-
1
-
-
0035810656
-
Metabolic control of recombinant protein N-glycan processing in NS0 and CHO cells
-
Baker KN, Rendall MH, Hills AE, Hoare M, Freedman RB, James DC (2001) Metabolic control of recombinant protein N-glycan processing in NS0 and CHO cells. Biotechnol Bioeng 73:188-202
-
(2001)
Biotechnol Bioeng
, vol.73
, pp. 188-202
-
-
Baker, K.N.1
Rendall, M.H.2
Hills, A.E.3
Hoare, M.4
Freedman, R.B.5
James, D.C.6
-
2
-
-
0033782015
-
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
-
Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D (2000) Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2:326-332
-
(2000)
Nat Cell Biol
, vol.2
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
3
-
-
0034192958
-
A new Chinese hamster ovary cell line expressing alpha2,6- sialyltransferase used as universal host for the production of human-like sialylated recombinant glycoproteins
-
Bragonzi A, Distefano G, Buckberry LD, Acerbis G, Foglieni C, Lamotte D, Campi G, Marc A, Soria MR, Jenkins N et al (2000) A new Chinese hamster ovary cell line expressing alpha2,6-sialyltransferase used as universal host for the production of human-like sialylated recombinant glycoproteins. Biochim Biophys Acta 1474:273-282
-
(2000)
Biochim Biophys Acta
, vol.1474
, pp. 273-282
-
-
Bragonzi, A.1
Distefano, G.2
Buckberry, L.D.3
Acerbis, G.4
Foglieni, C.5
Lamotte, D.6
Campi, G.7
Marc, A.8
Soria, M.R.9
Jenkins, N.10
-
4
-
-
33845923234
-
High throughput screening of protein formulation stability: Practical considerations
-
Capelle MA, Gurny R, Arvinte T (2007) High throughput screening of protein formulation stability: Practical considerations. Eur J Pharm Biopharm 65:131-148
-
(2007)
Eur J Pharm Biopharm
, vol.65
, pp. 131-148
-
-
Capelle, M.A.1
Gurny, R.2
Arvinte, T.3
-
5
-
-
33645784167
-
The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress
-
Chakravarthi S, Jessop CE, Bulleid NJ (2006) The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress. EMBO Rep 7:271-275
-
(2006)
EMBO Rep
, vol.7
, pp. 271-275
-
-
Chakravarthi, S.1
Jessop, C.E.2
Bulleid, N.J.3
-
6
-
-
24944512327
-
Identification and characterization of deamidation sites in the conserved regions of human immunoglobulin gamma antibodies
-
Chelius D, Rehder DS, Bondarenko PV (2005) Identification and characterization of deamidation sites in the conserved regions of human immunoglobulin gamma antibodies. Anal Chem 77:6004-6011
-
(2005)
Anal Chem
, vol.77
, pp. 6004-6011
-
-
Chelius, D.1
Rehder, D.S.2
Bondarenko, P.V.3
-
7
-
-
8344224534
-
Characterizing biological products and assessing comparability following manufacturing changes
-
Chirino AJ, Mire-Sluis A (2004) Characterizing biological products and assessing comparability following manufacturing changes. Nat Biotechnol 22:1383-1391
-
(2004)
Nat Biotechnol
, vol.22
, pp. 1383-1391
-
-
Chirino, A.J.1
Mire-Sluis, A.2
-
8
-
-
0035096123
-
A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody
-
Cleland JL, Lam X, Kendrick B, Yang J, Yang TH, Overcashier D, Brooks D, Hsu C, Carpenter JF (2001) A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody. J Pharm Sci 90:310-321
-
(2001)
J Pharm Sci
, vol.90
, pp. 310-321
-
-
Cleland, J.L.1
Lam, X.2
Kendrick, B.3
Yang, J.4
Yang, T.H.5
Overcashier, D.6
Brooks, D.7
Hsu, C.8
Carpenter, J.F.9
-
9
-
-
0242712492
-
Endoplasmic reticulum signaling as a determinant of recombinant protein expression
-
