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Volumn 114, Issue 10, 2004, Pages 1418-1432

An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice

Author keywords

[No Author keywords available]

Indexed keywords

LENTIVIRUS VECTOR; PRO SCATTER FACTOR; PROTEIN PRECURSOR; PROTEINASE; SCATTER FACTOR; UNCLASSIFIED DRUG; COLLAGEN; GLUTAMINE; METHIONINE; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN;

EID: 85047689927     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI22235     Document Type: Article
Times cited : (81)

References (55)
  • 1
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblast-derived modulator of epithelial cell motility
    • Stoker, N., Gherardi, E., Perryman, M., and Grey, J. 1987. Scatter factor is a fibroblast-derived modulator of epithelial cell motility. Nature. 327:239-242.
    • (1987) Nature , vol.327 , pp. 239-242
    • Stoker, N.1    Gherardi, E.2    Perryman, M.3    Grey, J.4
  • 2
    • 0008222162 scopus 로고
    • Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement
    • Gherardi, E., Gray, J., Stoker, M., Perryman, M., and Furlong, R. 1989. Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement. Proc. Natl. Acad. Sci. U. S. A. 86:5844-5848.
    • (1989) Proc. Natl. Acad. Sci. U. S. A. , vol.86 , pp. 5844-5848
    • Gherardi, E.1    Gray, J.2    Stoker, M.3    Perryman, M.4    Furlong, R.5
  • 3
    • 0000975548 scopus 로고    scopus 로고
    • Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures. 1986
    • Nakamura, T., Teramoto, H., and Ichihara, A. Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures. 1986. Proc. Natl. Acad. Sci. U. S. A. 83:6489-6493.
    • Proc. Natl. Acad. Sci. U. S. A. , vol.83 , pp. 6489-6493
    • Nakamura, T.1    Teramoto, H.2    Ichihara, A.3
  • 4
    • 0024356856 scopus 로고
    • Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes
    • Zarnegar, R., and Michalopoulos, G. 1989. Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes. Cancer Res. 49:3314-3320.
    • (1989) Cancer Res. , vol.49 , pp. 3314-3320
    • Zarnegar, R.1    Michalopoulos, G.2
  • 5
    • 0025886454 scopus 로고
    • Evidence for the identity of human scatter factor and human hepatocyte growth factor
    • Weidner, K.M., et al. 1991. Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc. Natl. Acad. Sci. U. S. A. 88:7001-7005.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 7001-7005
    • Weidner, K.M.1
  • 6
    • 0025771101 scopus 로고
    • Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor
    • Naldini, L., et al. 1991. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J. 10:2867-2878.
    • (1991) EMBO J. , vol.10 , pp. 2867-2878
    • Naldini, L.1
  • 7
    • 0025824738 scopus 로고
    • Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor
    • Montesano, R., Matsumoto, K., Nakamura, T., and Orci L. 1991. Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell. 67:901-908.
    • (1991) Cell , vol.67 , pp. 901-908
    • Montesano, R.1    Matsumoto, K.2    Nakamura, T.3    Orci, L.4
  • 8
    • 0027742111 scopus 로고
    • Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product
    • Rubin, J.S., Bottaro, D.P., and Aaronson, S.A. 1993. Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product. Biochim. Biophys. Acta. 1155:357-371.
    • (1993) Biochim. Biophys. Acta , vol.1155 , pp. 357-371
    • Rubin, J.S.1    Bottaro, D.P.2    Aaronson, S.A.3
  • 9
    • 0028999868 scopus 로고
    • The many faces of hepatocyte growth factor: From hepatopoiesis to hematopoiesis
    • Zarnegar, R., and Michalopoulos, G. 1995. The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis. J. Cell Biol. 129:1177-1180.
    • (1995) J. Cell Biol. , vol.129 , pp. 1177-1180
    • Zarnegar, R.1    Michalopoulos, G.2
  • 10
    • 0031170938 scopus 로고    scopus 로고
    • Control of invasive growth by hepatocyte growth factor (SF) and related scatter factors
    • Tamagnone, L., and Comoglio, P.M. 1997. Control of invasive growth by hepatocyte growth factor (SF) and related scatter factors. Cytokine Growth Factor Rev. 8:129-142.
    • (1997) Cytokine Growth Factor Rev. , vol.8 , pp. 129-142
    • Tamagnone, L.1    Comoglio, P.M.2
  • 11
    • 0036217866 scopus 로고    scopus 로고
    • Invasive growth: From development to metastasis
    • doi:10.1172/JCI200215392
    • Comoglio, P.M., and Trusolino, L. 2002. Invasive growth: from development to metastasis. J. Clin. Invest. 109:857-862. doi:10.1172/JCI200215392.
