Cutting edge: Stable epigenetic inheritance of regional IFN-γ promoter demethylation in CD44(high)CD8+ T lymphocytes

Journal of Immunology

Volumn 162, Issue 9, 1999, Pages 5053-5057

  Fitzpatrick, David R ^a   Shirley, Kym M ^a   Kelso, Anne ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; HERMES ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CLONE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEMETHYLATION; DNA METHYLATION; DNA SEQUENCE; GENE EXPRESSION; GENETIC STABILITY; LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULATOR GENE; REGULATORY MECHANISM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD44; CD8-POSITIVE T-LYMPHOCYTES; CELL LINEAGE; CLONE CELLS; DNA METHYLATION; GENE EXPRESSION REGULATION; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; MICE; MICE, INBRED C57BL; PROMOTER REGIONS (GENETICS); T-LYMPHOCYTE SUBSETS;

EID: 0033136308     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Mostoslavsky, R., and Y. Bergman. 1997. DNA methylation: regulation of gene expression and role in the immune system. Biochim. Biophys. Acta 1333: F29.
2. Wigler, M. H. 1981. The inheritance of methylation patterns in vertebrates. Cell 24:285.
3. Hendrich, B. D., and H. F. Willard. 1995. Epigenetic regulation of gene expression: the effect of altered chromatin structure from yeast to mammals. Hum. Mol. Genet. 4:1765.
4. Young, H. A., P. Ghosh, J. Ye, J. Lederer, A. Lichtman, J. Gerard, L. Penix, C. B. Wilson, A. J. Melvin, M. McGurn, D. B. Lewis, and D. Taub. 1994. Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-γ gene. J. Immunol. 153:3603.
5. Melvin, A. J., M. E. McGurn, S. J. Bort, C. Gibson, and D. B. Lewis. 1995. Hypomethylation of the interferon-γ gene correlates with its expression by primary T-lineage cells. Eur. J. Immunol. 25:426.
6. + T cells. Mol. Immunol. 35:39.
7. Mikovits, J. A., H. A. Young, P. Vertino, J. J. Issa, P. M. Pitha, S. Turcoski-Corrales, D. D. Taub, C. L. Petrow, S. B. Baylin, and F. W. Ruscetti. 1998. Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the γ-interferon (IFN-γ) promoter and subsequent downregulation of IFN-γ production. Mol. Cell. Biol. 18:5166.
8. + T cells. J. Exp. Med. 188:103.
9. Penix, L. A., M. T. Sweetser, W. M. Weaver, J. P. Hoeffler, T. K. Kerppola, and C. B. Wilson. 1996. The proximal regulatory element of the interferon-γ promoter mediates selective expression in T cells. J. Biol. Chem. 271:31964.
10. Fitzpatrick, D. R., and A. Kelso. 1995. Dissociated expression of granulocyte-macrophage CSF and IL-3 in short-term T cell clones from normal mice. J. Immunol. 155:5140.
11. + T cell can give rise to progeny expressing type 1 and/or type 2 cytokine genes and can retain its multipotentiality through many cell divisions. Proc. Natl. Acad. Sci. USA 94:8070.
12. Kelso, A., and N. M. Gough. 1989. Differential inhibition by cyclosporin A reveals two pathways for activation of lymphokine synthesis in T cells. Growth Factors 8:591.
13. Goldstein, S., and R. J. Schmookler Reis. 1985. Methylation patterns in the gene for the α subunit of chorionic gonadotropin are inherited with variable fidelity in clonal lineages of human fibroblasts. Nucleic Acids Res. 13:7055.
14. Swain, S. L., M. Croft, C. Dubey, L. Haynes, P. Rogers, X. Zhang, and L. M. Bradley. 1996. From naive to memory T cells. Immunol. Rev. 150:143.
15. Mackay, C. R. 1993. Immunological memory. Adv. Immunol. 53:217.
16. Sprent, J., and D. F. Tough. 1994. Lymphocyte life-span and memory. Science 265:1395.
17. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54.
18. Farber, D. L. 1998. Differential TCR signaling and the generation of memory T cells. J. Immunol. 160:535.
19. + T cell response. J. Immunol. 161:674.
20. Decker, D. J., P. Linton, S. Zaharevitz, M. Biery, T. R. Gingeras, and N. R. Klinman. 1995. Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro. Immunity 2:195.