-
1
-
-
34249736434
-
Molecular mechanisms for adaptive tolerance and other T cell anergy models
-
Choi, S., and R. H. Schwartz. 2007. Molecular mechanisms for adaptive tolerance and other T cell anergy models. Semin. Immunol. 19: 140-152.
-
(2007)
Semin. Immunol.
, vol.19
, pp. 140-152
-
-
Choi, S.1
Schwartz, R.H.2
-
3
-
-
33745074981
-
+ T cells
-
+ T cells. Immunol. Rev. 211: 81-92.
-
(2006)
Immunol. Rev.
, vol.211
, pp. 81-92
-
-
Mescher, M.F.1
Curtsinger, J.M.2
Agarwal, P.3
Casey, K.A.4
Gerner, M.5
Hammerbeck, C.D.6
Popescu, F.7
Xiao, Z.8
-
4
-
-
0000324490
-
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines
-
Thompson, C. B., T. Lindsten, J. A. Ledbetter, S. L. Kunkel, H. A. Young, S. G. Emerson, J. M. Leiden, and C. H. June. 1989. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc. Natl. Acad. Sci. USA 86: 1333-1337.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 1333-1337
-
-
Thompson, C.B.1
Lindsten, T.2
Ledbetter, J.A.3
Kunkel, S.L.4
Young, H.A.5
Emerson, S.G.6
Leiden, J.M.7
June, C.H.8
-
5
-
-
0026537347
-
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
-
Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356: 607-609.
-
(1992)
Nature
, vol.356
, pp. 607-609
-
-
Harding, F.A.1
McArthur, J.G.2
Gross, J.A.3
Raulet, D.H.4
Allison, J.P.5
-
6
-
-
0029041568
-
Transcriptional regulation of the IL-2 gene
-
Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7: 333-342.
-
(1995)
Curr. Opin. Immunol.
, vol.7
, pp. 333-342
-
-
Jain, J.1
Loh, C.2
Rao, A.3
-
7
-
-
0029025964
-
The architecture of the interleukin-2 promoter: A reflection of T lymphocyte activation
-
Serfling, E., A. Avots, and M. Neumann. 1995. The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation. Biochim. Biophys. Acta. 1263: 181-200.
-
(1995)
Biochim. Biophys. Acta.
, vol.1263
, pp. 181-200
-
-
Serfling, E.1
Avots, A.2
Neumann, M.3
-
8
-
-
0036679733
-
It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation
-
Kane, L. P., J. Lin, and A. Weiss. 2002. It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation. Trends Immunol. 23: 413-420.
-
(2002)
Trends Immunol.
, vol.23
, pp. 413-420
-
-
Kane, L.P.1
Lin, J.2
Weiss, A.3
-
9
-
-
38049141544
-
A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells
-
Zarek, P. E., C. T. Huang, E. R. Lutz, J. Kowalski, M. R. Horton, J. Linden, C. G. Drake, and J. D. Powell. 2008. A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells. Blood 111: 251-259.
-
(2008)
Blood
, vol.111
, pp. 251-259
-
-
Zarek, P.E.1
Huang, C.T.2
Lutz, E.R.3
Kowalski, J.4
Horton, M.R.5
Linden, J.6
Drake, C.G.7
Powell, J.D.8
-
10
-
-
34250351459
-
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
-
Deaglio, S., K. M. Dwyer, W. Gao, D. Friedman, A. Usheva, A. Erat, J. F. Chen, K. Enjyoji, J. Linden, M. Oukka, et al. 2007. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204: 1257-1265.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1257-1265
-
-
Deaglio, S.1
Dwyer, K.M.2
Gao, W.3
Friedman, D.4
Usheva, A.5
Erat, A.6
Chen, J.F.7
Enjyoji, K.8
Linden, J.9
Oukka, M.10
-
11
-
-
0036136463
-
Molecular mechanisms for protein kinase A-mediated modulation of immune function
-
Torgersen, K. M., T. Vang, H. Abrahamsen, S. Yaqub, and K. Tasken. 2002. Molecular mechanisms for protein kinase A-mediated modulation of immune function. Cell Signal. 14: 1-9.
-
(2002)
Cell Signal.
, vol.14
, pp. 1-9
-
-
Torgersen, K.M.1
Vang, T.2
Abrahamsen, H.3
Yaqub, S.4
Tasken, K.5
-
13
-
-
0028123444
-
CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon γ production
-
Seder, R. A., R. N. Germain, P. S. Linsley, and W. E. Paul. 1994. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon γ production. J. Exp. Med. 179: 299-304.