    • (2002) J. Clin. Invest. , vol.109 , pp. 857-862
    • Comoglio, P.M.1    Trusolino, L.2
  • 12
    • 0036551486 scopus 로고    scopus 로고
    • Scatter-factor and semaphorin receptors: Cell signalling for invasive growth
    • Trusolino, L., and Comoglio, P.M. 2002. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nat. Rev. Cancer. 4:289-300.
    • (2002) Nat. Rev. Cancer , vol.4 , pp. 289-300
    • Trusolino, L.1    Comoglio, P.M.2
  • 13
    • 0028798286 scopus 로고
    • Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros
    • Woolf, A.S., et al. 1995. Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros. J. Cell Biol. 128:171-184.
    • (1995) J. Cell Biol. , vol.128 , pp. 171-184
    • Woolf, A.S.1
  • 14
    • 0029973125 scopus 로고    scopus 로고
    • Scatter factor/ hepatocyte growth factor as a regulator of skeletal muscle and neural crest development
    • Takayama, H., La Rochelle, W.J., Anver, M., Bockman, D.E., and Merlino, G. 1996. Scatter factor/ hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proc. Natl. Acad. Sci. U. S. A. 93:5866-5871.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 5866-5871
    • Takayama, H.1    La Rochelle, W.J.2    Anver, M.3    Bockman, D.E.4    Merlino, G.5
  • 15
    • 0029869298 scopus 로고    scopus 로고
    • Co-expression of the SF/HGF and c-met genes during early mouse embryogenesis precedes reciprocal expression in adjacent tissues during organogenesis
    • Andermarcher, E., Surani, M., and Gherardi, E. 1996. Co-expression of the SF/HGF and c-met genes during early mouse embryogenesis precedes reciprocal expression in adjacent tissues during organogenesis. Dev. Genet. 18:254-266.
    • (1996) Dev. Genet. , vol.18 , pp. 254-266
    • Andermarcher, E.1    Surani, M.2    Gherardi, E.3
  • 16
    • 0029134104 scopus 로고
    • Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    • Bladt, F., Riethmacher, D., Isenmann, S., Aguzzi, A., and Birchmeier, C. 1995. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature. 376:768-771.
    • (1995) Nature , vol.376 , pp. 768-771
    • Bladt, F.1    Riethmacher, D.2    Isenmann, S.3    Aguzzi, A.4    Birchmeier, C.5
  • 17
    • 0028899952 scopus 로고
    • Scatter factor/hepatocyte growth factor is essential for liver development
    • Schmidt, C., et al. 1995. Scatter factor/hepatocyte growth factor is essential for liver development. Nature. 373:699-702.
    • (1995) Nature , vol.373 , pp. 699-702
    • Schmidt, C.1
  • 18
    • 0028911690 scopus 로고
    • Placental defect and embryonal lethality in mice lacking hepathocyte growth factor/scatter factor
    • Uehara, Y., et al. 1995. Placental defect and embryonal lethality in mice lacking hepathocyte growth factor/scatter factor. Nature. 373:702-705.
    • (1995) Nature , vol.373 , pp. 702-705
    • Uehara, Y.1
  • 19
    • 1842428601 scopus 로고    scopus 로고
    • Hepatocyte growth factor/ c-met signaling pathway is required for efficient liver regeneration and repair
    • Huh, C.G., et al. 2004. Hepatocyte growth factor/ c-met signaling pathway is required for efficient liver regeneration and repair. Proc. Natl. Acad. Sci. U. S. A. 101:4477-4482.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 4477-4482
    • Huh, C.G.1
  • 20
    • 0037312985 scopus 로고    scopus 로고
    • Neutralization of hepatocyte growth factor leads to retarded cutaneous wound healing associated with decreased neovascularization and granulation tissue formation
    • Yoshida, S., et al. 2003. Neutralization of hepatocyte growth factor leads to retarded cutaneous wound healing associated with decreased neovascularization and granulation tissue formation. J. Invest. Dermatol. 120:335-343.
    • (2003) J. Invest. Dermatol. , vol.120 , pp. 335-343
    • Yoshida, S.1
  • 21
    • 0027948378 scopus 로고
    • Hepatocyte growth factor induces proliferation and differentiation of multipotent and erythroid hemopoietic progenitors
    • Galimi, F., et al. 1994. Hepatocyte growth factor induces proliferation and differentiation of multipotent and erythroid hemopoietic progenitors. J. Cell Biol. 127:1743-1754.