Cudna RE, Dickson AJ (2003) Endoplasmic reticulum signaling as a determinant of recombinant protein expression. Biotechnol Bioeng 81:56-65
-
(2003)
Biotechnol Bioeng
, vol.81
, pp. 56-65
-
-
Cudna, R.E.1
Dickson, A.J.2
-
10
-
-
33645356185
-
Immunomics: Discovering new targets for vaccines and therapeutics
-
De Groot AS (2006) Immunomics: discovering new targets for vaccines and therapeutics. Drug Discov Today 11:203-209
-
(2006)
Drug Discov Today
, vol.11
, pp. 203-209
-
-
De Groot, A.S.1
-
11
-
-
33846037870
-
Characterization of protein aggregation: The case of a therapeutic immunoglobulin
-
Demeule B, Lawrence MJ, Drake AF, Gurny R, Arvinte T (2007) Characterization of protein aggregation: the case of a therapeutic immunoglobulin. Biochim Biophys Acta 1774:146-153
-
(2007)
Biochim Biophys Acta
, vol.1774
, pp. 146-153
-
-
Demeule, B.1
Lawrence, M.J.2
Drake, A.F.3
Gurny, R.4
Arvinte, T.5
-
12
-
-
0037384789
-
Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin
-
Egrie JC, Dwyer E, Browne JK, Hitz A, Lykos MA (2003) Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin. Exp Hematol 31:290-299
-
(2003)
Exp Hematol
, vol.31
, pp. 290-299
-
-
Egrie, J.C.1
Dwyer, E.2
Browne, J.K.3
Hitz, A.4
Lykos, M.A.5
-
13
-
-
10044237889
-
Control of rHuEPO biological activity: The role of carbohydrate
-
Elliott S, Egrie J, Browne J, Lorenzini T, Busse L, Rogers N, Ponting I (2004) Control of rHuEPO biological activity: the role of carbohydrate. Exp Hematol 32:1146-1155
-
(2004)
Exp Hematol
, vol.32
, pp. 1146-1155
-
-
Elliott, S.1
Egrie, J.2
Browne, J.3
Lorenzini, T.4
Busse, L.5
Rogers, N.6
Ponting, I.7
-
14
-
-
33646070900
-
Modulation of therapeutic antibody effector functions by glycosylation engineering: Influence of Golgi enzyme localization domain and co-expression of heterologous beta1, 4-N-acetylglucosaminyltransferase III and Golgi alpha-mannosidase II
-
Ferrara C, Brunker P, Suter T, Moser S, Puntener U, Umana P (2006) Modulation of therapeutic antibody effector functions by glycosylation engineering: influence of Golgi enzyme localization domain and co-expression of heterologous beta1, 4-N-acetylglucosaminyltransferase III and Golgi alpha-mannosidase II. Biotechnol Bioeng 93:851-861
-
(2006)
Biotechnol Bioeng
, vol.93
, pp. 851-861
-
-
Ferrara, C.1
Brunker, P.2
Suter, T.3
Moser, S.4
Puntener, U.5
Umana, P.6
-
15
-
-
0032551285
-
Improvement of interferon-gamma sialylation in Chinese hamster ovary cell culture by feeding of N-acetylmannosamine
-
Gu X, Wang DI (1998) Improvement of interferon-gamma sialylation in Chinese hamster ovary cell culture by feeding of N-acetylmannosamine. Biotechnol Bioeng 58:642-648
-
(1998)
Biotechnol Bioeng
, vol.58
, pp. 642-648
-
-
Gu, X.1
Wang, D.I.2
-
16
-
-
33644619972
-
Heterogeneity of recombinant antibodies: Linking structure to function
-
Harris RJ (2005) Heterogeneity of recombinant antibodies: linking structure to function. Dev Biol (Basel) 122:117-127
-
(2005)
Dev Biol (Basel)
, vol.122
, pp. 117-127
-
-
Harris, R.J.1
-
17
-
-
0035836065
-
Identification of multiple sources of charge heterogeneity in a recombinant antibody
-
Harris RJ, Kabakoff B, Macchi FD, Shen FJ, Kwong M, Andya JD, Shire SJ, Bjork N, Totpal K, Chen AB (2001) Identification of multiple sources of charge heterogeneity in a recombinant antibody. J Chromatogr B Biomed Sci Appl 752:233-245
-
(2001)
J Chromatogr B Biomed Sci Appl
, vol.752
