메뉴 건너뛰기




Volumn 183, Issue 5, 1996, Pages 2017-2023

Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR AP 1;

EID: 0029952223     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.5.2017     Document Type: Article
Times cited : (114)

References (45)
  • 1
    • 0023143676 scopus 로고
    • Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
    • Jenkins, M.K., and R.H. Schwartz. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:302-319.
    • (1987) J. Exp. Med. , vol.165 , pp. 302-319
    • Jenkins, M.K.1    Schwartz, R.H.2
  • 2
    • 0024327899 scopus 로고
    • Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
    • Mueller, D.L., M.K. Jenkins, and R.H. Schwartz. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7:445-480.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 445-480
    • Mueller, D.L.1    Jenkins, M.K.2    Schwartz, R.H.3
  • 3
    • 0024444165 scopus 로고
    • B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells
    • Freeman, G.J., A.S. Freedman, J.M. Segil, G. Lee, J.F. Whitman, and L.M. Nadler. 1989. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J. Immunol. 143:2714-2722.
    • (1989) J. Immunol. , vol.143 , pp. 2714-2722
    • Freeman, G.J.1    Freedman, A.S.2    Segil, J.M.3    Lee, G.4    Whitman, J.F.5    Nadler, L.M.6
  • 4
    • 0026698059 scopus 로고
    • The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells
    • Norton, S.D., L. Zuckerman, K.B. Urdahl, R. Shefner, J. Miller, and M.K. Jenkins. 1992. The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells. J. Immunol. 149:1556-1561.
    • (1992) J. Immunol. , vol.149 , pp. 1556-1561
    • Norton, S.D.1    Zuckerman, L.2    Urdahl, K.B.3    Shefner, R.4    Miller, J.5    Jenkins, M.K.6
  • 5
    • 0026537347 scopus 로고
    • CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
    • Harding, F.A., J.G. McArthur, J.A. Gross, D.H. Raulet, and J.P. Allison. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature (Lond.). 356:607-609.
    • (1992) Nature (Lond.) , vol.356 , pp. 607-609
    • Harding, F.A.1    McArthur, J.G.2    Gross, J.A.3    Raulet, D.H.4    Allison, J.P.5
  • 7
  • 8
    • 0024511201 scopus 로고
    • An accessory cell-derived costimulatory signal acts independently of protein kinase c activation to allow T cell proliferation and prevent the induction of unresponsiveness
    • Mueller, D.L., M.K. Jenkins, and R.H. Schwartz. 1989. An accessory cell-derived costimulatory signal acts independently of protein kinase c activation to allow T cell proliferation and prevent the induction of unresponsiveness. J. Immunol. 142: 2617-2628.
    • (1989) J. Immunol. , vol.142 , pp. 2617-2628
    • Mueller, D.L.1    Jenkins, M.K.2    Schwartz, R.H.3
  • 9
    • 0023390431 scopus 로고
    • Molecular events in the induction of a nonresponsive state in IL-2-producing helper T lymphocyte clones
    • Jenkins, M.K., D.M. Pardoll, J. Mizuguchi, T.M. Chused, and R.H. Schwartz. 1987. Molecular events in the induction of a nonresponsive state in IL-2-producing helper T lymphocyte clones. Proc Natl. Acad. S. USA. 84:5409-5413.
    • (1987) Proc Natl. Acad. S. USA , vol.84 , pp. 5409-5413
    • Jenkins, M.K.1    Pardoll, D.M.2    Mizuguchi, J.3    Chused, T.M.4    Schwartz, R.H.5
  • 10
    • 0025791940 scopus 로고
    • Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation
    • DeSilva, D.R., K.B. Urdahl, and M.K. Jenkins. 1991. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J. Immunol. 147:3261-3267.
    • (1991) J. Immunol. , vol.147 , pp. 3261-3267
    • DeSilva, D.R.1    Urdahl, K.B.2    Jenkins, M.K.3
  • 12
    • 0028181498 scopus 로고
    • Two-step TCRCζ/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases
    • Rudd, C.E., O. Janssen, Y.-C. Cai, A.J. da Silva, M. Raab and K.V.S. Prasad. 1994. Two-step TCRCζ/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases. Immunol. Today 15:225-234.
    • (1994) Immunol. Today , vol.15 , pp. 225-234
    • Rudd, C.E.1    Janssen, O.2    Cai, Y.-C.3    Da Silva, A.J.4    Raab, M.5    Prasad, K.V.S.6
  • 15
    • 0025002338 scopus 로고
    • Regulatory anatomy of the murine interleukin-2 gene
    • Novak, T.J., P.M. White, and E.V. Rothenberg. 1990. Regulatory anatomy of the murine interleukin-2 gene. Nucl. Acids Res. 19:4523-4533.