    • (1994) J. Cell Biol. , vol.127 , pp. 1743-1754
    • Galimi, F.1
  • 23
    • 0027077443 scopus 로고
    • Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
    • Naldini, L., et al. 1992. Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J. 11:4825-4833.
    • (1992) EMBO J. , vol.11 , pp. 4825-4833
    • Naldini, L.1
  • 24
    • 0026699904 scopus 로고
    • Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer
    • Naka, D., et al. 1992. Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer. J. Biol. Chem. 267:20114-20119.
    • (1992) J. Biol. Chem. , vol.267 , pp. 20114-20119
    • Naka, D.1
  • 25
    • 0028364241 scopus 로고
    • Hepatocyte growth factor specifically binds to sulfoglycolipids
    • Kobayashi, T., et al. 1994. Hepatocyte growth factor specifically binds to sulfoglycolipids. J. Biol. Chem. 269:9817-9821.
    • (1994) J. Biol. Chem. , vol.269 , pp. 9817-9821
    • Kobayashi, T.1
  • 26
    • 0028346380 scopus 로고
    • Interaction of hepatocyte growth factor with heparan-sulfate. Elucidation of the major heparan sulfate structural determinants
    • Lyon, M., Deakin, J.A., Mizuno, K., Nakamura, T., and Gallagher J.T. 1994. Interaction of hepatocyte growth factor with heparan-sulfate. Elucidation of the major heparan sulfate structural determinants. J. Biol. Chem. 269:11216-11223.
    • (1994) J. Biol. Chem. , vol.269 , pp. 11216-11223
    • Lyon, M.1    Deakin, J.A.2    Mizuno, K.3    Nakamura, T.4    Gallagher, J.T.5
  • 27
    • 0034069758 scopus 로고    scopus 로고
    • Production of hepatocyte growth factor during acute myocardial infarction
    • Zhu, Y., Hojo, Y., Ikeda, U., and Shimada, K. 2000. Production of hepatocyte growth factor during acute myocardial infarction. Heart. 83:450-455.
    • (2000) Heart , vol.83 , pp. 450-455
    • Zhu, Y.1    Hojo, Y.2    Ikeda, U.3    Shimada, K.4
  • 28
    • 0029549107 scopus 로고
    • Hepatocyte growth factor and acute phase proteins in patients with chronic liver diseases
    • Shiota, G., Umeki, K., Okano, J., and Kawasaki, H. 1995. Hepatocyte growth factor and acute phase proteins in patients with chronic liver diseases. J. Med. 26:295-308.
    • (1995) J. Med. , vol.26 , pp. 295-308
    • Shiota, G.1    Umeki, K.2    Okano, J.3    Kawasaki, H.4
  • 29
    • 0028245216 scopus 로고
    • Significant amount of hepatocyte growth factor detected in blood and bone marrow plasma of leukaemia patients
    • Nakamura, S., Gohda, E., Matsuo, Y., Yamamoto, I., and Minowada, J. 1994. Significant amount of hepatocyte growth factor detected in blood and bone marrow plasma of leukaemia patients. Br. J. Haematol. 87:640-642.
    • (1994) Br. J. Haematol. , vol.87 , pp. 640-642
    • Nakamura, S.1    Gohda, E.2    Matsuo, Y.3    Yamamoto, I.4    Minowada, J.5
  • 30
    • 0028305195 scopus 로고
    • Proteolytic activation of hepatocyte growth factor in response to tissue injury
    • Miyazawa, K., Shimomura, T., Naka, D., and Kitamura, N. 1994. Proteolytic activation of hepatocyte growth factor in response to tissue injury. J. Biol. Chem. 269:8966-8970.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8966-8970
    • Miyazawa, K.1    Shimomura, T.2    Naka, D.3    Kitamura, N.4
  • 31
    • 0027074266 scopus 로고
    • Proteolytic activation of a single-chain precursor of hepatocyte growth factor by extracellular serine-protease
    • Mizuno, K., Takehara, T., and Nakamura, T. 1992. Proteolytic activation of a single-chain precursor of hepatocyte growth factor by extracellular serine-protease. Biochem. Biophys. Res. Commun. 189:1631-1638.
    • (1992) Biochem. Biophys. Res. Commun. , vol.189 , pp. 1631-1638
    • Mizuno, K.1    Takehara, T.2    Nakamura, T.3
  • 32
    • 0037033006 scopus 로고    scopus 로고
    • Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa
    • Peek, M., Moran, P., Mendoza, N., Wickramasinghe, D., and Kirchhofer, D. 2002. Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa. J. Biol. Chem. 277:47804-47809.
