The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 51, 2006, Pages 19478-19483

  Podar, Klaus ^a   Tonon, Giovanni ^a   Sattler, Martin ^a   Tai, Yu Tsu ^a   LeGouill, Steven ^a,b   Yasui, Hiroshi ^a   Ishitsuka, Kenji ^a   Kumar, Shaji ^c   Kumar, Rakesh ^d   Pandite, Lini N ^d   Hideshima, Teru ^a   Chauhan, Dharminder ^a   Anderson, Kenneth C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NANTES UNIVERSITY HOSPITAL   (France)

^c MAYO CLINIC   (United States)

^d GLAXOSMITHKLINE   (United States)

Author keywords

Angiogenesis; Xenograft mouse model

Indexed keywords

BORTEZOMIB; DEXAMETHASONE; DOXORUBICIN; IMMUNOMODULATING AGENT; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MELPHALAN; MYC PROTEIN; PAZOPANIB; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR INHIBITOR;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL GROWTH; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; DEPIGMENTATION; DRUG CYTOTOXICITY; ENDOTHELIUM CELL; FATIGUE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HYPERTENSION; IN VITRO STUDY; LOW DRUG DOSE; MOUSE; MULTIPLE MYELOMA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL MOVEMENT; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MICE; MICROARRAY ANALYSIS; MULTIPLE MYELOMA; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS C-MYC; PYRIMIDINES; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 33845882259     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0609329103     Document Type: Article

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