    • (1990) Nucl. Acids Res. , vol.19 , pp. 4523-4533
    • Novak, T.J.1    White, P.M.2    Rothenberg, E.V.3
  • 16
    • 0026061865 scopus 로고
    • Regulation of IL-2 gene enhancer activity by the T cell accessory molecule CD28
    • Fraser, J.D., B.A. Irving, G.R. Crabtree, and A. Weiss. 1991. Regulation of IL-2 gene enhancer activity by the T cell accessory molecule CD28. Science (Wash. DC). 251:313-316.
    • (1991) Science (Wash. DC) , vol.251 , pp. 313-316
    • Fraser, J.D.1    Irving, B.A.2    Crabtree, G.R.3    Weiss, A.4
  • 17
    • 0026607074 scopus 로고
    • CD28 and and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation
    • Fraser, J.D., M.E. Newton, and A. Weiss. 1992. CD28 and and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation. J. Exp. Med. 175:1131-1134.
    • (1992) J. Exp. Med. , vol.175 , pp. 1131-1134
    • Fraser, J.D.1    Newton, M.E.2    Weiss, A.3
  • 18
    • 0026495105 scopus 로고
    • Evidence for a role of CD28RE as a response element for distinct mitogenic T cell activation signals
    • Civil, A., M. Geerts, and L.A. Arden. 1992. Evidence for a role of CD28RE as a response element for distinct mitogenic T cell activation signals. Eur. J. Immunol. 22:3041-3043.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 3041-3043
    • Civil, A.1    Geerts, M.2    Arden, L.A.3
  • 20
    • 0029032249 scopus 로고
    • The regulation of AP-1 activity by mitogen-activated protein kinases
    • Karin, M. 1995. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270:16483-16486.
    • (1995) J. Biol. Chem. , vol.270 , pp. 16483-16486
    • Karin, M.1
  • 21
    • 0029043582 scopus 로고
    • How MAP Kinases are regulated
    • Cobb, M.H., and E.J. Goldsmith. 1995. How MAP Kinases are regulated J. Biol. Chem. 270:14843-14846.
    • (1995) J. Biol. Chem. , vol.270 , pp. 14843-14846
    • Cobb, M.H.1    Goldsmith, E.J.2
  • 23
    • 0020506697 scopus 로고
    • Relationship between immune interferon production and proliferation by antigen-specific, MHC-restricted T cell lines and clones
    • Hecht, T.T., D.L. Longo, and L.A. Matis. 1983. Relationship between immune interferon production and proliferation by antigen-specific, MHC-restricted T cell lines and clones. J. Immunol. 131:1049-1055.
    • (1983) J. Immunol. , vol.131 , pp. 1049-1055
    • Hecht, T.T.1    Longo, D.L.2    Matis, L.A.3
  • 24
    • 0020576415 scopus 로고
    • The T lymphocyte response to cytochrome c. IV. Distinguishable sites on a peptide antigen which affect antigenic strength and memory
    • Hansburg, D., T. Fairwell, R.H. Schwartz, and E. Appella. 1983. The T lymphocyte response to cytochrome c. IV. Distinguishable sites on a peptide antigen which affect antigenic strength and memory. J. Immunol. 131:319-324.
    • (1983) J. Immunol. , vol.131 , pp. 319-324
    • Hansburg, D.1    Fairwell, T.2    Schwartz, R.H.3    Appella, E.4
  • 25
    • 0025964640 scopus 로고
    • Identification of eight determinants in the hemagglutinin molecule of influenza virus A/PR/8/34 (H1N1) which are recognized by Class II-restricted T cells from Balb/c mice
    • Gerhard, W., M. Haberman, P.A. Scherle, A.H. Taylor, G. Palladino, and A.J. Caton. 1991. Identification of eight determinants in the hemagglutinin molecule of influenza virus A/PR/8/34 (H1N1) which are recognized by Class II-restricted T cells from Balb/c mice. J. Virol. 65:364-372.
    • (1991) J. Virol. , vol.65 , pp. 364-372
    • Gerhard, W.1    Haberman, M.2    Scherle, P.A.3    Taylor, A.H.4    Palladino, G.5    Caton, A.J.6
  • 27
    • 0025058266 scopus 로고
    • Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody
    • Jenkins, M.K., C. Chen, G. Jung, D.L. Mueller, and R.H. Schwartz. 1990. Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J. Immunol. 144:16-22.
