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Volumn 177, Issue 4, 2006, Pages 2186-2194

Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; DIACYLGLYCEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; RAS PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT;

EID: 33746863731     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.4.2186     Document Type: Article
Times cited : (66)

References (46)
  • 2
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol, E. A., F. Bordello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3: 541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Bordello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 4
    • 0036360019 scopus 로고    scopus 로고
    • The enemy within: Keeping self-reactive T cells at bay in the periphery
    • Walker, L. S., and A. K. Abbas. 2002. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat. Rev. Immunol. 2: 11-19.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 11-19
    • Walker, L.S.1    Abbas, A.K.2
  • 5
    • 12344254024 scopus 로고    scopus 로고
    • Regulating the immune system: The induction of regulatory T cells in the periphery
    • Buckner, J. H., and S. F. Ziegler. 2004. Regulating the immune system: the induction of regulatory T cells in the periphery. Arthritis Res. Ther. 6: 215-222.
    • (2004) Arthritis Res. Ther. , vol.6 , pp. 215-222
    • Buckner, J.H.1    Ziegler, S.F.2
  • 6
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164.
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 10
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 13
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
    • (1998) J. Exp. Med. , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 18
    • 0034644505 scopus 로고    scopus 로고
    • Signaling takes shape in the immune system
    • Dustin, M. L., and A. C. Chan. 2000. Signaling takes shape in the immune system. Cell 103: 283-294.
    • (2000) Cell , vol.103 , pp. 283-294
    • Dustin, M.L.1    Chan, A.C.2
  • 19
    • 0033613826 scopus 로고    scopus 로고
    • T lymphocyte costimulation mediated by reorganization of membrane microdomains
    • Viola, A., S. Schroeder, Y. Sakakibara, and A. Lanzavecchia. 1999. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283: 680-682.
    • (1999) Science , vol.283 , pp. 680-682
    • Viola, A.1    Schroeder, S.2    Sakakibara, Y.3    Lanzavecchia, A.4
  • 20
    • 0033604513 scopus 로고    scopus 로고
    • Phospholipase C-γ as a signal-transducing element
    • Carpenter, G., and Q. Ji. 1999. Phospholipase C-γ as a signal-transducing element. Exp. Cell Res. 253: 15-24.
    • (1999) Exp. Cell Res. , vol.253 , pp. 15-24
    • Carpenter, G.1    Ji, Q.2
  • 21
    • 0037446523 scopus 로고    scopus 로고
    • Regulation of T cell activation and tolerance by phospholipase C γ-1-dependent integrin avidity modulation
    • Wells, A. D., Q. H. Liu, B. Hondowicz, J. Zhang, L. A. Turka, and B. D. Freedman. 2003. Regulation of T cell activation and tolerance by phospholipase C γ-1-dependent integrin avidity modulation. J. Immunol. 170: 4127-4133.
    • (2003) J. Immunol. , vol.170 , pp. 4127-4133
    • Wells, A.D.1    Liu, Q.H.2    Hondowicz, B.3    Zhang, J.4    Turka, L.A.5    Freedman, B.D.6
  • 22
    • 20644466433 scopus 로고    scopus 로고
    • NFAT proteins: Key regulators of T-cell development and function
    • Macian, F. 2005. NFAT proteins: key regulators of T-cell development and function. Nat. Rev. Immunol. 5: 472-484.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 472-484
    • Macian, F.1
  • 23
    • 85047682875 scopus 로고    scopus 로고
    • Protein kinase C(θ) in T cell activation
    • Isakov, N., and A. Altman. 2002. Protein kinase C(θ) in T cell activation. Annu. Rev. Immunol. 20: 761-794.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 761-794
    • Isakov, N.1    Altman, A.2
  • 24
    • 0032524389 scopus 로고    scopus 로고
    • RasGRP, a Ras guanyl nucleolide-releasing protein with calcium- and diacylglycerol-binding motifs
    • Ebinu, J. O., D. A. Bottorff, E. Y. Chan, S. L. Stang, R. J. Dunn, and J. C. Stone. 1998. RasGRP, a Ras guanyl nucleolide-releasing protein with calcium- and diacylglycerol-binding motifs. Science 280: 1082-1086.