, pp. 233-245
-
-
Harris, R.J.1
Kabakoff, B.2
MacChi, F.D.3
Shen, F.J.4
Kwong, M.5
Andya, J.D.6
Shire, S.J.7
Bjork, N.8
Totpal, K.9
Chen, A.B.10
-
19
-
-
33746340899
-
Determination of protein oxidation by mass spectrometry and method transfer to quality control
-
Houde D, Kauppinen P, Mhatre R, Lyubarskaya Y (2006) Determination of protein oxidation by mass spectrometry and method transfer to quality control. J Chromatogr A 1123:189-198
-
(2006)
J Chromatogr a
, vol.1123
, pp. 189-198
-
-
Houde, D.1
Kauppinen, P.2
Mhatre, R.3
Lyubarskaya, Y.4
-
20
-
-
0029837484
-
Getting the glycosylation right: Implications for the biotechnology industry
-
Jenkins N, Parekh RB, James DC (1996) Getting the glycosylation right: implications for the biotechnology industry. Nat Biotechnol 14:975-981
-
(1996)
Nat Biotechnol
, vol.14
, pp. 975-981
-
-
Jenkins, N.1
Parekh, R.B.2
James, D.C.3
-
21
-
-
0037289438
-
High affinity capture surface for matrix-assisted laser desorption/ionisation compatible protein microarrays
-
Koopmann JO, Blackburn J (2003) High affinity capture surface for matrix-assisted laser desorption/ionisation compatible protein microarrays. Rapid Commun Mass Spectrom 17:455-462
-
(2003)
Rapid Commun Mass Spectrom
, vol.17
, pp. 455-462
-
-
Koopmann, J.O.1
Blackburn, J.2
-
22
-
-
0034129568
-
Stability of human serum albumin during bioprocessing: Denaturation and aggregation during processing of albumin paste
-
Lin JJ, Meyer JD, Carpenter JF, Manning MC (2000) Stability of human serum albumin during bioprocessing: denaturation and aggregation during processing of albumin paste. Pharm Res 17:391-396
-
(2000)
Pharm Res
, vol.17
, pp. 391-396
-
-
Lin, J.J.1
Meyer, J.D.2
Carpenter, J.F.3
Manning, M.C.4
-
23
-
-
17944387597
-
Effects of buffering conditions and culture pH on production rates and glycosylation of clinical phase I anti-melanoma mouse IgG3 monoclonal antibody R24
-
Muthing J, Kemminer SE, Conradt HS, Sagi D, Nimtz M, Karst U, Peter-Katalinic J (2003) Effects of buffering conditions and culture pH on production rates and glycosylation of clinical phase I anti-melanoma mouse IgG3 monoclonal antibody R24. Biotechnol Bioeng 83:321-334
-
(2003)
Biotechnol Bioeng
, vol.83
, pp. 321-334
-
-
Muthing, J.1
Kemminer, S.E.2
Conradt, H.S.3
Sagi, D.4
Nimtz, M.5
Karst, U.6
Peter-Katalinic, J.7
-
24
-
-
32644434554
-
Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia a mice
-
Purohit VS, Middaugh CR, Balasubramanian SV (2006) Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice. J Pharm Sci 95:358-371
-
(2006)
J Pharm Sci
, vol.95
, pp. 358-371
-
-
Purohit, V.S.1
Middaugh, C.R.2
Balasubramanian, S.V.3
-
25
-
-
0036034873
-
Clinical pharmacokinetics and pharmacodynamics of insulin lispro mixtures
-
Roach P, Woodworth JR (2002) Clinical pharmacokinetics and pharmacodynamics of insulin lispro mixtures. Clin Pharmacokinet 41:1043-1057
-
(2002)
Clin Pharmacokinet
, vol.41
, pp. 1043-1057
-
-
Roach, P.1
Woodworth, J.R.2
-
26
-
-
0037140419
-
Induction of protein aggregation in an early secretory compartment by elevation of expression level
-
Schroder M, Schafer R, Friedl P (2002) Induction of protein aggregation in an early secretory compartment by elevation of expression level. Biotechnol Bioeng 78:131-140
-
(2002)
Biotechnol Bioeng
, vol.78
, pp. 131-140
-
-
Schroder, M.1
Schafer, R.2
Friedl, P.3
-
27
-
-
7044232898
-