-
(1994)
J. Exp. Med.
, vol.179
, pp. 299-304
-
-
Seder, R.A.1
Germain, R.N.2
Linsley, P.S.3
Paul, W.E.4
-
14
-
-
0348047537
-
The main function of IL-2 is to promote the development of T regulatory cells
-
Malek, T. R. 2003. The main function of IL-2 is to promote the development of T regulatory cells. J. Leukocyte Biol. 74: 961-965.
-
(2003)
J. Leukocyte Biol.
, vol.74
, pp. 961-965
-
-
Malek, T.R.1
-
15
-
-
34249657416
-
Cyclin-dependent kinases: Molecular switches controlling anergy and potential therapeutic targets for tolerance
-
Wells, A. D. 2007. Cyclin-dependent kinases: molecular switches controlling anergy and potential therapeutic targets for tolerance. Semin. Immunol. 19: 173-179.
-
(2007)
Semin. Immunol.
, vol.19
, pp. 173-179
-
-
Wells, A.D.1
-
16
-
-
33846909503
-
A role for mammalian target of rapamycin in regulating T cell activation versus anergy
-
Zheng, Y., S. L. Collins, M. A. Lutz, A. N. Allen, T. P. Kole, P. E. Zarek, and J. D. Powell. 2007. A role for mammalian target of rapamycin in regulating T cell activation versus anergy. J. Immunol. 178: 2163-2170. (Pubitemid 46233414)
-
(2007)
Journal of Immunology
, vol.178
, Issue.4
, pp. 2163-2170
-
-
Zheng, Y.1
Coffins, S.L.2
Lutz, M.A.3
Allen, A.N.4
Kole, T.P.5
Zarek, P.E.6
Powell, J.D.7
-
17
-
-
0033104824
-
Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
-
Powell, J. D., C. G. Lerner, and R. H. Schwartz. 1999. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation. J. Immunol. 162: 2775-2784.
-
(1999)
J. Immunol.
, vol.162
, pp. 2775-2784
-
-
Powell, J.D.1
Lerner, C.G.2
Schwartz, R.H.3
-
18
-
-
33749132566
-
Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN
-
Buckler, J. L., P. T. Walsh, P. M. Porrett, Y. Choi, and L. A. Turka. 2006. Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J. Immunol. 177: 4262-4266.
-
(2006)
J. Immunol.
, vol.177
, pp. 4262-4266
-
-
Buckler, J.L.1
Walsh, P.T.2
Porrett, P.M.3
Choi, Y.4
Turka, L.A.5
-
21
-
-
33749521081
-
kip1 is required for transplantation tolerance induced by costimulatory blockade
-
kip1 is required for transplantation tolerance induced by costimulatory blockade. J. Immunol. 177: 5169-5176.
-
(2006)
J. Immunol.
, vol.177
, pp. 5169-5176
-
-
Rowell, E.A.1
Wang, L.2
Hancock, W.W.3
Wells, A.D.4
-
22
-
-
0034142187
-
+ T cells is due to defective signaling through the common γ-chain of the IL-2 receptor
-
+ T cells is due to defective signaling through the common γ-chain of the IL-2 receptor. J. Immunol. 164: 1175-1184.
-
(2000)
J. Immunol.
, vol.164
, pp. 1175-1184
-
-
Grundstrom, S.1
Dohlsten, M.2
Sundstedt, A.3
-
26
-
-
0037446523
-
Regulation of T cell activation and tolerance by phospholipase Cγ-1-dependent integrin avidity modulation
-
Wells, A. D., Q. H. Liu, B. Hondowicz, J. Zhang, L. A. Turka, and B. D. Freedman. 2003. Regulation of T cell activation and tolerance by phospholipase Cγ-1-dependent integrin avidity modulation. J. Immunol. 170: 4127-4133.
-
(2003)
J. Immunol.
, vol.170
, pp. 4127-4133
-
-
Wells, A.D.1
Liu, Q.H.2
Hondowicz, B.3
Zhang, J.4
Turka, L.A.5
Freedman, B.D.6
-
27
-
-
12144290293
-
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
-
Heissmeyer, V., F. Macian, S. H. Im, R. Varma, S. Feske, K. Venuprasad, H. Gu, Y. C. Liu, M. L. Dustin, and A. Rao. 2004. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol. 5: 255-265.
