메뉴 건너뛰기




Volumn 173, Issue 12, 2004, Pages 7377-7384

A distinct region of the murine IFN-γ promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4;

EID: 10344237554     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.12.7377     Document Type: Article
Times cited : (77)

References (40)
  • 1
    • 0142216213 scopus 로고    scopus 로고
    • Methylation and demethylation in the regulation of genes, cells, and responses in the immune system
    • Fitzpatrick, D. R., and C. B. Wilson. 2003. Methylation and demethylation in the regulation of genes, cells, and responses in the immune system. Clin. Immunol. 109:37.
    • (2003) Clin. Immunol. , vol.109 , pp. 37
    • Fitzpatrick, D.R.1    Wilson, C.B.2
  • 2
    • 0037083250 scopus 로고    scopus 로고
    • Epigenetic regulation of T cell fate and function
    • Wilson, C. B., K. W. Makar, and M. Perez-Melgosa. 2002. Epigenetic regulation of T cell fate and function. J. Infect. Dis. 185(Suppl. 1):S37.
    • (2002) J. Infect. Dis. , vol.185 , Issue.SUPPL. 1
    • Wilson, C.B.1    Makar, K.W.2    Perez-Melgosa, M.3
  • 4
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch, R., and A. Bird. 2003. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 33 Suppl:245.
    • (2003) Nat. Genet. , vol.33 , Issue.SUPPL. , pp. 245
    • Jaenisch, R.1    Bird, A.2
  • 5
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird, A. 2002. DNA methylation patterns and epigenetic memory. Genes Dev. 16:6.
    • (2002) Genes Dev. , vol.16 , pp. 6
    • Bird, A.1
  • 6
    • 0037963483 scopus 로고    scopus 로고
    • The establishment and maintenance of lymphocyte identity through gene silencing
    • Smale, S. T. 2003. The establishment and maintenance of lymphocyte identity through gene silencing. Nat. Immunol. 4:607.
    • (2003) Nat. Immunol. , vol.4 , pp. 607
    • Smale, S.T.1
  • 7
    • 0142216237 scopus 로고    scopus 로고
    • DNA methylation in the immune system
    • Teitell, M., and B. Richardson. 2003. DNA methylation in the immune system. Clin. Immunol. 109:2.
    • (2003) Clin. Immunol. , vol.109 , pp. 2
    • Teitell, M.1    Richardson, B.2
  • 8
    • 0030792305 scopus 로고    scopus 로고
    • DNA methylation: Regulation of gene expression and role in the immune system
    • Mostoslavsky, R., and Y. Bergman. 1997. DNA methylation: regulation of gene expression and role in the immune system. Biochim. Biophys. Acta 1333:F29.
    • (1997) Biochim. Biophys. Acta , vol.1333
    • Mostoslavsky, R.1    Bergman, Y.2
  • 12
    • 0030627661 scopus 로고    scopus 로고
    • Molecular regulation of cytokine gene expression: Interferon-γ as a model system
    • Young, H. A., and P. Ghosh. 1997. Molecular regulation of cytokine gene expression: interferon-γ as a model system. Prog. Nucleic Acid Res. Mol. Biol. 56:109.
    • (1997) Prog. Nucleic Acid Res. Mol. Biol. , vol.56 , pp. 109
    • Young, H.A.1    Ghosh, P.2
  • 13
    • 0037087421 scopus 로고    scopus 로고
    • Differential patterns of methylation of the IFN-γ promoter at CpG and non-CpG sites underlie differences in IFN-γ gene expression between human neonatal and adult CD45RO T cells
    • White, G. P., P. M. Watt, B. J. Holt, and P. G. Holt. 2002. Differential patterns of methylation of the IFN-γ promoter at CpG and non-CpG sites underlie differences in IFN-γ gene expression between human neonatal and adult CD45RO T cells. J. Immunol. 168:2820.
    • (2002) J. Immunol. , vol.168 , pp. 2820
    • White, G.P.1    Watt, P.M.2    Holt, B.J.3    Holt, P.G.4
  • 14
    • 0041929384 scopus 로고    scopus 로고
    • Effect of promoter methylation on the regulation of IFN-γ gene during in vitro differentiation of human peripheral blood T cells into a Th2 population
    • Yano, S., P. Ghosh, H. Kusaba, M. Buchholz, and D. L. Longo. 2003. Effect of promoter methylation on the regulation of IFN-γ gene during in vitro differentiation of human peripheral blood T cells into a Th2 population. J. Immunol. 171:2510.
