c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations

Journal of Biological Chemistry

Volumn 283, Issue 5, 2008, Pages 2675-2683

  Bellon, Steven F ^a   Kaplan Lefko, Paula ^a   Yang, Yajing ^a   Zhang, Yihong ^a   Moriguchi, Jodi ^a   Rex, Karen ^a   Johnson, Carol W ^a   Rose, Paul E ^a   Long, Alexander M ^a   O'Connor, Anne B ^a   Gu, Yan ^a   Coxon, Angela ^a   Kim, Tae Seong ^a   Tasker, Andrew ^a   Burgess, Teresa L ^a   Dussault, Isabelle ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANIMAL CELL CULTURE; BINDING ENERGY; MOLECULES;

BINDING MODES; DRUG TARGETS; HUMAN CANCERS; HYDROPHOBIC BINDING SITES; INACTIVE CONFORMATIONS; NOVEL SERIES; RECEPTOR TYROSINE KINASES; RENAL CELL CARCINOMATA; SMALL MOLECULES; TUMOR GROWTHS;

BINDING SITES;

5 [3 FLUORO 4 [[6 (METHYLOXY) 7 [[3 (4 MORPHOLINYL)PROPYL]OXY] 4 QUINOLINYL]OXY]PHENYL] 3 METHYL 2 (PHENYLMETHYL) 4(3H)PYRIMIDINONE; AM 7; ANTINEOPLASTIC AGENT; MUTANT PROTEIN; N (3 CHLOROPHENYL) 3 [3,5 DIMETHYL 4 (4 METHYL 1 PIPERAZINYLCARBONYL) 1H PYRROL 2 YLMETHYLENE] 2,3 DIHYDRO N METHYL 2 OXO 1H INDOLE 5 SULFONAMIDE; PROTEIN TYROSINE KINASE INHIBITOR; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG; ((3Z) N (3 CHLOROPHENYL) 3 ((3,5 DIMETHYL 4 ((4 METHYLPIPERAZIN 1 YL)CARBONYL) 1H PYRROL 2 YL)METHYLENE) N METHYL 2 OXO 2,3 DIHYDRO 1H INDOLE 5 SULFONAMIDE); ((3Z)-N-(3-CHLOROPHENYL)-3-((3,5-DIMETHYL-4-((4-METHYLPIPERAZIN-1-YL)CARBONYL)-1H-PYRROL-2-YL)METHYLENE)-N-METHYL-2-OXO-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE); HYBRID PROTEIN; INDOLE DERIVATIVE; PIPERAZINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIMIDINONE DERIVATIVE; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER MODEL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG BINDING; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME CONFORMATION; FAMILIAL CANCER; FEMALE; GENE MUTATION; HEREDITARY PAPILLARY RENAL CELL CARCINOMA; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MOUSE; NONHUMAN; PAPILLARY CARCINOMA; PRIORITY JOURNAL; PROTEINASE INHIBITION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; WILD TYPE; ANIMAL; BINDING SITE; CANCER TRANSPLANTATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; ENZYMOLOGY; GENETICS; KIDNEY TUMOR; MUTATION; NUDE MOUSE; PATHOLOGY; PROTEIN CONFORMATION; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY; XENOGRAFT;

ANIMALS; BINDING SITES; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FEMALE; HUMANS; INDOLES; KIDNEY NEOPLASMS; MICE; MICE, NUDE; MODELS, MOLECULAR; MUTATION; NEOPLASM TRANSPLANTATION; PIPERAZINES; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-MET; PYRIMIDINONES; RECOMBINANT FUSION PROTEINS; SULFONAMIDES; TRANSPLANTATION, HETEROLOGOUS;

EID: 41449107739     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M705774200     Document Type: Article

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