The ability of antigen, but not interleukin-2, to promote n-butyrate-induced T helper 1 cell anergy is associated with increased expression and altered association patterns of cyclin-dependent kinase inhibitors

Immunology

Volumn 106, Issue 4, 2002, Pages 486-495

  Jackson, Stephanie K ^a   DeLoose, Annick ^a   Gilbert, Kathleen M ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; CYCLIN DEPENDENT KINASE INHIBITOR; INTERLEUKIN 2; PROTEIN P21; PROTEIN P27;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL CYCLE; CELL PROLIFERATION; CLONAL ANERGY; CONTROLLED STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH1 CELL;

ANIMALS; ANTIGENS; BLOTTING, WESTERN; BUTYRATES; CDC2 PROTEIN KINASE; CELL CYCLE; CELL CYCLE PROTEINS; CLONAL ANERGY; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; INTERLEUKIN-2; MALE; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; TUMOR SUPPRESSOR PROTEINS;

EID: 0036040669     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2002.01457.x     Document Type: Article

References (19)

1. Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: Specific induction of a long-lived state of proliferative nonresponsiveness
2. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
3. Th1 cell anergy and blockade in G1a phase of the cell cycle
4. Kip1
5. Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase
6. Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones
7. Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists
8. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
9. Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites
10. Sustained activation of the raf-MEK-ERK pathway elicits cytokine unresponsiveness in T cells
11. Sodium butyrate induces NIH3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1 in p53-independent manner
12. p21 (Waf1) is required for butyrate-mediated growth inhibition of human colon cancer cells
13. Cyclin E-CDK2 is a regulator of p27Kip1
14. p21WAF1 expression by an activator of protein kinase C is regulated mainly at the post-transcriptional level in cells lacking p53: Important role of RNA stabilization
15. Activation of protein kinase C augments butyrate-induced differentiation and turnover in human colonic epithelial cells in vitro
16. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
17. A non-enzymatic p21 protein inhibitor of stress-activated protein kinases
18. p21WAF1 is dynamically associated with JNK in human T-lymphocytes during cell cycle progression
19. Kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes