Retention of biologic activity of human epidermal growth factor following conjugation to a blood-brain barrier drug delivery vector via an extended poly(ethylene glycol) linker

Bioconjugate Chemistry

Volumn 10, Issue 1, 1999, Pages 32-37

  Deguchi, Yoshiharu ^a   Kurihara, Atsushi ^a   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; BRAIN; COENZYMES; CONTROLLED DRUG DELIVERY; ETHYLENE GLYCOL; MONOCLONAL ANTIBODIES; PEPTIDES; POLYOLS; TARGETED DRUG DELIVERY; TUMORS;

BIOLOGIC ACTIVITIES; BLOOD-BRAIN BARRIER; DELIVERY VECTOR; EPIDERMAL GROWTH FACTOR RECEPTORS; EPIDERMAL GROWTH FACTORS; GLIOMA CELLS; HUMAN BRAIN; HUMAN EPIDERMAL GROWTH FACTOR; SPACER ARMS; STREPTAVIDIN;

POLYETHYLENE GLYCOLS;

EID: 0032894155     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc9800522     Document Type: Article

References (21)

1. Torp, S. H., Helseth, E., Dalen, A., and Unsgaard, G. (1991) Epidermal growth factor receptor expression in human gliomas. Cancer Immunol. Immunother. 33, 61-64.
2. Fenstermaker, R. A., Capala, J., Barth, R. F., Hujer, A., Kung, H.-J., and Kaetzel, D. M. (1995) The effect of epidermal growth factor receptor (EGFR) expression on in vivo growth of rat C6 glioma cells. Leukemia 9 (Suppl. 1), S106-S112.
3. Nave, K. A., Probstmeier, R., and Schachner, M. (1985) Epidermal growth factor does not cross the blood-brain barrier. Cell Tissue Res. 241, 453-457.
4. Blasberg, R. G., and Groothuis, D. R. (1986) Chemotherapy of brain tumors: physiological and pharmacokinetic considerations. Sem. Oncol. 13, 70-82.
5. Inamura, T., and Black, K. L. (1994) Bradykinin selectively opens blood-tumor barrier in experimental brain tumors J. Cereb. Blood Flow Metabol. 14, 862-870.
6. Pardridge, W. M. (1991) Peptide Drug Delivery to the Brain, pp 1-357, Raven Press, New York.
7. Bickel, U., Yoshikawa, T., Landaw, E. M., Faull, K. F., and Pardridge, W. M. (1993) Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery. Proc. Natl. Acad. Sci. 90, 2618-2622.
8. Wu, D., Yang, J., and Pardridge, W. M. (1997) Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor. J. Clin. Invest. 100, 1804-1812.
9. Bickel, U., Kang, Y.-S., and Pardridge, W. M. (1995) In vivo cleavage of a disulfide-based chimeric opioid peptide in rat brain. Bioconjugate Chem. 6, 211-218.
10. Papini, E., Rappuoli, R., Murgia, M., and Montecucco, C. (1993) Cell penetration of diptheria toxin. J. Biol. Chem. 268, 1567-1574.
11. Sakane, T., and Pardridge, W. M. (1997) Carboxyl-directed pegylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity. Pharm. Res. 14, 1085-1091.
12. Wu, D., and Pardridge, W. M. (1996) CNS pharmacologic effect in conscious rats after intravenous injection of a biotinylated vasoactive intestinal peptide analogue coupled to a blood-brain barrier drug delivery system. J. Pharmacol. Exp. Ther. 279, 77-83.
13. Libermann, T. A., Nusbaum, H. R., Razon, N., Kris, R., Lax, I., Soreq, H., Whittle, N., Waterfield, M. D., Ullrich, A., and Schlessinger, J. (1984) Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 313, 144-147.
14. Wong, A. J., Bigner, S. H., Bigner, D. D., Kinzler, K. W., Hamilton, S. R., and Vogelstein, B. (1987) Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc. Natl. Acad. Sci. U.S.A. 84, 6899-6903.
15. Kalofonos, H. P., Pawlikowska, T. R., Hemingway, A., Courtenay-Luck, N., Dhokia, B., Snook, D., Sivolapenko, G. B., Hooker, G. R., McKenzie, C. G., Lavender, P. J., Thomas, D. G. T., and Epenetos, A. A. (1989) Antibody guided diagnosis and therapy of brain gliomas using radiolabeled monoclonal antibodies against epidermal growth factor receptor and placental alkaline phosphatase. J. Nucl. Med. 30, 1636-1645.
16. Rubin, P., Gash, D. M., Hansen, J. T., Nelson, D. F., and Williams, J. P. (1994) Disruption of the blood-brain barrier as the primary effect of CNS irradiation. Radiother. Oncol. 31, 51-60.
17. Zhang, R.-d., Price, J. E., Fujimaki, T., Bucana, C. D., and Fidler, I. J. (1992) Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice. Am. J. Pathol. 141, 1115-1124.
18. Hommel, U., Harvey, T. S., Driscoll, P. C., and Campbell, I. D. (1992) Human epidermal growth factor: high-resolution solution structure and comparison with human transforming growth factor α. J. Mol. Biol. 227, 271-282.
19. 111In labeled human epidermal growth factor derivatized with a bifunctional metal-chelating peptide. Bioconjugate Chem. 6, 683-690.
20. Ralph, L. D., Ransone, C. M., Treuheit, M., Lauren, S., Katta, V., and Litzinger, D. C. (1995) Site-specific conjugation of diethylenetriaminepentaacetic acid to recombinant human granulocyte-colony-simulating factor: preservation of protein structure and function. Biochemistry 34, 4889-4897.
21. Gospodarowicz, D., Brown, K. D., Birdwell, C. R., and Zetter, B. R. (1978) Control of proliferation of human vascular endothelial cells. J. Cell Biol. 77, 774-788.