    • (1998) Science , vol.280 , pp. 1082-1086
    • Ebinu, J.O.1    Bottorff, D.A.2    Chan, E.Y.3    Stang, S.L.4    Dunn, R.J.5    Stone, J.C.6
  • 25
    • 0037163130 scopus 로고    scopus 로고
    • Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase ζ
    • Zhong, X. P., E. A. Hainey, B. A. Olenchock, H. Zhao, M. K. Topham, and G. A. Koretzky. 2002. Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase ζ. J. Biol. Chem. 277: 31089-31098.
    • (2002) J. Biol. Chem. , vol.277 , pp. 31089-31098
    • Zhong, X.P.1    Hainey, E.A.2    Olenchock, B.A.3    Zhao, H.4    Topham, M.K.5    Koretzky, G.A.6
  • 28
    • 0033597338 scopus 로고    scopus 로고
    • Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions
    • Topham, M. K., and S. M. Prescott. 1999. Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions. J. Biol. Chem. 274: 11447-11450.
    • (1999) J. Biol. Chem. , vol.274 , pp. 11447-11450
    • Topham, M.K.1    Prescott, S.M.2
  • 29
    • 10844252294 scopus 로고    scopus 로고
    • + regulatory cell activation and function by dendritic cells
    • + regulatory cell activation and function by dendritic cells. Int. Immunol. 16: 1769-1780.
    • (2004) Int. Immunol. , vol.16 , pp. 1769-1780
    • Fehervari, Z.1    Sakaguchi, S.2
  • 31
    • 0023022087 scopus 로고
    • Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells
    • Siebenlist, U., D. B. Durand, P. Bressler, N. J. Holbrook, C. A. Norris, M. Kamoun, J. A. Kant, and G. R. Crabtree. 1986. Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells. Mol. Cell. Biol. 6: 3042-3049.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 3042-3049
    • Siebenlist, U.1    Durand, D.B.2    Bressler, P.3    Holbrook, N.J.4    Norris, C.A.5    Kamoun, M.6    Kant, J.A.7    Crabtree, G.R.8
  • 32
    • 0035888026 scopus 로고    scopus 로고
    • Chromatin remodeling, measured by a novel real-time polymerase chain reaction assay, across the proximal promoter region of the IL-2 gene
    • Rao, S., E. Procko, and M. F. Shannon. 2001. Chromatin remodeling, measured by a novel real-time polymerase chain reaction assay, across the proximal promoter region of the IL-2 gene. J. Immunol. 167: 4494-4503.
    • (2001) J. Immunol. , vol.167 , pp. 4494-4503
    • Rao, S.1    Procko, E.2    Shannon, M.F.3
  • 33
    • 0041695164 scopus 로고    scopus 로고
    • Continuous T cell receptor signaling required for synapse maintenance and full effector potential
    • Huppa, J. B., M. Gleimer, C. Sumen, and M. M. Davis. 2003. Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat. Immunol. 4: 749-755.
    • (2003) Nat. Immunol. , vol.4 , pp. 749-755
    • Huppa, J.B.1    Gleimer, M.2    Sumen, C.3    Davis, M.M.4
  • 35
    • 0034044135 scopus 로고    scopus 로고
    • Enhanced surface TCR replenishment mediated by CD28 leads to greater TCR engagement during primary stimulation
    • Schrum, A. G., A. D. Wells, and L. A. Turka. 2000. Enhanced surface TCR replenishment mediated by CD28 leads to greater TCR engagement during primary stimulation. Int. Immunol. 12: 833-842.
    • (2000) Int. Immunol. , vol.12 , pp. 833-842
    • Schrum, A.G.1    Wells, A.D.2    Turka, L.A.3
  • 36
    • 9244244736 scopus 로고    scopus 로고
    • Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    • van Santen, H. M., C. Benoist, and D. Mathis. 2004. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 200: 1221-1230.
    • (2004) J. Exp. Med. , vol.200 , pp. 1221-1230
    • Van Santen, H.M.1    Benoist, C.2    Mathis, D.3
  • 37
  • 38
    • 0035654908 scopus 로고    scopus 로고
    • Distinct patterns of membrane microdomain partitioning in Th1 and th2 cells
    • Balamuth, F., D. Leitenberg, J. Unternaehrer, I. Mellman, and K. Bottomly. 2001. Distinct patterns of membrane microdomain partitioning in Th1 and th2 cells. Immunity 15: 729-738.