Heterogeneous conditions in dissolved oxygen affect N-glycosylation but not productivity of a monoclonal antibody in hybridoma cultures
-
Serrato JA, Palomares LA, Meneses-Acosta A, Ramirez OT (2004) Heterogeneous conditions in dissolved oxygen affect N-glycosylation but not productivity of a monoclonal antibody in hybridoma cultures. Biotechnol Bioeng 88:176-188
-
(2004)
Biotechnol Bioeng
, vol.88
, pp. 176-188
-
-
Serrato, J.A.1
Palomares, L.A.2
Meneses-Acosta, A.3
Ramirez, O.T.4
-
28
-
-
33846867427
-
Commercial interest grows in glycan analysis
-
Sheridan C (2007) Commercial interest grows in glycan analysis. Nat Biotechnol 25:145-146
-
(2007)
Nat Biotechnol
, vol.25
, pp. 145-146
-
-
Sheridan, C.1
-
29
-
-
1842555298
-
Effects of sucrose on rFVIIa aggregation and methionine oxidation
-
Soenderkaer S, Carpenter JF, van de Weert M, Hansen LL, Flink J, Frokjaer S (2004) Effects of sucrose on rFVIIa aggregation and methionine oxidation. Eur J Pharm Sci 21:597-606
-
(2004)
Eur J Pharm Sci
, vol.21
, pp. 597-606
-
-
Soenderkaer, S.1
Carpenter, J.F.2
Van De Weert, M.3
Hansen, L.L.4
Flink, J.5
Frokjaer, S.6
-
30
-
-
0034282683
-
Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity
-
Taggart C, Cervantes-Laurean D, Kim G, McElvaney NG, Wehr N, Moss J, Levine RL (2000) Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity. J Biol Chem 275:27258-27265
-
(2000)
J Biol Chem
, vol.275
, pp. 27258-27265
-
-
Taggart, C.1
Cervantes-Laurean, D.2
Kim, G.3
McElvaney, N.G.4
Wehr, N.5
Moss, J.6
Levine, R.L.7
-
31
-
-
24944581330
-
Review: Why is arginine effective in suppressing aggregation?
-
Tsumoto K, Ejima D, Kita Y, Arakawa T (2005) Review: Why is arginine effective in suppressing aggregation? Protein Pept Lett 12:613-619
-
(2005)
Protein Pept Lett
, vol.12
, pp. 613-619
-
-
Tsumoto, K.1
Ejima, D.2
Kita, Y.3
Arakawa, T.4
-
32
-
-
33749860977
-
Post-translational modifications in the context of therapeutic proteins
-
Walsh G, Jefferis R (2006) Post-translational modifications in the context of therapeutic proteins. Nat Biotechnol 24:1241-1252
-
(2006)
Nat Biotechnol
, vol.24
, pp. 1241-1252
-
-
Walsh, G.1
Jefferis, R.2
-
33
-
-
33644816557
-
In vitro galactosylation of human IgG at 1 kg scale using recombinant galactosyltransferase
-
Warnock D, Bai X, Autote K, Gonzales J, Kinealy K, Yan B, Qian J, Stevenson T, Zopf D, Bayer RJ (2005) In vitro galactosylation of human IgG at 1 kg scale using recombinant galactosyltransferase. Biotechnol Bioeng 92:831-842
-
(2005)
Biotechnol Bioeng
, vol.92
, pp. 831-842
-
-
Warnock, D.1
Bai, X.2
Autote, K.3
Gonzales, J.4
Kinealy, K.5
Yan, B.6
Qian, J.7
Stevenson, T.8
Zopf, D.9
Bayer, R.J.10
-
34
-
-
0036008002
-
Effects of ammonia and glucosamine on the heterogeneity of erythropoietin glycoforms
-
Yang M, Butler M (2002) Effects of ammonia and glucosamine on the heterogeneity of erythropoietin glycoforms. Biotechnol Prog 18:129-138
-
(2002)
Biotechnol Prog
, vol.18
, pp. 129-138
-
-
Yang, M.1
Butler, M.2
-
35
-
-
33747175672
-
Simultaneous determination of protein aggregation, degradation, and absolute molecular weight by size exclusion chromatography-multiangle laser light scattering
-
Ye H (2006) Simultaneous determination of protein aggregation, degradation, and absolute molecular weight by size exclusion chromatography-multiangle laser light scattering. Anal Biochem 356:76-85
-
(2006)
Anal Biochem
, vol.356
, pp. 76-85
-
-
Ye, H.1
|