    • (2003) J. Immunol. , vol.171 , pp. 2510
    • Yano, S.1    Ghosh, P.2    Kusaba, H.3    Buchholz, M.4    Longo, D.L.5
  • 15
    • 0033949764 scopus 로고    scopus 로고
    • Correlation between DNA methylation and murine IFN-γ and IL-4 expression
    • Falek, P. R., S. Z. Ben-Sasson, and M. Ariel. 2000. Correlation between DNA methylation and murine IFN-γ and IL-4 expression. Cytokine 12:198.
    • (2000) Cytokine , vol.12 , pp. 198
    • Falek, P.R.1    Ben-Sasson, S.Z.2    Ariel, M.3
  • 16
    • 0028987326 scopus 로고
    • Hypomethylation of the interferon-γ gene correlates with its expression by primary T-lineage cells
    • Melvin, A. J., M. E. McGurn, S. J. Bort, C. Gibson, and D. B. Lewis. 1995. Hypomethylation of the interferon-γ gene correlates with its expression by primary T-lineage cells. Eur. J. Immunol. 25:426.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 426
    • Melvin, A.J.1    McGurn, M.E.2    Bort, S.J.3    Gibson, C.4    Lewis, D.B.5
  • 17
    • 0033526853 scopus 로고    scopus 로고
    • Anergy and cytokine-mediated suppression as distinct superantigen-induced tolerance mechanisms in vivo
    • Miller, C., J. A. Ragheb, and R. H. Schwartz. 1999. Anergy and cytokine-mediated suppression as distinct superantigen-induced tolerance mechanisms in vivo. J. Exp. Med. 190:53.
    • (1999) J. Exp. Med. , vol.190 , pp. 53
    • Miller, C.1    Ragheb, J.A.2    Schwartz, R.H.3
  • 19
    • 0037340215 scopus 로고    scopus 로고
    • Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process
    • Bruniquel, D., and R. H. Schwartz. 2003. Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process. Nat. Immunol. 4:235.
    • (2003) Nat. Immunol. , vol.4 , pp. 235
    • Bruniquel, D.1    Schwartz, R.H.2
  • 21
    • 0030022573 scopus 로고    scopus 로고
    • Immature T cells in peripheral lymphoid organs of recombinase-activating gene-1/-2-deficient mice: Thymus dependence and responsiveness to anti-CD3ε antibody
    • Falk, I., A. J. Potocnik, T. Barthlott, C. N. Levelt, and K. Eichmann. 1996. Immature T cells in peripheral lymphoid organs of recombinase-activating gene-1/-2-deficient mice: thymus dependence and responsiveness to anti-CD3ε antibody. J. Immunol. 156:1362.
    • (1996) J. Immunol. , vol.156 , pp. 1362
    • Falk, I.1    Potocnik, A.J.2    Barthlott, T.3    Levelt, C.N.4    Eichmann, K.5
  • 22
    • 0033104742 scopus 로고    scopus 로고
    • Dissecting NK cell development using a novel alymphoid mouse model: Investigating the role of the c-abl proto-oncogene in murine NK cell differentiation
    • Colucci, F., C. Soudais, E. Rosmaraki, L. Vanes, V. L. Tybulewicz, and J. P. Di Santo. 1999. Dissecting NK cell development using a novel alymphoid mouse model: investigating the role of the c-abl proto-oncogene in murine NK cell differentiation. J. Immunol. 162:2761.
    • (1999) J. Immunol. , vol.162 , pp. 2761
    • Colucci, F.1    Soudais, C.2    Rosmaraki, E.3    Vanes, L.4    Tybulewicz, V.L.5    Di Santo, J.P.6
  • 24
    • 0032567436 scopus 로고    scopus 로고
    • The roles of nuclear factor of activated T cells and ying-yang in activation-induced expression of the interferon-γ promoter in T cells
    • Sweetser, M. T., T. Hoey, Y. L. Sun, W. M. Weaver, G. A. Price, and C. B. Wilson. 1998. The roles of nuclear factor of activated T cells and ying-yang in activation-induced expression of the interferon-γ promoter in T cells. J. Biol. Chem. 273:34775.
