Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling during liver regeneration

Biochemical and Biophysical Research Communications

Volumn 279, Issue 3, 2000, Pages 974-979

  Hong, Feng ^a   Nguyen, Van Anh ^a   Shen, Xuening ^a   Kunos, George ^b   Gao, Bin ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bad; Growth factors; Liver regeneration; PI3 kinase; PKB Akt

Indexed keywords

DNA; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; INSULIN; INTERLEUKIN 6; PHENYLEPHRINE; PHOSPHATIDYLINOSITOL KINASE; PROTEIN KINASE; SCATTER FACTOR;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; ENZYME ACTIVATION; LIVER CELL; LIVER REGENERATION; LIVER RESECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034731449     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.4044     Document Type: Article

References (41)

1. Liver regeneration
2. Signal transduction during liver regeneration
3. Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF-kappa B, RelBp50, and c-Rel-p50) and PHF, a novel kappa B site-binding complex
4. Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
5. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
6. Alcohol and cytokine-inducible transcription factors
7. Differential regulation of the mitogenactivated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes
8. Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver
9. The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signaling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes
10. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes
11. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
12. Cellular survival: A play in three Akts
13. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
14. The role of phosphoinositide 3-kinase lipid products in cell function
15. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
16. Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways
17. Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway
18. Decreased alpha 1-adrenocepter responsiveness and density in liver cells of thyroidectomized rats
19. Microscale autoradiographic method for the qualitative and quantitative analysis of apoptetic DNA fragmentation
20. Specific activation of AP-1 but not Stat3 in regenerating liver in mice
21. Acute-phase response factor, increased binding, and target gene transcription during liver regeneration
22. Effect of ethanol on tumor necrosis factor signaling during liver regeneration
23. In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1
24. Apoptosis is induced by transforming growth factor-beta 1 within 5 hours in regressing liver without significant fragmentation of the DNA
25. Pathology of recombinant human transforming growth factor-beta 1 in rats and rabbits
26. Effect of transforming growth factor beta on cell death of cultured rat hepatocytes
27. Transforming growth factor beta mRNA increases during liver regeneration: A possible paracrine mechanism of growth regulation
28. Transforming growth factor-beta (TGF-beta) isoforms in rat liver regeneration: Messenger RNA expression and activation of latent TGF-beta
29. Expression of HGF and TGF-beta 1 mRNA after partial hepatectomy in rats with liver cirrhosis
30. Fas engagement accelerates liver regeneration after partial hepatectomy
31. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptesis
32. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration
33. Epidermal growth factor impairs the cytochrome c/caspase-3 apoptotic pathway induced by transforming growth factor beta in rat fetal hepatocytes via a phosphoinositide 3-kinase-dependent pathway
34. The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor alpha-mediated rat hepatocyte survival and apoptosis
35. Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway
36. Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene
37. Modulation of apoptosis-associated genes bcl-2, bcl-x, and bax during rat liver regeneration
38. Insulin and catecholamines act at different stages of rat liver regeneration
39. Regenerating rat liver: Insulin and glucagon serum levels and receptor binding
40. The role of PI 3-kinase in insulin action