Multifactor cis-Dominant Negative Regulation of IL-2 Gene Expression in Anergized T Cells

Journal of Immunology

Volumn 157, Issue 6, 1996, Pages 2328-2339

  Kitagawa Sakakida, Satoru ^a,b   Schwartz, Ronald H ^a,c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY; TRANSCRIPTION FACTOR AP 1;

ANIMAL; ARTICLE; CELL CLONE; CLONAL ANERGY; ENHANCER REGION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; MUTATION; REPORTER GENE; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; CLONAL ANERGY; CLONE CELLS; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; INTERLEUKIN-2; MICE; MUTATION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC;

EID: 0030587135     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Schwartz, R. H. 1992. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71:1065.
2. Lindsten, T., C. H. June, J. A. Ledbetter, G. Stella, and C. B. Thompson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244:339.
3. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
4. Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248:1349.
5. Jenkins, M. K., and R. H. Schwartz. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:302.
6. Quill, H., and R. H. Schwartz. 1987. Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness. J. Immunol. 138:3704.
7. Beverly, B., S.-M. Kang, M. J. Lenardo, and R. H. Schwartz. 1992. Reversal of in vitro T cell clonal anergy by interleukin 2 stimulation. Int. Immunol. 4:661.
8. Jenkins, M. K., C. A. Chen, G. Jung, D. L. Mueller, and R. H. Schwartz. 1990. Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J. Immunol. 144: 16.
9. Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1993. Induction of T-cell anergy by altered T-cell receptor ligand on live antigen-presenting cells. Nature 363:156.
10. a-expressing cells. Nature 399:541.
11. Rellahan, B. L., L. A. Jones, A. M. Kruisbeek, A. M. Fry, and L. A. Matis. 1991. In vivo induction of anergy in peripheral T cells by staphylococcal enterotoxin B. J. Exp. Med. 172:1091.
12. + T cells. J. Immunol. 151:2355.
13. Lamb, J. R., B. J. Skidmore, N. Green, H. M. Chiller, and M. Feldmann. 1983. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J. Exp. Med. 157:1434.
14. Boussiotis, U. A., D. L. Barber, T. Nakarai, G. J. Freeman, J. G. Gribben, G. M. Bernstein, A. D. D'Andrea, J. Ritz, and L. M. Nadler. 1994. Prevention of T cell anergy by signaling through the γ chain of the IL-2 receptor. Science 266:1039.
15. Beverly, B., L. Chiodetti, K. Brorson, R. H. Schwartz, and D. L. Mueller. 1993. T cell anergy. In Molecular Mechanisms of Immunological Self-Recognition. F. W. Alt and H. J. Vogel, eds. Academic Press, New York, pp. 39-53.
16. fyn. J. Immunol. 149:2887.
17. Cho, E. A., M. P. Reley, A. L. Sillman, and H. Quill. 1993. Altered protein tyrosine phosphorylation in anergic Th1 cells. J. Immunol. 151:20.
18. + T cells. Science 271:1276.
19. + T cells. Science 271:1272.
20. Kang, S.-M., B. Beverly, A. C. Tran, K. Brorson, R. H. Schwartz, and M. J. Lenardo. 1992. Transactivation by AP-1 is a molecular target of T cell clonal anergy. Science 257:1134.
21. Ishida, Y., M. Nishi, O. Taguchi, K. Inaba, N. Minato, M. Kawai, and T. Honjo. 1989. Effects of the deregulated expression of human interleukin-2 in transgenic mice. Int. Immunol. 1:113.
22. Jain, J., V. E. Valge-Archer, and A. Rao. 1992. Analysis of the AP-1 sites in the IL-2 promoter. J. Immunol. 148:1240.
23. Pierce, J. W., M. Lenardo, and D. Baltimore. 1988. Oligonucleotide that binds nuclear factor NF-κB acts as a lymphoid-specific and inducible enhancer element. Proc. Natl. Acad. Sci. USA 85:1482.
24. Ho, S. N., H. D. Hunt, J. K. Pullen, and L. R. Pearce. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51.
25. Suzuki, G., Y. Kawase, S. Koyasu, Y. Kobayashi, and R. H. Schwartz. 1988. Antigen-induced suppression of the proliferative response of T cell clones. J. Immunol. 140:1359.
