Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1α protein

Toxicological Sciences

Volumn 107, Issue 2, 2009, Pages 394-403

  Kaczmarek, Monika ^a   Cachau, Raul E ^b   Topol, Igor A ^b   Kasprzak, Kazimierz S ^a   Ghio, Andy ^c   Salnikow, Konstantin ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Antioxidants; Metals; Transcription factors

Indexed keywords

ASCORBIC ACID; CHROMIUM; COBALT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRON; METAL ION; NICKEL;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; EXPOSURE; HUMAN; HUMAN CELL; HYDROXYLATION; IMMUNOBLOTTING; MOLECULAR DYNAMICS; MOLECULAR MODEL; OXIDATION; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTIOXIDANTS; ASCORBIC ACID; BLOTTING, WESTERN; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENES, REPORTER; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INDICATORS AND REAGENTS; IRON; KINETICS; LUCIFERASES; MAGNETIC RESONANCE SPECTROSCOPY; METALS; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OXIDATION-REDUCTION; STIMULATION, CHEMICAL;

EID: 59149091875     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn251     Document Type: Article

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