Harnessing chaperons to generate small-molecule inhibitors of amyloid β aggregation

Science

Volumn 306, Issue 5697, 2004, Pages 865-869

  Gestwicki, Jason E ^a   Crabtree, Gerald R ^a   Graef, Isabella A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; DISEASES; POLYPEPTIDES; SYNTHESIS (CHEMICAL);

CHAPERONS; NEURODEGENERATION; PATHOGENESIS; SMALL-MOLECULE INHIBITORS;

PROTEINS;

AMYLOID BETA PROTEIN; CHAPERONE; CONGO RED; FK 506 BINDING PROTEIN LIGAND; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); CROSS LINKING REAGENT; DRUG DERIVATIVE; FK 506 BINDING PROTEIN; LIGAND; PEPTIDE FRAGMENT; PIPERIDINE DERIVATIVE; SLF CR COMPOUND; SLF-CR COMPOUND;

BIOLOGY;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN INTERACTION; ANIMAL; CELL CULTURE; CELL DEATH; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; FLUORESCENCE; FLUORESCENCE MICROSCOPY; HIPPOCAMPUS; METABOLISM; NERVE CELL; NEURITE; NICK END LABELING; RAT; SYNTHESIS; ULTRASTRUCTURE;

ANIMALIA;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CONGO RED; CROSS-LINKING REAGENTS; FLUORESCENCE; HIPPOCAMPUS; IN SITU NICK-END LABELING; LIGANDS; MICROSCOPY, FLUORESCENCE; MOLECULAR CHAPERONES; MOLECULAR STRUCTURE; NEURITES; NEURONS; PEPTIDE FRAGMENTS; PIPERIDINES; RATS; TACROLIMUS BINDING PROTEINS;

EID: 7444221875     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1101262     Document Type: Article

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27. This work is dedicated to A. Graef. We thank Y.-M. Lin and T. Wandless for starting materials; V. Devasthali for experimental support; and L. Mucke, C. Cairo, T. Buchholz, and Crabtree laboratory members for helpful discussions. Supported by National Institute of Neurological Disorders and Stroke grant NS046789 and by an award from the Christopher Reeve Paralysis Foundation. J.E.G. is a Helen Hay Whitney postdoctoral fellow. G.R.C. is an Investigator of the Howard Hughes Medical Institute.