    • (2002) J. Biol. Chem. , vol.277 , pp. 47804-47809
    • Peek, M.1    Moran, P.2    Mendoza, N.3    Wickramasinghe, D.4    Kirchhofer, D.5
  • 33
    • 0027373246 scopus 로고
    • Activation of the zymogen of hepatocyte growth factor activator by thrombin
    • Shimomura, T., et al. 1993. Activation of the zymogen of hepatocyte growth factor activator by thrombin. J. Biol. Chem. 268:22927-22932.
    • (1993) J. Biol. Chem. , vol.268 , pp. 22927-22932
    • Shimomura, T.1
  • 34
    • 0030774060 scopus 로고    scopus 로고
    • Roles of hepatocyte growth factor and its receptor Met during gastric ulcer healing in rats
    • Schmassmann, A., et al. 1997. Roles of hepatocyte growth factor and its receptor Met during gastric ulcer healing in rats. Gastroenterology. 113:1858-1872.
    • (1997) Gastroenterology , vol.113 , pp. 1858-1872
    • Schmassmann, A.1
  • 35
    • 0000161710 scopus 로고    scopus 로고
    • Enhancement of wound tissue expansion and angiogenesis by matrix-embedded fibroblast (dermagraft), a role of hepatocyte growth factor/scatter factor
    • Jiang, W.G., and Harding, K.G. 1998. Enhancement of wound tissue expansion and angiogenesis by matrix-embedded fibroblast (dermagraft), a role of hepatocyte growth factor/scatter factor. Int. J. Mol. Med. 2:203-210.
    • (1998) Int. J. Mol. Med. , vol.2 , pp. 203-210
    • Jiang, W.G.1    Harding, K.G.2
  • 36
    • 0034915561 scopus 로고    scopus 로고
    • Production and activation of hepatocyte growth factor in acute renal failure
    • Sugimura, K., et al. 2001. Production and activation of hepatocyte growth factor in acute renal failure. Ren. Fail. 23:597-603.
    • (2001) Ren. Fail , vol.23 , pp. 597-603
    • Sugimura, K.1
  • 37
    • 0033565976 scopus 로고    scopus 로고
    • Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype
    • Aguirre Ghiso, J.A., Alonso, D.F., Farias, E.F., Gomez, D.E., and de Kier Joffe, E.B. 1999. Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype. Eur. J. Biochem. 263:295-304.
    • (1999) Eur. J. Biochem. , vol.263 , pp. 295-304
    • Aguirre Ghiso, J.A.1    Alonso, D.F.2    Farias, E.F.3    Gomez, D.E.4    De Kier Joffe, E.B.5
  • 38
    • 1642535487 scopus 로고    scopus 로고
    • The hepatocyte growth factor regulatory factors in human breast cancer
    • Parr, C., Watkins, G., Mansel, R.E., and Jiang, W.G. 2004. The hepatocyte growth factor regulatory factors in human breast cancer. Clin. Cancer Res. 10:202-211.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 202-211
    • Parr, C.1    Watkins, G.2    Mansel, R.E.3    Jiang, W.G.4
  • 39
    • 0037478437 scopus 로고    scopus 로고
    • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    • Pennacchietti, S., et al. 2003. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell. 3:347-361.
    • (2003) Cancer Cell , vol.3 , pp. 347-361
    • Pennacchietti, S.1
  • 40
    • 0032079312 scopus 로고    scopus 로고
    • Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway
    • Graham, C.H., Fitzpatrick, T.E., and McCrae, K.R. 1998. Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway. Blood. 91:3300-3307.
    • (1998) Blood , vol.91 , pp. 3300-3307
    • Graham, C.H.1    Fitzpatrick, T.E.2    McCrae, K.R.3
  • 41
    • 0028912590 scopus 로고
    • Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction
    • Naldini, L., et al. 1995. Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction. J. Biol. Chem. 270:603-611.
    • (1995) J. Biol. Chem. , vol.270 , pp. 603-611
    • Naldini, L.1
  • 42
    • 0035912757 scopus 로고    scopus 로고
    • Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models
    • Cao, B., et al. 2001. Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models. Proc. Natl. Acad. Sci. U. S. A. 98:7443-7448.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 7443-7448
    • Cao, B.1
  • 43
    • 0037850880 scopus 로고    scopus 로고
    • NK4 (HGF-antagonist/angiogenesis inhibitor) in cancer biology and therapeutics
    • Matsumoto, K., and Nakamura, T. 2003. NK4 (HGF-antagonist/angiogenesis inhibitor) in cancer biology and therapeutics. Cancer Sci. 94:321-327.
