochrome P450 isoforms involved in the 7-hydroxylation of chlorpromazine by human liver microsomes, Life Sciences 67, 175-184.
    • (2000) Life Sciences , vol.67 , pp. 175-184
    • Yoshii, K.1    Kobayashi, K.2    Tsumuji, M.3
  • 228
    • 0031668683 scopus 로고    scopus 로고
    • Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes
    • Yue, Q. Y., Zhong, Z. H., Tybring, G., Dalen, P., Dahl, M.-L., Bertilsson, L., Sjöqvist, F., 1998, Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes, Clin. Pharmacol. Ther. 64, 384-390.
    • (1998) Clin. Pharmacol. Ther. , vol.64 , pp. 384-390
    • Yue, Q.Y.1    Zhong, Z.H.2    Tybring, G.3    Dalen, P.4    Dahl, M.-L.5    Bertilsson, L.6    Sjöqvist, F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.