-
(2004)
Nat Immunol.
, vol.5
, pp. 255-265
-
-
Heissmeyer, V.1
Macian, F.2
Im, S.H.3
Varma, R.4
Feske, S.5
Venuprasad, K.6
Gu, H.7
Liu, Y.C.8
Dustin, M.L.9
Rao, A.10
-
28
-
-
0030812812
-
Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1
-
Boussiotis, V. A., G. J. Freeman, A. Berezovskaya, D. L. Barber, and L. M. Nadler. 1997. Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science 278: 124-128.
-
(1997)
Science
, vol.278
, pp. 124-128
-
-
Boussiotis, V.A.1
Freeman, G.J.2
Berezovskaya, A.3
Barber, D.L.4
Nadler, L.M.5
-
31
-
-
0036519296
-
Haematopoietic cell-fate decisions, chromatin regulation and ikaros
-
Georgopoulos, K. 2002. Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat. Rev. Immunol. 2: 162-174. (Pubitemid 37328763)
-
(2002)
Nature Reviews Immunology
, vol.2
, Issue.3
, pp. 162-174
-
-
Georgopoulos, K.1
-
33
-
-
33947723986
-
Control of interleukin-2 gene transcription: A paradigm for inducible, tissue-specific gene expression
-
Bunting, K., J. Wang, and M. F. Shannon. 2006. Control of interleukin-2 gene transcription: a paradigm for inducible, tissue-specific gene expression. Vitam. Horm. 74: 105-145.
-
(2006)
Vitam. Horm.
, vol.74
, pp. 105-145
-
-
Bunting, K.1
Wang, J.2
Shannon, M.F.3
-
36
-
-
61349103873
-
The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cells
-
Wang, J., S. Lee, C. E. Teh, K. Bunting, L. Ma, and M. F. Shannon. 2009. The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cells. Int. Immunol. 21: 227-235.
-
(2009)
Int. Immunol.
, vol.21
, pp. 227-235
-
-
Wang, J.1
Lee, S.2
Teh, C.E.3
Bunting, K.4
Ma, L.5
Shannon, M.F.6
-
37
-
-
51049092937
-
Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival
-
Martins, G. A., L. Cimmino, J. Liao, E. Magnusdottir, and K. Calame. 2008. Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival. J. Exp. Med. 205: 1959-1965.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1959-1965
-
-
Martins, G.A.1
Cimmino, L.2
Liao, J.3
Magnusdottir, E.4
Calame, K.5
-
38
-
-
0035202540
-
Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells
-
Tzachanis, D., G. J. Freeman, N. Hirano, A. A. van Puijenbroek, M. W. Delfs, A. Berezovskaya, L. M. Nadler, and V. A. Boussiotis. 2001. Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat. Immunol. 2: 1174-1182.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 1174-1182
-
-
Tzachanis, D.1
Freeman, G.J.2
Hirano, N.3
Van Puijenbroek, A.A.4
Delfs, M.W.5
Berezovskaya, A.6
Nadler, L.M.7
Boussiotis, V.A.8
-
39
-
-
0029055186
-
Induction of the increased Fyn kinase activity in anergic T helper type 1 clones requires calcium and protein synthesis and is sensitive to cyclosporin A
-
Gajewski, T. F., P. Fields, and F. W. Fitch. 1995. Induction of the increased Fyn kinase activity in anergic T helper type 1 clones requires calcium and protein synthesis and is sensitive to cyclosporin A. Eur. J. Immunol. 25: 1836-1842.
-
(1995)
Eur. J. Immunol.
, vol.25
, pp. 1836-1842
-
-
Gajewski, T.F.1
Fields, P.2
Fitch, F.W.3
-
41
-
-
0023390431
-
Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones
-
Jenkins, M. K., D. M. Pardoll, J. Mizuguchi, T. M. Chused, and R. H. Schwartz. 1987. Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones. Proc. Natl. Acad. Sci. USA 84: 5409-5413.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 5409-5413
-
-
Jenkins, M.K.1
Pardoll, D.M.2
Mizuguchi, J.3
Chused, T.M.4
Schwartz, R.H.5
-
42
-
-
0037077135
-
Transcriptional mechanisms underlying lymphocyte tolerance
-
Macian, F., F. Garcia-Cozar, S. H. Im, H. F. Horton, M. C. Byrne, and A. Rao. 2002. Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109: 719-731.
