CD8+ T-cell memory: Only the good ones last

Current Opinion in Immunology

Volumn 16, Issue 4, 2004, Pages 451-455

  Northrop, John K ^a   Shen, Hao ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

antigen presenting cell; APC; central memory T cells; effector memory T cells; helper T cells; IFN ; IL; interferon gamma; interleukin; major histocompatibility complex; memory T cells; MHC; T M; TCM; TEM; TH

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

CELLULAR IMMUNITY; HUMAN; HUMORAL IMMUNITY; IMMUNITY; IMMUNOLOGICAL MEMORY; INFECTION PREVENTION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMORY CELL; QUANTITATIVE ANALYSIS; REVIEW; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VACCINATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; COMMUNICABLE DISEASES; HUMANS; IMMUNOLOGIC MEMORY; VACCINATION;

EID: 3042776479     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.05.004     Document Type: Review

References (28)

1. Kaech S.M., Wherry E.J., Ahmed R. Effector and memory T-cell differentiation: implications for vaccine development. Nat Rev Immunol. 2:2002;251-262
2. McHeyzer-Williams M.G., Ahmed R. B cell memory and the long-lived plasma cell. Curr Opin Immunol. 11:1999;172-179
3. Sallusto F., Lenig D., Forster R., Lipp M., Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 401:1999;708-712
4. Seder R.A., Ahmed R. Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat Immunol. 4:2003;835-842
5. Masopust D., Vezys V., Marzo A.L., Lefrancois L. Preferential localization of effector memory cells in nonlymphoid tissue. Science. 291:2001;2413-2417
6. Lauvau G., Vijh S., Kong P., Horng T., Kerksiek K., Serbina N., Tuma R.A., Pamer E.G. Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. Science. 294:2001;1735-1739
7. + T cells, which represent the true memory population. Only central memory is maintained stably over time and this population provides superior protective immunity through generation of greater numbers of secondary effectors.
8. Kaech S.M., Hemby S., Kersh E., Ahmed R. Molecular and functional profiling of memory CD8 T cell differentiation. Cell. 111:2002;837-851
9. Kaech S.M., Tan J.T., Wherry E.J., Konieczny B.T., Surh C.D., Ahmed R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol. 4:2003;1191-1198
10. von Herrath M.G., Yokoyama M., Dockter J., Oldstone M.B., Whitton J.L. CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge. J Virol. 70:1996;1072-1079
11. Riberdy J.M., Christensen J.P., Branum K., Doherty P.C. Diminished primary and secondary influenza virus-specific CD8(+) T-cell responses in CD4-depleted Ig(-/-) mice. J Virol. 74:2000;9762-9765
12. Shedlock D.J., Whitmire J.K., Tan J., MacDonald A.S., Ahmed R., Shen H. Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection. J Immunol. 170:2003;2053-2063
13. Bourgeois C., Rocha B., Tanchot C. A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science. 297:2002;2060-2063
14. Fernando G.J., Khammanivong V., Leggatt G.R., Liu W.J., Frazer I.H. The number of long-lasting functional memory CD8+ T cells generated depends on the nature of the initial nonspecific stimulation. Eur J Immunol. 32:2002;1541-1549
15. ••].
16. ••].
17. + T cells.
18. Wang J.C., Livingstone A.M. Cutting edge: CD4+ T cell help can be essential for primary CD8+ T cell responses in vivo. J Immunol. 171:2003;6339-6343
19. Khanolkar A., Fuller M.J., Zajac A.J. CD4 T cell-dependent CD8 T cell maturation. J Immunol. 172:2004;2834-2844
20. Kawabe T., Naka T., Yoshida K., Tanaka T., Fujiwara H., Suematsu S., Yoshida N., Kishimoto T., Kikutani H. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity. 1:1994;167-178
21. Ridge J.P., Di Rosa F., Matzinger P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature. 393:1998;474-478
22. Bennett S.R., Carbone F.R., Karamalis F., Flavell R.A., Miller J.F., Heath W.R. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature. 393:1998;478-480
23. Schoenberger S.P., Toes R.E., van der Voort E.I., Offringa R., Melief C.J. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature. 393:1998;480-483
24. Ichii H., Sakamoto A., Hatano M., Okada S., Toyama H., Taki S., Arima M., Kuroda Y., Tokuhisa T. Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells. Nat Immunol. 3:2002;558-563
25. + T cells.
26. + T-cell development.
27. Thomsen A.R., Nansen A., Christensen J.P., Andreasen S.O., Marker O. CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus. J Immunol. 161:1998;4583-4590
28. Bachmann M.F., Hunziker L., Zinkernagel R.M., Storni T., Kopf M. Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key. Eur J Immunol. 34:2004;317-326