Functional analysis of tumour necrosis factor-α-related apoptosis-inducing ligand (TRAIL): Cysteine-230 plays a critical role in the homotrimerization and biological activity of this novel tumoricidal cytokine

Biochemical Journal

Volumn 350, Issue 2, 2000, Pages 505-510

  Trabzuni, D ^a   Famulski, K S ^a   Ahmad, M ^a  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

Glutathione S transferase; Soluble TNF related apoptosis inducing ligand; sTRAIL; TdT mediated dUTP nick end labelling

Indexed keywords

CYSTEINE; RECOMBINANT CYTOKINE; THIOL; TUMOR NECROSIS FACTOR ALPHA RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; ZINC;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL STRUCTURE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DIMERIZATION; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; MICROSCOPY; MOLECULAR WEIGHT; NICK END LABELING; PRIORITY JOURNAL; PROTEIN ANALYSIS; SITE DIRECTED MUTAGENESIS;

APOPTOSIS REGULATORY PROTEINS; CHROMATOGRAPHY; COLON; COLONIC NEOPLASMS; CYSTEINE; DIMERIZATION; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE TRANSFERASE; HUMANS; MEMBRANE GLYCOPROTEINS; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; TIME FACTORS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; ZINC;

EID: 0034283184     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3500505     Document Type: Article

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