-
(2002)
Cell
, vol.109
, pp. 719-731
-
-
Macian, F.1
Garcia-Cozar, F.2
Im, S.H.3
Horton, H.F.4
Byrne, M.C.5
Rao, A.6
-
45
-
-
33750094147
-
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy
-
Olenchock, B. A., R. Guo, J. H. Carpenter, M. Jordan, M. K. Topham, G. A. Koretzky, and X. P. Zhong. 2006. Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. Nat. Immunol. 7: 1174-1181.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 1174-1181
-
-
Olenchock, B.A.1
Guo, R.2
Carpenter, J.H.3
Jordan, M.4
Topham, M.K.5
Koretzky, G.A.6
Zhong, X.P.7
-
46
-
-
33750093594
-
T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α
-
Zha, Y., R. Marks, A. W. Ho, A. C. Peterson, S. Janardhan, I. Brown, K. Praveen, S. Stang, J. C. Stone, and T. F. Gajewski. 2006. T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α. Nat. Immunol. 7: 1166-1173.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 1166-1173
-
-
Zha, Y.1
Marks, R.2
Ho, A.W.3
Peterson, A.C.4
Janardhan, S.5
Brown, I.6
Praveen, K.7
Stang, S.8
Stone, J.C.9
Gajewski, T.F.10
-
47
-
-
4644285392
-
E3 ubiquitin ligases as T cell anergy factors
-
Mueller, D. L. 2004. E3 ubiquitin ligases as T cell anergy factors. Nat. Immunol. 5: 883-890.
-
(2004)
Nat. Immunol.
, vol.5
, pp. 883-890
-
-
Mueller, D.L.1
-
48
-
-
48749086577
-
Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells
-
Puga, I., A. Rao, and F. Macian. 2008. Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cells. Immunity 29: 193-204.
-
(2008)
Immunity
, vol.29
, pp. 193-204
-
-
Puga, I.1
Rao, A.2
Macian, F.3
-
49
-
-
40449139114
-
Cutting edge: Requirement for TRAF6 in the induction of T cell anergy
-
King, C. G., J. L. Buckler, T. Kobayashi, J. R. Hannah, G. Bassett, T. Kim, E. L. Pearce, G. G. Kim, L. A. Turka, and Y. Choi. 2008. Cutting edge: requirement for TRAF6 in the induction of T cell anergy. J. Immunol. 180: 34-38.
-
(2008)
J. Immunol.
, vol.180
, pp. 34-38
-
-
King, C.G.1
Buckler, J.L.2
Kobayashi, T.3
Hannah, J.R.4
Bassett, G.5
Kim, T.6
Pearce, E.L.7
Kim, G.G.8
Turka, L.A.9
Choi, Y.10
-
50
-
-
34249333893
-
Preservation of self: An overview of E3 ubiquitin ligases and T cell tolerance
-
Schartner, J. M., C. G. Fathman, and C. M. Seroogy. 2007. Preservation of self: an overview of E3 ubiquitin ligases and T cell tolerance. Semin. Immunol. 19: 188-196.
-
(2007)
Semin. Immunol.
, vol.19
, pp. 188-196
-
-
Schartner, J.M.1
Fathman, C.G.2
Seroogy, C.M.3
-
51
-
-
18244375249
-
Egr-2 and Egr-3 are negative regulators of T cell activation
-
Safford, M., S. Collins, M. A. Lutz, A. Allen, C. T. Huang, J. Kowalski, A. Blackford, M. R. Horton, C. Drake, R. H. Schwartz, and J. D. Powell. 2005. Egr-2 and Egr-3 are negative regulators of T cell activation. Nat. Immunol. 6: 472-480.
-
(2005)
Nat. Immunol.
, vol.6
, pp. 472-480
-
-
Safford, M.1
Collins, S.2
Lutz, M.A.3
Allen, A.4
Huang, C.T.5
Kowalski, J.6
Blackford, A.7
Horton, M.R.8
Drake, C.9
Schwartz, R.H.10
Powell, J.D.11
-
53
-
-
33947611357
-
Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells
-
Bandyopadhyay, S., M. Dure, M. Paroder, N. Soto-Nieves, I. Puga, and F. Macian. 2006. Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells. Blood 109: 2878-2886.