    • (2003) Cancer Sci. , vol.94 , pp. 321-327
    • Matsumoto, K.1    Nakamura, T.2
  • 44
    • 3142512610 scopus 로고    scopus 로고
    • Targeting the tumor and its microenvironment by a dual-function decoy Met receptor
    • Michieli, P., et al. 2004. Targeting the tumor and its microenvironment by a dual-function decoy Met receptor. Cancer Cell. 6:61-73.
    • (2004) Cancer Cell , vol.6 , pp. 61-73
    • Michieli, P.1
  • 45
    • 0034040751 scopus 로고    scopus 로고
    • Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences
    • Follenzi, A., Ailles, L.E., Bakovic, S., Geuna, M., and Naldini, L. 2000. Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat. Genet. 25:217-222.
    • (2000) Nat. Genet. , vol.25 , pp. 217-222
    • Follenzi, A.1    Ailles, L.E.2    Bakovic, S.3    Geuna, M.4    Naldini, L.5
  • 46
    • 0026734672 scopus 로고
    • Structure-function analysis of hepatocyte growth factor: Identification of variants that lack mitogenic activity yet retain high affinity receptor binding
    • Lokker, N.A., et al. 1992. Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding. EMBO J. 11:2503-2510.
    • (1992) EMBO J. , vol.11 , pp. 2503-2510
    • Lokker, N.A.1
  • 47
    • 0026722243 scopus 로고
    • Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
    • Bussolino, F., et al. 1992. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J. Cell Biol. 119:629-641.
    • (1992) J. Cell Biol. , vol.119 , pp. 629-641
    • Bussolino, F.1
  • 48
    • 0036171327 scopus 로고    scopus 로고
    • Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors
    • Follenzi, A., Sabatino, G., Lombardo, A., Boccaccio, C., and Naldini, L. 2002. Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors. Hum. Gene Ther. 13:243-260.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 243-260
    • Follenzi, A.1    Sabatino, G.2    Lombardo, A.3    Boccaccio, C.4    Naldini, L.5
  • 49
    • 0032483531 scopus 로고    scopus 로고
    • Cooperative interaction between alpha- And beta-chains of hepatocyte growth factor on c-Met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses
    • Matsumoto, K., Kataoka, H., Date, K., and Nakamura, T. 1998. Cooperative interaction between alpha- and beta-chains of hepatocyte growth factor on c-Met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses. J. Biol. Chem. 273:22913-22920.
    • (1998) J. Biol. Chem. , vol.273 , pp. 22913-22920
    • Matsumoto, K.1    Kataoka, H.2    Date, K.3    Nakamura, T.4
  • 50
    • 3142595278 scopus 로고    scopus 로고
    • Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor
    • Stamos, J., Lazarus, R.A., Yao, X., Kirchhofer, D., and Wiesmann, C. 2004. Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. EMBO J. 23:2325-2335.
    • (2004) EMBO J. , vol.23 , pp. 2325-2335
    • Stamos, J.1    Lazarus, R.A.2    Yao, X.3    Kirchhofer, D.4    Wiesmann, C.5
  • 51
    • 4544338194 scopus 로고    scopus 로고
    • Structural and functional basis of the serine protease-like HGF beta-chain in Met binding and signaling
    • Kirchhofer, D., et al. 2004. Structural and functional basis of the serine protease-like HGF beta-chain in Met binding and signaling. J. Biol. Chem. 279:39915-39924.
    • (2004) J. Biol. Chem. , vol.279 , pp. 39915-39924
    • Kirchhofer, D.1
  • 52
    • 0026485023 scopus 로고
    • A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis
    • Hartmann, G., et al. 1992. A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc. Natl. Acad. Sci. U. S. A. 89:11574-11578.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 11574-11578
    • Hartmann, G.1
  • 53
    • 15244346073 scopus 로고    scopus 로고
    • Urokinase plasminogen activator system: A multifunctional role in tumor progression and metastasis
    • Choong, P.F., and Nadesapillai, A.P. 2003. Urokinase plasminogen activator system: a multifunctional role in tumor progression and metastasis. Clin. Orthop. 415:546-558.
    • (2003) Clin. Orthop. , vol.415 , pp. 546-558
    • Choong, P.F.1    Nadesapillai, A.P.2
  • 54
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch, S.M., and Francis, H. 1994. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124:619-626.
    • (1994) J. Cell Biol. , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 55
    • 0034278156 scopus 로고    scopus 로고
    • Lentiviral vectors: Excellent tools for experimental gene transfer and promising candidates for gene therapy
    • Vigna, E., and Naldini, L. 2000. Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy. J. Gene Med. 2:308-316.
    • (2000) J. Gene Med. , vol.2 , pp. 308-316
    • Vigna, E.1    Naldini, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.