    • (2001) Immunity , vol.15 , pp. 729-738
    • Balamuth, F.1    Leitenberg, D.2    Unternaehrer, J.3    Mellman, I.4    Bottomly, K.5
  • 39
    • 0036839104 scopus 로고    scopus 로고
    • Dynamic association of CD45 with detergent-insoluble microdomains in T lymphocytes
    • Edmonds, S. D., and H. L. Ostergaard. 2002. Dynamic association of CD45 with detergent-insoluble microdomains in T lymphocytes. J. Immunol. 169: 5036-5042.
    • (2002) J. Immunol. , vol.169 , pp. 5036-5042
    • Edmonds, S.D.1    Ostergaard, H.L.2
  • 40
    • 0034730188 scopus 로고    scopus 로고
    • A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation
    • Johnson, K. G., S. K. Bromley, M. L. Dustin, and M. L. Thomas. 2000. A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation. Proc. Natl. Acad. Sci. USA 97: 10138-10143.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10138-10143
    • Johnson, K.G.1    Bromley, S.K.2    Dustin, M.L.3    Thomas, M.L.4
  • 41
    • 12444292069 scopus 로고    scopus 로고
    • CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production
    • Zhang, M., M. Moran, J. Round, T. A. Low, V. P. Patel, T. Tomassian, J. D. Hernandez, and M. C. Miceli. 2005. CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production. J. Immunol. 174: 1479-1490.
    • (2005) J. Immunol. , vol.174 , pp. 1479-1490
    • Zhang, M.1    Moran, M.2    Round, J.3    Low, T.A.4    Patel, V.P.5    Tomassian, T.6    Hernandez, J.D.7    Miceli, M.C.8
  • 42
    • 15444379874 scopus 로고    scopus 로고
    • Cross-linking of CD45 on suppressive/regulatory T cells leads to the abrogation of their suppressive activity in vitro
    • Shimizu, J., R. Iida, Y. Sato, E. Moriizumi, A. Nishikawa, and Y. Ishida. 2005. Cross-linking of CD45 on suppressive/regulatory T cells leads to the abrogation of their suppressive activity in vitro. J. Immunol. 174: 4090-4097.
    • (2005) J. Immunol. , vol.174 , pp. 4090-4097
    • Shimizu, J.1    Iida, R.2    Sato, Y.3    Moriizumi, E.4    Nishikawa, A.5    Ishida, Y.6
  • 43
    • 0028291525 scopus 로고
    • JNK is involved in signal integration during costimulation of T lymphocytes
    • Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77: 727-736.
    • (1994) Cell , vol.77 , pp. 727-736
    • Su, B.1    Jacinto, E.2    Hibi, M.3    Kallunki, T.4    Karin, M.5    Ben-Neriah, Y.6
  • 44
    • 0032566435 scopus 로고    scopus 로고
    • IκB kinases serve as a target of CD28 signaling
    • Harhaj, E. W., and S. C. Sun. 1998. IκB kinases serve as a target of CD28 signaling. J. Biol. Chem. 273: 25185-25190.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25185-25190
    • Harhaj, E.W.1    Sun, S.C.2
  • 45
    • 0346195644 scopus 로고    scopus 로고
    • Rel is required for chromatin remodeling across the IL-2 gene promoter
    • Rao, S., S. Gerondakis, D. Woltring, and M. F. Shannon. 2003. c-Rel is required for chromatin remodeling across the IL-2 gene promoter. J. Immunol. 170: 3724-3731.
    • (2003) J. Immunol. , vol.170 , pp. 3724-3731
    • Rao, S.1    Gerondakis, S.2    Woltring, D.3    Shannon, M.F.4
  • 46
    • 17044393922 scopus 로고    scopus 로고
    • Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells
    • Bettelli, E., M. Dastrange, and M. Oukka. 2005. Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. USA 102: 5138-5143.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5138-5143
    • Bettelli, E.1    Dastrange, M.2    Oukka, M.3


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