-
(2006)
Blood
, vol.109
, pp. 2878-2886
-
-
Bandyopadhyay, S.1
Dure, M.2
Paroder, M.3
Soto-Nieves, N.4
Puga, I.5
Macian, F.6
-
54
-
-
0032540278
-
Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes
-
Bodor, J., and J. F. Habener. 1998. Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes. J. Biol. Chem. 273: 9544-9551.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9544-9551
-
-
Bodor, J.1
Habener, J.F.2
-
55
-
-
0032759619
-
The - 180 site of the IL-2 promoter is the target of CREB/CREM binding in T cell anergy
-
Powell, J. D., C. G. Lerner, G. R. Ewoldt, and R. H. Schwartz. 1999. The - 180 site of the IL-2 promoter is the target of CREB/CREM binding in T cell anergy. J. Immunol. 163: 6631-6639.
-
(1999)
J. Immunol.
, vol.163
, pp. 6631-6639
-
-
Powell, J.D.1
Lerner, C.G.2
Ewoldt, G.R.3
Schwartz, R.H.4
-
56
-
-
33646168597
-
FOXP3: Of mice and men
-
Ziegler, S. F. 2006. FOXP3: of mice and men. Annu. Rev. Immunol. 24: 209-226.
-
(2006)
Annu. Rev. Immunol.
, vol.24
, pp. 209-226
-
-
Ziegler, S.F.1
-
57
-
-
38349095578
-
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
-
Tone, Y., K. Furuuchi, Y. Kojima, M. L. Tykocinski, M. I. Greene, and M. Tone. 2008. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat. Immunol. 9: 194-202.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 194-202
-
-
Tone, Y.1
Furuuchi, K.2
Kojima, Y.3
Tykocinski, M.L.4
Greene, M.I.5
Tone, M.6
-
58
-
-
33746228122
-
FOXP3 controls regulatory T cell function through cooperation with NFAT
-
Wu, Y., M. Borde, V. Heissmeyer, M. Feuerer, A. D. Lapan, J. C. Stroud, D. L. Bates, L. Guo, A. Han, S. F. Ziegler, et al. 2006. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126: 375-387.
-
(2006)
Cell
, vol.126
, pp. 375-387
-
-
Wu, Y.1
Borde, M.2
Heissmeyer, V.3
Feuerer, M.4
Lapan, A.D.5
Stroud, J.C.6
Bates, D.L.7
Guo, L.8
Han, A.9
Ziegler, S.F.10
-
59
-
-
33846016948
-
Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation
-
Chen, C., E. A. Rowell, R. M. Thomas, W. W. Hancock, and A. D. Wells. 2006. Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation. J. Biol. Chem. 281: 36828-36834.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 36828-36834
-
-
Chen, C.1
Rowell, E.A.2
Thomas, R.M.3
Hancock, W.W.4
Wells, A.D.5
-
60
-
-
33847220736
-
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
-
Zheng, Y., S. Z. Josefowicz, A. Kas, T. T. Chu, M. A. Gavin, and A. Y. Rudensky. 2007. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 445: 936-940.
-
(2007)
Nature
, vol.445
, pp. 936-940
-
-
Zheng, Y.1
Josefowicz, S.Z.2
Kas, A.3
Chu, T.T.4
Gavin, M.A.5
Rudensky, A.Y.6
-
61
-
-
33847242598
-
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
-
Marson, A., K. Kretschmer, G. M. Frampton, E. S. Jacobsen, J. K. Polansky, K. D. Macisaac, S. S. Levine, E. Fraenkel, H. von Boehmer, and R. A. Young. 2007. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 445: 931-935.
-
(2007)
Nature
, vol.445
, pp. 931-935
-
-
Marson, A.1
Kretschmer, K.2
Frampton, G.M.3
Jacobsen, E.S.4
Polansky, J.K.5
Macisaac, K.D.6
Levine, S.S.7
Fraenkel, E.8
Von Boehmer, H.9
Young, R.A.10
-
62
-
-
43549112146
-
FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1
-
Lee, S. M., B. Gao, and D. Fang. 2008. FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1. Blood 111: 3599-3606.
-
(2008)
Blood
, vol.111
, pp. 3599-3606
-
-
Lee, S.M.1
Gao, B.2
Fang, D.3
-
63
-
-
33751103681
-
Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection
-
Chang, X., L. Chen, J. Wen, V. L. Godfrey, G. Qiao, Y. Hussien, J. Zhang, and J. X. Gao. 2006. Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection. Clin. Immunol. 121: 274-285.
-
(2006)
Clin. Immunol.