    • (1998) J. Biol. Chem. , vol.273 , pp. 34775
    • Sweetser, M.T.1    Hoey, T.2    Sun, Y.L.3    Weaver, W.M.4    Price, G.A.5    Wilson, C.B.6
  • 25
    • 0029819030 scopus 로고    scopus 로고
    • Regulation of interferon-γ gene expression
    • Young, H. A. 1996. Regulation of interferon-γ gene expression. J. Interferon Cytokine Res. 16:563.
    • (1996) J. Interferon Cytokine Res. , vol.16 , pp. 563
    • Young, H.A.1
  • 27
    • 0025006860 scopus 로고
    • High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines
    • Antequera, F., J. Boyes, and A. Bird. 1990. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell 62:503.
    • (1990) Cell , vol.62 , pp. 503
    • Antequera, F.1    Boyes, J.2    Bird, A.3
  • 30
    • 0029983704 scopus 로고    scopus 로고
    • Interleukin-12 stimulates B cell growth by inducing IFN-γ
    • Li, L., D. Young, S. F. Wolf, and Y. S. Choi. 1996. Interleukin-12 stimulates B cell growth by inducing IFN-γ. Cell Immunol. 168:133.
    • (1996) Cell Immunol. , vol.168 , pp. 133
    • Li, L.1    Young, D.2    Wolf, S.F.3    Choi, Y.S.4
  • 31
    • 0026627870 scopus 로고
    • Interferon-γ gene expression in human B-cell lines: Induction by interleukin-2, protein kinase C activators, and possible effect of hypomethylation on gene regulation
    • Pang, Y., Y. Norihisa, D. Benjamin, R. R. Kantor, and H. A. Young. 1992. Interferon-γ gene expression in human B-cell lines: induction by interleukin-2, protein kinase C activators, and possible effect of hypomethylation on gene regulation. Blood 80:724.
    • (1992) Blood , vol.80 , pp. 724
    • Pang, Y.1    Norihisa, Y.2    Benjamin, D.3    Kantor, R.R.4    Young, H.A.5
  • 32
    • 3242771189 scopus 로고    scopus 로고
    • Innate production of IFN-γ by NK cells is independent of epigenetic modification of the IFN-γ promoter
    • Tato, C. M., G. A. Martins, F. A. High, C. B. DiCioccio, S. L. Reiner, and C. A. Hunter. 2004. Innate production of IFN-γ by NK cells is independent of epigenetic modification of the IFN-γ promoter. J. Immunol. 173:1514.
    • (2004) J. Immunol. , vol.173 , pp. 1514
    • Tato, C.M.1    Martins, G.A.2    High, F.A.3    DiCioccio, C.B.4    Reiner, S.L.5    Hunter, C.A.6
  • 33
    • 1442281449 scopus 로고    scopus 로고
    • Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation
    • Zhou, W., S. Chang, and T. M. Aune. 2004. Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation. Proc. Natl. Acad. Sci. USA 101:2440.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 2440
    • Zhou, W.1    Chang, S.2    Aune, T.M.3
  • 34
    • 0035660104 scopus 로고    scopus 로고
    • TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27(Kip1)
    • Powell, J. D., D. Bruniquel, and R. H. Schwartz. 2001. TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27(Kip1). Ear. J. Immunol. 31:3737.
    • (2001) Ear. J. Immunol. , vol.31 , pp. 3737
    • Powell, J.D.1    Bruniquel, D.2    Schwartz, R.H.3
  • 35
    • 0033975856 scopus 로고    scopus 로고
    • Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity
    • Chang, J. T., B. M. Segal, and E. M. Shevach. 2000. Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity. J. Immunol. 164:100.
    • (2000) J. Immunol. , vol.164 , pp. 100
    • Chang, J.T.1    Segal, B.M.2    Shevach, E.M.3
  • 39
    • 0346458664 scopus 로고    scopus 로고
    • Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation
    • Eivazova, E. R., and T. M. Aune. 2004. Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation. Proc. Natl. Acad. Sci. USA 101:251.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 251
    • Eivazova, E.R.1    Aune, T.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.