26. Beverly, B., K. Brorson, S. Umlauf, and R. H. Schwartz. 1993. Technology to study gene transcription in normal T lymphocyte clones. In Methods in Molecular Genetics, Vol. 2. K. Adolph, ed. Academic Press, Inc., Orlando, pp. 331-341.
27. Umlauf, S. W., B. Beverly, O. Lantz, and R. H. Schwartz. 1995. Regulation of IL-2 gene expression by CD28 costimulation in mouse T cell clones: both nuclear and cytoplasmic mechanisms are regulated with complex kinetics. Mol. Cell. Biol. 15:3197.
28. Kubo, R. T., W. Born, J. W. Kappler, P. Marrack, and M. Pigeon. 1989. Characterization of a monoclonal antibody which detects all murine αβ T cell receptors. J. Immunol. 142:2736.
29. Gross, J. A., T. St. John, and J. P. Allison. 1990. The murine homologue of the T lymphocyte antigen CD28: molecular cloning and cell surface expression. J. Immunol. 144:3201.
30. Ashwell, J. D., R. E. Cunningham, P. Noguchi, and D. Hernandez. 1987. Cell growth cycle block of T cell hybridomas upon activation with antigen. J. Exp. Med. 165:173.
31. Mosmann, T. R., H. Cherwinski, W. Bond, M. A. Gieldman, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
32. Ohlsson, H., and T. Edlund. 1986. Sequence-specific interactions of nuclear factors with the insulin gene enhancer. Cell 45:35.
33. Durand, D. B., J.-P. Shaw, M. R. Bush, R. E. Replogle, R. Belagaje, and G. R. Crabtree. 1988. Characterization of antigen receptor response elements within the interleukin-2 enhancer. Mol. Cell. Biol. 8:1715.
34. Muegge, K., T. M. Williams, J. Kant, M. Karin, R. Chiu, A. Schmidt, U. Siebenlist, H. A. Young, and S. K. Durum. 1989. Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1. Science 246:249.
35. Chen, D., and E. V. Rothenberg, 1994. Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles. J. Exp. Med. 179:931.
36. Suzuki, G., M. Nomura, A. Uzawa, and Y. Nakata. 1995. Impaired CD28-mediated co-stimulation in anergic T cells. Int. Immunol. 7:37.
37. Garrity, P. A., D. Chen, E. V. Rothenberg, and B. J. Wold. 1994. IL-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors. Mol. Cell. Biol. 14:2159.
38. Crabtree, G. R. 1989. Contingent genetic regulatory events in T lymphocyte activation. Science 243:355.
39. Angel, P., and M. Karin. 1991. The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochim. Biophys. Acta 1072:129.
40. Rao, A. 1994. NF-APp: a transcription factor required for the coordinate induction of several cytokine genes. Immunol. Today 15:274.
41. Hunter, T., and M. Karin. 1992. The regulation of transcription by phosphorylation. Cell 70:375.
42. Coso, O. A., M. Chiariello, J.-C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. J. S. Gutkind. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137.
43. Minden, A., A. Lin, F.-X., Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147.
44. Williams, T. M., D. Moolten, J. Burlein, J. Romano, R. Bhaerman, A. Godillot, M. Mellon, F. J. Rauscher III, and J. A. Kant. 1991. Identification of a zinc finger protein that inhibits IL-2 gene expression. Science 254:1791.
45. Becker, J. C., T. Brabletz, T. Kirchner, C. T. Conrad, E.-B. Bröcker, and R. A. Reisfeld. 1995. Negative transcriptional regulation in anergic T cells. Proc. Natl. Acad. Sci. USA 92:2375.
46. Serfling, E., R. Barthelmas, I. Pfeuffer, B. Schenk, S. Zarius, R. Swoboda, F. Mercurio, and M. Karin. 1989. Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes. EMBO J. 8:465.
47. Brunvand, M. W., A. Krumm, and M. Groudine. 1993. In vivo footprinting of the human IL-2 gene reveals a nuclear factor bound to the transcription start site in T cells. Nucleic Acids Res. 21:4824.
48. Bohmann, D., T. J. Bos, A. Admon, T. Nishimura, P. K. Bogt, and R. Tjian. 1987. Human proto-oncogene c-jun encodes a binding protein with structural and functional properties of transcription factor AP-1. Science 238:1386.
49. Angel, P., M. Imagawa, R. Chiu, B. Stein, R. J. Imbra, H. J. Rahmsdorf, C. Jonat, P. Herrlick, and M. Karin. 1987. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-activating factor. Cell 49:729.