, vol.121
, pp. 274-285
-
-
Chang, X.1
Chen, L.2
Wen, J.3
Godfrey, V.L.4
Qiao, G.5
Hussien, Y.6
Zhang, J.7
Gao, J.X.8
-
64
-
-
0033082519
-
Evidence for repression of IL-2 gene activation in anergic T cells
-
Telander, D. G., E. N. Malvey, and D. L. Mueller. 1999. Evidence for repression of IL-2 gene activation in anergic T cells. J. Immunol. 162: 1460-1465.
-
(1999)
J. Immunol.
, vol.162
, pp. 1460-1465
-
-
Telander, D.G.1
Malvey, E.N.2
Mueller, D.L.3
-
65
-
-
0030587135
-
Multifactor cis-Dominant Negative Regulation of IL-2 Gene Expression in Anergized T Cells
-
Kitagawa-Sakakida, S., and R. H. Schwartz. 1996. Multifactor cis-dominant negative regulation of IL-2 gene expression in anergized T cells. J. Immunol. 157: 2328-2339. (Pubitemid 126450442)
-
(1996)
Journal of Immunology
, vol.157
, Issue.6
, pp. 2328-2339
-
-
Kitagawa-Sakakida, S.1
Schwartz, R.H.2
-
66
-
-
0034823168
-
Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy
-
Wells, A. D., M. C. Walsh, J. A. Bluestone, and L. A. Turka. 2001. Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J. Clin. Invest. 108: 895-903.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 895-903
-
-
Wells, A.D.1
Walsh, M.C.2
Bluestone, J.A.3
Turka, L.A.4
-
67
-
-
0036884923
-
Clonal anergy is maintained independently of T cell proliferation
-
Colombetti, S., F. Benigni, V. Basso, and A. Mondino. 2002. Clonal anergy is maintained independently of T cell proliferation. J. Immunol. 169: 6178-6186. (Pubitemid 36903463)
-
(2002)
Journal of Immunology
, vol.169
, Issue.11
, pp. 6178-6186
-
-
Colombetti, S.1
Benigni, F.2
Basso, V.3
Mondino, A.4
-
68
-
-
0035253697
-
A new regulatory region of the IL-2 locus that confers position-independent transgene expression
-
Yui, M. A., G. Hernandez-Hoyos, and E. V. Rothenberg. 2001. A new regulatory region of the IL-2 locus that confers position-independent transgene expression. J. Immunol. 166: 1730-1739. (Pubitemid 32114657)
-
(2001)
Journal of Immunology
, vol.166
, Issue.3
, pp. 1730-1739
-
-
Yui, M.A.1
Hernandez-Hoyos, G.2
Rothenberg, E.V.3
-
69
-
-
20144385672
-
Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cells
-
Adachi, S., and E. V. Rothenberg. 2005. Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cells. Nucleic Acids Res. 33: 3200-3210.
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 3200-3210
-
-
Adachi, S.1
Rothenberg, E.V.2
-
70
-
-
17044410174
-
Signals from CD28 induce stable epigenetic modification of the IL-2 promoter
-
Thomas, R. M., L. Gao, and A. D. Wells. 2005. Signals from CD28 induce stable epigenetic modification of the IL-2 promoter. J. Immunol. 174: 4639-4646. (Pubitemid 40504545)
-
(2005)
Journal of Immunology
, vol.174
, Issue.8
, pp. 4639-4646
-
-
Thomas, R.M.1
Gao, L.2
Wells, A.D.3
-
71
-
-
35548989729
-
+ T cell tolerance is associated with DNA methylation and histone hypo-acetylation at cytokine gene loci
-
+ T cell tolerance is associated with DNA methylation and histone hypo-acetylation at cytokine gene loci. Genes Immun. 8: 613-618.
-
(2007)
Genes Immun.
, vol.8
, pp. 613-618
-
-
Thomas, R.M.1
Saouaf, S.J.2
Wells, A.D.3
-
72
-
-
33750370863
-
The transcriptional repressor cAMP response element modulator α interacts with histone deacetylase 1 to repress promoter activity
-
Tenbrock, K., Y. T. Juang, N. Leukert, J. Roth, and G. C. Tsokos. 2006. The transcriptional repressor cAMP response element modulator α interacts with histone deacetylase 1 to repress promoter activity. J. Immunol. 177: 6159-6164. (Pubitemid 44628833)
-
(2006)
Journal of Immunology
, vol.177
, Issue.9
, pp. 6159-6164
-
-
Tenbrock, K.1
Juang, Y.-T.2
Leukert, N.3
Roth, J.4
Tsokos, G.C.5
-
74
-
-
33745861718
-
Epigenetic remodeling of the IL-2 and IFN-γ loci in memory CD8 T cells is influenced by CD4 T cells
-
Northrop, J. K., R. M. Thomas, A. D. Wells, and H. Shen. 2006. Epigenetic remodeling of the IL-2 and IFN-γ loci in memory CD8 T cells is influenced by CD4 T cells. J. Immunol. 177: 1062-1069.
-
(2006)
J. Immunol.
, vol.177
, pp. 1062-1069
-
-
Northrop, J.K.1
Thomas, R.M.2
Wells, A.D.3
Shen, H.4
-
76
-
-
35948980739
-
Deacetylase inhibition promotes the generation and function of regulatory T cells
-
Tao, R., E. F. de Zoeten, E. Ozkaynak, C. Chen, L. Wang, P. M. Porrett, B. Li, L. A. Turka, E. N. Olson, M. I. Greene, et al. 2007. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat. Med. 13: 1299-1307.
-
(2007)
Nat. Med.
, vol.13
, pp. 1299-1307
-
-
Tao, R.1
De Zoeten, E.F.2
Ozkaynak, E.3
Chen, C.4
Wang, L.5
Porrett, P.M.6
Li, B.7
Turka, L.A.8
Olson, E.N.9
Greene, M.I.10
-
77
-
-
33646255425
-
Foxp3 represses retroviral transcription by targeting both NF-κB and CREB pathways
-
Grant, C., U. Oh, K. Fugo, N. Takenouchi, C. Griffith, K. Yao, T. E. Newhook, L. Ratner, and S. Jacobson. 2006. Foxp3 represses retroviral transcription by targeting both NF-κB and CREB pathways. PLoS Pathog. 2: e33.
-
(2006)
PLoS Pathog.
, vol.2
-
-
Grant, C.1
Oh, U.2
Fugo, K.3
Takenouchi, N.4
Griffith, C.5
Yao, K.6
Newhook, T.E.7
Ratner, L.8
Jacobson, S.9
-
78
-
-
34248379172
-
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
-
Li, B., A. Samanta, X. Song, K. T. Iacono, K. Bembas, R. Tao, S. Basu, J. L. Riley, W. W. Hancock, Y. Shen, et al. 2007. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc. Natl. Acad. Sci. USA 104: 4571-4576.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 4571-4576
-
-
Li, B.1
Samanta, A.2
Song, X.3
Iacono, K.T.4
Bembas, K.5
Tao, R.6
Basu, S.7
Riley, J.L.8
Hancock, W.W.9
Shen, Y.10
-
79
-
-
0029936359
-
Selective inhibition of IL-2 gene expression by trichostatin A, a potent inhibitor of mammalian histone deacetylase
-
Takahashi, I., H. Miyaji, T. Yoshida, S. Sato, and T. Mizukami. 1996. Selective inhibition of IL-2 gene expression by trichostatin A, a potent inhibitor of mammalian histone deacetylase. J. Antibiot. (Tokyo) 49: 453-457.
-
(1996)
J. Antibiot. (Tokyo)
, vol.49
, pp. 453-457
-
-
Takahashi, I.1
Miyaji, H.2
Yoshida, T.3
Sato, S.4
Mizukami, T.5
-
80
-
-
0036040669
-
The ability of antigen, but not interleukin-2, to promote n-butyrate-induced T helper 1 cell anergy is associated with increased expression and altered association patterns of cyclin-dependent kinase inhibitors
-
Jackson, S. K., A. DeLoose, and K. M. Gilbert. 2002. The ability of antigen, but not interleukin-2, to promote n-butyrate-induced T helper 1 cell anergy is associated with increased expression and altered association patterns of cyclin-dependent kinase inhibitors. Immunology 106: 486-495.
-
(2002)
Immunology
, vol.106
, pp. 486-495
-
-
Jackson, S.K.1
DeLoose, A.2
Gilbert, K.M.3
-
81
-
-
34250711440
-
Disruption of HDAC4/N-CoR complex by histone deacetylase inhibitors leads to inhibition of IL-2 gene expression
-
Matsuoka, H., T. Fujimura, M. Hayashi, K. Matsuda, Y. Ishii, I. Aramori, and S. Mutoh. 2007. Disruption of HDAC4/N-CoR complex by histone deacetylase inhibitors leads to inhibition of IL-2 gene expression. Biochem. Pharmacol. 74: 465-476.
-
(2007)
Biochem. Pharmacol.
