Dynamic analysis of GS-NS0 cells producing a recombinant monoclonal antibody during fed-batch culture

Biotechnology and Bioengineering

Volumn 97, Issue 2, 2007, Pages 410-424

  Stansfield, Scott H ^a   Allen, Emma E ^b   Dinnis, Diane M ^a   Racher, Andrew J ^b   Birch, John R ^b   James, David C ^c  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b LONZA AG   (Switzerland)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

2D PAGE; Fed batch culture; Monoclonal antibody; NS0 murine myeloma; Partial least squares regression; Proteomics

Indexed keywords

2D PAGE; FED-BATCH CULTURE; PARTIAL LEAST SQUARES REGRESSION; PRODUCTION RATE (QP);

ANIMAL CELL CULTURE; CELLS; GROWTH RATE; MAMMALS; MONOCLONAL ANTIBODIES; PH EFFECTS; PROTEINS; RNA;

BATCH CELL CULTURE;

CELL PROTEIN; GLUTAMIC ACID; LACTIC ACID; MONOCLONAL ANTIBODY; RECOMBINANT MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CONTROLLED STUDY; FED BATCH CULTURE; FLOW CYTOMETRY; ISOTOPE LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN SYNTHESIS; PROTEOMICS;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; MICE; MULTIPLE MYELOMA; PROTEIN ENGINEERING; RECOMBINANT PROTEINS;

MAMMALIA; MURINAE;

EID: 34249804788     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21263     Document Type: Article

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