    • (1990) J. Immunol. , vol.144 , pp. 16-22
    • Jenkins, M.K.1    Chen, C.2    Jung, G.3    Mueller, D.L.4    Schwartz, R.H.5
  • 28
    • 0023266396 scopus 로고
    • Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: Specific induction of a long-lived state of proliferative nonresponsiveness
    • Quill, H., and R.H. Schwartz. 1987. Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness. J. Immunol. 138:3704-3712.
    • (1987) J. Immunol. , vol.138 , pp. 3704-3712
    • Quill, H.1    Schwartz, R.H.2
  • 29
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • Derijard, B., M. Hibi, I.-H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R.J. Davis. 1994. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037.
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Derijard, B.1    Hibi, M.2    Wu, I.-H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 31
    • 0027301903 scopus 로고
    • Altered protein phosphorylation in anergic Th1 cells
    • Cho, E.A., M.P. Riley, A.L. Silman, and H. Quill. 1993. Altered protein phosphorylation in anergic Th1 cells. J. Immunol. 151:20-28.
    • (1993) J. Immunol. , vol.151 , pp. 20-28
    • Cho, E.A.1    Riley, M.P.2    Silman, A.L.3    Quill, H.4
  • 34
    • 0030067653 scopus 로고    scopus 로고
    • Mek1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells
    • Whitehurst, C.E., and T.D. Geppert. 1996. Mek1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells. J. Immunol. 156: 1020-1029.
    • (1996) J. Immunol. , vol.156 , pp. 1020-1029
    • Whitehurst, C.E.1    Geppert, T.D.2
  • 36
    • 0027385030 scopus 로고
    • Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human Raf-1 protein kinase
    • Samuels, M.L., M.J. Weber, J.M. Bishop, and M. McMahon. 1993. Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human Raf-1 protein kinase. Mol. Cell. Biol. 13:6241-6252.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 6241-6252
    • Samuels, M.L.1    Weber, M.J.2    Bishop, J.M.3    McMahon, M.4
  • 39
    • 0029055812 scopus 로고
    • The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
    • Coso, O.A., M. Chiariello, J.-C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, J.S. Gutkind. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell. 81:1137-1146.
    • (1995) Cell , vol.81 , pp. 1137-1146
    • Coso, O.A.1    Chiariello, M.2    Yu, J.-C.3    Teramoto, H.4    Crespo, P.5    Xu, N.6    Miki, T.7    Gutkind, J.S.8
  • 40
    • 0029070887 scopus 로고
    • Selective activation of the JNK signaling cascade and c-jun transcriptional activity by the small GTPases Rac and Cdc42Hs
    • Minden, A., A. Lin, F.-X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell. 81:1147-1157.
    • (1995) Cell , vol.81 , pp. 1147-1157
    • Minden, A.1    Lin, A.2    Claret, F.-X.3    Abo, A.4    Karin, M.5
  • 41
    • 0024281396 scopus 로고
    • Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells
    • Lo, D., L.C. Burkly, G. Widera, C. Lowing, R.A. Flavell, R.D. Palmiter, and R.L. Brinster. 1988. Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell. 53:159-168.
    • (1988) Cell , vol.53 , pp. 159-168
    • Lo, D.1    Burkly, L.C.2    Widera, G.3    Lowing, C.4    Flavell, R.A.5    Palmiter, R.D.6    Brinster, R.L.7
  • 42
    • 0024398589 scopus 로고
    • T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I-E
    • Burkly, L.C., D. Lo, O. Kanagawa, R.L. Brinster, and R.A. Flavell. 1989. T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I-E. Nature (Lond.). 342:564-566.
    • (1989) Nature (Lond.) , vol.342 , pp. 564-566
    • Burkly, L.C.1    Lo, D.2    Kanagawa, O.3    Brinster, R.L.4    Flavell, R.A.5
  • 43
    • 0026701534 scopus 로고
    • Maintenance of in vivo tolerance by persistence of antigen
    • Ramsdell, F., and B.J. Fowlkes. 1992. Maintenance of in vivo tolerance by persistence of antigen. Science (Wash. DC). 257: 1130-1134.
    • (1992) Science (Wash. DC) , vol.257 , pp. 1130-1134
    • Ramsdell, F.1    Fowlkes, B.J.2
  • 44
    • 0028428910 scopus 로고
    • The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenence of tolerance to peripheral antigen
    • Guerder, S., J. Meyerhoff, and R. Flavell. 1994. The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenence of tolerance to peripheral antigen. Immunity. 1:155-166.
    • (1994) Immunity. , vol.1 , pp. 155-166
    • Guerder, S.1    Meyerhoff, J.2    Flavell, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.