, vol.74
, pp. 465-476
-
-
Matsuoka, H.1
Fujimura, T.2
Hayashi, M.3
Matsuda, K.4
Ishii, Y.5
Aramori, I.6
Mutoh, S.7
-
82
-
-
0038638583
-
An epigenetic view of helper T cell differentiation
-
Ansel, K. M., D. U. Lee, and A. Rao. 2003. An epigenetic view of helper T cell differentiation. Nat. Immunol. 4: 616-623.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 616-623
-
-
Ansel, K.M.1
Lee, D.U.2
Rao, A.3
-
83
-
-
49049110982
-
Cutting edge: Chromatin remodeling as a molecular basis for the enhanced functionality of memory CD8 T cells
-
Northrop, J. K., A. D. Wells, and H. Shen. 2008. Cutting edge: chromatin remodeling as a molecular basis for the enhanced functionality of memory CD8 T cells. J. Immunol. 181: 865-868.
-
(2008)
J. Immunol.
, vol.181
, pp. 865-868
-
-
Northrop, J.K.1
Wells, A.D.2
Shen, H.3
-
84
-
-
18244365863
-
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
-
Lee, P. P., D. R. Fitzpatrick, C. Beard, H. K. Jessup, S. Lehar, K. W. Makar, M. Perez-Melgosa, M. T. Sweetser, M. S. Schlissel, S. Nguyen, et al. 2001. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15: 763-774.
-
(2001)
Immunity
, vol.15
, pp. 763-774
-
-
Lee, P.P.1
Fitzpatrick, D.R.2
Beard, C.3
Jessup, H.K.4
Lehar, S.5
Makar, K.W.6
Perez-Melgosa, M.7
Sweetser, M.T.8
Schlissel, M.S.9
Nguyen, S.10
-
85
-
-
4644231710
-
DNA methylation is a nonredundant repressor of the Th2 effector program
-
Makar, K. W., and C. B. Wilson. 2004. DNA methylation is a nonredundant repressor of the Th2 effector program. J. Immunol. 173: 4402-4406.
-
(2004)
J. Immunol.
, vol.173
, pp. 4402-4406
-
-
Makar, K.W.1
Wilson, C.B.2
-
86
-
-
10344237554
-
A distinct region of the murine IFN-γ promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells
-
Winders, B. R., R. H. Schwartz, and D. Bruniquel. 2004. A distinct region of the murine IFN-γ promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells. J. Immunol. 173: 7377-7384.
-
(2004)
J. Immunol.
, vol.173
, pp. 7377-7384
-
-
Winders, B.R.1
Schwartz, R.H.2
Bruniquel, D.3
-
88
-
-
0037340215
-
Selective, stable demethylation of the interleukin- 2 gene enhances transcription by an active process
-
Bruniquel, D., and R. H. Schwartz. 2003. Selective, stable demethylation of the interleukin- 2 gene enhances transcription by an active process. Nat. Immunol. 4: 235-240.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 235-240
-
-
Bruniquel, D.1
Schwartz, R.H.2
-
89
-
-
33644854871
-
A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory
-
Murayama, A., K. Sakura, M. Nakama, K. Yasuzawa-Tanaka, E. Fujita, Y. Tateishi, Y. Wang, T. Ushijima, T. Baba, K. Shibuya, et al. 2006. A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory. EMBO J. 25: 1081-1092.
-
(2006)
EMBO J.
, vol.25
, pp. 1081-1092
-
-
Murayama, A.1
Sakura, K.2
Nakama, M.3
Yasuzawa-Tanaka, K.4
Fujita, E.5
Tateishi, Y.6
Wang, Y.7
Ushijima, T.8
Baba, T.9
Shibuya, K.10
-
90
-
-
33646058925
-
Rapid demethylation of the IFN-γ gene occurs in memory but not naive CD8 T cells
-
Kersh, E. N., D. R. Fitzpatrick, K. Murali-Krishna, J. Shires, S. H. Speck, J. M. Boss, and R. Ahmed. 2006. Rapid demethylation of the IFN-γ gene occurs in memory but not naive CD8 T cells. J. Immunol. 176: 4083-4093.
-
(2006)
J. Immunol.
, vol.176
, pp. 4083-4093
-
-
Kersh, E.N.1
Fitzpatrick, D.R.2
Murali-Krishna, K.3
Shires, J.4
Speck, S.H.5
Boss, J.M.6
Ahmed, R.7
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