Egr-2 and Egr-3 are negative regulators of T cell activation

Nature Immunology

Volumn 6, Issue 5, 2005, Pages 472-480

  Safford, Meredith ^a   Collins, Samuel ^a   Lutz, Michael A ^a   Allen, Amy ^a   Huang, Ching Tai ^b   Kowalski, Jeanne ^a   Blackford, Amanda ^a   Horton, Maureen R ^c   Drake, Charles ^a   Schwartz, Ronald H ^d   Powell, Jonathan D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CBL PROTEIN; EARLY GROWTH RESPONSE FACTOR 1; EARLY GROWTH RESPONSE FACTOR 2; EARLY GROWTH RESPONSE FACTOR 3; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CBLB PROTEIN, MOUSE; DNA BINDING PROTEIN; EGR2 PROTEIN, MOUSE; EGR3 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; GENE FUNCTION; IN VIVO CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; T LYMPHOCYTE ACTIVATION; ANIMAL; CELL CULTURE; CLONAL ANERGY; CYTOLOGY; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE MUTANT; MUTATION; T LYMPHOCYTE; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELLS, CULTURED; CLONAL ANERGY; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 2; EARLY GROWTH RESPONSE PROTEIN 3; GENE EXPRESSION; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-CBL; T-LYMPHOCYTES; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION;

EID: 18244375249     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1193     Document Type: Article

References (32)

1. Schwartz, R.H. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71, 1065-1068 (1992).
2. Medzhitov, R. & Janeway, C.A., Jr. How does the immune system distinguish self from nonself? Semmin. Immunol. 12, 185-188 (2000).
3. Diehn, M. et al. Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc. Natl. Acad. Sci. USA 99, 11796-11801 (2002).
4. Riley, J.L. et al. Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc. Natl. Acad. Sci. USA 99, 11790-11795 (2002).
5. Macian, F. et al. Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109, 719-731 (2002).
6. Schwartz, R.H. A cell culture model for T lymphocyte clonal anergy. Science 248, 1349-1356 (1990).
7. Schwartz, R.H. T cell anergy. Annu. Rev. Immunol. 21, 305-334 (2003).
8. Hammerling, G.J. et al. Non-deletional mechanisms of peripheral and central tolerance: studies with transgenic mice with tissue-specific expression of a foreign MHC class I antigen. Immunol. Rev. 122, 47-67 (1991).
9. Staveley-O'Carroll, K. er al. Induction of antigen-specific T cell anergy: An early event in the course of tumor progression. Proc. Natl. Acad. Sci. USA 95, 1178-1183 (1998).
10. Heissmeyer, V. et al. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5, 255-265 (2004).
11. Jeon, M.S. et al. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity 21, 167-177 (2004).
12. Seroogy, C.M. et al. The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells. J. Immunol. 173, 79-85 (2004).
13. Kowalski, J., Drake, C., Schwartz, R.H. & Powell, J. Non-parametric, hypothesis-based analysis of microarrays for comparison of several phenotypes. Bioinformatics 20, 364-373 (2004).
14. O'Donovan, K.J., Tourtellotte, W.G., Millbrandt, J. & Baraban, J.M. The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience. Trends Neurosci. 22, 167-173 (1999).
15. Decker, E.L., Skerka, C. & Zipfel, P.F. The early growth response protein (EGR-1) regulates interleukin-2 transcription by synergistic interaction with the nuclear factor of activated T cells J. Biol. Chem. 273, 26923-26930 (1998).
16. Lin, J.X. & Leonard, W.J. The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor β-chain promoter through noncanonical Egr and Sp1 binding sites. Mol. Cell. Biol. 17, 3714-3722 (1997).
17. Mittelstadt, P.R. & Ashwell, J.D. Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression. Mol. Cell. Biol. 18, 3744-3751 (1998).
18. Mittelstadt, P.R. & Ashwell, J.D. Role of Egr-2 in up-regulation of Fas ligand in normal T cells and aberrant double-negative lpr and gld T cells. J. Biol. Chem. 274, 3222-3227 (1999).
19. + single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180, 25-34 (1994).
20. + T cells pass through an effector phase during the process of in vivo tolerance induction. J. Immunol. 170, 3945-3953 (2003).
21. Warner, L.E., Svaren, J., Milbrandt, J. & Lupski, J.R. Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies. Hum. Mol. Genet. 8, 1245-1251 (1999).
22. Turman, J.E., Jr., Chopiuk, N.B. & Shuler, C.F. The Krox-20 null mutation differentially affects the development of masticatory muscles. Dev. Neurosci. 23, 113-121 (2001).
23. Pape, K.A. et al. Use of adoptive transfer of T-cell-antigen-receptor- transgenic T cell for the study of T-cell activation in vivo. Immunol. Rev. 156, 67-78 (1997).
24. Perez, V.L. et al. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6, 411-417 (1997).
25. Glynne, R. et al. How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis. Nature 403, 672-676 (2000).
26. Lechner, O. et al. Fingerprints of anergic T cells. Curr. Biol. 11, 587-595 (2001).
27. + T cells. J. Immunol. 173, 7331-7338 (2004).
28. Powell, J.D., Ragheb, J.A., Kitagawa-Sakakida, S. & Schwartz, R.H. Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy. Immunol. Rev. 165, 287-300 (1998).
29. Mueller, D.L. E3 ubiquitin ligases as T cell anergy factors. Nat. Immunol. 5, 883-890 (2004).
30. Powell, J.D., Bruniquel, D. & Schwartz, R.H. TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27(Kip1). Eur. J. Immunol. 31, 3737-3746 (2001).
31. + T cell tolerance induction versus priming is independent of the rate and number of cell divisions. J. Immunol. 164, 649-655 (2000).
32. Warner, L.E. et al. Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. Nat. Genet. 18, 382-384 (1998).