In vitro metabolism of mirtazapine enantiomers by human cytochrome P450 enzymes

Human Psychopharmacology

Volumn 16, Issue 7, 2001, Pages 541-544

  Dodd, Seetal ^a   Boulton, David W ^b   Burrows, Graham D ^b   De Lindsay Vane, C ^b   Norman, Trevor R ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Antidepressant; Chiral HPLC; Cytochrome P450; Mirtazapine; Pharmacokinetics

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; MIRTAZAPINE;

ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG METABOLISM; ENANTIOMER; GENETIC TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOBLAST; MICROSOME; PRIORITY JOURNAL; VALIDATION PROCESS;

EID: 0034751363     PISSN: 08856222     EISSN: None     Source Type: Journal    
DOI: 10.1002/hup.328     Document Type: Article

References (10)

1. Human cell lines, derived from Ahh-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450
2. CYP2D6 multiallelism
3. Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, ORG 3770 and its enantiomers
4. 1A-mediated serotonergic neurotransmission
5. Chiral determination of mirtazapine in human blood plasma by high-performance liquid chromatography
6. A comparison of the physicochemical and biological properties of mirtazapine and mianserin
7. Neurochemical effects of the enantiomers of mirtazapine in normal rats
8. EZ-FIT: A practical curve fitting microcomputer program for the analysis of enzyme kinetic data on IBM-PC compatible computers
9. Selection of an antidepressant: Mirtazapine
10. Metabolism of the antidepressant mirtazapine in vitro: Contribution of cytochromes P-450 1A2, 2D6, and 3A4